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3 ee different scenarios and conclude that the thrifty gene hypothesis is untenable but the other two i
5 isk alleles specifically as predicted by the thrifty gene hypothesis, and may not be related to influ
8 antageous, many people did not inherit these thrifty genes and in modern society are able to remain s
11 he Bering Strait land bridge (Beringia) when thrifty genes would have ensured sufficient fat reserves
13 ing on the potential survival advantages of "thrifty" genes that are now maladaptive, are of great in
14 this predisposition is polygenic involving "thrifty" genes that conferred survival advantages when P
19 ing the hypothesis that, in addition to the "thrifty genotype" and "thrifty phenotype" hypotheses, di
20 the Ossabaw Island (Ossabaw pigs) exhibit a thrifty genotype, and when fed a high-calorie diet they
21 conceptuses, which may possess a so-called "thrifty genotype," are at a competitive advantage over a
22 tions is believed to be the expression of a "thrifty genotype," which conferred survival advantages d
25 festyles selected for adaptive metabolically thrifty genotypes and phenotypes are rendered deleteriou
29 FGF21 response to a low-protein diet have a thrifty metabolism and are at risk for future weight gai
30 ary adaptation to famine and identified as a thrifty microRNA that controls energy expenditure, contr
32 onvolutions on 3-mer embeddings, we develop 'thrifty' models of SHM of various sizes; these can have
33 ll but variable between subjects, revealing "thrifty" or "spendthrift" metabolic phenotypes related t
35 ics may bridge both the thrifty genotype and thrifty phenotype hypotheses and provide a link between
39 , in addition to the "thrifty genotype" and "thrifty phenotype" hypotheses, diet-induced changes in "
40 To test the hypothesis that a metabolically "thrifty phenotype" is advantageous during intestinal nem
43 paternal exercise produces offspring with a thrifty phenotype, potentially via miRNA-induced modific
45 e analyzed whether obese individuals with a "thrifty" phenotype, that is, greater reductions in 24-h
46 l size at birth are suggested to have energy-thrifty physiology, a tendency to conserve energy due to
48 This observation is in agreement with the "thrifty telomere hypothesis" predicting that longer telo
49 abolic phenotypes (spendthrift compared with thrifty) that characterize susceptibility to weight gain
50 the allele encoding p.Arg457Gln, support a 'thrifty' variant hypothesis as a factor in human obesity
51 EE response to COLD further identifies the "thrifty" versus "spendthrift" phenotype, providing an ad