ライフサイエンスコーパス: threonine

1 hioether cross-linked to the gamma carbon of threonine.

2 erved acidic residue is replaced by a serine/threonine.

3 idine, but limiting for lysine, leucine, and threonine.

4 rdered linker with multiple phospho-acceptor threonines.

5 in Arabidopsis thaliana is phosphorylated at Threonine 101 (T101).

6 In budding yeast, histone H3 threonine 11 phosphorylation (H3pT11) acts as a marker o

7 ent light chain (NFL); tau phosphorylated at threonine 181 (p-tau), and NFL in cerebrospinal fluid (C

8 CSF tau phosphorylated at threonine 181 (p-tau181) is a highly specific biomarker

9 fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer'

10 a1-42 peptide, tau protein phosphorylated at threonine 181, total tau, and the ratio of phosphorylate

11 ERG and TMPRSS2-ERG oncoprotein through ERG threonine-187 and tyrosine-190 phosphorylation mediated

12 cid was consistently expressed on serine 94, threonine 194, and threonine 289 of APOE in L5 and was p

13 sphorylation of Polo-like kinase 1 (PLK1) on threonine 210, and phosphorylation of targeting protein

14 Plasma levels of tau phosphorylated at threonine-217 (p-tau217) is a candidate tool to monitor

15 rily dependent on CDK4/6-mediated serine-249/threonine-252 (S249/T252) phosphorylation of RB.

16 The CDK phosphorylates Rad21 on Threonine 262.

17 Expression and MEKK1-mediated threonine 288 phosphorylation of CNN-3 is induced by ext

18 ells, as were phosphorylation of Aurora A on threonine 288, phosphorylation of Polo-like kinase 1 (PL

19 y expressed on serine 94, threonine 194, and threonine 289 of APOE in L5 and was predicted to contrib

20 ng increase in histone H3 phosphorylation at threonine 3 (H3T3ph) and accumulation of major satellite

21 f survivin with histone H3 phosphorylated at threonine 3, and we provide a complete structure of this

22 e kinase Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), creating a docking site for the Ch

23 Aurora B recruitment accompanies histone H3 threonine-3 phosphorylation and requires Haspin kinase.

24 by phosphorylation of the activation loop at threonine 308.

25 2 or by VopS from Vibrio parahaemolyticus at threonine 35.

26 form delta (PKC-delta) was phosphorylated at threonine 505 by phospholipase C (PLC)-mediated signalin

27 ane DAT levels and/or phosphorylation of the threonine 53 site on the DAT accounts for fluctuations i

28 t serine 67, counteracting GSK3beta-directed threonine 58 phosphorylation and subsequent FBXW7-mediat

29 e effect of a new Cytc phosphorylation site, threonine 58, which we mapped in rat kidney Cytc by mass

30 nd also directly phosphorylates Frizzled3 on threonine 598 (T598).

31 ophosphorylation at multiple sites including threonine 676 in the activation segment or "T-loop." We

32 roach, we identify loss of STAT3 O-GlcNAc at Threonine 717 as a driver of astrocyte differentiation.

33 Rubisco activase (Rca) is phosphorylated at threonine-78 (Thr78) in low light and in the dark, sugge

34 osolic, and mitochondrial proteins on serine/threonine amino acid residues, a process termed protein

35 Rapid death of threonine and homoserine auxotrophs points to a distinct

36 ts the protein kinase C phosphorylation of a threonine and is associated with protection against MDD,

37 on-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and methionine.

38 cestodes consumed glucose and, surprisingly, threonine and produced succinate, acetate, and alanine a

39 we demonstrate that a stretch of consecutive threonine and serine residues, T(21) T(22) S(23) S(24,)

40 se events leave behind deaminated serine and threonine and thus can lead to ambiguous structural conc

41 Next, we analyzed the activation of serine/threonine and tyrosine kinases after treatment using a b

42 gnized but conserved feature of other serine/threonine and tyrosine kinases, suggesting a Mg(2+) regu

43 tigative focus has primarily been on serine, threonine and tyrosine phosphorylation, but mounting evi

44 inct motifs, which are substrates for serine/threonine and tyrosine phosphorylation.

45 re, we identify that mutation in dual serine/threonine and tyrosine protein kinase (dstyk) lead to CS

46 Enzymes often use nucleophilic serine, threonine, and cysteine residues to achieve the same typ

47 eversible protein phosphorylation on serine, threonine, and tyrosine residues is essential for fast,

48 n the off-target amino acid residues serine, threonine, and tyrosine was observed to pose a challenge

49 hopeptides with enriched regions of serines, threonines, and tyrosines that often orchestrate critica

50 Western blot analysis using anti-pan-serine/threonine antibodies demonstrated enhanced phosphorylati

51 logues containing other stereoisomers of aza-threonine are inactive.

52 oncentrations of free essential amino acids: threonine, arginine and lysine; non-essential amino acid

53 ssential amino acids (EAA) except lysine and threonine, as required by pre-school children (FAO/WHO).

54 or proteolytic cleavage by the endopeptidase threonine aspartase 1 (taspase1); however, the biologica

55 In silico analysis suggests that a threonine at position 152 of tau confers a new phosphory

56 tin containing all four stereoisomers of aza-threonine at position 8 were synthesized on a solid supp

57 ntaining amino acid substitutions alanine to threonine at residues 125 (A125T) and 151 (A151T) and le

58 ng chimpanzee CD4 requires reversion of both threonines at sites 34 and 68, destroying both of the gl

59 rine toxicity results from interference with threonine biosynthesis.

60 e degradation and in increased expression of threonine biosynthetic enzymes suggesting that serine to

61 mers are converted to the diastereomeric aza-threonines by mesylation, azide displacement, and reduct

62 isingly, IkappaBzeta phosphorylation at this threonine cluster promoted the recruitment of histone de

63 sitivity through increased mistranslation of threonine codons leading to cell death.

64 The threonine contents of the control and sample B were high

65 By deleting all threonine deaminases, we generated a strain in which iso

66 PPPs perform much of the serine/threonine dephosphorylation in eukaryotic cells and achi

67 t from commercially available stereoisomeric threonine derivatives.

68 tions are promoted by a readily accessible l-threonine-derived aminophenol-based boryl catalyst, affo

69 e essentials such as lysine, tryptophan, and threonine) displayed a relative-to-protein increasing co

70 rsion of methionine residues, but to the iso-threonine form.

71 uencing of 18 independent STF (Suppressor of Threonine Four) isolates revealed, in every case, a muta

72 ructured N- and C-terminal regions at Serine/Threonine-Glutamine (SQ) motifs.

73 negative charge of phosphorylated serines or threonines had mostly negative impacts on viability and

74 pendent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA levels in vivo in bo

75 N-acetylglucosamine (O-GlcNAc) to serine and threonine hydroxyls.

76 of the FXIII-A Isoleucine-Leucine-Aspartate-Threonine (ILDT) motif prevented Lys679Met FXIII-A-depen

77 of the residues adjacent to threonine or iso-threonine in a peptide sequence.

78 Substitution of a leucine by threonine in helix 8 of the ligand-binding domain of the

79 o demonstrate that translocation relies on a threonine in motif Ic, widely conserved in translocases,

80 vels are regulated by the phosphorylation of threonine in the cytoplasmic C-terminal domain, providin

81 ntacts between an isoleucine and a conserved threonine in the selectivity filter.

82 alNAc onto the hydroxyl groups of serines or threonines in protein substrates.

83 specifically O-glycosylated on 2 neighboring threonines in the C-terminal part and this modification

84 We show that phosphorylation of this serine/threonine is critical for non-conventional FFAT motifs (

85 This results in AKT serine/threonine kinase (Akt) activation, membrane focal adhesi

86 phosphoinositide 3-kinase (PI3K)/Akt serine/threonine kinase (Akt) and mitogen-activated protein kin

87 henotype (CIMP), B-Raf proto-oncogene serine/threonine kinase (BRAF) mutation, and Kirsten rat sarcom

88 horylated at Thr-50 within the LDS by serine/threonine kinase (STK) 3 and STK4.

89 clins associate with cyclin-dependent serine/threonine kinase 1 (CDK1) to generate the M phase-promot

90 Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cispla

91 Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) is the major energy sensor f

92 sregulation of microtubule-associated serine/threonine kinase 2 and protein-o-mannose kinase SGK196 i

93 ed in TGF-beta signaling, such as AKT Serine/Threonine Kinase 3 (AKT3) and Sulfatase 1 (SULF1).

94 -12, and -8 and receptor interacting serine/threonine kinase 3 (RIPK3).

95 ted that IkappaB kinase beta is a key serine/threonine kinase activated by autophagy stimuli and that

96 ied a signaling pathway-involving the serine-threonine kinase AKT and the transcription factor XBP1s,

97 In response to growth factors, the serine/threonine kinase AKT phosphorylates Thr(24) and Ser(256)

98 nhibitor of all three isoforms of the serine/threonine kinase AKT.

99 has led to the identification of the serine/threonine kinase ALK2 as a potential target for therapeu

100 se (NLK) is an evolutionary conserved serine/threonine kinase and a negative regulator of the Wnt sig

101 Here we show that SPA1 acts as a serine/threonine kinase and directly phosphorylates PIF1 in vit

102 downstream signaling through the ERK serine/threonine kinase and the Fos transcription factor, there

103 ivity is controlled by the Pkn8/Pkn14 serine/threonine kinase cascade, which phosphorylates MrpC on t

104 Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2

105 p21-activated kinases (PAKs) are serine/threonine kinase effectors of the small GTPases Rac and

106 Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is asso

107 e specificity of the host pleiotropic serine/threonine kinase GSK3.

108 ul stimulus or treatment with the AKT Serine/Threonine kinase inhibitor SH-6 restored splicing factor

109 l-originated protein kinase (TOPK), a serine-threonine kinase is activated by SUV irradiation and inv

110 K2 induced spine loss through the serine and threonine kinase LIMK1.

111 We identify the serine/threonine kinase LKB1 as a key driver of synapse layer e

112 chore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1).

113 The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin)

114 The serine/threonine kinase mTOR participates in growth factor sign

115 nous PTEN-induced kinase 1 (PINK1), a serine/threonine kinase mutated in a recessive forms of Parkins

116 protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase STK17A,

117 protein kinase (Drak), a cytoplasmic serine/threonine kinase orthologous to the human kinase STK17A.

118 The serine-threonine kinase PINK1 is responsible for recruiting Par

119 UHMK1 is a nuclear serine/threonine kinase recently implicated in carcinogenesis.

120 Here, we have identified the serine threonine kinase receptor-associated protein (STRAP) as

121 g cell-death-inducing activity of the serine/threonine kinase RIPK1.

122 n protein folding, protein synthesis, serine/threonine kinase signalling, glycolysis and gluconeogene

123 on-like (drl-1) gene, which encodes a serine/threonine kinase similar to the mammalian MEKK3 kinase.

124 identify a previously uncharacterized serine/threonine kinase STK19 as a novel NRAS activator.

125 n Lm vacuolar rupture, among them the serine/threonine kinase Taok2.

126 The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its ho

127 vel gene fusion of MAP3K8, encoding a serine-threonine kinase that activates MEK(3,4).

128 mTOR is a serine/threonine kinase that acts in two distinct complexes, mT

129 ontaining protein kinase 2 (ROCK2), a serine-threonine kinase that can be therapeutically targeted by

130 apamycin (MTOR) is a highly conserved serine/threonine kinase that critically regulates cell growth,

131 racting protein kinase 1 (RIPK1) is a serine/threonine kinase that dictates whether cells survive or

132 Aurora B is a serine/threonine kinase that has been implicated in regulating

133 The HipA toxin functions as a serine/threonine kinase that inhibits cell growth, while the Hi

134 e (AMPK) is an evolutionary conserved serine/threonine kinase that integrates cellular energy status

135 led that Polo-like kinase 1 (PLK1), a serine/threonine kinase that is essential for cell cycle progre

136 ublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that is overexpressed in gastrointestin

137 is PIM2, which encodes a prosurvival serine-threonine kinase that phosphorylates and inhibits the pr

138 ns was GSG2 (also known as Haspin), a serine/threonine kinase that phosphorylates histone H3 at Thr-3

139 of the essential autophagy initiator serine-threonine kinase ULK1, and increased in the activity upo

140 ROCK2 is a serine-threonine kinase whose role in lymphomagenesis is unknow

141 Casein kinase 1 alpha (CK1alpha) is a serine/threonine kinase with numerous functions, including regu

142 y ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required f

143 e 7-amino acid truncation in NUAK2, a serine/threonine kinase, completely abrogated its catalytic act

144 nase 1 (DCLK1), a microtubule binding serine threonine kinase, emerged as a promising target due to i

145 synthase kinase-3 beta (GSK-3beta), a serine/threonine kinase, has been identified as a potential the

146 se (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brain, but

147 In this context, the serine/threonine kinase, polo-like kinase (PLK1) regulates mult

148 The serine/threonine kinases and sole phosphatase of Mtb tune phosp

149 tivated kinases (PAK) are a family of serine/threonine kinases downstream of multiple critical tumori

150 alciparum exports a family of 18 FIKK serine/threonine kinases into the host cell, suggesting that ph

151 The specificity of serine/threonine kinases is partly determined by interactions w

152 are a family of constitutively active serine/threonine kinases that are partially redundant and regul

153 mologous and functionally overlapping serine/threonine kinases that phosphorylate multiple protein su

154 y of abundant, ubiquitously expressed serine/threonine kinases that regulate multiple cellular proces

155 e examine the STE20 family of protein serine-threonine kinases to investigate basic mechanisms of sub

156 Aurora kinases are a family of serine/threonine kinases vital for cell division.

157 AKT and mTOR are serine/threonine kinases which play important roles in cell gro

158 c analysis reveals that inability to produce threonine leads to deregulation of aspartate kinase, cau

159 id mutation at position 84 from histidine to threonine minimizes the mitogenicity of the wild-type le

160 Phosphorylation of a conserved threonine motif (T788/T789) in the integrin beta cytopla

161 typical proline, glutamic acid, serine, and threonine motif specifically existing in Smurf1 is neces

162 plice variants, as well as of a histidine-to-threonine mutant (MGL(short) H259T).

163 s, only one of which involves the proline to threonine mutation, suggesting that the low sakuranetin

164 ng N-glycosylation sites asparagine-X-serine/threonine (N-gly sites) within the V-region that are rar

165 The second threonine of the SF signature sequence (e.g., TTVGYG) ha

166 ata support an important role for the second threonine of the SF signature sequence in the U-type ina

167 type inactivation, we substituted the second threonine of the TTVGYG sequence by an alanine in the hK

168 are independent of the residues adjacent to threonine or iso-threonine in a peptide sequence.

169 own that dysregulated synthesis of O-linked (threonine or serine) sugars occurs in many cancers, and

170 positions that are uncommon in either serine/threonine or tyrosine kinases.

171 folds less prone than S" to substitutions to Threonine or Tyrosine that could potentially retain the

172 racts with HDAC1, HDAC2, and with the serine-threonine phosphatase PP1CC.

173 Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of

174 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that regulates a diverse array of

175 PGAM5 is a mitochondrial serine/threonine phosphatase that regulates multiple metabolic

176 or protein phosphatase 2A (PP2A) is a serine/threonine phosphatase whose activity is inhibited in mos

177 down of Nqo1 enhanced activity of the serine/threonine phosphatase, protein phosphatase 2A, which ope

178 n that regulates functions of protein serine/threonine phosphatase-1 in cell proliferation and lineag

179 e a curative option for other proline-serine-threonine phosphatase-interacting protein 1-associated i

180 Proline-serine-threonine phosphatase-interacting protein 1-associated m

181 ry a missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) ge

182 a conserved and essential nuclear serine and threonine phosphatase.

183 Members of the PP2A family of serine/threonine phosphatases are important human tumor suppres

184 phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for

185 ed distribution and lower activity of serine/threonine phosphatases in the context of HIV infection m

186 Serine/threonine phosphatases such as PP1 lack substrate specif

187 e phosphorylated residues (79%), compared to threonine phosphorylated sites (21%).

188 On the contrary, we identified that threonine phosphorylation (T669) in the latch domain neg

189 ity is regulated by a balance between serine/threonine phosphorylation and dephosphorylation.

190 tor of kinase activity and global serine and threonine phosphorylation.

191 system, we discovered a novel form of serine/threonine protein glycosylation (O-linked beta-GlcNAc; O

192 PK downstream of receptor-interacting serine/threonine protein kinase 3 (RIPK3) and destabilization o

193 anoma 2 (AIM2), receptor-interacting serine/ threonine protein kinase 3 (RIPK3), and caspase recruitm

194 The p38alphaMAPK is a serine/threonine protein kinase and a key node in the intracell

195 Here, we show that a serine/threonine protein kinase encoding gene KERNEL NUMBER PER

196 The Akt serine/threonine protein kinase family is linked to maintaining

197 sia mutated and RAD3-related (ATR), a serine/threonine protein kinase involved in the response to DNA

198 ine protease homologous to DegP and a serine/threonine protein kinase of unknown function.

199 n a process that is controlled by the serine/threonine protein kinase PLK4 (refs.

200 ociated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulat

201 ATM is a serine/threonine protein kinase that is recruited and activated

202 istic target of rapamycin (mTOR) is a serine/threonine protein kinase that mediates phosphoinositide-

203 nase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals

204 thway for mitophagy that utilizes the serine/threonine protein kinase Unc-51-like kinase 1 (Ulk1) and

205 The serine/threonine protein kinase v-AKT homologs (AKTs), are impl

206 type protein tyrosine phosphatase, a serine/threonine protein kinase, and a Kruppel-type zinc-finger

207 her alphaherpesviruses, MDV encodes a serine/threonine protein kinase, U(S)3.

208 oliferating and cancerous cells, is a serine/threonine protein kinase, well known to orchestrate key

209 STA-domain containing eukaryotic-like serine/threonine protein kinases (PASTA-eSTK) that sense PG fra

210 Rho-associated coiled-coil containing serine/threonine protein kinases (ROCKs) have recently been sug

211 The Pim and AKT serine/threonine protein kinases are implicated as drivers of c

212 The characterization of prokaryotic serine/threonine protein kinases in bacterial pathogens is emer

213 ngly, activation of the Akt family of serine/threonine protein kinases is linked to maintenance of la

214 the protein kinase C (PKC) family of serine/threonine protein kinases.

215 K2 are two closely related AGC-family serine/threonine protein kinases.

216 s a member of the magnesium-dependent serine/threonine protein phosphatase (PPM) family and is induce

217 The serine/threonine Protein Phosphatase 2A (PP2A) functions as a t

218 9, which was driven by dysfunction of serine/threonine protein phosphatase 2A in the nerve terminals.

219 51 (FKBP51), in conjunction with the serine/threonine protein phosphatase 5C (PPP5C), inhibits I(SOC

220 lcineurin (Cn) is a calcium-activated serine/threonine protein phosphatase that is broadly implicated

221 ylation (pS(307) IRS1/total IRS1) and serine/threonine-protein kinase (AKT) phosphorylation (pT(308)

222 MAPK-interacting serine/threonine-protein kinase 1 (MNK1) signaling can promote

223 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a critical regulat

224 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of

225 nery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master swit

226 f caspase-8- and receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated inflammatory

227 us that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of

228 e undergo RIPK3 (receptor-interacting serine/threonine-protein kinase 3)-MLKL (mixed lineage kinase d

229 While targeted serine/threonine-protein kinase B-Raf (BRAF) and immune checkpo

230 were treated with vehicle or combined serine/threonine-protein kinase B-Raf (BRAF) kinase inhibitor (

231 Serine/threonine-protein kinase B-Raf inhibitor and anti-progra

232 gous variant in the gene encoding the serine/threonine-protein kinase BRSK2.

233 f the sucrose non-fermentable-related serine/threonine-protein kinase SNRK in glomerular endothelial

234 Raf1/c-Raf is a well-characterized serine/threonine-protein kinase that links Ras family members w

235 Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-accel

236 The receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 play important

237 lated to changes in the levels of the serine/threonine-protein phosphatase PP1-alpha catalytic subuni

238 ally occluded tyrosine residues and a distal threonine residue (T187), triggering degradation of p27.

239 beta), we find that mutation of this surface threonine residue impacts critical Polbeta protein-prote

240 s well as two analogues of P-A1 in which the threonine residue in P-A1 was replaced with l-2,3-diamin

241 n-dependent kinase 1 (CDK1) phosphorylated a threonine residue on the catalytic subunit of the phosph

242 e non-canonical H-bond formed by a serine or threonine residue whose hydroxyl side chain H-bonds to a

243 kinase cascade, which phosphorylates MrpC on threonine residue(s) located in its extreme amino-termin

244 e in the peptide core instead of a serine or threonine residue, the inclusion of a non-heme iron, alp

245 lypeptides with carboxy-terminal alanine and threonine residues (CAT tails).

246 ce-binding proteins, which present arrays of threonine residues (matched to the ice lattice) that ord

247 phosphorylation of the four activation-loop threonine residues and binding of ATP-Mg(2+).

248 strong H-bonds serve to stabilize serine and threonine residues in hydrophobic environments while con

249 n the C terminus of ubiquitin and serine and threonine residues in its substrates.

250 epends on phosphorylation of both serine and threonine residues in NS5A.

251 dentified several phospho-serine and phospho-threonine residues in the known TLR pathway kinases, Int

252 is revealed that a highly conserved layer of threonine residues in the pore conveys a basal K(+) sele

253 d for reliable identification of isoforms of threonine residues in tryptic peptides.

254 Pah1 phosphorylation on multiple serine/threonine residues is complex and catalyzed by diverse p

255 ptor at the so-called T6' ring, wherein five threonine residues line the permeation pathway of the pe

256 tion sites, including a conserved cluster of threonine residues located in the N-terminus of the prot

257 have hydroxyl groups of specific serine and threonine residues modified by the monosaccharide N-acet

258 Several serine and threonine residues of the papillomavirus early E2 protei

259 hobic interactions with all five pore-lining threonine residues of the pentameric receptor.

260 ng triggers transphosphorylation of critical threonine residues proximal to the CaM-binding site lead

261 ciniphila cleaves N-terminally to serine and threonine residues that are modified with (preferably as

262 N-terminal region that is rich in serine and threonine residues, several of which are reportedly phos

263 hosphorylated by CKII on multiple serine and threonine residues, with the former being major sites.

264 ating tryptophan, asparagine, glutamine, and threonine residues.

265 PM and dephosphorylation of Art1 at specific threonine residues.

266 e rings originate from cysteine, serine, and threonine residues.

267 iphilic ice-binding sites based on arrays of threonine residues.

268 he structure of the CTD showed that a serine/threonine-rich stretch causes a backbone twist in the N-

269 on a unique motif with conserved serine and threonine (S/T) residues that have a high capacity for h

270 I3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regul

271 - 1.2%) had lower fumarate levels and higher threonine, serine, proline, asparagine, aspartic acid, p

272 o differential phosphorylation of serine and threonine sites within proteins regulating T cell activa

273 ns, is a calcium-calmodulin-dependent serine-threonine-specific phosphatase that orchestrates cellula

274 These biomolecules include activated serine/threonine-specific protein kinases (pRAF), mitogen-activ

275 The threonine stereoisomers are converted to the diastereome

276 lene, bicyclic pyrrolidine (Aoc), and methyl-threonine structural motifs.

277 The missense isoleucine to threonine substitution at position 73 (I73T) in the alve

278 We identified a proline to threonine substitution in Kasalath relative to Nipponbar

279 We found that mutation of threonine (T) T923 to an alanine disrupted synaptic traf

280 Changing a tyrosine (Y) or threonine (T), located on the protein surface within 10

281 s (leucine [L], proline [P], serine [S], and threonine [T]).

282 In studies to elucidate the role of threonine T38 in CAR regulation, we found that the T38D

283 epended upon phosphorylation of a PXTP motif threonine (Thr(349)) located within the C-terminal alpha

284 ctivates mTORC1 in response to variations in threonine (Thr) levels via mitochondrial threonyl-tRNA s

285 y at four carboxyl-terminal serine (Ser) and threonine (Thr) residues, namely, Ser(346), Ser(351), Th

286 expression of EWSR1/FLI1-T79A, containing a threonine (Thr) to alanine (Ala) substitution at amino a

287 r peptides containing methionine (Met; M) or threonine (Thr; T), which differentially influence natur

288 ibility of AAs ranged from 87.4 +/- 2.7% for threonine to 98.4 +/- 1.0% for methionine in the WPI gro

289 o mutation in the SLC6A3 gene resulting in a threonine to methionine substitution at site 356 (DAT T3

290 amino acids, including a frequent change of threonine to serine at position 590.

291 In addition to YbeC, the threonine transporters BcaP and YbxG make minor contribu

292 down-regulation of a number of amino acids (threonine, tryptophan, l-cysteine, methionine, cycloleuc

293 Here we report using our QTY (glutamine, threonine, tyrosine) code to systematically replace 29 m

294 cently investigated the role of three serine/threonine/tyrosine (STY) kinases, STY8, STY17, and STY46

295 n-1-yl)-sulfonamides derived from serine and threonine were synthesized using solid-phase synthesis a

296 ibition impacting primarily dephosphorylated threonines, whereas PP2A reactivation results in dephosp

297 actions of its dual HxT motif histidines and threonines with phosphate in the active site.

298 cleaved at the N-terminal end of serine and threonine, with O-glycan remaining intact.

299 icated that the acidic residues, but not the threonine, within the EDTEE motif are important for the

300 le asparagine residue in ZnT10 (Asp-43) with threonine (ZnT10 N43T) converted the Mn(2+)/Ca(2+) excha