ライフサイエンスコーパス: thirst

1 rrent internal motivational state (hunger or thirst).

2 ng about financial security and experiencing thirst).

3 ted with increased AVP levels and suppressed thirst.

4 e subfornical organ that trigger or suppress thirst.

5 g overdrinking compared with drinking during thirst.

6 hese responses correlated significantly with thirst.

7 e level of water in a pitcher and quench its thirst.

8 ve, similar to temperature, itch, hunger and thirst.

9 by drinking inherent in the consciousness of thirst.

10 ng to physiological state, such as hunger or thirst.

11 r liver is necessary for sodium appetite and thirst.

12 nd elicit concordant responses to hunger and thirst.

13 al osmolality changes, and how they modulate thirst.

14 and while they imagined drinking to satiate thirst.

15 physiological deficiency states: hunger and thirst.

16 uple osmolyte retention with potentiation of thirst.

17 h imagined thirst and physiologically evoked thirst.

18 r substrates that underlie distinct types of thirst.

19 n response to dehydration, humans experience thirst.

20 owing motivational shifts between hunger and thirst.

21 large volumes of dilute urine and persistent thirst.

22 and thalamus after overdrinking, relative to thirst.

23 e signals and oppositely regulate hunger and thirst.

24 creased in the papilla of mice after 36 h of thirsting.

25 +/- 22% in the papilla of mice after 36 h of thirsting.

26 253% (P < 0.01) in the papilla upon 36 h of thirsting.

27 ncreased further in the papilla upon 36 h of thirsting.

28 at is mainly caused by two distinct types of thirst(1-3).

29 PVS have awareness and experience hunger and thirst; 30% believe they experience pain.

30 Thirst also permitted flies to learn olfactory cues pair

31 patient well-being, measured as preoperative thirst, amount of fluid ingested, postoperative nausea a

32 Older persons fail to recognize thirst and as such have an increased risk of dehydration

33 and arginine-vasopressin (AVP) release: ( a) Thirst and AVP release are regulated by the classical ho

34 V and hypothalamic neurons in the control of thirst and AVP-mediated body fluid homeostasis.

35 urons sensed both NaCl and AngII to regulate thirst and body fluid homeostasis.

36 ed NaCl and AngII concentrations to regulate thirst and body fluid homeostasis.SIGNIFICANCE STATEMENT

37 bjective appetite responses while increasing thirst and core-body temperature.

38 This decoupling of thirst and diuresis enables water retention by the kidne

39 GLP-1 has also been shown to play a role in thirst and drinking behavior.

40 Tolvaptan caused increased thirst and dry mouth, but frequencies of major adverse e

41 the early phase of sepsis features impaired thirst and enhanced vasopressin release, the basis for t

42 lling is not required for sodium appetite or thirst and highlight the need to identify alternative si

43 The motivational states of thirst and hunger are represented in the brain by shared

44 NPF neurons use NPF to regulate thirst and hunger behaviors.

45 Thirst and hunger drives are fundamental survival mechan

46 serve as neural circuit elements underlying thirst and hunger drives.

47 of interoception by tracking and predicting thirst and hunger states.

48 l needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to

49 ity (HRV) was measured, and they rated their thirst and mood.

50 milar neural network underlies both imagined thirst and physiologically evoked thirst.

51 tient well-being with regard to preoperative thirst and PONV.

52 onstrate a pivotal role in the regulation of thirst and salt appetite of angiotensin II generated in

53 eostatic and behavioral responses associated thirst and salt appetite, although clearly it may relate

54 mation is integrated in the brain to produce thirst and salt appetite; and how these motivational dri

55 ding how motivated behaviors such as hunger, thirst and sexual behaviors arise.

56 thought to be responsible for the increased thirst and sodium appetite caused by hypovolaemia, produ

57 use the physiological mechanisms controlling thirst and sodium appetite continued functioning without

58 We next tested whether thirst and sodium appetite require angiotensinogen produ

59 active ligands in brain angiotensin-mediated thirst and sodium appetite.

60 n II (AngII) and angiotensin III (AngIII) on thirst and sodium appetite.

61 ing summer, whereas during winter, they lack thirst and survive without water for months.

62 ge brain region involved in the detection of thirst and the regulation of water intake.

63 At maximum thirst and then during irrigation of the mouth with wate

64 These anticipatory signals for thirst and vasopressin release concentrate on the same h

65 hanges in extracellular osmolarity stimulate thirst and vasopressin secretion through a central osmor

66 mitted to key forebrain neurons that control thirst and vasopressin secretion.

67 c NaCl and other osmolytes readily stimulate thirst and vasopressin secretion.

68 hat play key roles in the central control of thirst and water homeostasis, but the extent to which th

69 pants while they imagined a state of intense thirst and while they imagined drinking to satiate thirs

70 ulosum lamina terminalis (OVLT; which drives thirst) and attenuates that of neurosecretory neurons in

71 be pursued (e.g., when balancing hunger and thirst) and how to combine these signals with estimates

72 eral sensations, vasomotor activity, hunger, thirst, and 'air hunger'.

73 and physiological variables, such as hunger, thirst, and effort levels, by orchestrating sensory, pro

74 include difficulty swallowing and speaking, thirst, and halitosis.

75 nsin II (AngII)-regulated behaviors, such as thirst, and may do so by influencing the central renin-a

76 rocesses and ingestive drives (i.e., hunger, thirst, and salt appetite).

77 Participants rated hunger, thirst, and satiety at baseline and at 20-min intervals

78 aditionally used to treat cholera, alleviate thirst, and serves as an important water source and live

79 by the hormone asprosin, leading to enhanced thirst, and that optogenetic or chemogenetic activation

80 rinking during meals, the rapid satiation of thirst, and the fact that oral cooling is thirst-quenchi

81 ress competing motivational systems, such as thirst, anxiety-related behavior, innate fear, and socia

82 Selection of hunger- or thirst-appropriate memory emerges from competition betwe

83 Hunger and thirst are ancient homeostatic drives for food and water

84 r neonatal mammals, however, both hunger and thirst are sated by consuming milk from their dams.

85 during the appetitive phase, both hunger and thirst are sensed by a nearly identical population of in

86 Hunger and thirst are two fundamental drives for maintaining homeos

87 erse reactions primarily included dry mouth, thirst, bradycardia and hypertension.

88 enetic excitation of OVLT neurons stimulated thirst but not salt appetite.

89 Thirst, but not hunger, potentiated the phasic dopamine

90 y between these two regions is needed before thirst can be experienced.

91 opriate antidiuresis combined with increased thirst, causing polydipsia and water intoxication.

92 pacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movement

93 ess, palpitations, change in smell or taste, thirst, chronic cough, chest pain, shortness of breath,

94 translated into hormonal signals to regulate thirst circuit activity through the HPA pathway.

95 otivational mechanism by which the forebrain thirst circuit drives drinking.

96 onstrating preservation of the physiological thirst circuit during hibernation.

97 These findings reveal a distributed thirst circuit that motivates drinking by the common mec

98 irst were significantly higher for imagining thirst compared with imagining drinking or baseline, rev

99 The imagine thirst condition activated brain regions similar to thos

100 ing, suggesting the neural representation of thirst contains a drinking-related component.

101 off, and probably functions as a centre for thirst control in the mammalian brain.

102 Our results reveal that these thirst-controlling sCVOs possess intrinsic circadian tim

103 Here we show that thirst converts water avoidance into water-seeking in na

104 ring winter that blunts their sensitivity to thirst cues.

105 ial therapeutic target for the management of thirst disorders.

106 relationship between fatigue, pruritus, and thirst distress (TD) with QOL of patients receiving hemo

107 Secondary outcomes included thirst distress and safety events.

108 tion form, the Fatigue Assessment Scale, the Thirst Distress Scale, the Pruritus Severity Scale, the

109 Thirst distress was higher in the fluid restriction grou

110 ingly, spontaneous drinking behavior but not thirst drive reduction triggered DA release.

111 dependently, interactions between hunger and thirst drives are important to coordinate competing need

112 stinct neural circuits underlying hunger and thirst drives in the adult brain have been characterized

113 We show that thirst-driving neurons receive temporally distinct satia

114 associated with tolvaptan included increased thirst, dry mouth, and increased urination.

115 We propose that thirst elevates astrocytic D-serine release, which awake

116 Thirst emerges from a range of cellular changes that ult

117 lated to vegetative and affective aspects of thirst experiences, whereas activity in neocerebellar (p

118 ts attributed to tolvaptan were pollakiuria, thirst, fatigue, dry mouth, polydipsia, and polyuria.

119 cemia, such as frequent urination, increased thirst, fatigue, or visual changes, and had no known fam

120 In the liberal policy, thirst feelings decreased (37% [4982 of 8615] vs 46% [33

121 in humans that drinking water in response to thirst following fluid loss is a pleasant experience.

122 During artificial hunger or thirst, food or water cues further shifted activity beyo

123 During natural hunger or thirst, food or water cues rapidly and transiently shift

124 line, revealing a successful dissociation of thirst from underlying physiology.

125 However, continuing to drink water once thirst has been satiated becomes unpleasant and, eventua

126 Thirst has conventionally been viewed as a homeostatic r

127 While central neural circuits regulating thirst have been well studied, it is still unclear how m

128 Hunger and thirst have distinct goals but control similar ingestive

129 c mice display high blood pressure, enhanced thirst, high urine output, proteinuria, and kidney damag

130 across the cerebellum is similar to that for thirst, hunger, and their satiation.

131 rnal state of an individual-as it relates to thirst, hunger, fear, or reproductive drive-can be infer

132 vegetative systems including hunger for air, thirst, hunger, pain, micturition, and sleep, is discuss

133 ma sodium concentration and the emergence of thirst in 10 healthy adults.

134 We induced either moderate or severe thirst in humans using intravenous saline, and examined

135 Thus, neural representations of hunger and thirst in mice become distinct before food- and water-se

136 rgan (SFO) in the anticipatory regulation of thirst in mice.

137 gly, while artificial induction of hunger or thirst in sated mice via activation of specific hypothal

138 r the distinct representations of hunger and thirst in the adult brain.

139 the loss of body fluid induces hypovolaemic thirst, in which animals seek both water and minerals (s

140 n previous studies of physiologically evoked thirst, including the anterior midcingulate cortex (aMCC

141 organs of the hypothalamus are activated by thirst-inducing conditions.

142 are critical sites for sensing both types of thirst-inducing stimulus(4-6).

143 ncovered, less is known about how hunger and thirst interact.

144 Thirst is a highly potent drive that motivates organisms

145 Thirst is a motivational state that drives behaviors to

146 Together, these results show that thirst is a multimodal physiological state, and that dif

147 how the neural representation of subjective thirst is generated and how it subsequently motivates dr

148 Thirst is the basic instinct to drink water.

149 ysiological drives, such as hunger, sex, and thirst, it is less obvious what drives us to sleep and w

150 o cognitive function, dyspnea, constipation, thirst, leg swelling, numbness, dry mouth, and balance p

151 Hunger, thirst, loneliness and ambition determine the reward val

152 ly, the volume of water drunk in response to thirst matches the deficit.

153 NA species, whereas a behavior as complex as thirst may be influenced by changes in multiple genes.

154 influence of motivational state (hunger and thirst), memory demand, and spatial behavior in 2 tasks:

155 However, how different thirst modalities are encoded in the brain remains unkno

156 e the cellular logic that underlies distinct thirst modalities.

157 Furthermore, optogenetic gain of function in thirst-modality-specific cell types recapitulated water-

158 Our results show that the cerebellum is a thirst-modulating brain area and that asprosin-Ptprd sig

159 ive internal state that dynamically controls thirst-motivated behavior.

160 m ~24,000 neurons in 34 brain regions during thirst-motivated choice behavior in 21 mice as they cons

161 Thirst motivates animals to drink in order to maintain f

162 Moreover, there is a thirst need of precision standardization for coal analyz

163 contains NaCl-sensitive neurons to regulate thirst, neuroendocrine function, and autonomic outflow.

164 Recording from forebrain thirst neurons and behavioural analyses show that HPA-de

165 he identification and functional analysis of thirst neurons and vasopressin-producing neurons.

166 er neurons drive feeding behaviors more than thirst neurons do.

167 molality sensing in the gut rapidly inhibits thirst neurons upon water intake.

168 ntaining solutions in mice, independently of thirst or hunger.

169 Hunger, thirst or predator cues suppressed sustained pain, regar

170 dictably increased water losses and impaired thirst or restricted free water intake or both.

171 response to overnight fluid deprivation, or thirst or salt appetite in response to an isotonic hypov

172 ilar to physiological drives such as hunger, thirst or sleep(3,6).

173 minating Agt from hepatocytes did not reduce thirst or sodium appetite, and in fact, these mice consu

174 rocytes and hepatocytes also did not prevent thirst or sodium appetite.

175 rain, deleting astrocytic Agt did not reduce thirst or sodium appetite.

176 Agt from brain and liver also did not reduce thirst or sodium appetite.

177 ting angiotensinogen levels without reducing thirst or sodium appetite.

178 for all angiotensin peptides, did not reduce thirst or sodium appetite.

179 -related quality of life measures, perceived thirst or xerostomia, or dietary sodium intake.

180 rimination cued by internal state (hunger or thirst) or on performance of conditional visuospatial ob

181 For thirst, oropharyngeal cues have a critical role in drivi

182 Despite the induction of even severe thirst, our subjects rejected unfair offers.

183 pparently not involved in the computation of thirst per se but rather is activated during changes in

184 ients and an additional 15 matched controls, thirst perception and neuronal activity in response to b

185 To elicit thirst, previous studies have manipulated blood chemistr

186 Complementary experiments activating thirst-promoting neurons also conditioned avoidance.

187 ng deep-brain calcium dynamics, we show that thirst-promoting SFO neurons respond to inputs from the

188 We show that thirst-promoting subfornical organ neurons are negativel

189 of thirst, and the fact that oral cooling is thirst-quenching.

190 Here, we show that hypothalamic hunger and thirst regions already exhibit specific responses to sta

191 ppreciated role of GABAergic MnPO neurons in thirst regulation.

192 nervous system (CNS), including promotion of thirst, regulation of vasopressin secretion, and modulat

193 lumn, orofacial motor-related, humorosensory/thirst-related, brainstem autonomic control network, neu

194 connectivity with the insula during imagined thirst relative to imagined drinking, implying functiona

195 ntidiuretic hormone levels are restored, but thirst remains suppressed.

196 ntial homeostatic processes, such as hunger, thirst, reproduction and immune responses(1)(,)(2)(,)(3)

197 Increasing dietary sodium drives the thirst response.

198 ced AVP release but had no effect on osmotic thirst response.

199 compensatory thresholds for antidiuretic and thirst responses.

200 contributing to the fine top-down control of thirst responses.

201 Although thirst-responsive neuronal signals have been reported, t

202 lality signals are required for feed-forward thirst satiation and drinking termination.

203 re, we identified neural circuits underlying thirst satiation and examined their contribution to rewa

204 Together, this study dissected the thirst satiation circuit, the activity of which is funct

205 fast dopamine (DA) sensor to examine whether thirst satiation itself stimulates the reward-related ci

206 Importantly, chemogenetic stimulation of thirst satiation neurons did not activate DA neurons und

207 We demonstrate that individual thirst satiation signals are mediated by anatomically di

208 se but rather is activated during changes in thirst/satiation state when the brain is "vigilant" and

209 focal optogenetic activation of hypothalamic thirst-sensing neurons returned global activity to the p

210 erebral blood flow with subjects' ratings of thirst showed major activation in the vermal central lob

211 Finally, we demonstrate that the thirst signal exits these regions through at least three

212 urons (ISNs) respond to intrinsic hunger and thirst signals to oppositely regulate sucrose and water

213 w dopamine signals associated with quenching thirst, singing a good song and courting a mate change a

214 ating dopaminergic neurons (DANs) to promote thirst-specific water memory expression, whereas it acti

215 odal physiological state, and that different thirst states are mediated by specific neuron types in t

216 decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as

217 across sexes, and how inter-drinking session thirst states predict future alcohol intakes in females,

218 its on interoceptive knowledge of hunger and thirst states to guide decision-making.

219 enetic inhibition of OVLT neurons attenuated thirst stimulated by hypernatremia or elevated AngII but

220 ons play a pivotal role in the regulation of thirst stimulated by NaCl and AngII.

221 e transitions and in response to optogenetic thirst stimulation.

222 d blood chemistry to produce a physiological thirst stimulus.

223 atal regions that respond to both hunger and thirst, subpopulations of neurons respond distinctly to

224 standing of internal osmolyte regulation and thirst suppression could translate to advancements in hu

225 In this work, we show that long-term thirst suppression occurs despite hormonal and behaviora

226 provide a detailed anatomy and physiology of thirst, taste for water, and arginine-vasopressin (AVP)

227 hes fluid loss and satiates the sensation of thirst that accompanies dehydration.

228 Increased blood osmolality induces osmotic thirst that drives animals to consume pure water.

229 VGLUT2) neurons are a hub between hunger and thirst that specifically controls motivation for food an

230 sleep disturbance, or unsatisfied hunger or thirst that they rated as moderate or severe, whereas de

231 During the development of thirst, the anterior and posterior quadrangular lobule,

232 atients seems to be due to an abnormally low thirst threshold, a condition termed dipsogenic DI.

233 ingestion, which promotes acute satiation of thirst through the subfornical organ and other downstrea

234 hysiological stimulus is indeed required for thirst to be experienced.

235 sent distinct cellular processes to regulate thirst, vasopressin secretion and autonomic function.

236 The instinct of thirst was a cardinal element in the successful coloniza

237 At 90 min, an increase in thirst was associated with a decline in subjective energ

238 In the short-term, thirst was associated with poorer memory.

239 Thirst was moderately intense, and shortness of breath,

240 tate during random foraging, when hunger and thirst were incidental to behavior, and signals derived

241 ass, urine osmolality, body temperature, and thirst were monitored.

242 Subjective ratings of thirst were significantly higher for imagining thirst co

243 y weakness, frequent urination and excessive thirst when diagnosed of diabetes mellitus and later exp

244 pid correction of hyponatremia and increased thirst with vaptans).

245 n, possibly reflecting anticipatory prandial thirst, with again no influence on the amount of fluid c

246 -OH-DPAT-induced 5-HT hypofunction increases thirst without substantially affecting the palatability