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1 ung NODCCR7(ko/ko) mice by immunization with thyroglobulin.
2 s, perhaps by augmenting the antigenicity of thyroglobulin.
3 particularly in patients with elevated serum thyroglobulin.
4 oid peroxidase, sodium iodine symporter, and thyroglobulin.
5 nding to the fucose-containing glycoprotein, thyroglobulin.
6 l surface to catalyze iodination of secreted thyroglobulin.
7 antigen, neu, and an unrelated self-antigen, thyroglobulin.
8 that crucially involves the iodoglycoprotein thyroglobulin.
9 an influence on tyrosine sulfate content of thyroglobulin.
10 bonucleoprotein, four to histone and none to thyroglobulin.
11 ession of MHC class II, and up-regulation of thyroglobulin.
12 osylation sites in the homologous segment of thyroglobulin.
13 ereby allowing prompt thyroxine release from thyroglobulin.
14 ylococcus enterotoxin B, ribonuclease A, and thyroglobulin.
15 multiple sites within its protein precursor thyroglobulin.
16 gative DTC patients with elevated and rising thyroglobulin.
17 gative DTC patients with elevated and rising thyroglobulin.
18 ive congenital hypothyroidism with deficient thyroglobulin.
19 of recombinant human thyrotropin-stimulated thyroglobulin.
20 ha(1)-acid glycoprotein, immunoglobulin, and thyroglobulin.
21 of the parameters evaluated, including serum thyroglobulin.
22 yoglobin (17 kDa), transferrin (77 kDa), and thyroglobulin (670 kDa) proteins was accomplished in a s
23 In addition, four of 22 tumors co-express thyroglobulin (a non-neuroendocrine follicular epithelia
24 h post-translational processing of wild-type thyroglobulin (a secretory glycoprotein) as well as endo
25 amma also inhibited 4-fold the expression of thyroglobulin, a native cAMP-responsive gene, in primary
26 Thyroid hormonogenesis requires secretion of thyroglobulin, a protein comprising Cys-rich regions I,
28 er than GRP94 did not detectably differ, and thyroglobulin achieved transport competence in both kind
31 N-gamma(-/-) donor mice activated with mouse thyroglobulin and anti-IL-2R mAb induced severe granulom
32 carcinoma (DTC) patients with elevated serum thyroglobulin and both negative radioiodine imaging and
33 Preincubation of cells with glycoproteins (thyroglobulin and fetuin), but not simple sugars, blocks
34 a specific combination of polymorphisms for thyroglobulin and HLA-DR markedly increases the odds rat
35 found that supplementation reduced maternal thyroglobulin and in 3 RCTs, it prevented or diminished
40 tion in vivo, CBA/J mice were immunized with thyroglobulin and then injected with IFN-gamma and TNF-a
41 cement is specific for TSHR Abs, with Abs to thyroglobulin and thyroid peroxidase remaining unchanged
42 se spontaneously occurring autoantibodies to thyroglobulin and thyroid peroxidase were unaffected.
43 develops in NOD.H2(h4) mice associated with thyroglobulin and thyroid-peroxidase, but not TSHR, Abs.
45 the substrate for thyroid hormone synthesis (thyroglobulin) and the ability to recover and retain int
46 t chain did not cleave radiolabeled albumin, thyroglobulin, and annexin V under conditions that readi
47 inent early iodination sites in this part of thyroglobulin, and because the N-terminal region was pre
48 ated with circulating autoantibodies against thyroglobulin, and development of primary hypothyroidism
49 histologic subtype of tumor, levels of serum thyroglobulin, and morphologic findings on full-dose CT
50 storis, hen ovalbumin, bovine fetuin, bovine thyroglobulin, and several invertase preparations from w
51 serum sample have been demonstrated for anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (ant
53 3), and autoimmunity [thyroid peroxidase and thyroglobulin antibodies (TPOAb and TgAb, respectively)]
54 In long-term follow-up of DTC patients with thyroglobulin antibodies, 96% with undetectable TSHR mRN
55 (e.g., elevated thyroglobulin level without thyroglobulin antibodies, positive results on recent fin
59 ovide an overview of the clinical utility of thyroglobulin antibody (TgAb) measurements in the manage
61 and CdtC-II(Ec) bind immobilized fetuin and thyroglobulin as well as fucose and to a lesser degree N
62 of TRA, parathyroid hormone, calcitonin, and thyroglobulin, as part of an effort to better define the
63 of the asialoglycoprotein receptor (ASGP-R), thyroglobulin, asialothyroglobulin, and antibody against
65 id glands in Mct8-KO mice contained more non-thyroglobulin-associated T4 and triiodothyronine than di
66 e present the structure of full-length human thyroglobulin at a resolution of approximately 3.5 angst
68 nd inhibited further increases in anti-mouse thyroglobulin autoantibodies when administered to mice t
69 une thyroiditis (SAT) and produce anti-mouse thyroglobulin autoantibodies when they receive 0.05% NaI
70 letion also resulted in increased anti-mouse thyroglobulin autoantibody responses and increased expre
72 Tg(+) mice always had reduced anti-mouse thyroglobulin autoantibody responses, compared with Tg(-
76 yr5, the most important hormonogenic site of thyroglobulin, because Tyr5 and Tyr130 are proximate, be
77 fter thyroidectomy and radioiodine ablation, thyroglobulin becomes a sensitive marker for the presenc
78 or alpha-Gal-containing analytes CTX, bovine thyroglobulin (Bos d TG), and human serum albumin (HSA)-
79 the Engelbreth-Holm-Swarm sarcoma and bovine thyroglobulin, both of which contain multiple Galalpha1,
80 letion did not alter the balance of free vs. thyroglobulin-bound I(-) in the thyroid (distinguished u
81 glands of TSHR-KO mice produced uniodinated thyroglobulin, but the ability to concentrate and organi
84 stimulates both uptake in and production of thyroglobulin by thyroid cells and the results are compa
86 induced diabetes of youth, and misfolding of thyroglobulin can result in autosomal recessive congenit
89 lysis was performed, 81% had decreased serum thyroglobulin concentrations during treatment, as compar
93 nding, we have studied recombinant nonmutant thyroglobulin expressed in control Chinese hamster ovary
94 l lines with DLCs robustly restored hNIS and thyroglobulin expression and iodide uptake capacity.
95 able to prevent, and to reverse, the loss of thyroglobulin expression which occurs normally in TSH-de
96 n of colonies with epithelial morphology and thyroglobulin expression, capable of 10 - 15 population
97 um-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid ho
98 SH-stimulated changes in cell morphology and thyroglobulin expression, while RasG37 had no effect on
99 in humans and rodents; these mutations block thyroglobulin from exiting the ER and induce ER stress.
100 in (NLGN) and associated with autism and the thyroglobulin G2320R (G221R in NLGN) mutation responsibl
105 congenital hypothyroid goiter with defective thyroglobulin, GRP94 and thyroglobulin associate in a pr
106 as phosphatidylserine, myelin basic protein, thyroglobulin, histone, insulin, cytochrome C, and beta-
109 l activity as a transcriptional regulator of thyroglobulin in 1989, the bulk of the ensuing research
110 oexpression of secretory ChEL with truncated thyroglobulin increased intracellular folding, promoted
111 in mice undergoing TUBO tumor rejection and thyroglobulin injection than in those experiencing eithe
113 NKX2.1, while the thyroid hormone precursor thyroglobulin is expressed at comparable levels to tissu
115 a central intrafollicular compartment, where thyroglobulin is iodinated to form the protein precursor
116 xenoantibodies and reactive with epitopes of thyroglobulin, laminin, and heparan sulfate proteoglycan
117 duce thyroid hormone at the acceptor site in thyroglobulin, leaving dehydroalanine or pyruvate at the
118 94% of hypothyroid patients) and stimulated thyroglobulin less than 2 ng/ml (95%, euthyroid; 96%, hy
120 fter ablation and also an undetectable serum thyroglobulin level in the absence of antithyroglobulin
121 unnecessary to repeat a Thyrogen-stimulated thyroglobulin level in the surveillance of patients with
122 al evidence of disease included a suppressed thyroglobulin level of less than 1 ng/mL and a stimulate
123 level of less than 1 ng/mL and a stimulated thyroglobulin level of less than 2 ng/mL, rhTSH-assisted
124 quent in patients with a postoperative serum thyroglobulin level of more than 1 ng per milliliter dur
125 was normal in 652 (95%), and the stimulated thyroglobulin level was 1.0 ng per milliliter or less in
126 f having metastasis from DTC (e.g., elevated thyroglobulin level without thyroglobulin antibodies, po
130 ultrasound, I whole body scan, and/or serum thyroglobulin levels for recurrence at the treatment sit
131 ient group and for those patients with serum thyroglobulin levels of less than 5, 5-10, and more than
132 The sensitivities of 18F-FDG PET/CT at serum thyroglobulin levels of less than 5, 5-10, and more than
133 ation, 61 consecutive patients with elevated thyroglobulin levels or a clinical suspicion of recurren
135 w improved understanding of the use of serum thyroglobulin levels to predict future risk of recurrenc
136 venteen (95%) of 19 patients for whom serial thyroglobulin levels were available showed a marked and
143 e-stranded and double-stranded DNA, insulin, thyroglobulin, LPS, influenza virus, and Borrelia burgdo
144 ration of region I is a limiting step in the thyroglobulin maturation process, and this step is facil
146 .7%), zinc (mean: +2.3%; 95% CI: 0.5, 4.2%), thyroglobulin (mean: +20.1%; 95% CI: 9.0, 32.2%) and thy
147 ed strategies rely primarily on serial serum thyroglobulin measurements combined with cervical ultras
149 catalytic (esterases) and the noncatalytic (thyroglobulin) members of the esterase/lipase family of
150 mice permit thyroiditis induction with mouse thyroglobulin (mTg) after depleting regulatory T cells (
152 autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) autoantibodies, the levels of which
156 responses to human ErbB-2 (Her-2) and mouse thyroglobulin (mTg) were tested in transgenic mice expre
158 mice with autoimmune thyroiditis using mouse thyroglobulin (mTg)-pulsed anti-CTLA-4 agonistic Ab-coat
159 athological features can be induced by mouse thyroglobulin (MTg)-sensitized spleen cells activated in
160 regulatory T cells that could suppress mouse thyroglobulin (mTg)-specific T cell responses in vitro,
166 patient sera with FcepsilonRIalpha, but not thyroglobulin or thyroid peroxidase, resulted in the dec
167 presence of antibodies to thyroperoxidase or thyroglobulin, or thyroid-stimulating hormone receptor a
168 , cepharanthine blocked T-cell activation by thyroglobulin peptides, in particular Tg.2098 in mice th
169 expressed in Abs formed on immunization with thyroglobulin, pneumococcal polysaccharide, and ssDNA-me
172 hat further assessment of 131I WBS-negative, thyroglobulin-positive patients by 18F-FDG PET/CT may ai
174 t not O-linked carbohydrates from fetuin and thyroglobulin prevents binding of CdtA-II(Ec) and CdtC-I
175 at transgenic mice expressing CCL21 from the thyroglobulin promoter (TGCCL21 mice) have significant l
176 irus serotype 8 (AAV8) with a liver-specific thyroglobulin promoter was used to stably express human
177 ice expressing TGF-beta under control of the thyroglobulin promoter were generated to assess the role
178 e (HSVI-TK) is driven in thyrocytes from the thyroglobulin promoter, the drug Ganciclovir causes the
184 l iodine uptake restoration with significant thyroglobulin reduction after radioactive iodine therapy
189 protein product bound to IGFBP-2 through the thyroglobulin-RGD region of the C terminus of IGFBP-2.
190 DR3 by separately treating 20 purified human thyroglobulin samples with cathepsins B, D, or L, lysoso
193 mune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized spleen cells activated in vitro
194 mune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized splenocytes activated in vitro
195 mune thyroiditis (G-EAT) is induced by mouse thyroglobulin-sensitized splenocytes activated in vitro
196 n of an alpha-Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response.
197 ression of the thyroid-specific target genes thyroglobulin, sodium iodide symporter, thyroperoxidase,
199 mma(-/-) mice produced lower levels of mouse thyroglobulin-specific autoantibodies after immunization
200 ultifactorial analysis identified stimulated thyroglobulin (sTg) as the sole independent risk factor.
201 roid slices, isolated and iodinated the [14C]thyroglobulin (Tg I), separated its N-terminal approxima
203 cal synergism between amino acid variants in thyroglobulin (Tg) and specific HLA-DR3 pocket sequence
205 unction (as shown by increased expression of thyroglobulin (Tg) and the sodium/iodide symporter).
207 ans and association studies have established thyroglobulin (TG) as a major AITD susceptibility gene.
208 dal T4 production results from iodination of thyroglobulin (TG) at residues Tyr(5) and Tyr(130), wher
213 erminal cholinesterase-like (ChEL) domain of thyroglobulin (Tg) has been identified as critically imp
214 t factor by binding to the secretory protein thyroglobulin (Tg) in the ER, thereby facilitating its s
220 ted thyroid carcinoma, based on an increased thyroglobulin (Tg) level and negative neck ultrasound (U
225 tudy, we show that the previously identified thyroglobulin (Tg) T cell epitope p2549-2560 containing
226 n the apical surface of thyroid cells, binds thyroglobulin (Tg) with high affinity in solid phase ass
227 nated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid g
228 f secretory proteins, we studied the fate of thyroglobulin (Tg), a large oligomeric secretory glycopr
229 n reflection mode for the detection of human Thyroglobulin (TG), a protein marker of differentiated t
230 thyrocytes, GRP94 interacts transiently with thyroglobulin (Tg), and in thyrocytes of animals sufferi
231 permits disease induction with heterologous thyroglobulin (Tg), but unlike conventional susceptible
232 cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escherichia coli LPS, or intact Porp
233 ance, the thyroid hormone precursor protein, thyroglobulin (Tg), has been experimentally investigated
234 iditis, induced in mice after challenge with thyroglobulin (Tg), is known to be under the genetic con
244 nts included response correlation with serum thyroglobulin (Tg); functional imaging; tumor genotype;
248 FT3], thyroid-stimulating hormone [TSH], and thyroglobulin [Tg]) and levels of Pb, Hg, and Cd in bloo
250 TSH regulates post-translational changes in thyroglobulin that selectively enhance its capacity for
251 are now known to exist in TG (encoding human thyroglobulin) that can lead to defective thyroid hormon
252 pression of thyroid differentiation markers, thyroglobulin, thyroid-stimulating hormone receptor, thy
253 SH and the agonists increase mRNA levels for thyroglobulin, thyroperoxidase, sodium iodide symporter,
254 ained significantly lower levels of AIRE and thyroglobulin, to which tolerance is typically lost in a
255 ction including thyroid-stimulating hormone, thyroglobulin, total and free thyroxine, and total and f
258 er, we surmise that in the natural precursor thyroglobulin, two evolutionary late and slower hormonog
259 domain (GA733 type 1 motif), a cysteine-rich thyroglobulin type 1A domain (GA733 type 2 motif), and a
260 recently determined disulfide pattern of the thyroglobulin type 1A domain of insulin-like growth fact
262 ing hormone (TSH), free thyroxine (FT4), and thyroglobulin, vary widely due to variability in the com
263 amined for BRAF and RAS mutations, and serum thyroglobulin was measured at baseline and at each visit
264 ccal vaccines; and autoantibodies to DNA and thyroglobulin were assessed before and after supplementa
266 lum-associated protein degradation of mutant thyroglobulin, whereas degradation of a nonglycosylated
267 ons (thyroid extract, desiccated thyroid, or thyroglobulin), which contain both thyroxine (T4) and tr
268 timulated secretion of the secretory protein thyroglobulin with an efficiency similar to that of wild
269 60 fullerene derivative conjugated to bovine thyroglobulin yielded a population of fullerene-specific