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2 p1 inhibition enhanced calcium signaling and thereby abrogated an anergic response to BCR stimulation
3 to obtain a composite material (PF-TMPPCo), thereby achieving a homogeneous catalysis environment in
5 e best synthesizability and phase stability, thereby achieving the highest conductivity of 2.3 x 10(-
6 e same partners, MtTT8 and MtWD40-1, as RH1, thereby acting as a competitor in the regulatory complex
9 improved aqueous solubility (up to 28-fold), thereby addressing a key shortcoming of this antibiotic.
10 and functional trait profiles and diversity, thereby affecting ecosystem processes of the whole tundr
11 P degraded p3 through the autophagy pathway, thereby affecting the silencing suppression activity of
14 potentially elucidate mechanisms of injury, thereby aiding the medical diagnosis and decision-making
16 nd CD38 inhibition improved NAD homeostasis, thereby alleviating telomere damage, defective mitochond
17 formalisms), and genetic repressor kinetics, thereby allowing a large class of models to be transform
18 ring ESC differentiation de-represses Dot1l, thereby allowing coordinated expression of differentiati
19 f the reaction with the organozinc reagents, thereby allowing for the synthesis of cyclic and acyclic
21 tery cell as a resonator in a tuned circuit, thereby allowing signals to be excited inside the cell,
22 cenario associated with CcMADS19 repression, thereby allowing the activation of CiFT2 the following c
23 regulating chromatin accessibility changes, thereby allowing the activation of gene expression progr
24 -cysteine depleted both NADPH and GSH pools, thereby allowing toxic accumulation of reactive oxygen s
25 extensive, highly selective loss of DG GCs (thereby also reinforcing the notion of selective DG vuln
28 in de-epoxidase requires Asc as a reductant; thereby, Asc is required for the energy-dependent compon
29 orods and the stability of their assemblies, thereby assisting the design of ordered, anisotropic nan
31 the activity of protein phosphatase 2A, and thereby attenuates the phospho-Ser-127 modification and
32 ors from triggering nitric oxide production, thereby attenuating the flow increase evoked by neural a
34 classic miR-146a targets (IRAK1 and TRAF6), thereby blocking activation of NF-kappaB in target cells
35 HSP27 phosphorylation and depolymerization, thereby blocking HSP27-regulated survival signaling and
36 ese projects in other low-resource settings, thereby bringing genomic medicine in these countries clo
38 ness in response to increasing temperatures, thereby "buying time" for subsequent genetic adaptation
39 ral modulations on face scanning strategies, thereby challenging the notion of universality in face p
40 ssociation of individual replisome subunits, thereby challenging the notion that lagging-strand DNA p
41 ors continuously logging absorbance spectra, thereby challenging their applicability for monitoring.
42 nfidence judgments varied across conditions, thereby changing the amount of action information (e.g.,
44 sional (2D) (15)N-(1)H NMR correlations, and thereby combining an enhanced spectral resolution with s
45 leads to the selective reaction of graphene, thereby completing direct laser writing on graphene towa
47 therwise MHC class I-deficient C57BL/6 mice, thereby conditionally ablating MHC class I-restricted Ag
48 , upregulates inflammatory genes in DTPs and thereby confers susceptibility to anti-inflammatory gluc
49 properly suspended when they are not needed, thereby conserving energy for growth and development.
51 the monocyte chemoattractants CCL2 and CCL7, thereby contributing to the replenishment of the RPM net
52 ration, proliferation and immune reactivity, thereby contributing to tumour immune evasion and promot
53 low resistance of all brain vessel segments, thereby controlling capillary flow while protecting the
54 by-area fixed effects in all specifications, thereby controlling for overall trends in antidepressant
55 tuned through the addition of a surfactant, thereby controlling the surface energies, which then lea
56 ion-specific neuronal differentiation genes, thereby controlling the timing of neuronal maturation.
57 creates intranuclear polarity in emerin, and thereby controls nuclear actin filaments that spatially
58 lls and migrate along the midgut epithelium, thereby conveying endosymbionts to midgut sites where fu
59 This step may activate ESCRT proteins and thereby coordinate ESCRT function with virion assembly.
60 is upregulated under obesity conditions and thereby counteracts inflammation of peripheral insulin-s
61 ectively reduces oxidized actin monomers and thereby counteracts MICAL1, an enzyme known to depolymer
62 ost, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thur
63 on-quiescence decision in daughter cells and thereby couples protein production with cell proliferati
64 s to supporting inclusivity in cell biology, thereby creating a future where diversity, equity, and i
65 on global network states and state changes, thereby creating a unifying account of local influences
66 d/or infiltration of microglia to the region thereby curtailing the deleterious consequences of neuro
67 of Class I histone deacetylases (HDACs 1/2), thereby decreased histone acetylation of H3K9/14ac and H
69 PG polymerization by the FtsWI synthase and thereby define an essential regulatory step in the proce
70 ) to detect poorly soluble natural products, thereby defining a form of contact-dependent, aquatic ch
71 s were subjected to accurate quantification, thereby defining operative ranges to accept/reject incom
72 ptional upregulation and expression of KCC2, thereby delaying the GABA switch in pups of both sexes.
73 giogenic process in normal dermal wounds and thereby delays healing, whereas the stimulation of dopam
74 rosetta C-type lectin gene, rosetteless, and thereby demonstrate its necessity for multicellular rose
75 on through the EGF receptor/ERK/Fos pathway, thereby demonstrating a potential neuroprotective mechan
76 excellent yields and with high selectivity, thereby demonstrating its broad utility and functional g
77 multivoxel patterns; optimal action policies thereby depend on multidimensional brain activity taking
79 onitor liver-attenuation more accurately and thereby detect liver steatosis as a sign of liver damage
80 ematic investigation of the above issues and thereby development of optimal strategies for accurate t
85 9orf72-HRE impairs Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerbating proteostas
86 at activates C-terminal Src kinase (CSK) and thereby down-regulates kinases involved in proximal TCR
87 r down, altering viscoelastic properties and thereby driving immiscibility between different condensa
88 d HSP70 dimers, which leaves them intact and thereby eliminates an inhibitory effect of TOMM34 on HSP
90 ccessibility and photoreceptor degeneration, thereby elucidating a potential new therapeutic strategy
91 alkylates RNA at high levels in seconds, and thereby enables time-resolved, single-molecule, through-
92 ria secrete and sense a diffusible molecule, thereby enabling bacterial groups to coordinate their be
93 dy can be used to trap GFP in the cell body, thereby enabling direct visualization of previously unde
94 ith fast kinetics and exquisite selectivity, thereby enabling facile modification of NCys-bearing pro
95 t the bifurcation anatomy and plaque burden, thereby enabling planning, education, and decision makin
96 ing to substantially reduce measurement time thereby enabling the acquisition of reasonably large tra
97 llow expanding current screening capacities, thereby enabling the expansion of detection in the commu
98 Beclin-1 from LRPPRC-mediated sequestration, thereby enabling the initialization of downstream autoph
99 tor, carboxy-S-adenosyl-l-ethionine (cxSAE), thereby enabling the stereoselective transfer of a chira
102 ass by oxidatively cleaving polysaccharides, thereby enhancing the efficiency of glycoside hydrolases
103 inciple within real-life cultural processes, thereby enriching both sociocultural theories and Bayesi
104 r adequate expression of maternal behaviour, thereby ensuring proper development of the offspring.
108 HD1 loss results in chromatin dysregulation, thereby establishing a state of transcriptional plastici
109 nsion of the 5'Hoxd second expression phase, thereby establishing anterior-posterior asymmetry in the
110 ably maintains methylation over generations, thereby establishing the robustness of the epigenetic co
111 ath, inflammation, and immune responses, and thereby exert both adaptive and maladaptive roles in dis
112 ce the evolution of oxygenic photosynthesis, thereby exerting key influence on Earth's climate and th
113 nt organic and metal cation functionalities, thereby expanding the key physicochemical properties tha
114 nding of miRNA-AGO complexes to target RNAs, thereby explaining the basis of cooperative action.
115 ndent of methyltransferase activity or PRC2, thereby facilitating DDB2 localization to cyclobutane py
116 nd macrophages carry out hematoma clearance, thereby facilitating functional recovery after ICH.
117 nd promotes PMN apoptosis and efferocytosis, thereby facilitating resolution of E. coli-evoked lung i
118 te to such a teaching signal for plasticity, thereby facilitating the formation of fear memories.
119 gens spread and the impact of interventions, thereby facilitating the safe reopening of schools.
120 m conventional diagnostics and therapeutics, thereby facilitating their clinical applications in a ra
121 ons alter mitochondrial dynamics in neurons, thereby facilitating viral replication and pathogenesis.
123 e graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues.
124 osomes with the non-canonical histone H2A.Z, thereby focusing the pathway on select sites such as tra
125 erentiation of immature Schwann cells (SCs), thereby forming and maintaining the myelin sheath around
126 e the potential to generate new myocytes and thereby fulfill an essential central criterion for heart
127 ovided substantial insights into PC biology, thereby further enhancing our understanding of PC popula
128 gnals that guide vascular fate and assembly, thereby further informing our understanding of different
129 ed 6 trillion liters of oil from the ground, thereby giving a striking illustration of the impact of
130 ints on the backbone to the gold electrodes, thereby giving rise to multiple conductance pathways.
131 ing of reef geography and its human impacts, thereby guiding environmental management for reef resili
133 change factor eIF2B to block eIF2 recycling, thereby halting translation initiation and reducing glob
134 etection of certain GPL classes over others, thereby hampering the analysis of suppressed species and
136 ncorporation of trace impurities in TiO(2) , thereby, having a strong effect on applications in energ
137 educed lipopolysaccharides content in blood, thereby helping to reduce systemic inflammation and reve
138 o the field of far-IR spectroscopy is given, thereby highlighting the opportunities that are provided
139 fluorine-substituted cyclohexene analogues, thereby identifying 8 and 9 as novel selective hOAT time
140 variance and covariance in risk for disease, thereby identifying underlying biological processes and
141 es the position of the coding nucleotide and thereby impacts the identity of the incoming nucleotide.
142 ke volume, cardiac output and O(2) delivery, thereby impairing VO2 peak and thus exercise capacity.
143 biont strain, then embryos develop properly, thereby imparting a relative fitness benefit to symbiont
145 t (HFD)-induced adipose tissue inflammation, thereby improving adipose tissue and hepatic insulin sen
146 broadly attenuate sympathetic dysregulation, thereby improving cardiovascular regulation and immunity
148 lant responses to eCO(2) under P limitation, thereby improving projections of future global change im
149 ees -view increases small-bowel CE accuracy, thereby improving the clinical management of CD patients
152 sion of thrombin-induced phosphorylation and thereby inactivation of Cofilin1, an actin-depolymerizin
154 n for both signal extraction and scoring and thereby increase the specificity for precursor identific
158 ood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when o
159 wanella oneidensis MR-1 to a gold electrode, thereby increasing biocurrent ~150-fold over control bio
160 nd to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as
161 roxymethylation of genes important for GSCs, thereby increasing GSC tumorigenicity and resistance to
162 enerates modifications to the RNA sequences, thereby increasing protein diversity and shaping various
163 ulation to exchange cell surface components, thereby increasing survival during mammalian infection.
166 n the electrolyte surrounding the electrode, thereby increasing the sensitivity of the SWV-based dete
167 of the channel in the top virus-PEDOT layer, thereby increasing the sensitivity of the VBR and enabli
169 and 3.2 Ga and soon afterwards disappeared, thereby indicating a complex ancient Martian hydrosphere
170 for degradation products of sulfur mustard, thereby indicating suitability of the SMS-PID unit for f
176 istribution of tumor cells within an animal, thereby influencing the global pattern of metastasis in
178 the conversion of l-tyrosine to dopaquinone, thereby initiating melanin synthesis, i.e., melanogenesi
179 , and histone modifiers to engage chromatin, thereby initiating the formation of an activating or rep
180 urfs downslope along an elevational gradient thereby introducing them to warmer climates and novel pl
181 inferred relationships that include reward, thereby "joining-the-dots" between events that have not
182 NMDP induces PDE3A-SLFN12 complex formation, thereby killing cancer cells with high levels of PDE3A a
187 ng during imaging with high-speed detectors, thereby lessening demands on cryostage precision and sta
188 phosphine reduction of azide trigger groups, thereby liberating the individual RNA components for fur
189 nteraction of the CaM N-domain with RyR2 and thereby likely cause the arrhythmogenic phenotype of thi
190 ligand-binding modes of FPR2 remain elusive, thereby limiting the development of potential drugs.
191 f inducing a profound cell state transition, thereby linking genomic plasticity, phenotypic plasticit
192 the inositol trisphosphate receptor (IP3R), thereby linking the endo-/sarcoplasmic reticulum to the
193 tin expression on erythroid precursor cells, thereby lowering potentially toxic-free intracellular ir
194 ystems by releasing drug at a constant rate, thereby maintaining drug concentrations within the thera
196 cluding appropriate rehabilitative services, thereby maintaining health, productivity, and quality of
197 a gatekeeper of presequence translocase and thereby maintains quality control of inner membrane prep
199 iptional regulation, and RNA processing, and thereby mediating developmental and metabolic processes
200 s with lifetimes as long as 61 microseconds, thereby mimicking the functions of the natural systems.
202 novel therapeutic strategy to restore PTEN, thereby obliterating PTEN deficiency-induced malignancie
203 homeostatic reduction in ribosomal subunits, thereby offering a mechanism for the suppression results
204 r reductively monofunctionalized byproducts, thereby offering rapid access to these privileged scaffo
205 ion of chitin from shrimp shell waste (SSW), thereby offering water-soluble chitin hydrolysates for t
206 ioners to facilitate targeted interventions, thereby, offering an immediate prognostic approach as th
207 mesenchymal-myeloid unit of the distal lung, thereby opening numerous new avenues to study lung devel
213 edd8 conjugated VHL is unable to bind to p53 thereby preventing the induction of antiangiogenic facto
214 only recognizes cultures as 'type material', thereby preventing the naming of uncultivated organisms.
215 termediate acceptors of cellular-derived UC, thereby preventing the saturation of HDL particles and f
216 rystals enables ordered grain growth and can thereby produce material samples with uniform GB defects
218 ithin interphase bridges and then shattered, thereby producing micronuclei whose encapsulated ecDNAs
221 uctures in the bacterial plasma membrane and thereby promotes rapid permeabilization of the plasma me
222 it tumor progression by stabilizing LATS and thereby promoting activity of the Hippo tumor suppressor
223 1)-DNA complexes trapped by PARP inhibitors, thereby promoting cell survival after drug treatment.
228 stabilization of the domain-domain interface-thereby promoting the allosteric transition that trigger
229 ates non-degradative ubiquitination of TSC1, thereby promoting TSC1-TSC2 dimerization and TSC2 stabil
230 he nascent A-tail from uridylation and decay thereby protecting pre-mRNA upon KPAF3 displacement by e
231 age in decision processing on single trials, thereby providing a detailed picture of the network dyna
232 found to affect the local glycan processing, thereby providing a molecular basis of the site-specific
233 ergent functionality of the heterostructure, thereby providing a new approach to designing oxide hete
234 gether to form intralamellar water channels, thereby providing a pathway for the permeation of hydrop
235 distinct gene sets at each transition point, thereby providing an accurate transcriptional timeline f
236 s associated with the stepwise condensation, thereby providing critical information for a variety of
237 pplied to interpretation of literature data, thereby providing more rigorous insights into previous o
239 rmula: see text] compounds may now be drawn, thereby providing suggestions for additional experiments
240 Fe site has a suitable coordination number, thereby providing support for the intermediacy of organo
241 iPr(i) (2) CHMeCH(2) )}] (4) by thermolysis; thereby, providing an unprecedented example of reductive
242 e depth of synthesized vector DNA libraries, thereby raising the discovery cost of novel vectors.
244 der of magnitude below the background value, thereby realizing a long-lived sample of polar molecules
245 ote rapid Cdk8-dependent Notch turnover, and thereby reduce Notch-dependent transcription at other lo
250 mal tubule, these agents promote glycosuria, thereby reducing blood glucose concentrations and often
251 sample collected from a single cultivation, thereby reducing by a factor of 2 both the number of cul
252 hotel" to simultaneously image up to 4 mice, thereby reducing costs and maximizing the efficiency of
253 r latent HIV reactivation in CNS reservoirs, thereby reducing HIV-associated neuroinflammation.IMPORT
256 itude current and desensitize the receptors, thereby reducing the peak amplitude of subsequent synapt
257 umor volumes, angiogenesis, and oxygenation, thereby reflecting its effectiveness for extending progr
260 K and PI3K-Akt signaling pathway activation, thereby regulating cementoblast function and affecting I
263 of Uqcrb, and with the 5'UTR of Ndufb6 mRNA, thereby regulating the splicing of Apob mRNA and the tra
264 ABA(A)R accumulation at inhibitory synapses, thereby regulating the strength of synaptic inhibition.
268 ciency governs monogenic TCRbeta expression, thereby restraining the expression of multiple AgRs on a
269 s a phenotypic trait beyond a tipping point, thereby resulting (after a substantial delay) in a selec
270 tion can be excessive and/or become chronic, thereby resulting in considerable tissue damage and path
271 he feedback to down-regulate Spo11 activity, thereby revealing an additional function for the SC.
272 extends to both size and spatial topologies, thereby rivaling the synaptic specificity of chemical sy
273 PFL9 help to coordinate ovule patterning and thereby seed number with gynoecium and fruit growth thro
274 al expression in the glandular trichomes and thereby seem to be potential candidate genes for future
275 formation that can bind specific DNA motifs, thereby serving to either activate or repress transcript
276 l layers represent perceptual hypotheses and thereby shed light on the computational architecture of
277 light reflex and circadian photoentrainment, thereby shifting the dynamic range of these behaviors to
279 s in cells of mammals, flies, and nematodes, thereby specifying the half-lives of most short-lived mi
280 nd modification of a nearby cysteine (C665), thereby stabilizing the loop in an activating configurat
281 ctivate chemoreflex and suppress baroreflex, thereby stimulating the sympathetic nervous system and c
283 ed depend on the type of gene and/or stress, thereby suggesting a 'personalized', rather than general
284 HIV-1 replication in primary CD4(+) T cells, thereby suggesting that Tim-3 expression might represent
285 ysulfides target the caspase-9/3 cascade and thereby suppress cancer cell apoptosis, and highlight th
288 rized, those that maintain the symmetry, and thereby the stability of the synapse, remain unknown.
290 ctor Ndt80 upstream of the integration site, thereby tightly linking its transcriptional activation t
291 om the extracellular matrix to tendon cells, thereby triggering cell signaling pathways which lead to
292 site-specific phosphorylation of protamine, thereby triggering protamine-to-histone exchange in the
294 maller than those found in related hydrides, thereby violating the so-called Switendick criterion.
298 rogram toward ferroptosis in cardiomyocytes, thereby worsening the progression of diabetic cardiomyop
299 ange rates between the amides and the water, thereby yielding diagnostic information about solvent ac