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1 selectively (turn on) after the addition of thiamine.
2 containing either thiamine pyrophosphate or thiamine.
3 all essential vitamins with the exception of thiamine.
4 hysiological concentrations of extracellular thiamine.
5 rsed at high extracellular concentrations of thiamine.
6 oxymethyl-2-methylpyrimidine (HMP) moiety of thiamine.
7 olished the biosynthesis of s(4)U but not of thiamine.
8 r the biosynthesis of 4-thiouridine, but not thiamine.
9 ification in tRNA and the thiazole moiety of thiamine.
10 acid (1500 mg), hydrocortisone (50 mg), and thiamine (100 mg) every 6 hours for 4 days (n = 103) or
14 urce of protein (10.7%), beta-glucan (2.1%), thiamine (687.1 mug/100 g), riboflavin (218.4 mug/100 g)
15 rgy (74.1%, P = .04), iron (73.4%, P = .01), thiamine (74.0%, P = .00), and riboflavin (73.3%, P = .0
16 od, it was possible to relate the amounts of thiamine added in model cooked hams to the amounts of 2-
19 s also indicated competition for the vitamin thiamine and downregulation of dissimilatory sulfate red
20 tection of 0.5 nM) and specific bioassay for thiamine and its phosphorylated derivatives can be desig
21 se, the mean +/- SD maximal concentration of thiamine and net area under the thiamine concentration-t
22 ls at 24 hours after study start between the thiamine and placebo groups (median: 2.5 mmol/L [1.5, 3.
26 alysis revealed remarkable concentrations of thiamine and pyridoxine in pistachios (57%, 79% of the r
31 deficient, with median (range) total plasma thiamine and TDP concentrations of 2.4 nmol/L (0-4.4 nmo
34 thylpyrimidine (HMP) pyrophosphate moiety of thiamine and the last intermediate in the common HMP/pur
35 ntial enzyme involved in the biosynthesis of thiamine and the tRNA thionucleoside modification, 4-thi
36 ntermediates and to enable plants to produce thiamine and thiamine pyrophosphate for growth and devel
37 was found that 5% (w/v) lactose, 0.1% (w/v) thiamine, and 0.1% (w/v) FeCl3 led to the maximal produc
39 of inorganic nitrogen, inorganic sulfur, and thiamine, and genes encoding carbohydrate active enzymes
41 hiamin pyrophosphate-dependent enzymes using thiamine antagonists - amprolium (AM), oxythiamine (OT)
44 nalysis of different phosphorylated forms of thiamine, as well as of activities and amount of holoenz
48 ding protein (TBP) from Escherichia coli for thiamine biorecognition and dye-encapsulating liposomes
49 cytidine diphosphates, and to precursors of thiamine biosynthesis (HMP-PP), and we outline new subcl
50 nella enterica, sulfur is trafficked to both thiamine biosynthesis and 4-thiouridine biosynthesis by
51 ular thiamine concentration due to increased thiamine biosynthesis and transport, implicating NAD(+)
52 and K96243 that are deficient in adenine and thiamine biosynthesis but replication competent in vitro
55 at a Thi5-dependent pathway is necessary for thiamine biosynthesis in Legionella pneumophila and prov
56 ear-complete de novo pyrimidine, purine, and thiamine biosynthesis pathways and is unique amongst stu
57 with two proteins involved in isoprenoid and thiamine biosynthesis, 1-hydroxy-2-methyl-2-(E)-butenyl-
58 nnections between cofactors biosynthesis and thiamine biosynthesis, and how metabolites from one bios
59 ily was previously thought to be involved in thiamine biosynthesis, but our characterization of TP079
65 scU for FeS cluster biogenesis, and ThiI for thiamine biosynthesis/tRNA thiolation), which bind at di
68 ation of ascorbic acid, corticosteroids, and thiamine, compared with placebo, did not result in a sta
70 Sum1 HDAC complex elevated the intracellular thiamine concentration due to increased thiamine biosynt
73 entration of thiamine and net area under the thiamine concentration-time curve were 73.4 +/- 45.6 nmo
74 ightly regulated such that low environmental thiamine concentrations activate transcription and high
75 ly lactation had higher eTDP and breast milk thiamine concentrations and their infants had higher eTD
76 n and newborn infants and higher breast milk thiamine concentrations compared with a control sauce.
78 hiamine, with sharp increases in breast milk thiamine concentrations, but their breastfed infants rem
79 maternal thiamine intake reduces breast milk thiamine concentrations, placing breastfed infants at ri
80 grees C for 720 days was 55% of the original thiamine content after thermal processing, 42% for split
83 aracterization of 79 patients with inherited thiamine defects causing encephalopathy in childhood, id
87 occur during the acute and chronic phases of thiamine deficiency and describe how rodent models of We
88 mical and cognitive deficits associated with thiamine deficiency as well as proven useful toward grea
89 ley rats were assigned to one of 4 stages of thiamine deficiency based on behavioral symptoms: pre-sy
90 Primary and secondary conditions leading to thiamine deficiency have overlapping features in childre
96 effects, we demonstrate that the problem of thiamine deficiency is considerably more widespread and
98 extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemical alterati
99 rugs inhibit ThTR-2, which may contribute to thiamine deficiency, especially in at-risk populations.
100 iovascular traits previously associated with thiamine deficiency, including elevated cardiac stroke v
102 iberi, a potentially fatal disease caused by thiamine deficiency, remains a public health concern in
105 trations, but their breastfed infants remain thiamine deficient after 5 d of maternal supplementation
109 nd split pea soup demonstrated resistance to thiamine degradation, while thiamine in beef brisket was
110 amount of holoenzyme and apoenzyme forms of thiamine-dependent enzymes, revealed episodically occurr
111 retion of organic acids that are specific of thiamine-dependent mitochondrial enzymes, mainly lactate
112 in comparison with glucose, fructose induces thiamine-dependent transketolase flux and is preferentia
113 iamine metabolite, and benfotiamine, another thiamine derivative, did not interfere with the effect o
119 -d-xylulose 5-phosphate synthase (DXPS) uses thiamine diphosphate (ThDP) to convert pyruvate and d-gl
121 rtified fish sauce yields higher erythrocyte thiamine diphosphate concentrations (eTDP) among lactati
123 the structure of the holo form indicates how thiamine diphosphate organizes the active site pocket of
124 alidated by the determination of KD(app) for thiamine diphosphate, the TK cofactor and the inhibition
125 synthase, is a flavin adenine dinucleotide-, thiamine diphosphate- and magnesium-dependent enzyme tha
126 quinone biosynthesis is catalyzed by MenD, a thiamine diphosphate-dependent enzyme comprising three d
128 nto the role of metabolic cofactors, such as thiamine, during the proliferation of stem and initial c
129 ng the first day of admission: 200-500 mg IV thiamine every 8 hours, 64 mg/kg magnesium sulfate (appr
130 u(2+) ion modified C-dots in the presence of thiamine exhibits a linear relationship within the thiam
132 men in the control group, women who consumed thiamine-fortified fish sauce through pregnancy and earl
133 Objective: To determine if consumption of thiamine-fortified fish sauce yields higher erythrocyte
134 vo biosynthesis pathways or uptake exogenous thiamine from the environment via specific transporters.
135 aseline thiamine deficiency, patients in the thiamine group had significantly lower lactate levels at
136 ation of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for
137 hydrocortisone, high-dose ascorbic acid, and thiamine (HAT therapy) was published online.Objectives:
140 hols in (0.05, 0.15, 0.25 and 0.35)molkg(-1) thiamine HCl(aq) and pyridoxine HCl(aq) solutions over t
142 absorbable and could contribute toward host thiamine homeostasis, especially toward cellular nutriti
146 re and characterize nanoliposomes containing thiamine hydrochloride and study their physicochemical s
148 eveloped was applied to the determination of thiamine in certified reference material (BCR-485), phar
150 riments is that raising the plasma levels of thiamine in FeLV-infected cats may ameliorate the pathog
153 crobiota synthesize a considerable amount of thiamine in the form of thiamine pyrophosphate (TPP).
154 t strain could grow independent of exogenous thiamine in the presence of cysteine, suggesting there w
157 In this study, the degradation kinetics of thiamine in three NASA spaceflight foods (brown rice, sp
158 y (AdSV), for determination of vitamin B(1) (thiamine) in pharmaceutical preparation and food is desc
160 ion for the presence of a thiazolium ring in thiamine instead of the otherwise generally more availab
163 rupt thiamine uptake into cells and, because thiamine is an essential nutrient, whether this disrupti
165 oxymethyl-2-methylpyrimidine (HMP) moiety of thiamine is synthesized from 5-aminoimidazole ribotide (
167 ethod for the simultaneous quantification of thiamine, its mono- and diphosphate derivatives and its
168 ing electronic health records suggested that thiamine laboratory values are reduced in individuals re
171 sauce consumption for 6 months: control (no thiamine), low-concentration (2 g/L), or high-concentrat
174 of folate metabolism, the down-regulation of thiamine metabolism, and tight regulation of oxidative p
176 he binding of Ca(2+) to calmodulin (CaM) and thiamine monophosphate (ThMP) to thiamine binding protei
177 thesis, the ATP-dependent phosphorylation of thiamine monophosphate (TMP) to thiamine pyrophosphate.
181 ultiple endogenous compounds, including IBC, thiamine, N(1)-methylnicotinamide (1-NMN), creatinine, c
183 overexpressing plants were supplemented with thiamine or thiamine pyrophosphate throughout the life c
184 ciated with poor intake of energy (P = .04), thiamine (P = .02), and riboflavin (P = .01).The proport
187 The high-throughput method relies upon the thiamine periplasmic binding protein (TBP) from Escheric
194 new thiamine amperometric biosensor based on thiamine pyrophosphate (ThDP)-dependent transketolase (T
195 a lack of consensus on the cooperativity of thiamine pyrophosphate (TPP) binding into the two active
196 We analyzed the structure of the native thiamine pyrophosphate (TPP) riboswitch aptamer domain a
198 g is central to the regulatory mechanisms of thiamine pyrophosphate (TPP) riboswitches and has not be
199 ate kinase (ThiL) catalyzes the last step of thiamine pyrophosphate (TPP) synthesis, the ATP-dependen
200 lase, TK(low), which also binds the cofactor thiamine pyrophosphate (TPP) with an affinity up to two-
207 ic structural model of PtDXS in complex with thiamine pyrophosphate and Mg(2+) was built by homology
208 rredoxin oxidoreductase family, OOR contains thiamine pyrophosphate and three [Fe(4)S(4)] clusters.
213 distinct [4Fe-4S] iron-sulfur clusters and a thiamine pyrophosphate radical upon reduction by pyruvat
214 lso found in the structure of the eukaryotic thiamine pyrophosphate riboswitch in the context of a he
216 ng plants were supplemented with thiamine or thiamine pyrophosphate throughout the life cycle, they g
217 ion of expression of the human mitochondrial thiamine pyrophosphate transporter (the product of the S
219 thetic theophylline- and naturally occurring thiamine pyrophosphate-binding RNA aptamers as test case
220 lation of the MEP pathway and indicates that thiamine pyrophosphate-dependent enzymes may often be af
225 mutations have been described as a cause of thiamine-responsive megaloblastic anemia (TRMA), an auto
226 viously defined enhancer region bound by the thiamine-responsive Thi2/Thi3/Pdc2 transcriptional activ
227 ed at the conclusion of each stage following thiamine restoration and subjects were perfused 24 hours
231 al phenolics, reducing sugar and B vitamins (thiamine, riboflavin, and niacin) content of steamed spr
232 vided adequate nutrient density for protein, thiamine, riboflavin, and vitamins B-6, B-12, and C but
233 osphorous, boron, cobalt, Vitamins A, D, B6, thiamine, riboflavin, niacin and cobalamin with insignif
240 R mutant phenotypes are rescued by exogenous thiamine supplementation, suggesting that blk1-R is a th
241 synthesis of AIR and thus demonstrates that thiamine synthesis can be uncoupled from the early purin
242 The production of the pyrimidine moiety in thiamine synthesis, 2-methyl-4-amino-5-hydroxymethylpyri
244 y other bioactive compounds like the vitamin thiamine, the anti-cancer drug bleomycin, the antibacter
245 Based on a pharmacokinetic assessment of thiamine, the banana bag approach likely fails to optimi
250 nated trees across all 10 cultivars, whereas thiamine thizole synthase and CP12, a Calvin Cycle maste
253 Mice lacking the gene for the high-affinity thiamine transporter (Slc19a2) have normal cochlear stru
257 Carrier Family 19 Member 2 (SLC19A2) encodes thiamine transporter 1 (THTR1), which facilitates thiami
259 binding of FeLV-A Env to its viral receptor, thiamine transporter feTHTR1, is the first step of infec
260 hat therapeutic drugs inhibit the intestinal thiamine transporter ThTR-2, which may lead to thiamine
261 y locus, uncovering a previously unsuspected thiamine transporter whose genetic variants predicted se
265 ingle nucleotide polymorphisms (SNPs) in two thiamine transporters (SLC19A2/3) and their transcriptio
266 e, we hypothesized that variants in specific thiamine transporters are associated with risk of severe
267 e cat ortholog of the other of the two known thiamine transporters in mammals, THTR2, and we show tha
268 e cognate genes allowed us to establish that thiamine transporters Thi7 and Thi72 can efficiently tak
270 In this predefined subgroup, those in the thiamine treatment group had statistically significantly
271 ith a substrate- and product-bound mammalian thiamine triphosphatase and with previously reported str
272 of adenosine triphosphate, the hydrolysis of thiamine triphosphate, and the synthesis and breakdown o
273 ced experimentally via interference with the thiamine uptake and/or inhibition of the thiamin pyropho
274 essed whether FeLV-A infection might disrupt thiamine uptake into cells and, because thiamine is an e
277 ine THTR1 (feTHTR1) and feTHTR2 both mediate thiamine uptake, but feTHTR2 does not function as a rece
278 ent beta-cells are characterized by impaired thiamine uptake, which is not rescued by overexpression
281 standing plant health, including the role of thiamine (vitamin B(1)), iron, and the plant immune syst
282 osphate (TPP), a biologically active form of thiamine (vitamin B(1)), is an essential cofactor in all
289 BP) to provide high affinity recognition for thiamine (vitamin B1), an analyte of great importance to
291 nt deficiencies after gastric bypass include thiamine, vitamin B(1)(2), vitamin D, iron, and copper.
292 trial of ascorbic acid, corticosteroids, and thiamine vs placebo for adult patients with septic shock
296 ine diphosphate (TDP), and breast milk total thiamine were measured in 16 healthy Cambodian mothers a
297 r the synthesis of the essential vitamin B1 (thiamine) were lost in an ancestor of a yeast lineage, t
299 nt Cambodian mothers effectively absorb oral thiamine, with sharp increases in breast milk thiamine c