ライフサイエンスコーパス: thymus

1 non-skin tissues (e.g. in cornea, vagina or thymus).

2 onmental compartment of the developing mouse thymus.

3 the prevalence of MR1 + CD4/CD8 cells in the thymus.

4 ted CD34(-) fractions in the human postnatal thymus.

5 luding self-peptides that select them in the thymus.

6 ity that undergo effector programming in the thymus.

7 ed endocrine-paracrine signaling axis in the thymus.

8 rom early immature stages in bone marrow and thymus.

9 iated mRNA decay and T cell selection in the thymus.

10 +) T, and Foxp3(+) regulatory T cells in the thymus.

11 ll interactions with epithelial cells in the thymus.

12 une function in the intestines, airways, and thymus.

13 thymoproteasome and immunoproteasome in the thymus.

14 terminants of T(reg) cell development in the thymus.

15 mmunogen are the product of the foster pup's thymus.

16 ent transplantation with allogeneic cultured thymus.

17 /genome higher than 1 in the BM and 2 in the thymus.

18 -expressing regulatory T (Treg) cells in the thymus.

19 the level of early T cell development in the thymus.

20 rs (GCs) development and inflammation in the thymus.

21 exogenous strategies to help regenerate the thymus.

22 ents with advanced carcinoids of the lung or thymus.

23 their escape from negative selection in the thymus.

24 roid tissue is not infrequently found in the thymus.

25 airs the core immunological functions of the thymus.

26 a reprogrammed primordial germ cell from the thymus.

27 their antigen receptors prior to leaving the thymus.

28 ctor subsets during their development in the thymus.

29 diverse antigen receptors is selected in the thymus.

30 -CCL20-dependent migration of Tregs into the thymus.

31 fewer CD4(+) T cells of both subsets in the thymus.

32 3(+), CD14(+), and epithelial cells from the thymus.

33 cquire effector functions before exiting the thymus.

34 mplement resistance during maturation in the thymus, a complement-privileged organ.

35 eliminated during negative selection in the thymus, a process important for establishing self-tolera

36 ents, and antioxidant activities of fourteen Thymus accessions belonging to ten species were evaluate

37 uencing to create a cell census of the human thymus across the life span and to reconstruct T cell di

38 a provide a comprehensive atlas of the human thymus across the life span with new insights into human

39 tosis and its pathologic consequences in the thymus after dexamethasone treatment and in advanced ath

40 During normal T cell development in the thymus, alphabeta TCRs signal immature thymocytes to dif

41 rs of the immune system, are produced in the thymus, an organ that serves as their 'training camp'.

42 ent mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhi

43 13/monocyte chemoattractant protein 4, CCL17/thymus and activation-regulated chemokine, CCL18/pulmona

44 For blood-based platforms, eotaxin-3, thymus and activation-regulated chemokine, IL-5, and thy

45 rogenitors and differentiated T cells in the thymus and altered T cell numbers in the spleens of A20

46 Most Tregs develop in the thymus and are then released into the immune periphery.

47 effects we find are nearly identical between thymus and blood, suggesting that our analysis mainly de

48 defective, exhibiting reduced cellularity of thymus and bone marrow, and stage-specific blockage of B

49 d identify B cell clones that resided in the thymus and circulation before and 12 mo after thymectomy

50 However, some Tregs populate the thymus and constitute a major subset of yet poorly under

51 ately expressed with MBNL1 in the developing thymus and DM2 CCTG expansions induce similar transcript

52 hich in turn extends the growth phase of the thymus and enhances thymic output; meanwhile, inducible

53 y occurring murine pathogen that infects the thymus and establish a novel infection model for MRV in

54 roperties develop in the embryonic and adult thymus and have been identified as critical players in a

55 tion of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in co

56 t S. suis infection can cause atrophy of the thymus and induce apoptosis of thymocytes in mice, thus

57 drome virus (PRRSV) dramatically affects the thymus and its ability to carry out its normal functions

58 high levels in cerebellum, skeletal muscle, thymus and kidney.

59 on complex surgery to transplant human fetal thymus and liver.

60 Cotransplantation of allogeneic thymus and parental parathyroid tissue has been attempte

61 ment and function of NKT cell subsets in the thymus and periphery.

62 R(+)-ETP-derived DCs function as APCs in the thymus and promote deletion of myelin-reactive T cells.

63 1960 practically nothing was known about the thymus and some of its products, T cells bearing alphabe

64 finding equivalent expression levels in both thymus and spleen.

65 se data indicate that IL-2R signaling in the thymus and the periphery leads to distinctive effects on

66 nt of regulatory T cells (Treg cells) in the thymus and their suppressive function remains incomplete

67 inct stages during T cell development in the thymus and they control the development of innate lympho

68 (pos) antigen-presenting cells (APCs) in the thymus and throughout the body.

69 rogenitors transform their identities in the thymus and undergo commitment to become T cells.

70 atures were already present in the postnatal thymus and were further enhanced upon selection in vitro

71 arts with recognition of self-ligands in the thymus, and finishes in peripheral tissues.

72 oietic system in mice, including the spleen, thymus, and haematopoietic stem and progenitor cells, as

73 cence signals were detected in LAD coronary, thymus, and liver.

74 DR2b of human primary B cells and monocytes, thymus, and MS brain tissue.

75 od and hematopoietic organs, such as the BM, thymus, and spleen.

76 ctious agents due the effect of PRRSV on the thymus, and this susceptibility phenomenon is long recog

77 e signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and ma

78 irst dose of BV, and reduced serum levels of thymus- and activation-regulated chemokine concurrent wi

79 Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune homeost

80 the majority of IL-2-producing cells in the thymus are mature CD4 single-positive (CD4SP) thymocytes

81 Notch receptors further validates the human thymus as a DC-poietic organ, which provides selective m

82 Most T lymphocytes leave the thymus as naive cells with limited functionality.

83 T cell IL-17 and IFN-gamma production in the thymus as well as in peripheral tissues.

84 th tissue residency was already expressed in thymus, as confirmed by adoptive transfer experiments.

85 ML generated in NP23-NHD13 mice arose in the thymus, as opposed to the bone marrow (BM).

86 Thymus-associated B cell clones were detected in the cir

87 Many circulating thymus-associated B cell clones were inferred to have or

88 mectomy is related to persistent circulating thymus-associated B cell clones.

89 We speculate that thymus-associated B cells and plasma cells persist in th

90 The persistence of thymus-associated B cells correlated with less favorable

91 In T lymphocytes, hypozincemia promotes thymus atrophy, polarization imbalance, and altered cyto

92 that includes wasting, hepatosteatosis, and thymus atrophy.

93 results provide evidence that the atrophied thymus attempts to balance the defective negative select

94 ched an incidence of 80%, demonstrating that thymus autonomy bears a high risk of leukemia.

95 s, the difference in cellularity detected in thymus autonomy bore no impact on onset, incidence, immu

96 antation experiments in mice, we report that thymus autonomy can occur in several experimental condit

97 Thymus autonomy is the capacity of the thymus to maintai

98 Prolonging thymus autonomy was shown to be permissive to the develo

99 ll repertoire sequencing to characterize the thymus B cell repertoire and identify B cell clones that

100 have originated and initially matured in the thymus before emigration from the thymus to the circulat

101 Conventional CD4(+) T cell populations in thymus, blood, and spleen of MHCIIKR(KI/KI) and March8 (

102 tissues of ART-suppressed bone-marrow-liver-thymus (BLT) humanized mice and rhesus macaques infected

103 -induced pathogenesis in bone marrow, liver, thymus (BLT) humanized mice.

104 ination within BM of HIV-1-infected BM/liver/thymus (BLT) mice.

105 LV-1(p12KO) infection in a bone marrow-liver-thymus (BLT) mouse model prone to graft-versus-host dise

106 n humanized mice, including the lymph nodes, thymus, bone marrow, liver and lung.

107 itors and committed T cell precursors in the thymus, both in vivo and in vitro.

108 as biased toward the iNKT2/17 subsets in the thymus but not in peripheral tissues.

109 ient de novo generation of Treg cells in the thymus but simultaneously permitted homeostatic expansio

110 ertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restri

111 epends on the continuous colonization of the thymus by bone-marrow-derived hematopoietic progenitors

112 gammadelta T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent alphabeta TCR-me

113 ral control of T cell differentiation in the thymus by normally repressing Tc17 differentiation and p

114 udied tTreg cell generation in the atrophied thymus by utilizing both postnatal TEC-defective (result

115 tolerance, and discuss how imbalance in the thymus can result in loss of T cell tolerance.

116 nder the same edaphoclimatic conditions, and Thymus carnosus.

117 iency of p53 partially rescued the defect in thymus cellularity (in contrast to early B cells) of Sma

118 These thymic ILC2s exit the thymus, circulate in the blood, and home to peripheral t

119 itiating cells were increased 14-fold in the thymus compared to BM.

120 If such thymuses could be identified, we propose that their use

121 As the regular function of the thymus declines with age, it is of fundamental and clini

122 models as well as in vivo immunization with thymus-dependent and thymus-independent Ags.

123 Thymus-derived lung ILC2s of E protein-deficient mice sh

124 overy of thymopoiesis and development of new thymus-derived peripheral T cells.

125 cription factor critical for the function of thymus-derived regulatory T (Treg) cells (ie, FOXP3), re

126 Nrp1 also helps migrate thymus-derived regulatory T cells to vascular endothelia

127 rity of gingival gammadeltaT cells are fetal thymus-derived Vgamma6(+) cells, and to a lesser extent

128 onic dystrophy (DM), is essential for normal thymus development and function.

129 pulate it clinically, because alterations of thymus development or function can result in severe immu

130 nalyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thym

131 regulator of TEPC and mTEC fate during fetal thymus development, and are thus of high relevance to st

132 leted, results in a near total disruption of thymus development.

133 occasional myocardial fibrosis and minimized thymus development.

134 In the thymus, distinct cortex and medulla areas emphasize the

135 onding interaction between 7ESTAC01 and calf thymus DNA (ctDNA) was confirmed by UV-Vis absorption sp

136 ntification of G and A concentration in calf-thymus DNA and detected ratio of G and A (i.e., [G]/[A])

137 formaldehyde- and chlorambucil-treated calf thymus DNA.

138 Despite a lack of HLA-matching between thymus donor and recipient, the reconstituted immune sys

139 immune system displays tolerance toward the thymus donor.

140 chemical biosensor based on immobilized calf thymus double-stranded DNA (dsDNA) on the carbon-based s

141 ted antigen-1, was not seen in the spleen or thymus during dysbiosis.

142 s female sex hormones to the rewiring of the thymus during pregnancy.

143 uced to express IL-23R and IL-17 outside the thymus during skin inflammation.

144 renal tubules), lungs (bronchial epithelia), thymus (epithelial cells inside the Hassall's corpuscles

145 ereas T-like cells develop in the thymoid, a thymus-equivalent region at the gill fold tips.

146 -) mice fail to express self-antigens in the thymus, exhibit reduced central tolerance, and develop a

147 he importance of salvianolic acids levels in Thymus extracts and their in vitro anti-proliferative/cy

148 inity self-reactive T cells also escaped the thymus following HSCT during chronic infection.

149 so quantified BCR and TCR transcripts in the thymus for BCR (IgHV-IgHC), chimeric (IgHV-TCRdeltaC), a

150 We addressed this by studying the thymus from a rat model of developmental programming.

151 Thymus function depends on the epithelial compartment of

152 The thymus generates cells of the T cell lineage that seed t

153 The neonatal thymus generates Foxp3(+) regulatory T (tT(reg)) cells t

154 C and CD4/CD8 coreceptor-deficient mice, the thymus generates mature T cells expressing MHC-independe

155 sion, our data indicate that the human fetal thymus generates, in an HSPC/Lin28b-dependent manner, in

156 -standing interest in processes underpinning thymus generation and the potential to manipulate it cli

157 (/) (-) We found that the cellularity of the thymus grafts is influenced exclusively by the genotype

158 an hematopoietic stem cells (HSCs) and human thymus grafts.

159 of T cells specific for self-antigens in the thymus has been widely studied, primarily by approaches

160 ndence on a single cytokine in the mammalian thymus has catastrophic consequences in cases of congeni

161 process because prior TCR engagement in the thymus has initiated their commitment to the gammadeltaT

162 In the thymus, hematopoietic progenitors commit to the T cell l

163 velopment, but molecular insights on TEC and thymus homeostasis are still lacking.

164 ing is critical for the induction of the key thymus-homing chemokine receptor - CCR6 on Tregs.

165 s hematopoietic cells in the bone marrow and thymus; however, the long-term effects of irradiation wi

166 When incorporated into bone marrow/liver/thymus humanized mice, lung implants are repopulated wit

167 BLT (bone marrow-liver-thymus) humanized mice, which reconstitute a functional

168 that mutant Copa in epithelial cells of the thymus impairs the thymic selection of T cells and resul

169 ed by microbes migrate from the colon to the thymus in early life to regulate PLZF(+) cell homeostasi

170 natural killer T (iNKT) cells (NKT2) in the thymus in the steady state, where it conditions CD8(+) T

171 In contrast, thymus-independent Ags generally do not induce germinal

172 vivo immunization with thymus-dependent and thymus-independent Ags.

173 ery asymmetrically distributed and uncover a thymus-independent pathway for mature T cell production

174 , despite sustained virus replication in the thymus, indicating an impairment in negative selection.

175 cell antigen receptor (TCR) signaling in the thymus initiates positive selection, but the CD8(+)-line

176 cells that develop and differentiate in the thymus into iNKT1/2/17 subsets, akin to T(H)1/2/17 conve

177 In the mouse thymus, invariant gammadelta T cells are generated at we

178 The thymus is a primary lymphoid organ necessary for optimal

179 The thymus is a primary lymphoid organ required for the indu

180 The thymus is a primary lymphoid organ that plays an essenti

181 The thymus is a primary lymphoid organ, essential for T cell

182 The MG thymus is a reservoir of plasma cells that secrete disea

183 pertoire following negative selection in the thymus is able to recognize a vastly larger antigenic po

184 The thymus is composed of two different types of epithelial

185 The thymus is critical for central tolerance and diverse T-l

186 The thymus is critical for the establishment of the adaptive

187 ls to the periphery when phagocytosis in the thymus is impaired.

188 differentiation of gammadelta T cells in the thymus is incompletely understood.

189 us stages of T cell development in the human thymus is missing.

190 cell number, suggesting that the size of the thymus is regulated primarily by rate-limiting morpholog

191 egulatory T (T(reg)) cell compartment in the thymus is required to maintain immune homeostasis and pr

192 , respectively) resident in the steady-state thymus is whether early thymic progenitors (ETPs) could

193 , and therefore their differentiation in the thymus, is dependent upon T cell receptor (TCR) and inte

194 ding the brain cortex (Epstein-Barr) and the thymus, kidneys, and adrenal glands (human herpesvirus 6

195 The marked infiltration of thymus led to the intriguing hypothesis that AML generat

196 Lung-only mice and bone marrow/liver/thymus-lung humanized mice substantially increase the nu

197 R) was used to detect ZIKV RNA in the brain, thymus, lungs, kidneys, adrenal glands, spleen, liver, a

198 compared to those of Thymus pulegioides and Thymus mastichina, grown under the same edaphoclimatic c

199 -infected huBLT (humanized Bone marrow-Liver-Thymus) mice.

200 e therapy approach that directly targets the thymus might improve outcomes.

201 in a xenografted humanized bone marrow-liver-thymus mouse model.

202 activated T cells in various contexts in the thymus, mucosa and tumours.

203 Yet, T cell education in the thymus occurs through negative and positive selection, a

204 h results in an altered aging profile in the thymus of male rats.

205 equence repertoires taken from the blood and thymus of mice of different ages, we quantify the change

206 Taken together, these results show that the thymus of NP23-NHD13 mice acts as a reservoir for AML in

207 roxidase (TPO) is positively selected in the thymus of RAG KO mice on both T effector (T(eff)) and T

208 uation in mammals, T cell development in the thymus of teleosts is driven by a degenerate multicompon

209 ) of Lineage-Sca1 + Kit + (LSK) cells in the thymus of the NP23-NHD13 mice.

210 the spleen and liver of mice but not in the thymus or adipose tissues.

211 During thymus organogenesis, these functionally distinct sub-li

212 ce of antibodies, symptoms, age at onset and thymus pathology.

213 extracellular matrix (ECM) obtained by whole thymus perfusion.

214 CD4(+) and CD8(+) T cell development in the thymus, peripheral homeostasis, and differentiation into

215 The thymus plays a key role post allogeneic hematopoietic st

216 In the thymus, precursor cells recognize self-glycolipids by vi

217 iption factor Eomes during maturation in the thymus, prior to induction of the full memory phenotype,

218 effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describi

219 support a combination treatment of rATG and thymus-protective strategies such as keratinocyte growth

220 The thymus provides a nurturing environment for the differen

221 and bioactivities were compared to those of Thymus pulegioides and Thymus mastichina, grown under th

222 Here we describe a subset of thymus recirculating IL18R(+) Tregs with molecular chara

223 This anatomical human thymus reconstruction is functional, as judged by its ca

224 ly showed impaired T cell reconstitution and thymus regeneration after allogeneic bone marrow nucleat

225 T cell receptor (TCR) self-affinities in the thymus, regulating T cell trafficking between anatomical

226 Even in advanced atrophy, however, the thymus remains plastic, and can be regenerated by approp

227 hanisms by which immune tissues, such as the thymus, respond to heat stress.

228 outcome of alphabeta T cell selection in the thymus, resulting in death if the affinity of the rearra

229 presentation and iNKT cell selection in the thymus, resulting in decreased iNKT cell levels and resi

230 rate because leaky antigen expression in the thymus results in central T cell tolerance.

231 of ARID5B in immature thymocytes results in thymus retention, differentiation arrest, radioresistanc

232 d precursor datasets identified two putative thymus seeding progenitors that varied in expression of

233 development to support the rapid increase of thymus size during fetal life.

234 ms in TEC, and establishes that Myc controls thymus size.

235 nduce any significant effect on carvacrol of Thymus species in comparison to the greenhouse condition

236 ential oils and antioxidant activity of four Thymus species were evaluated under five light spectra (

237 ATA3, and RAR-related orphan receptor gamma, thymus-specific isoform (RORgammat) (required for differ

238 Thymus-specific serine protease (TSSP) is expressed by t

239 -cre Runx1 cKO mice lack iNKT17 cells in the thymus, spleen and liver.

240 nal affinity on individual live T cells from thymus, spleen, pancreatic lymph nodes, and islets befor

241 s that depends upon continuous guidance from thymus stromal cell microenvironments.

242 Thymus structure, immunophenotyping, T-cell receptor clo

243 ich led to a decrease of CD3(+) cells in the thymus, subsequently decreasing the numbers of CD4(+) an

244 The thymus supports multiple alphabeta T cell lineages that

245 ays after birth, growth slows and the murine thymus switches from fetal to adult morphology and funct

246 CT enhanced T cell progenitor seeding of the thymus, T cell neogenesis and diversification of the T c

247 In the thymus, T cell-specific ablation of the Roquin paralogs

248 Following their exit from the thymus, T cells are endowed with potent effector functio

249 endowed with higher capacity to populate the thymus than their IL18R(-) or IL18R(-/-) counterparts, h

250 e-like phenotype have been identified in the thymus that are distinct from conventional Th17 and Th1

251 It has long been known that the thymus, the central lymphoid organ, changes markedly dur

252 erentiated NKT and gammadelta T cells in the thymus, the colon submucosa, and during early tumorigene

253 This is first observed in the thymus, the primary lymphoid organ that generates and se

254 In the thymus, the T lymphocyte repertoire is purged of a subst

255 amage to central tolerance mechanisms in the thymus, these findings outline a critical one-two punch

256 nding tolerance initially established in the thymus, these functions of DCs help to regulate autoimmu

257 In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17

258 fate choice is promoted by signaling in the thymus through one dominant pathway, the Notch pathway,

259 rtantly, this mTEC heterogeneity enables the thymus to differentially control iNKT sublineages posses

260 ity depends on mature thymocytes leaving the thymus to enter the bloodstream and the trafficking of T

261 proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the

262 d can be 'developmentally programmed' in the thymus to generate discrete gammadelta T cell effector s

263 into innate lymphoid cells or migrate to the thymus to give rise to embryonic T cell receptor-invaria

264 Thymus autonomy is the capacity of the thymus to maintain T lymphocyte development and export i

265 erative strategies may ultimately enable the thymus to play as prominent a role after transplant as i

266 Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous expression

267 red in the thymus before emigration from the thymus to the circulation.

268 g the journey of T cells traversing from the thymus to the periphery and during the immune response,

269 logeneic parathyroid tissue in the patient's thymus transplant biopsy.

270 his study confirms the previous reports that thymus transplantation can reconstitute T cells in patie

271 In this study, performing thymus transplantation experiments in mice, we report th

272 Thymus transplantation is a promising strategy for the t

273 Thymus transplantation shows this requirement maps to IL

274 orge syndrome can be corrected by allogeneic thymus transplantation.

275 blem in these patients, which persists after thymus transplantation.

276 n of hypoparathyroidism in one patient after thymus transplantation.

277 ed markers of natural Tregs derived from the thymus, Tregs in regressing plaques lacked Nrp1 expressi

278 ell differentiation from the fetal and adult thymus using single-cell RNA sequencing.

279 In the thymus, Vgamma1 and Vgamma4 T cells that exhibited an SL

280 ytes through maturation processes within the thymus via interaction with self-ligands displayed on th

281 on the microemulsion (ME) characteristics of Thymus vulgaris essential oil (TVO).

282 nol compositions of Thymus x citriodorus and Thymus vulgaris extracts as obtained by exhaustive hydro

283 ntaurea cyanus L., Matricaria chamomilla L., Thymus vulgaris L.) and dried fruit (currants, chokeberr

284 t studying the effect of red thyme oil (RTO, Thymus vulgaris L.) on the shelf-life and Penicillium de

285 Furthermore, the thymus was not necessary for PTCy's efficacy.

286 fic tissues (liver, spleen, lymph nodes, and thymus) was also dependent on delivery method and dose.

287 ed smaller body weights and relatively lower thymus weights in heterozygous compared with wild-type a

288 ntrols housed in flight hardware (GC), while thymus weights were 35% greater in FLT than GC.

289 ecreased circulating lymphocytes, spleen and thymus weights, increased free fatty acids (FFA) and pro

290 Transcriptome responses in the thymus were identified by RNA-sequencing (RNA-seq).

291 tropism of GPgV revealed that the spleen and thymus were the organs bearing the highest viral loads.

292 dergo a process of positive selection in the thymus when their new T cell receptor (TCR) engages and

293 nstitute an anatomic phenocopy of the native thymus, when combined with thymic interstitial cells and

294 (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restr

295 es must be produced throughout life, yet the thymus, where T lymphocytes are made, exhibits accelerat

296 elta2 T cells find their origin in the fetal thymus whereas adult blood Vgamma9Vdelta2 T cells are ge

297 lympho-myeloid progenitors that colonize the thymus, while lymphoid progenitors become specialized in

298 months, characterized by replacement of the thymus with leukemic myeloblasts.

299 ferentiated carcinoid tumours of the lung or thymus, with radiological progression within 12 months b

300 The polyphenol compositions of Thymus x citriodorus and Thymus vulgaris extracts as obt