ライフサイエンスコーパス: thiamin

1 ynthesis of vitamins B6 (pyridoxine) and B1 (thiamin).

2 al or a nonsuicidal THI4, or by catabolizing thiamin.

3 monstrated how TbpA binds all three forms of thiamin.

4 ates the precursor of the TPK reaction, free thiamin.

5 d in the synthesis of the thiazole moiety of thiamin.

6 r basis of specificity for the HMP moiety of thiamin.

7 estinal thiamin uptake was measured using [H]thiamin.

8 itive effect of LNSs for all vitamins except thiamin.

9 biosynthesis with riboswitches in the THI4 (Thiamin 4) and THIC (Thiamin C) genes, respectively, to

10 hanges due to milling were most profound for thiamin (-69%), IDF (-66%) followed by phytate (-66%).

11 Thiamin, a water-soluble B-complex vitamin, functions as

12 carrier) could provide sufficient intestinal thiamin absorption.

13 complex with 3-deazathiamin, a noncleavable thiamin analog and enzyme inhibitor (2.7 A; R, 0.233; Rf

14 atography analysis reveals that the level of thiamin and its derivatives in Ixodes scapularis ticks,

15 , 2 nutrients were selected as case studies: thiamin and phosphorus (DRIs were last set in 1998 and 1

16 Thiamin and thiamin pyrophosphate (TPP) are well known f

17 Taken together, our studies suggest that thiamin and TPP function as important stress-response mo

18 inity, and oxidative treatments, accumulated thiamin and TPP.

19 and reveal an unanticipated intersection of thiamin and vitamin B12 biosynthesis.

20 n (FES) (d-glucose, d-ribose, l-cysteine and thiamin) and of sous-vide cooking or roasting on moistur

21 rly effective at increasing milk riboflavin, thiamin, and pyridoxal and infant intakes, whereas only

22 , ascorbic acid, biotin, folate, riboflavin, thiamin, and pyridoxine).

23 h it attenuated the associations of folacin, thiamin, and riboflavin intake with BP.

24 Thiamin application was also found to protect the reacti

25 This enzyme is able to use thiamin as a substrate and is active with amines such as

26 be significantly compromised if B vitamins (thiamin B(1), riboflavin B(2), pyridoxine B(6), biotin B

27 ThiY is also structurally homologous to thiamin binding protein (TbpA) and to thiaminase-I.

28 These structures define the mode of thiamin binding to this class of thiaminases and indicat

29 The gene for the thiamin-binding protein tbpA has been identified in both

30 genes coding for lignocellulose degradation, thiamin biosynthesis and cytosolic fatty acid synthase.

31 d for the identification of genes related to thiamin biosynthesis and degradation.

32 Here, we explored the regulation of thiamin biosynthesis and the consequences of thiamin pyr

33 Bb lacks genes for thiamin biosynthesis and transport as well as known ThDP

34 ntification of all of the enzymes needed for thiamin biosynthesis by the major bacterial pathway.

35 , the results also indicate that the rate of thiamin biosynthesis directs the activity of thiamin-req

36 witch act simultaneously to tightly regulate thiamin biosynthesis in a circadian manner and consequen

37 Our results show that thiamin biosynthesis is largely regulated by the circadi

38 ase activity, and the role of this enzyme in thiamin biosynthesis remains unknown.

39 nslated region of this gene controls overall thiamin biosynthesis.

40 hiosugar moiety could resemble that found in thiamin biosynthesis.

41 enhanced expression of transcripts encoding thiamin biosynthetic enzymes.

42 t in the 3' untranslated region (UTR) of the thiamin biosynthetic gene THIC of all plant species exam

43 Hits from the selection included the known thiamin biosynthetic genes thiC, thiE, and dxs as well a

44 s have elucidated most of the details of the thiamin biosynthetic pathway in bacteria.

45 In contrast, details of the thiamin biosynthetic pathway in yeast are only just begi

46 ymethyl)-2-methylpyrimidine phosphate in the thiamin biosynthetic pathway of eukaryotes and is approx

47 methylpyrimidine (HMP) and recycled into the thiamin biosynthetic pathway.

48 sults suggest that by dispensing with use of thiamin, Borrelia, and perhaps other tick-transmitted ba

49 The configuration of the predecarboxylation thiamin-bound intermediate was clarified by the structur

50 ct, resembling the common predecarboxylation thiamin-bound intermediate, which exists in its 1',4'-im

51 st hydrolyze thiamin monophosphate (ThMP) to thiamin, but dedicated enzymes for this hydrolysis step

52 A structure suggests that the degradation of thiamin by TenA likely proceeds via the same addition-el

53 the circadian clock via the activity of the THIAMIN C SYNTHASE (THIC) promoter, while the riboswitch

54 boswitches in the THI4 (Thiamin 4) and THIC (Thiamin C) genes, respectively, to investigate this ques

55 Thiamin can also be transported into the cell and can be

56 failure, suggesting that the absence of the thiamin carrier could be overcome by diffusion-mediated

57 ts inclusion in our understanding of general thiamin catalysis is important.

58 C2 position in the first fundamental step of thiamin catalysis.

59 Under conditions of thiamin challenge, the apoptotic cell loss extended to e

60 other eukaryotic organisms and is central to thiamin cofactor activation.

61 s a hitherto unrecognized versatility of the thiamin cofactor.

62 THTR-2-deficient mice had reduced uptake of thiamin compared with those of wild-type littermate mice

63 Erythrocyte thiamin pyrophosphate and urine thiamin concentrations were significantly higher in the

64 , or exercise capacity, despite increases in thiamin concentrations.

65 diffusion-mediated transport at supranormal thiamin concentrations.

66 Because thiamin could protect the salicylic acid induction-defic

67 ds) enabled the observation of the substrate-thiamin covalent intermediate via the 1',4'-iminopyrimid

68 Plants synthesize the thiazole precursor of thiamin (cThz-P) via THIAMIN4 (THI4), a suicide enzyme t

69 Thiamin deficiency is highly prevalent in patients with

70 s, but the mechanism by which sepsis induces thiamin deficiency is unknown.

71 ible to apoptosis triggered by intracellular thiamin deficiency than any other tissue type.

72 In addition, two thiamin degrading enzymes have been characterized, one o

73 A comparison of TbpA and thiaminase-I, a thiamin-degrading enzyme, revealed structural similarity

74 ide variation in the affinities of different thiamin-dependent enzymes for ThTDP and ThDP.

75 Data suggest that thiamin depletion occurs in heart failure (HF).

76 nonical 4'-aminopyrimidine tautomer of bound thiamin diphosphate (AP).

77 ecarboxylation intermediate, C2-alpha-lactyl-thiamin diphosphate (LThDP), which has subsequent decarb

78 2-(C2alpha-hydroxy)-gamma-carboxypropylidene thiamin diphosphate (ThDP) cation radical was detected b

79 Thiamin diphosphate (ThDP) dependent enzymes perform cru

80 previously recognized as involved in binding thiamin diphosphate (ThDP) in all ThDP-dependent enzymes

81 an transfer information to the active center thiamin diphosphate (ThDP) located at the interface of t

82 In the bifunctional coenzyme, thiamin diphosphate (ThDP), both aromatic rings particip

83 To synthesize the cofactor thiamin diphosphate (ThDP), plants must first hydrolyze

84 r-order transition upon substrate binding to thiamin diphosphate (ThDP), play a critical role in modu

85 Thiamin diphosphate (ThDP)-dependent decarboxylations ar

86 The thiamin diphosphate (ThDP)-dependent enzyme 1-deoxy-D-xy

87 determined, three-dimensional structure of a thiamin diphosphate (ThDP)-dependent enzyme containing a

88 eta-lactamase inhibitor, is catalyzed by the thiamin diphosphate (ThDP)-dependent enzyme N2-(2-carbox

89 yde lyase (BAL) from Pseudomonas putida is a thiamin diphosphate (ThDP)-dependent enzyme that catalyz

90 dehydrogenase (BCKD) metabolic machine is a thiamin diphosphate (ThDP)-dependent enzyme with a heter

91 is 2-hydroxy-3-oxoadipate synthase (HOAS), a thiamin diphosphate (ThDP)-dependent enzyme, produces 2-

92 that DXPS is unique among the superfamily of thiamin diphosphate (ThDP)-dependent enzymes in stabiliz

93 Two circular dichroism signals observed on thiamin diphosphate (ThDP)-dependent enzymes, a positive

94 It is widely accepted that, in thiamin diphosphate (ThDP)-dependent enzymes, much of th

95 boxylase (BFDC), which carries out a typical thiamin diphosphate (ThDP)-dependent nonoxidative decarb

96 with greater affinity than does the cofactor thiamin diphosphate (ThDP).

97 C2-(2alpha-hydroxy)-gamma-carboxypropylidene thiamin diphosphate (the "ThDP-enamine"/C2alpha-carbanio

98 ge of ( R)-benzoin to benzaldehyde utilizing thiamin diphosphate and Mg (2+) as cofactors.

99 nt addition of substrate to the enzyme-bound thiamin diphosphate by reducing the free energy of activ

100 gest that the 4'-aminopyrimidine ring of the thiamin diphosphate coenzyme participates in catalysis,

101 tabolic fluxes during episodes of organellar thiamin diphosphate deficiency.

102 for the internal thermodynamic equilibria on thiamin diphosphate enzymes for the various ionization a

103 forms of the 4'-aminopyrimidine ring on four thiamin diphosphate enzymes, all of which decarboxylate

104 This finding is likely a general feature of thiamin diphosphate enzymes.

105 nzymes is almost certainly applicable to all thiamin diphosphate enzymes: this tautomer is the intram

106 ompounds; thiamin, thiamin monophosphate and thiamin diphosphate in bovine milk.

107 ion resulting from the binding of MBP to the thiamin diphosphate in the active centers.

108 dine and iminopyrimidine tautomeric forms of thiamin diphosphate on enzymes has enabled us to assign

109 o tautomer of the 4'-aminopyrimidine ring of thiamin diphosphate recently found to exist on the pathw

110 stent with its assignment to the 1',4'-imino thiamin diphosphate tautomer on the enzyme, chiral by vi

111 It requires thiamin diphosphate to bring about the decarboxylation o

112 Thiamin diphosphate, a key coenzyme in sugar metabolism,

113 on pathways, yet this has been possible with thiamin diphosphate, in some cases even in the absence o

114 Thiamin diphosphate, the vitamin B1 coenzyme, plays crit

115 Benzoylformate decarboxylase (BFDC) is a thiamin diphosphate- (ThDP-) dependent enzyme acting on

116 e analog that is capable of forming a stable thiamin diphosphate-bound covalent intermediate.

117 Direct spectroscopic observation of thiamin diphosphate-bound intermediates was achieved on

118 en the PDHc-E1 and PDHc-E2 subunits: (1) the thiamin diphosphate-bound substrate on PDHc-E1 and the l

119 nsketolase domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-o

120 xylase from Pseudomonas putida (PpBFDC) is a thiamin diphosphate-dependent enzyme that carries out th

121 The hypothesis that thiamin diphosphate-dependent enzymes achieve a signific

122 on between subunits when the entire class of thiamin diphosphate-dependent enzymes is considered.

123 C) and pyruvate decarboxylase (PDC) are both thiamin diphosphate-dependent enzymes.

124 d compared to the complex of the enzyme with thiamin diphosphate.

125 able thiazolium salt 5, a simple analogue of thiamin diphosphate.

126 ly and reduced binding affinity for cofactor thiamin diphosphate.

127 f enzymes that are dependent on the cofactor thiamin diphosphate.

128 nnecting the 4'-aminopyrimidine N1' atoms of thiamin diphosphates (ThDPs) in the two active centers o

129 the reduced-folate (encoded by SLC19A1) and thiamin (encoded by SLC19A2) transporters.

130 he keto tautomer is a general feature of all thiamin enzymes, as it could provide for stable storage

131 efficiently under the repressing effects of thiamin, especially in medium lacking pyridoxine and wit

132 measured content of all ingredients (except thiamin) exceeded labeled amounts (overages).

133 BP, and dietary phosphorus, magnesium, iron, thiamin, folacin, and riboflavin were inversely associat

134 ber of the bacterially synthesized vitamins (thiamin, folate, biotin, riboflavin, pantothenic acid) h

135 nzymatic synthesis of the thiazole moiety of thiamin from glycine, cysteine, and deoxy-D-xylulose-5-p

136 ntly higher in the placebo group than in the thiamin group (38%; 95% CI: 36%, 39% compared with 35%;

137 in vivo using BcmE, an enzyme that degrades thiamin, has no impact on Bb growth and survival during

138 nique biosynthesis of the thiazole moiety of thiamin in eukaryotes.

139 THTR-2 is required for normal uptake of thiamin in the intestine and can fulfill normal levels o

140 and examined the role of THTR-2 in uptake of thiamin in the intestine of mice.

141 Animals must have thiamin in their diet, whereas bacteria, fungi, and plan

142 However, intestinal uptake of thiamin in THTR-1-deficient mice was not significantly d

143 out and used to examine intestinal uptake of thiamin in vitro (isolated cells) and in vivo (intact in

144 We showed that eliminating thiamin in vitro and in vivo using BcmE, an enzyme that

145 -deficient1 mutant against oxidative stress, thiamin-induced oxidative protection is likely independe

146 Thiamin-induced tolerance to oxidative stress was accomp

147 s revealed that under conditions of standard thiamin intake, tissues affected in the syndrome (pancre

148 anism by which exogenous and de novo derived thiamin is converted to the enzyme cofactor TPP.

149 ere, we report the unprecedented result that thiamin is dispensable for the growth of the Lyme diseas

150 novo via a massively expressed THI4 and that thiamin is not involved.

151 Thiamin is synthesized by most prokaryotes and by eukary

152 al changes in MVT emission, extractable MVT, thiamin level, and THI4 expression indicated that C. bic

153 amin-responsive megaloblastic anemia, plasma thiamin levels are within normal range, indicating that

154 ssociated with a decrease (P < .01) in blood thiamin levels in THTR-2-deficient mice.

155 s iron-sulfur (FeS) clusters, molybdopterin, thiamin, lipoic acid, biotin, and the thiolation of tRNA

156 nine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and

157 on on how modulation of riboswitches affects thiamin metabolism in vivo.

158 Our study reveals that regulation of thiamin metabolism is not the simple dogma of negative f

159 identified or characterized for its role in thiamin metabolism.

160 74.3) mug; Control: 34.5 (30.0, 39.6) mug], thiamin [milk: Bolus: 10.9 (10.1, 11.7) mug . min-1 . mL

161 orimetric data confirmed that YkoF binds two thiamin molecules with varying affinities and a thiamine

162 oxylates are involved in the biosynthesis of thiamin, molybdopterin, thioquinolobactin, and cysteine.

163 domly assigned to receive either 200 mg oral thiamin mononitrate per day or placebo for 6 mo.

164 hosphate (ThDP), plants must first hydrolyze thiamin monophosphate (ThMP) to thiamin, but dedicated e

165 talyzes the ATP-dependent phosphorylation of thiamin monophosphate (TMP) to form thiamin pyrophosphat

166 nation vitamin B1 active compounds; thiamin, thiamin monophosphate and thiamin diphosphate in bovine

167 Thiamin monophosphate kinase (ThiL) catalyzes the ATP-de

168 similar dissociation constants for thiamin, thiamin monophosphate, and thiamin pyrophosphate.

169 d milk samples showed significant amounts of thiamin monophosphate, which can make up to 53.9% of the

170 al structure of TbpA from E. coli with bound thiamin monophosphate.

171 genous sources or through de novo synthesis, thiamin must be pyrophosphorylated for cofactor activati

172 Moisture, phenolic compounds, thiamin, niacin, and tocopherols decreased, whereas, fat

173 F products could cover the nutrient gaps for thiamin, niacin, iron, and folate (range: 22-86% of the

174 um derivative, N1'-methyl-2-(1-hydroxybenzyl)thiamin (NMHBnT), which shows no deviations from the Bro

175 Genetic data suggested that this could be a thiamin or HMP-binding site.

176 ent enzymes(4), and we were unable to detect thiamin or its derivatives in Bb cells.

177 a comprehensive systematic review for either thiamin or phosphorus.

178 this feature represents a specific trait of thiamin oxidases.

179 te (P-trend = 0.007) and were borderline for thiamin (P-trend = 0.05).

180 ia coli tRNA requires the action of both the thiamin pathway enzyme ThiI and the cysteine desulfurase

181 phosphorus) to 0.39 mm Hg lower systolic BP (thiamin) per 1-SD difference in nutrient variable.

182 sphate synthase, the purified protein has no thiamin phosphate synthase activity, and the role of thi

183 tion 119, while the corresponding residue in thiamin phosphate synthase is glycine.

184 enI shows significant structural homology to thiamin phosphate synthase, it has no known enzymatic fu

185 ile TenI shows high sequence similarity with thiamin phosphate synthase, the purified protein has no

186 ructure suggests that TenI is unable to bind thiamin phosphate, largely resulting from the presence o

187 branches of the pathway and coupled to form thiamin phosphate.

188 mfB also converts thiamin pyrophosphate into thiamin phosphate.

189 rs sulfur to form the thiazole moiety of the thiamin precursor HET-P.

190 t thiS motif RNAs function as sensors of the thiamin precursor HMP-PP, which is fused with HET-P ulti

191 ches that bacteria use to tune the levels of thiamin precursors during the biosynthesis of this unive

192 Many features of the thiamin pyrimidine binding site are shared between ThiY

193 In Saccharomyces cerevisiae , thiamin pyrimidine is formed from histidine and pyridoxa

194 Comparative genomics of the bacterial thiamin pyrimidine synthase (thiC) revealed a paralogue

195 Here we show that ThiC, the thiamin pyrimidine synthase in plants and bacteria, cont

196 Thiamin pyrophosphate (ThDP), the active form of thiamin

197 Thiamin and thiamin pyrophosphate (TPP) are well known for their imp

198 Thiamin pyrophosphate (TPP) is an essential enzyme cofac

199 Thiamin pyrophosphate (TPP) is the active form of vitami

200 Thiamin pyrophosphate (TPP) riboswitches are found in or

201 ation of thiamin monophosphate (TMP) to form thiamin pyrophosphate (TPP), the active form of vitamin

202 is responsive to the vitamin B(1) derivative thiamin pyrophosphate (TPP).

203 ultimately to form the final active coenzyme thiamin pyrophosphate (TPP).

204 r the biosynthesis of the thiazole moiety of thiamin pyrophosphate and describe the structure of the

205 Erythrocyte thiamin pyrophosphate and urine thiamin concentrations w

206 he proteins required for the biosynthesis of thiamin pyrophosphate have been known for more than a de

207 ynthesis of the thiazole phosphate moiety of thiamin pyrophosphate in Bacillus subtilis is proposed.

208 YmfB also converts thiamin pyrophosphate into thiamin phosphate.

209 Thiamin pyrophosphate is a required cofactor in all orga

210 thiamin biosynthesis and the consequences of thiamin pyrophosphate riboswitch deficiency on metabolis

211 brane thiamin transporters and mitochondrial thiamin pyrophosphate transporter expression levels were

212 -1, thiamin transporter-2, and mitochondrial thiamin pyrophosphate transporter proteins and messenger

213 essed thiamin transporters and mitochondrial thiamin pyrophosphate transporter, leading to adenosine

214 nd thiamin transporter-2), and mitochondrial thiamin pyrophosphate transporter.

215 The derivative of vitamin B1, thiamin pyrophosphate, is a cofactor of enzymes performi

216 A final phosphorylation gives thiamin pyrophosphate, the active form of the cofactor.

217 the thiamine uptake and/or inhibition of the thiamin pyrophosphate-dependent enzymes using thiamine a

218 In the case of the thiamin pyrophosphate-dependent thiM riboswitch, we find

219 contrast to other riboswitches, such as the thiamin pyrophosphate-sensing thiM riboswitch, which tri

220 ants for thiamin, thiamin monophosphate, and thiamin pyrophosphate.

221 yzes the formation of the thiazole moiety of thiamin pyrophosphate.

222 ascade for generating the essential cofactor thiamin pyrophosphate.

223 d in the formation of the thiazole moiety of thiamin pyrophosphate.

224 important mechanism for this control is via thiamin-pyrophosphate (TPP) riboswitches, regions of the

225 at in Arabidopsis, the THIC promoter and the thiamin-pyrophosphate riboswitch act simultaneously to t

226 The enzyme thiamin pyrophosphokinase (TPK) catalyzes the conversion

227 important finding of the studies is that all thiamin-related intermediates are in a chiral environmen

228 different organisms, in all cases exogenous thiamin represses expression of one or more of the biosy

229 utant of At5g32470 accumulated ThMP, and the thiamin requirement of the th2-1 mutant was complemented

230 The biosynthesis of thiamin requires the independently synthesized 4-amino-5

231 thiamin biosynthesis directs the activity of thiamin-requiring enzymes and consecutively determines t

232 The classical thiamin-requiring th2-1 mutation in Arabidopsis thaliana

233 crease ThMP levels 5-fold, implying that the THIAMIN REQUIRING2 (TH2) gene product could be a dedicat

234 A mouse model of thiamin-responsive megaloblastic anemia (diabetes mellit

235 Mutations in THTR-1 cause thiamin-responsive megaloblastic anemia, a tissue-specif

236 However, in patients with thiamin-responsive megaloblastic anemia, plasma thiamin

237 mented E1 activity is responsible for robust thiamin responsiveness in homozygous patients carrying t

238 progression to GA with increasing intake of thiamin, riboflavin, and folate after adjusting for age,

239 ve the Recommended Nutrient Intake (RNI) for thiamin, riboflavin, niacin, folate, vitamin B-12, calci

240 selenium, magnesium, sodium, and B-vitamins (thiamin, riboflavin, niacin, pantothenic acid, B-6, and

241 18% of the Recommended Dietary Allowances of thiamin, riboflavin, niacin, pyridoxine, and vitamin B-1

242 t the At5g32470 TenA domain has the expected thiamin salvage activity.

243 5-(aminomethyl)-2-methylpyrimidine (FAMP), a thiamin salvage pathway intermediate, into cells.

244 ogenase) family phosphatase fused to a TenA (thiamin salvage) family protein.

245 Y shares only 16% sequence identity with the thiamin-specific S component ThiT from the same organism

246 mbulatory patients with HF and reduced LVEF, thiamin supplementation for 6 mo did not improve LVEF, q

247 We sought to determine whether oral thiamin supplementation improves left ventricular ejecti

248 Therefore, thiamin supplementation in HF patients may improve cardi

249 ssigned: 34 received placebo and 35 received thiamin supplementation.

250 One patient (2.9%) in the thiamin-supplemented group and none in the control group

251 e determination vitamin B1 active compounds; thiamin, thiamin monophosphate and thiamin diphosphate i

252 ts showed similar dissociation constants for thiamin, thiamin monophosphate, and thiamin pyrophosphat

253 Thiamin thiazole biosynthesis in eukaryotes is still not

254 nI is found clustered with genes involved in thiamin thiazole biosynthesis.

255 nistic insights into the biosynthesis of the thiamin thiazole in eukaryotes.

256 describe an optimized reconstitution of the thiamin thiazole synthase (ThiG) catalyzed reaction and

257 fur incorporation in the biosynthesis of the thiamin thiazole.

258 ynthase and identifies the final step of the thiamin-thiazole biosynthesis.

259 Thiamin thiazolone diphosphate (ThTDP), a potent inhibit

260 elimination of the thiazole ring moiety from thiamin through substitution of the methylene group with

261 g proteins deliver ions or molecules such as thiamin to the membrane-bound ABC transporter.

262 inase (TPK) catalyzes the conversion of free thiamin to TPP in plants and other eukaryotic organisms

263 ighlight an unexpected and critical role for thiamin transport and metabolism in spermatogenesis.

264 ale germ cells, particularly those with high thiamin transporter expression beyond the blood-testis b

265 ific effects of absence of the high-affinity thiamin transporter, Tht1.

266 ivity of the corresponding transfected human thiamin transporter-1 (SLC19A2) and -2 (SLC19A3) promote

267 vitamin; in vitro studies suggest that both thiamin transporter-1 (THTR-1) and -2 (THTR-2) are invol

268 transgenic mice carrying promoters for human thiamin transporter-1 and -2 (hTHTR-1 and hTHTR-2), we a

269 evel of expressions of thiamin transporters (thiamin transporter-1 and thiamin transporter-2), and mi

270 Expressions of thiamin transporter-1, thiamin transporter-2, and mitoch

271 amin transporters (thiamin transporter-1 and thiamin transporter-2), and mitochondrial thiamin pyroph

272 Expressions of thiamin transporter-1, thiamin transporter-2, and mitochondrial thiamin pyropho

273 inal thiamin uptake, level of expressions of thiamin transporters (thiamin transporter-1 and thiamin

274 Both cell membrane thiamin transporters and mitochondrial thiamin pyrophosp

275 as a function of sepsis severity, suppressed thiamin transporters and mitochondrial thiamin pyrophosp

276 pe and transgenic mice by demonstrating that thiamin uptake and mRNA levels of the mouse THTR-1 and T

277 sepsis inhibited carrier-mediated intestinal thiamin uptake as a function of sepsis severity, suppres

278 We also examined intestinal thiamin uptake in THTR-1-deficient mice.

279 cells is associated with an up-regulation in thiamin uptake process and that this up-regulation appea

280 ation-dependent regulation of the intestinal thiamin uptake process and the cellular and molecular me

281 Intestinal thiamin uptake process is vital for maintaining normal b

282 induced sepsis, carrier-mediated intestinal thiamin uptake was measured using [H]thiamin.

283 Sepsis inhibited [H]thiamin uptake, and the inhibition was a function of sep

284 ity of sepsis on carrier-mediated intestinal thiamin uptake, level of expressions of thiamin transpor

285 ignificant up-regulation in carrier-mediated thiamin uptake.

286 f maintaining appropriate cellular levels of thiamin vitamers for the plant's metabolic flexibility a

287 ) riboswitch mutant plants, which accumulate thiamin vitamers.

288 sis, and is also used in the biosynthesis of thiamin (vitamin B1) and pyridoxal (vitamin B6).

289 Thiamin (vitamin B1) is an essential micronutrient neede

290 min pyrophosphate (ThDP), the active form of thiamin (vitamin B1), is believed to be an essential cof

291 uxotrophic for vitamins niacin (vitamin B3), thiamin (vitamin B1), or folate (vitamin B9).

292 hic for the vitamins niacin (vitamin B3) and thiamin (vitamin B1), whereas strain-specific auxotrophi

293 In contrast, thiamin, vitamin B-6, calcium, iron, and zinc had linear

294 significance level included calcium, folate, thiamin, vitamin B6, and vitamin C, with nutrient supply

295 Injection of high-dose thiamin was effective in reversing the spermatogenic fai

296 Thiamin was not influenced by the study interventions.

297 Using the evidence scan for thiamin, we identified 70 potentially relevant abstracts

298 All B vitamins were low in milk, and all but thiamin were increased by maternal supplementation with

299 d milk concentrations of all vitamins except thiamin, whereas antiretrovirals lowered concentrations

300 When supplemented with exogenous thiamin, wild-type plants displayed enhanced tolerance t