ライフサイエンスコーパス: thumb

1 stics-guided appraisal (i.e. mental rules of thumb).

2 coordinate actions of another effector (the thumb).

3 based model (ABM) that embodies this rule of thumb.

4 m the globular domain of M like a finger and thumb.

5 ed instead to stimuli located near the right thumb.

6 bilizes the open and apo conformation of the Thumb.

7 pabilities and evolution of the modern human thumb.

8 One nsp13 also contacts the nsp12 thumb.

9 the presumptive anterior wrist and proximal thumb.

10 to be the most common cause of triphalangeal thumb.

11 r all five digits as well as rotation of the thumb.

12 arm movement and an isometric press with the thumb.

13 he helix-loop-helix domain of the polymerase thumb.

14 nger, with the greatest concentration on the thumb.

15 replicate the motion of the index finger and thumb.

16 onserved subdomains called palm, fingers and thumb(1,2).

17 s and TR band application in the homolateral thumb (-32%, -32%, respectively) and contralateral thumb

18 (-32%, -32%, respectively) and contralateral thumb (-34%, -21%, respectively).

19 w well the same subjects learned a ballistic thumb abduction task using the APB muscle.

20 ity in six subjects trained to perform rapid thumb abductions over 5 d.

21 EMG signals recorded from the short and long thumb abductor muscles during steady isometric contracti

22 eater relative weakness (lower MRC score) in thumb abductors versus elbow extensors, for hand extenso

23 cts in individuals with OS range from subtle thumb abnormalities to truncated limbs.

24 compared tissue perfusion of the homolateral thumb (access site) with the contralateral thumb (compar

25 raction obtained while subjects abducted the thumb against a manipulandum.

26 The benzimidazoles bind to the thumb allosteric pocket and inhibit the conformational c

27 lso observed a cross interaction between the thumb allosteric pocket and the initiation pocket using

28 to the structural dynamics propagate to the thumb and connection subdomains and RNase H domain of th

29 This hand reveals a long, robust thumb and derived wrist morphology that is shared with N

30 p59 insert into the interface created by the thumb and exonuclease domains of gp43.

31 onserved Pol III residues along the fingers, thumb and exonuclease domains.

32 jor domains in the extracellular region, the thumb and finger domains.

33 strength of the interaction between adjacent thumb and finger domains.

34 M cells that project to motoneurons of three thumb and finger muscles.

35 es LRET efficiency between the probes at the thumb and finger subdomains in the extracellular domain

36 rdered transition of several segments of the thumb and fingers modules and an inward motion of the fi

37 ormation in which the separation between the thumb and fingers subdomains is much higher than in the

38 s consistent with forceful opposition of the thumb and fingers typically adopted during tool use.

39 pocket of a basic cleft adjacent to flexible thumb and forefinger loops, which could provide further

40 in M1 while participants either tapped their thumb and forefinger together or simply imagined doing s

41 nd hypoplasia or aplasia of the nails of the thumb and great toe.

42 s reappearance, reached to grasp it with the thumb and index finger along one of its two symmetry axe

43 grasping a small (6 mm) cylinder between the thumb and index finger and during index finger abduction

44 hat the recovery of precision grip using the thumb and index finger depends on the survival of affere

45 Wnt engages FZD through protruding thumb and index finger domains, which are each assembled

46 idence for our theory that grasping with the thumb and index finger is based on a combination of two

47 retrieve a target object from a clamp using thumb and index finger opposition.

48 gically identified axons projecting from the thumb and index finger were then cut in two monkeys (Gro

49 e densest in the distal pads of the opposing thumb and index finger, with the greatest concentration

50 the control of a precision grip between the thumb and index finger.

51 reen users, the cortical potentials from the thumb and index fingertips were directly proportional to

52 tical representations of the stroke-affected thumb and little finger following TFD but not following

53 nied by a distance increase between adjacent thumb and palm domains as well as a movement of Glu-235

54 nhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as de

55 e H domain of the p66 subunit as well as the thumb and palm subdomains of the p51 subunit.

56 cular wedges", disrupting the region between thumb and palm subdomains of the p66 subunit and locking

57 report that one histidine at the base of the thumb and residues in the channel pore influence proton

58 lecule in which the fingers/palm/connection, thumb and RH substructures are connected by flexible (di

59 combination with the biodegradation rules of thumb and some basic organic chemistry has allowed 281 p

60 cular communications between residues of the thumb and the C-terminal domains are important for HCV r

61 ike and cytokine-like domains, including the thumb and the index finger in Wnt folding/secretion and

62 index finger into a pocket at the top of the thumb and the presence of Trp403 on the thumb domain are

63 of interaction of the DNA with the extended thumb and thioredoxin.

64 World monkeys that have evolved an opposable thumb and use tools in the wild.

65 own protein folds, resembling a "hand" with "thumb" and "index" fingers extended to grasp the Fz8-CRD

66 affinity through a palmitoylated N-terminal "thumb" and a disulfide-stabilized C-terminal "index fing

67 n/activity, those in the amino terminus, the thumb, and at the tip of the index finger are incompatib

68 requencies, greater or equal to those of the thumb, and frequently the same or greater than those of

69 sical abnormalities, including craniofacial, thumb, and heart anomalies, whereas isolated thumb malfo

70 e cavity formed by the reverse transcriptase thumb, and the endonuclease-like and RNaseH-like domains

71 Combined treatment with a thumb- and a palm-binding polymerase inhibitor had a dra

72 Rules of thumb appropriate for neuroscience and cardiology may no

73 ulation to alter functional responses in the thumb area of the primary motor cortex.

74 signals to two fingertips (index finger and thumb) as they traveled along collinear paths.

75 suggested by an empirical but robust rule of thumb based on household secondary attack rate.

76 various resistance mutations in the palm and thumb binding sites correlated well with resistance -fol

77 ingly, however, following the closing of the thumb but prior to the rotation of Arg258, the E295K mut

78 in the loop containing beta-strand 8 in the thumb, but closing occurred only in the Ile(492)Ala muta

79 Back-of-the-envelope or rule-of-thumb calculations involving rough estimates of quantiti

80 or of these drugs is contrary to the rule of thumb called Overton's rule, which holds that more lipop

81 Patients underwent serial assessments of thumb capillary lactate (the primary endpoint), thumb pl

82 Analyses reveal that the thumb closing of pol beta before chemistry is hampered w

83 reaction after partial closing or even full thumb closing, we suggest that pol beta is tightly contr

84 l thumb (access site) with the contralateral thumb (comparator) during radial access as primary outco

85 inhibitor (NNRTI) and dsDNA; a hyperextended thumb conformation helps to accommodate the relatively w

86 nds from southern England with triphalangeal thumb, demonstrated significant linkage of the phenotype

87 understanding the special morphology of the thumb (digit 1), the acquisition of which was an importa

88 on of ASIC1a involving the upper part of the thumb domain (residues Asp-349 and Phe-350), the palm do

89 the polyadenylation of virion RNA include a thumb domain alpha helix that is positioned in the minor

90 date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) conserved in the homologou

91 inding site lying at the surface between the thumb domain and the fingertip about 30 A away from the

92 the thumb and the presence of Trp403 on the thumb domain are key interactions required to maintain t

93 C1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel

94 hrough the inability of hPolbeta to complete thumb domain closure.

95 A unique beta-strand motif in the PolC thumb domain contacts the minor groove, allowing replica

96 tion and of ENaC gating and suggest that the thumb domain contributes to the channel gating machinery

97 The interactions between the Delta1 loop and thumb domain in NS5B are required for de novo initiation

98 map to thealpha5 helix in the extracellular thumb domain in the chicken acid sensing ion channel 1 s

99 The thumb domain in the extracellular region of ASIC1 has a

100 also examined the importance of the fingers-thumb domain interaction for the function and structural

101 We further noted that thumb domain interactions with product RNA regulate tran

102 5-6 degrees C while mutations in the fingers-thumb domain interface destabilize the protein and reduc

103 by removing residues that bind at the finger-thumb domain interface.

104 We propose that the thumb domain moves upon continuous exposure to an acidic

105 One is formed by residues in the thumb domain of alphaENaC and the palm domain of betaENa

106 s formed by residues at the interface of the thumb domain of betaENaC and the palm domain of gammaENa

107 In contrast, mutations in the thumb domain of gammaENaC and palm of alphaENaC had litt

108 curs via an arginine patch in the C-terminal thumb domain of RdRp.

109 e inhibitors that bind to the surface of the thumb domain of the viral RNA-dependent RNA polymerase (

110 e highly conserved regions of the telomerase thumb domain referred to as motifs E-I (thumb loop and h

111 The intrinsically flexible Thumb domain seems to play a major role in accommodating

112 fingers domain interacts with the top of the thumb domain to create a tunnel through which nucleotide

113 at used a fluorescent probe located near the thumb domain to measure the kinetic properties of Dpo4 c

114 he human telomerase C-terminal extension (or thumb domain) determined by the method of single-wavelen

115 omerase, which have a dramatically augmented Thumb domain, and of reverse transcriptase, which extend

116 in the region surrounding the H-helix of the thumb domain.

117 Leu419, Met423, and Ile482 in the polymerase thumb domain.

118 One set of polymerase contacts, between the "thumb" domain of one polymerase and the back of the "pal

119 e transmembrane pore lies a disulphide-rich 'thumb' domain poised to couple the binding of protons to

120 ed grip on the DNA by the palm, fingers, and thumb domains and the PAD and provides additional thermo

121 regulate translocation and that the palm and thumb domains coordinately control elongation complex st

122 e for the dynamic interaction of fingers and thumb domains in an environment that supports the format

123 gineered disulfide bond between the palm and thumb domains leads to partial channel closure.

124 s to specific residues within the finger and thumb domains of ENaC.

125 ive reagents revealed that the beta-ball and thumb domains reside apart in the resting state but that

126 e contribution of the finger, beta-ball, and thumb domains to activation and desensitization through

127 We examined whether loops at the base of the thumb domains within ENaC subunits have a similar role i

128 ight hand" structure with palm, fingers, and thumb domains, and these RdRPs also possess a unique con

129 ess a unique contact between the fingers and thumb domains.

130 by exchanging the fingers, pinky finger, or thumb domains.

131 MutS mismatch recognition and DNA polymerase thumb domains.

132 (HCV) polymerase, including in the palm and thumb domains.

133 The lemurs adopted the thumb-down posture when that hand position afforded a th

134 canonical thumb-up posture or a noncanonical thumb-down posture.

135 ce between the homolateral and contralateral thumb during radial access (217; interquartile range, 11

136 Reduced perfusion of the thumb during radial access was not associated with incom

137 The Csm3 thumb elements introduce periodic kinks in the crRNA-tar

138 e structures ("predigits"), such as pandas' "thumbs." Elephants similarly have expanded structures in

139 evolution in hylobatids (extreme digital and thumb elongation), convergent adaptation between chimpan

140 Three rules of thumb emerge from our studies to aid further design: (i)

141 We have characterized the gene emperor's thumb (et) and showed that it is required for the regula

142 Rules of thumb exist for RICS image acquisitioning, yet a rigorou

143 Finger and thumb extension were full against gravity in 1 patient (

144 ade possible by significant movements of the thumb, finger, and beta-binding domains relative to thei

145 66 resulted in even greater increases in the thumb/fingers opening, RT sliding, dNTP binding disrupti

146 s of RT, which contributes to opening of the thumb/fingers subdomains.

147 subjective due to its dependence on rules of thumb for deriving geometric constraints and suitable va

148 We further propose rules of thumb for guiding the choice of strategy: For example, s

149 cteristics could serve as pragmatic rules of thumb for identifying candidate sequences likely to be u

150 The rule of thumb for such efforts is that a factor-of-four sample s

151 Our approach can serve as a UHI rule of thumb for the comparison of urban development scenarios.

152 new insight but it provides a simple rule of thumb for the design of monitoring programmes in practic

153 We propose a 'rule-of-thumb' for estimating the maximum number of guest molecu

154 the identification of conservation 'rules of thumb' for these taxa, and supports the notion of local

155 (S) decreases exponentially, with a "rule-of-thumb" formula S=0.75*0.85(depth).

156 These rules of thumb illustrate how cost-effective conservation outcome

157 the object by opposing the index finger and thumb in >80% of trials.

158 ubdomains of the p66 subunit and locking the thumb in a wide-open conformation.

159 er speckle imprinting and provides a rule of thumb in selecting the laser power required to optimally

160 to identify the reorganized region of D1-D3 (thumb, index finger, and middle finger) representation.

161 cutaneous and proprioceptive input from the thumb, index finger, and middle finger.

162 nkeys, the region deprived of input from the thumb, index, and middle finger was found to be unrespon

163 dorsal rhizotomy that removes input from the thumb, index, and middle fingers, the macaque is unable

164 tials in response to mechanical touch on the thumb, index, and middle fingertips of touchscreen phone

165 ch-dynamic parameters and the grip aperture (thumb-index finger distance) were calculated.

166 Although the thumb interacted predominantly with the screen, the pote

167 idues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the m

168 operative unfolding in the fingers extension-thumb interface and primer grip, which may contribute th

169 Most notably, F587L at the Palm and Thumb interface stabilizes the open and apo conformation

170 Formation of the inter-subunit RH:thumb' interface occurs at an early stage, while maturat

171 ojecting from serine 187 at the tip of Wnt's thumb into a deep groove in the Fz8-CRD.

172 A simple rule of thumb is also presented.

173 grasping with the fingers, while that of the thumb is consistent with human-like manipulation.

174 rase thumb domain referred to as motifs E-I (thumb loop and helix), E-II, and E-III (the FVYL pocket,

175 thumb, and heart anomalies, whereas isolated thumb malformations are predominantly present in patient

176 This empirical "rule of thumb" may help applied researchers identify situations

177 election is normally made based on a rule of thumb, meaning that the calculated threshold level may b

178 Our theoretical analyses provided a rule-of-thumb method for the selection of geometrical device par

179 is formed by the previously uncharacterized thumb mini-loop (NSH motif) and the positively charged h

180 ion of additional muscles that integrate the thumb more closely with surrounding structures.

181 a particular focus on subtle differences in thumb morphology and how this may reflect differences in

182 domain (DRD), a unique RED motif, a flexible thumb motif (ThM), and implied conformational changes wi

183 the apo enzyme, suggesting the constraint of thumb motion is not as complete as previously believed.

184 for subtle active-site rearrangements after thumb movement but before chemistry.

185 separate muscles (flexor pollicis longus, a thumb muscle, and flexor digitorum profundus, an index-f

186 e as that for pairs of units both within the thumb muscle.

187 one of the few taxa we studied in which the thumb musculoskeletal structures do not form an independ

188 a direct interaction between the back of the thumb of 3Dpol and 3C that is required for 3Dpol recruit

189 p66 ribonuclease H (RNase H) domain and p51 thumb of human immunodeficiency virus reverse transcript

190 They differ in whether the wrist or the thumb of the hand is controlled.

191 polymerase, and a unique loop located on the thumb of the polymerase also stabilizes this primer exte

192 es in response to tactile stimulation of the thumb of the stroke-affected hand during TFD but not fol

193 le they either imagined or executed a finger-thumb opposition sequence.

194 n consisting of self-paced, bilateral finger-thumb opposition task, 3) resting-state with ESB (Stim-1

195 actional dimer concentration and the fingers/thumb orientation are found to depend strongly on the ex

196 ergoes a conformational change involving the thumb, palm, and finger domains in one of the subunits (

197 The thumb, palm, and fingers subdomains of POL form an exten

198 efined domains termed the finger, beta-ball, thumb, palm, and knuckle.

199 Thumb pinch force was measured by a pressure sensor, whe

200 M1) at different frequencies during an index-thumb pinch-grip observation task.

201 mb capillary lactate (the primary endpoint), thumb plethysmography, and ulnar frame count to investig

202 evaluation led to the discovery of the first thumb pocket 1 NS5B inhibitor (BILB 1941) that demonstra

203 low-up compound (BI 207524, 27) to the first thumb pocket 1 NS5B inhibitor to demonstrate antiviral a

204 We have discovered allosteric (thumb pocket 1) non-nucleoside inhibitors of HCV NS5B po

205 H-quinazolin-4-one (QAZ) allosteric HCV NS5B thumb pocket 2 (TP-2) inhibitors was recently reported.

206 An anthranilic acid series of allosteric thumb pocket 2 HCV NS5B polymerase inhibitors exhibited

207 ckbone carbonyl groups, leading to the first thumb pocket 2 NS5B inhibitor with picomolar antiviral p

208 nhibitors of NS5B polymerase that act at the thumb pocket 2 site.

209 , consistent with more extended and adducted thumb postures that may reflect habitual use of grips co

210 Patients with an altered thumb print due to other causes and palmar hyperhidrosis

211 gh the analyses of VOC profiles of the human thumb prints recovered from a nonbiological smooth surfa

212 rigger finger persisted in 10 cases, and one thumb pulley could not be released.

213 DRRS had radial ray abnormalities including thumb, radial artery, radial bone, and pectoral muscle h

214 malities, abnormal skin pigmentation, and/or thumb/radius malformations.

215 distinguished from apes by possessing longer thumbs relative to fingers.

216 ensory processing from the hand and that the thumb representation was updated daily depending on its

217 ng 3Dpol-R455A, a residue on the back of the thumb required for VPg uridylylation.

218 sented with isolated bilateral triphalangeal thumb resembling the heterozygous phenotype, suggesting

219 In addition, we identify other thumb residues (Arg538, Lys521, Arg517, and Arg514) that

220 ons, were compared, and a simplified rule-of-thumb (RoT) correction factor (CF) was derived for lesio

221 As simple 'rules of thumb', sequence identity thresholds do not require a bi

222 nuckle), flexor pulley injuries, and skier's thumb, should also be detected.

223 After a single treatment with a thumb site inhibitor (thiophene-2-carboxylic acid NNI-1)

224 The binding affinity of four palm and thumb site representative non-nucleoside inhibitors (NNI

225 wed that nonnucleoside inhibitors binding to thumb site-2 (NNI2) do not block initiation or elongatio

226 how that nonnucleoside inhibitors binding to thumb site-2 (NNI2) lead to the accumulation of abortive

227 ges indicative of binding to both allosteric thumb sites I and II of NS5BDelta21 and induces long-ran

228 temporally overlap, the brain controlled the thumb solely based on an internal estimate of time.

229 s callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus).

230 utations at highly conserved residues in the thumb subdomain (G848S, c.2542g-->a; T851A, c.2551a-->g;

231 ct incoming nucleotide, alpha-helix N of the thumb subdomain believed to be required for pol beta's c

232 ese processes, we analysed the function of a thumb subdomain beta-hairpin using initiation, elongatio

233 ese processes, we analysed the function of a thumb subdomain beta-hairpin using initiation, elongatio

234 the first structure-function analysis of the thumb subdomain in pol gamma and examines the consequenc

235 state with incoming nucleotide exhibit more thumb subdomain motion, particularly in the loop contain

236 Some, but not all, of the unstable RT thumb subdomain mutants we analyzed have a temperature-s

237 quire an interaction between the back of the thumb subdomain of 3Dpol and an undefined region of the

238 nding sites at the subunit interface between thumb subdomain of alphahENaC and palm subdomain of beta

239 redoxin binding domain (TBD), located in the thumb subdomain of bacteriophage T7 gene 5 DNA polymeras

240 ghtly (Kd = 5 nM) to a unique segment in the thumb subdomain of gp5 and increases processivity.

241 e single point mutations we generated in the thumb subdomain of HIV-1 (RT) affect the stability of RT

242 data suggest an interaction between the p66 thumb subdomain of HIV-1 reverse transcriptase, and the

243 scriptase (HIV-1 RT) by interacting with the thumb subdomain of its non-catalytic p51 subunit.

244 beta12-beta13-beta14 lies at the base of the thumb subdomain of p66 and contains highly conserved res

245 the C-terminal domain of the PA subunit, the thumb subdomain of PB1 and the N1 subdomain of PB2.

246 oming nucleotide, and two divalent ions, the thumb subdomain of pol X undergoes a large conformationa

247 the ribonuclease H (RNase H) active site and thumb subdomain of the p66 RT subunit, suggest that desp

248 xin binds to a segment of 76 residues in the thumb subdomain of the polymerase and increases the proc

249 Amino acid substitutions in the thumb subdomain of the RNA-dependent RNA polymerase (RdR

250 ction and in an upstream 5' region where the thumb subdomain of Ty3 RT putatively grips the substrate

251 gamma revealed that Alpers mutations in the thumb subdomain reduced polymerase activity more than 99

252 25 A from the active site in the polymerase thumb subdomain.

253 to evaluate the conformation of the fingers/thumb subdomain.

254 redoxin, via a unique loop at the tip of the thumb subdomain.

255 domain, connecting loops between fingers and thumb subdomains and in the putative RNA binding channel

256 a "fisted right hand" with Fingers, Palm and Thumb subdomains connected to an N-terminal domain.

257 ight hand (containing the fingers, palm, and thumb subdomains), a hydrophobic C-terminal region, and

258 nce for the open conformation of the fingers/thumb subdomains, and a reported variation of three orde

259 ing to RT induces opening of the fingers and thumb subdomains, which increases the dynamic sliding mo

260 es positioned near the tip of the fingers or thumb subdomains.

261 s subdomain as it closed toward the palm and thumb subdomains.

262 rigid-body motion between the "fingers" and "thumb" subdomains of the p66 subunit.

263 increase in self-comforting behaviors (e.g., thumb sucking) over development, whereas in contrast, mo

264 tardation, Aphasia, Shuffling gait, Adducted thumbs) syndrome.

265 in 3D during 15-s repetitive index finger-to-thumb tapping trials.

266 The rule of thumb that logistic and Cox models should be used with a

267 study also supports a fairly simple rule of thumb that may be useful in the interpretation of dietar

268 hese results are an exception to the rule-of-thumb that membrane-spanning bolaamphiphiles are inheren

269 are exceptions to the long-standing rule-of-thumb that proteins with as little as 30% sequence ident

270 urements and also identify a general rule of thumb that the surface contacted by electrolyte is of th

271 Here, a third domain of L3 called the basic thumb, that protrudes roughly perpendicular from the W-f

272 As a rule of thumb, the achievable spatial resolution is on the order

273 imensional array inside a chip the size of a thumb, the lateral dimension of each oscillator must be

274 Remarkably, the thumb tip was sensitive to the day-to-day fluctuations i

275 We also give simple rules of thumb to achieve the best separation efficacy in nanocha

276 f basically charged amino acids of the basic thumb to alanines followed by detailed analyses suggests

277 on trait profiles that may serve as rules of thumb to distinguish reservoirs from nonreservoir specie

278 We give rules of thumb to guide the user on system behavior, such as adve

279 al (shoulder to finger) and anteroposterior (thumb to little finger) axes.

280 dicating that it specifies antero-posterior (thumb to little finger) positional values.

281 it pattern across the antero-posterior axis (thumb to little finger).

282 inct behaviors that result, develop rules of thumb to quickly determine how a given system will behav

283 Proximity of the p51 thumb to the p66 RNase H domain implied that inhibitor b

284 -20 min and 60-70 min and tapped their right thumb to their fingers at 35-45 min and 85-95 min.

285 We discover a "rule of thumb" to safeguard against the long-term catch depletio

286 The human (and australopith) high thumb-to-digits ratio required little change since the L

287 itar), emblems (conventional gestures, e.g., thumb up), and meaningless gestures.

288 n posture when that hand position afforded a thumb-up posture following object transport, thereby exh

289 d measured the grasp used-either a canonical thumb-up posture or a noncanonical thumb-down posture.

290 porally overlapped, the brain controlled the thumb using an estimate of the state of the arm.

291 dent and cannot be approximated by a rule-of-thumb value because these residues can contribute to bot

292 A locus for triphalangeal thumb, variably associated with pre-axial polydactyly, w

293 A rule of thumb we find is that, for Galilean and Saturnian icy mo

294 imensional positions of the index finger and thumb were recorded while subjects with bilateral scotom

295 nded to visual stimuli located near the left thumb, which was targeted by PAS, LTP-like increases in

296 ng a 6 mm cylinder with the index finger and thumb while the hand was held in the neutral position or

297 of reverse transcriptase, which extends its Thumb with the RNase H domain.

298 t arises through relatively simple "rules of thumb" without requiring advanced cognitive mechanisms s

299 ourinary tract of women, was isolated from a thumb wound in a male patient subsequent to trauma.

300 ans share a suite of derived features in the thumb, wrist, and radial carpometacarpal joints that is