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1 hymus and circulation before and 12 mo after thymectomy.
2 d B cells persisted in the circulation after thymectomy.
3 for MG decreased thymopoiesis independent of thymectomy.
4 nt ways: total body irradiation and neonatal thymectomy.
5 fficacy is questionable or unproved, such as thymectomy.
6 loantigenic stimulation 2 wk after the adult thymectomy.
7 ejected and survival was not affected by the thymectomy.
8  frequency that is enhanced significantly by thymectomy.
9 ow chimeras prepared after complete surgical thymectomy.
10 s by combined cyclophosphamide treatment and thymectomy.
11 imilar to the previously described effect of thymectomy.
12 n, and these cells disappear following early thymectomy.
13 hymus prevents the induction of disease post-thymectomy.
14          Most (72.9%) patients had undergone thymectomy.
15 97; P < .001) after adjusting for center and thymectomy.
16 rgone similar cardiothoracic surgery without thymectomy.
17  functional diversity is lost after neonatal thymectomy.
18 utes of Health-funded international trial of thymectomy.
19 ult male C57BL/6 mice with and without prior thymectomy.
20  cells, and rapidly decreased after complete thymectomy.
21  reduction surgery, lung transplantation and thymectomy.
22 n target peripheral T cells up to 2 mo after thymectomy.
23 eated with FK506, anti-CD4 mAbs (GK1.5), and thymectomy.
24 atients before and from 27 to 517 days after thymectomy.
25 d MG patients studied at varying times after thymectomy (1 day to 41 years), we found no significant
26                    Group 5 animals underwent thymectomy 100 days after co-transplantation (n=4).
27 uction of tolerance by performing a complete thymectomy 21 d before renal transplantation.
28 2 days of CyA underwent either (1) a partial thymectomy 21 days before kidney transplantation (day -2
29 urse of cyclosporine (CyA), and that a total thymectomy 21 days before transplantation abrogates the
30                                              Thymectomy 3 wk after neonatal MTLV infection enhances t
31  treated with modified regimens that omitted thymectomy, 3 Gy TBI, anti-Thy1.2, and anti-NK1.1 mAbs,
32  prognosis was good, with a reduced need for thymectomy (6.3% vs 19.2%) and a high proportion of pati
33 ptide induces operational tolerance, whereas thymectomy abrogates this effect.
34           Moreover, halting thymic output by thymectomy accelerates the age-dependent decline in peri
35 IL-7R, or devoid of T cell renewal via adult thymectomy, all exhibited significant increases in TCE i
36 ally transplanted into recipients undergoing thymectomy alone or recipients undergoing thymectomy plu
37                                              Thymectomy also appeared be associated with an increased
38  exclusions, 1420 patients who had undergone thymectomy and 6021 controls were included in the study;
39 st, using the complementary methods of early thymectomy and adoptive transfers, we found that PTEN-de
40                            Here we have used thymectomy and antibody depletion to examine the effect
41 tment using acetylcholinesterase inhibitors, thymectomy and immunotherapy.
42 c age of residual PTK7 (+) T cells following thymectomy and may also explain in part the prematurely
43                                   When adult thymectomy and postgraft donor ThyTx were combined with
44 n be induced in normal laboratory rats after thymectomy and split dose gamma-irradiation.
45 etes, induced in rats by a protocol of adult thymectomy and split-dose gamma irradiation, can be prev
46  with naive CD4+CD25- effector T cells after thymectomy and T-cell depletion in CBA mice that receive
47 lasma cells persist in the circulation after thymectomy and that their persistence could explain inco
48 rgan-specific autoimmune disease after day 3 thymectomy and the effector function of cloned autoantig
49  responses could first be detected 5 wk post-thymectomy and were accompanied by high background respo
50 ed through a partial (n=6) or complete (n=2) thymectomy, and growth of the autologous thymic graft wa
51  pure ocular MG, suspected thymoma, previous thymectomy, and prior noncorticosteroid immunosuppressan
52               The long-term effects of early thymectomy are just being appreciated.
53  the response to extended cervicomediastinal thymectomy as a component of the integrated management o
54 sease among adult patients who had undergone thymectomy as compared with demographically matched cont
55            A cohort of BALB/c mice underwent thymectomy at day 3 after birth (d3Tx).
56 D mice did not result in suppression of post-thymectomy autoimmunity.
57                                              Thymectomy before HIV-1 infection did not preclude eithe
58                                              Thymectomy before i.v. injection of P5-activated syngene
59  primary response to H-Y for some time after thymectomy but lost this ability at approximately 6 mo.
60 press not only the induction of disease post-thymectomy, but can also efficiently suppress disease in
61 ents Receiving Prednisone (MGTX) showed that thymectomy combined with prednisone was superior to pred
62 ast, mice that were primed to H-Y just after thymectomy continued to display immunological memory to
63                                        Day 3 thymectomy (D3Tx) leads to a paucity of CD4(+)CD25(+) su
64                                        Day 3 thymectomy (D3Tx) results in a loss of peripheral tolera
65                                        Day 3 thymectomy (D3Tx) results in a loss of peripheral tolera
66                                We found that thymectomy decreased CD4 or CD8 T cell TREC concentratio
67 ting to the relevance of the thymic effects, thymectomy decreases by approximately 50% the bone loss
68                                              Thymectomy did not influence xenograft survival in any t
69                                Pretransplant thymectomy diminished the efficacy of CD4-targeted thera
70 the T cell pool in fetal life, but postnatal thymectomy does not lead to immunodeficiency in humans.
71                                     However, thymectomy does not result in homeostatic proliferation
72                               In conclusion, thymectomy during infancy may increase future risk of in
73 t is not seen in most patients who underwent thymectomy during infancy.
74                                 In contrast, thymectomy eliminated LN recent thymic emigrants.
75                                        Timed thymectomy experiments confirmed that the CD8-SP autoeff
76 s' most recent 100 consecutive transcervical thymectomies for nonthymoma-associated MG was performed
77 ecutive patients who underwent trans-sternal thymectomy for symptomatic myasthenia gravis from 1969 t
78               The transcervical approach for thymectomy for the treatment of MG produces results simi
79 ne (6.15 vs. 8.99, P<0.001); patients in the thymectomy group also had a lower average requirement fo
80 sma cytokine levels were measured (22 in the thymectomy group and 19 in the control group; mean follo
81 between groups (P=0.73), but patients in the thymectomy group had fewer treatment-associated symptoms
82 rgery, all-cause mortality was higher in the thymectomy group than in the control group (8.1% vs. 2.8
83 trol), all-cause mortality was higher in the thymectomy group than in the general U.S. population (9.
84                        Fewer patients in the thymectomy group than in the prednisone-only group requi
85 ne alone group and 35 in the prednisone plus thymectomy group).
86 ne alone group and 26 in the prednisone plus thymectomy group.
87  by multiple doses of AH.F5 with and without thymectomy (groups 7 and 8).
88                       Patients who underwent thymectomy had a lower time-weighted average Quantitativ
89 tudy; 1146 of the patients who had undergone thymectomy had a matched control and were included in th
90 ostoperative years), those who had undergone thymectomy had less new production of CD4+ and CD8+ lymp
91                                              Thymectomy has been a mainstay in the treatment of myast
92                                              Thymectomy improved clinical outcomes over a 3-year peri
93 ase-causing AChR autoantibodies and although thymectomy improves clinical scores, many patients fail
94 pread acceptance of the notion that complete thymectomy improves the course of the disease.
95                                     Neonatal thymectomy in BALB/c mice has been described as a model
96                                      Because thymectomy in humans is performed for treatment of myast
97 ld be reserved for difficult cases or before thymectomy in lieu of plasma exchange.
98  provide further support for the benefits of thymectomy in patients with generalised non-thymomatous
99                                  The role of thymectomy in the management of the disease remains unpr
100                                  The role of thymectomy in the management of these patients remains u
101 ll with acute hepatitis B after undergoing a thymectomy in which a thoracic-surgery resident who had
102 lls in PG and SMG following short-term adult thymectomy indicated that immature salivary gland T cell
103 ls that inhibit SAT were eliminated by day 3 thymectomy, indicating they belong to the subset of natu
104 A/J and (C57BL/6J x A/J)F1 hybrids, neonatal thymectomy-induced autoimmune ovarian dysgenesis (AOD) i
105 uggests that, as in adult myasthenia gravis, thymectomy is a viable therapeutic option for selected c
106 tes that the diminished clinical response to thymectomy is related to persistent circulating thymus-a
107                  Extended cervicomediastinal thymectomy is the procedure of choice as a component of
108  and naive CD4 T cells, is enhanced by 3-day thymectomy, is independent of IL-7, and requires a class
109                                   Autoimmune thymectomy models have revealed suppressor cell populati
110 ment, compared to conventional trans-sternal thymectomy, neither the pathologic diagnosis (presence o
111 e gastritis spontaneously develops following thymectomy of 3-day-old BALB/c mice (d3Tx).
112                                              Thymectomy of BALB/c mice on day 3 of life results in th
113                                              Thymectomy of neonatal mice can result in the developmen
114                                              Thymectomy of recipient animals before transplantation d
115 of donor-specific thymus combined with adult thymectomy of recipients enhances the tolerogenic effect
116                                              Thymectomy of susceptible strains of mice on day 3 of li
117 plant tolerance, which was then abrogated by thymectomy of the recipient before intravenous injection
118 contrast, there was no significant effect of thymectomy on absolute numbers of naive PB T cells.
119                 Animals undergoing a partial thymectomy on day -21 or serial thymic biopsies showed s
120 ay 0 host-type thymocyte infusions following thymectomy on day -21, developed donor-specific hyporesp
121 ithout changes in thymic volume), (3) a sham thymectomy on day -21, or serial sham thymic surgery on
122     Female (C57BL/6xA/J)F(1) mice undergoing thymectomy on day 3 after birth (d3tx) developed autoimm
123        We have also determined the effect of thymectomy on levels of PB cells containing signal joint
124 have studied patients with MG for effects of thymectomy on peripheral blood (PB) naive (CD45RA(+), CD
125 le tolerance induction, because either prior thymectomy or a series of thymic biopsies induce a spont
126   Suppression of resistance of recipients by thymectomy or injections of granulocyte colony-stimulati
127 ssential for tolerance because pretransplant thymectomy or peritransplant depletion of CD25(+) cells
128                                    A partial thymectomy or serial thymic biopsies markedly interfere
129 nosuppressive-conditioning regimen including thymectomy or thymic irradiation, extracorporeal immunoa
130 equently performed surgical procedure (e.g., thymectomy) or in cases where there was no predominant p
131 ies (p = 0.02), lobectomies (p = 0.003), and thymectomies (p = 0.02).
132       When considering the effects of infant thymectomy, patients with partial DiGeorge syndrome or h
133 myasthenic patients, for whom treatment with thymectomy, plasmapheresis, and conventional immunothera
134            We compared extended transsternal thymectomy plus alternate-day prednisone with alternate-
135 ng thymectomy alone or recipients undergoing thymectomy plus either CD4+ or CD8+ T cell depletion.
136                                  At 5 years, thymectomy plus prednisone continues to confer benefits
137                  At 5 years, patients in the thymectomy plus prednisone group had significantly lower
138  prednisone group, and 12 (34%) of 35 in the thymectomy plus prednisone group, had at least one adver
139 ients were randomly assigned (1:1) to either thymectomy plus prednisone or prednisone alone.
140 ed a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone.
141 ic rats before the onset of disease by adult thymectomy plus short-term anti-CD8alpha mAb treatment.
142 r-old man with myasthenia gravis and a prior thymectomy presenting with 2 months of diffuse, involunt
143                                              Thymectomy prevented disease, confirming the causal asso
144                                              Thymectomy prevented the induction of tolerance.
145                  The results show that adult thymectomy prevents the inhibition of trinitrophenol (TN
146 sponse of patients with myasthenia gravis to thymectomy primarily with respect to the bivariate endpo
147                                     Although thymectomy prolongs enhanced CTLA-4 expression, long-ter
148 ntinuous isotype-matched control mAb, 3) the thymectomy/pulse anti-CD8alpha regimen, or 4) no treatme
149  and contrast-enhanced CT groups had similar thymectomy rates (P = .97) and disease-related symptom t
150 ted with RIB 5/2 plus an i.v. alloantigen +/-thymectomy received kidney transplants after 40 days.
151 ever, the best technique to achieve complete thymectomy remains controversial.
152                                              Thymectomy resulted in the gradual loss of these DNA del
153                                              Thymectomy showed that thymic output of IGRP-specific tr
154                                              Thymectomy significantly reduces survival after MCMV cha
155 ons most when thymopoiesis was active before thymectomy (six of six patients), but had little effect
156 aboons underwent a conditioning regimen with thymectomy, splenectomy, and anti-monkey CD3 antibody co
157 ppressive conditioning regimen that included thymectomy, splenectomy, extracorporeal immunoadsorption
158  patient with myasthenia gravis treated with thymectomy subsequently developed extensive granulomatou
159  days, whereas anti-CD4, in combination with thymectomy, synergistically prolonged survival of pancre
160  in patients without bilateral transcervical thymectomy (TCT).
161 were higher among patients who had undergone thymectomy than among controls.
162 onships between performance on the UPSIT and thymectomy, time since diagnosis, type of treatment regi
163                                   Failure of thymectomy to affect the course of tolerance after day +
164 t disease requiring sternotomy often undergo thymectomy to clear the surgical field.
165               We now report: (a) addition of thymectomy to the protocol permitted skin allografts to
166                         In agreement, adding thymectomy to the regimen results in permanent engraftme
167                                          The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Pa
168 c graft-vs-host reaction (synGVHR) and timed thymectomy (Tx) assays revealed that autoeffector T cell
169     We investigated the long-term effects of thymectomy up to 5 years on clinical status, medication
170 s were created by subjecting juvenile RMs to thymectomy versus sham surgery, respectively, followed b
171 ereas the use of extended cervicomediastinal thymectomy was associated with a greater than twofold ch
172                                The effect of thymectomy was particularly notable in those individuals
173                                        Adult thymectomy was performed 4 weeks before grafting.
174                                              Thymectomy was performed in 17 children, of whom 11 expe
175                           Minimally invasive thymectomy was rated as usually inappropriate (regardles
176 ldren and adolescents who underwent neonatal thymectomy, we demonstrate that the naive CD4+ T cell co
177 s without adoptive transfer, irradiation, or thymectomy, we developed genetically modified mice that
178                                        Total thymectomies were performed in six animals (postoperativ
179                                              Thymectomies were performed on days -21, 0, +8, +21, and
180 n in a 29-year-old patient with a history of thymectomy who presented to the emergency department for
181 at their numbers progressively decline after thymectomy with a half-life of approximately 2 weeks.
182 th a history of thymoma or thymic neoplasms, thymectomy within 12 months before screening, or use of
183 y the escape of self-reactive T cells before thymectomy without accompanying T reg cells.
184 e neonatal thymus/T cells (e.g., by neonatal thymectomy) without virus infection.

 
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