ライフサイエンスコーパス: thyroid hormone receptor

1 ia SMRT (silencing mediator for retinoid and thyroid hormone receptor).

2 and SMRT (silencing mediator of retinoid and thyroid hormone receptors).

3 expression in the liver are mediated via the thyroid hormone receptor.

4 epressor silencing mediator for retinoid and thyroid hormone receptor.

5 t but essential for repression by unliganded thyroid hormone receptor.

6 proteins that facilitate the function of the thyroid hormone receptor.

7 anner but not with retinoic acid receptor or thyroid hormone receptor.

8 nding to a receptor homologous to vertebrate thyroid hormone receptors.

9 and silencing mediator of retinoic acid and thyroid hormone receptors.

10 ar receptors (NRs), such as the retinoid and thyroid hormone receptors.

11 and was thought not to be a coactivator for thyroid hormone receptors.

12 thyroid hormone inactivation proximal to the thyroid hormone receptors.

13 ses of pomc promoter sequences revealed that thyroid hormone receptor 1beta-binding motif insertions

14 MRT (silencing mediator of retinoic acid and thyroid hormone receptor), a nuclear corepressor involve

15 ASO-T3 (NAT3) and ApoB-ASO-T3 (AAT3) enhance thyroid hormone receptor activity.

16 Eprotirome is a liver-selective thyroid hormone receptor agonist that has been shown to

17 yroid hormone triiodothyronine and synthetic thyroid hormone receptor agonists, such as sobetirome (G

18 , including cardiac effects, are mediated by thyroid hormone receptor alpha (THR-alpha).

19 ozygous nonsense mutation in a gene encoding thyroid hormone receptor alpha (THRA) and generating a m

20 Thyroid hormone receptor alpha (THRA) gene mutations, vi

21 v-ErbA, an oncogenic derivative of the thyroid hormone receptor alpha (TRalpha) carried by the

22 generated mice with a point mutation in the thyroid hormone receptor alpha (TRalpha) gene producing

23 family, liver X receptor beta (LXRbeta) and thyroid hormone receptor alpha (TRalpha), have been foun

24 Mutations in the thyroid hormone receptor alpha 1 gene (THRA) have recent

25 Mutations of the thyroid hormone receptor alpha gene (THRA) cause hypothy

26 evidence from patients with mutations of the thyroid hormone receptor alpha gene (THRA) indicates tha

27 The thyroid hormone receptor alpha gene (THRA) transcript is

28 Mice with a knock-in mutation in the thyroid hormone receptor alpha gene (TRalpha1PV) were cr

29 mmaturity markers anti-Mullerian hormone and thyroid hormone receptor alpha in adults and fail to exp

30 ter with either the ligand-binding domain of thyroid hormone receptor alpha or its viral relative, vE

31 TH-responsive (thyroid hormone receptors alpha (thra) and beta (thrb))

32 We have provided evidence that thyroid hormone receptor-alpha (TR-alpha), a transcripti

33 The thyroid hormone receptor alpha1 (TRalpha) exhibits a dua

34 was localized to a 41-amino acid segment of thyroid hormone receptor alpha1 between the second zinc

35 Mice heterozygous for a point mutation in thyroid hormone receptor alpha1 display increased thermo

36 Our prior studies showed that thyroid hormone receptor alpha1 exits the nucleus throug

37 These results reveal that thyroid hormone receptor alpha1 is required for normal n

38 using isolated tail arteries, that defective thyroid hormone receptor alpha1 signaling impairs acetyl

39 ear localization signal in the A/B domain of thyroid hormone receptor alpha1 that is absent in thyroi

40 in mice heterozygous for a point mutation in thyroid hormone receptor alpha1 was reversed with the se

41 identified patients that have a mutation in thyroid hormone receptor alpha1.

42 FOG-2 physically interacts with thyroid hormone receptor-alpha1 and abrogated even high

43 We show that thyroid hormone receptors also are single-stranded RNA b

44 noic acid receptor, retinoid X receptor, and thyroid hormone receptor and induced silencing mediator

45 processes through modulation of the nuclear thyroid hormone receptors and several other proteins.

46 findings define an important function of the thyroid hormone receptors and suggest TR ligands could h

47 sor SMRT (silencing mediator of retinoid and thyroid hormone receptors) and with histone deacetylase

48 expression analysis and the use of different thyroid hormone receptor antagonists suggest thyroid hor

49 the JCI, Mittag et al. provide evidence that thyroid hormone receptors are essential for the formatio

50 tinoic acid receptors (RARs or rars) and the thyroid hormone receptors are members of the steroid rec

51 Thyroid hormone receptors are required for the action of

52 The TRAP (thyroid hormone receptor associated proteins)/Mediator c

53 The human thyroid hormone receptor-associated protein (TRAP)-Media

54 ost prominent of these are components of the thyroid hormone receptor-associated protein (TRAP)/Media

55 P is an integral component of a multiprotein thyroid hormone receptor-associated protein (TRAP)/vitam

56 of the gene encoding the Mediator component thyroid hormone receptor-associated protein (TRAP)230/ME

57 eceptor-binding protein (PBP), also known as thyroid hormone receptor-associated protein 220/vitamin

58 We show here that Thrap3 (thyroid hormone receptor-associated protein 3) can direc

59 We show that the RNA-binding protein THRAP3 (thyroid hormone receptor-associated protein 3) regulates

60 xploiting the specificity of the coactivator thyroid hormone receptor-associated protein 80 (TRAP80).

61 that mouse BMAL1 complexes include TRAP150 (thyroid hormone receptor-associated protein-150; also kn

62 The TRAP (thyroid hormone receptor-associated proteins) transcript

63 PBP serves as an anchor for TRAP (thyroid hormone receptor-associated proteins)/mediator m

64 nt mouse harbors a dominant-negative mutated thyroid hormone receptor beta (denoted PV).

65 evels are primarily due to its action at the thyroid hormone receptor beta (THR-beta) in the liver, w

66 ion of a cis-regulatory module (CRM) for the thyroid hormone receptor beta (Thrb) gene, an early cone

67 In the retina, thyroid hormone receptor beta (thrb) is required for exp

68 a (PPARG), glucocorticoid receptor (GR), and thyroid hormone receptor beta (THRB), when exposed to 14

69 suggest that UCP1 is primarily dependent on thyroid hormone receptor beta (TR beta) while the normal

70 Mice harbouring a dominant-negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mice) spont

71 boring a knock-in dominantly negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mouse) spon

72 mouse harboring a dominantly negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mouse) that

73 Mutations of the thyroid hormone receptor beta (TRbeta) gene cause resist

74 Mutations in the thyroid hormone receptor beta (TRbeta) gene result in re

75 Mice with mutations in the thyroid hormone receptor beta (TRbeta) gene that cannot

76 utations in the ligand-binding domain of the thyroid hormone receptor beta (TRbeta) lead to resistanc

77 required for induction of FGF21 expression: thyroid hormone receptor beta (TRbeta), retinoid X recep

78 Thyroid hormone receptor beta 2 (TR beta 2) is a ligand-

79 ction with the transcription factors CRX and thyroid hormone receptor beta 2, it enhances M-opsin exp

80 The crystal structure of human thyroid hormone receptor beta at 2.8-A resolution with G

81 d the tail, two tissues that strongly induce thyroid hormone receptor beta during metamorphosis.

82 ing in KO mice, likely a result of decreased thyroid hormone receptor beta expression without Mdr2.

83 re, we have identified two binding sites for thyroid hormone receptor beta in the promoter of the rat

84 (RTH) disorders, due to mutations in either thyroid hormone receptor beta or alpha (beta: female n =

85 Treatment of Xenopus thyroid hormone receptor beta subtype A1 (xTRbetaA1) exp

86 ated that PI3K/Akt signaling is important in thyroid hormone receptor beta(PV/PV) knock-in (PV) mice

87 binding of the transcription factor THRbeta (thyroid hormone receptor beta).

88 X6 (Sex Determining Region Y-Box 6) and cTR (Thyroid hormone receptor beta).

89 tor repression was conserved with respect to thyroid hormone receptor beta-1, whereas cyclin D1 activ

90 is suboptimal because of lower expression of thyroid hormone receptor beta.

91 hyroid receptor, GC-24, an agonist for human thyroid hormone receptor beta.

92 Mice harboring a dominant-negative mutant thyroid hormone receptor-beta (TRbeta(PV/PV) mice) spont

93 tracellular dynamics and distribution of the thyroid hormone receptor-beta (TRbeta) in living cells,

94 Correlative data suggest that thyroid hormone receptor-beta (TRbeta) mutations could i

95 s a liver-directed, orally active, selective thyroid hormone receptor-beta agonist designed to improv

96 Down-regulation of the thyroid hormone receptor beta1 (TRbeta) appears to be as

97 erminal ductal lobular units encompasses the thyroid hormone receptor beta1 (TRbeta1) gene.

98 Since thyroid hormone receptor beta1 (TRbeta1) regulates sever

99 id hormone receptor alpha1 that is absent in thyroid hormone receptor beta1 and inactive in the oncop

100 thyroid hormone receptor antagonists suggest thyroid hormone receptor beta1 as the major player media

101 on NES-H12 suggest that altered shuttling of thyroid hormone receptor beta1 may be a contributing fac

102 The best-documented of these include thyroid hormone receptor beta2 (Tr beta2), retinoid rela

103 Mice deleted for thyroid hormone receptor beta2 (TRbeta2) and neural reti

104 Cone loss is mediated by cone-specific thyroid hormone receptor beta2 (TRbeta2) as deletion of

105 A prior study showed that thyroid hormone receptor beta2 (TRbeta2) is necessary to

106 Transgenic fish in which the thyroid hormone receptor beta2 (trbeta2) promoter drives

107 mponent of the cone precursor circuitry, the thyroid hormone receptor beta2 (TRbeta2), enables the ab

108 Thyroid hormone, and one of its receptors [thyroid hormone receptor beta2 (TRbeta2)], is an importa

109 and we found a mutation of the gene encoding thyroid hormone receptor beta2 associated with a decreas

110 two of these potential targets, the Jak2 and thyroid hormone receptor beta2 genes, was lost in the ne

111 uired RXRgamma, as well as the cone-specific thyroid hormone receptor-beta2.

112 We conclude that thyroid hormone receptors bind RNA through a novel domai

113 These benzamides generally lack undesirable thyroid hormone receptor binding and COX-1 inhibition ac

114 ding domain was necessary and sufficient for thyroid hormone receptor binding to the steroid receptor

115 We previously cloned and characterized thyroid hormone receptor-binding protein, TRBP (NcoA6: A

116 We also identified two new functional thyroid hormone receptor-binding sites in the CYP7A1 5'

117 ociates with coactivator as tightly as human thyroid hormone receptor bound to thyroid hormone and is

118 improvement of pharmacological properties of thyroid hormone receptor coactivator binding inhibitors.

119 he SMRT (silencing mediator for retinoid and thyroid hormone receptor) corepressor that blocks this s

120 rotein, vitellogenin, estrogen receptor, and thyroid hormone receptor, demonstrated that blood is a u

121 ow that MED1 phosphorylation by ERK enhances thyroid hormone receptor-dependent transcription in vitr

122 0/Med1 in vivo and correlates with increased thyroid hormone receptor-dependent transcription.

123 transcription but not estrogen receptor- or thyroid hormone receptor-dependent transcription.

124 NH-3 binds Xenopus laevis thyroid hormone receptors directly in vitro and induces

125 sis by developing a dominant positive mutant thyroid hormone receptor (dpTR).

126 methyltransferase Dot1L is a coactivator for thyroid hormone receptor during Xenopus development.

127 FP) chimeras of estrogen, retinoic acid, and thyroid hormone receptors (ERs, RARs, and TRs, respectiv

128 Thyroid hormone receptor expression analysis and the use

129 eptor (CAR), a member of the nuclear steroid/thyroid hormone receptor family, activates transcription

130 In addition, NH-3 prevents X. laevis thyroid hormone receptors from binding to the p160 famil

131 n with SRA, and perhaps other RNAs, enhances thyroid hormone receptor function.

132 cid receptors (RARs), members of the steroid/thyroid hormone receptor gene family, are ligand-depende

133 ion factors which are members of the steroid/thyroid hormone receptor gene family.

134 Aberrant expression and mutations of thyroid hormone receptor genes (TRs) are closely associa

135 TRalpha1 and TRbeta1, the two main thyroid hormone receptors in mammals, are transcription

136 sor SMRT (silencing mediator of retinoid and thyroid hormone receptors) in C57BL/6 mice (SMRTmRID) pr

137 nd SMRT (silencing mediator for retinoid and thyroid hormone receptors) interact with unliganded nucl

138 The AAA-ATPase thyroid hormone receptor interacting protein 13 (TRIP13)

139 We identified TRIP12 (thyroid hormone receptor-interacting protein 12), an E3

140 In this study, a role for thyroid hormone receptor-interacting protein 6 (TRIP6) i

141 The LIM domain-containing TRIP6 (Thyroid Hormone Receptor-interacting Protein 6) is a foc

142 CIP4 (Cdc42-interacting protein 4)/TRIP10 (thyroid hormone receptor interactor 10) was identified a

143 Affected mice had a nonsense mutation in the thyroid hormone receptor interactor 11 gene (Trip11), wh

144 how that activation by androgen receptor and thyroid hormone receptor is associated with the promoter

145 We conclude that TRbeta2-46 is an oncogenic thyroid hormone receptor isoform that promotes SKP2 expr

146 ransactivation dose-response curves for both thyroid hormone receptor isotypes, designated TRalpha an

147 stance occurs when a genetic mutation in the thyroid hormone receptor leads to reduced hormone bindin

148 with the ligand-binding domain of the human thyroid hormone receptor led to specific thyroid hormone

149 Inhibition of thyroid hormone receptor locally in the retina is a ther

150 TTR, while displaying minimal binding to the thyroid hormone receptor (<20%).

151 and SMRT (silencing mediator of retinoid and thyroid hormone receptors; NCoR2) are well-recognized co

152 ncluding silencing mediator for retinoid and thyroid hormone receptors, nuclear receptor coreceptor,

153 Thyroid hormone receptors often regulate gene transcript

154 oidogenesis inhibitors that lack undesirable thyroid hormone receptor or COX-1 binding.

155 The thyroid hormone receptor regulates a diverse set of gene

156 In this report, we demonstrate that the thyroid hormone receptor/retinoblastoma-interacting prot

157 n of appropriate reporter genes and that the thyroid hormone receptor RNA-binding domain is important

158 (3) regulatory region (-2.8/-2.5 kb) binding thyroid hormone receptor/RXR heterodimers.

159 rs SMRT (silencing mediator for retinoid and thyroid hormone receptors), SHARP (SMRT and histone deac

160 s in the anterior hypothalamus that requires thyroid hormone receptor signaling for proper developmen

161 epressor silencing mediator for retinoid and thyroid hormone receptor (SMRT) and coactivator.

162 Silencing mediator for retinoid and thyroid hormone receptor (SMRT) and nuclear receptor cor

163 ning silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor cor

164 proteins silencing mediator for retinoid and thyroid hormone receptor (SMRT) and the nuclear receptor

165 n as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components

166 epressor silencing mediator for retinoid and thyroid hormone receptor (SMRT) associates with the DNA-

167 the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor functions wi

168 and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressors and is larg

169 and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressors establish r

170 the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) gene that maps at chromo

171 epressor silencing mediator for retinoid and thyroid hormone receptor (SMRT) in vitro.

172 Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional cor

173 ssor silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) or histone deacetylase 1

174 that silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) represses the expression

175 the silencing mediator for retinoic acid and thyroid hormone receptor (SMRT)-histone deacetylase 3 (H

176 inal silencing mediator of retinoic acid and thyroid hormone receptor (SMRT)-interacting domain.

177 h as the silencing mediator for retinoid and thyroid hormone receptor (SMRT).

178 repressor silencing mediator of retinoid and thyroid hormone receptor (SMRT).

179 t of the silencing mediator for retinoid and thyroid hormone receptor (SMRT)/histone deacetylase 3 (H

180 repressor silencing mediator of retinoid and thyroid hormone receptors (SMRT(mRID)) produced a transp

181 R and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) and determined the role

182 The silencing mediator of retinoic and thyroid hormone receptors (SMRT) corepressor mediates tr

183 epressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D rece

184 The silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) is an established histo

185 The silencing mediator of retinoid and thyroid hormone receptors (SMRT) serves as a corepressor

186 The silencing mediator for retinoid and thyroid hormone receptors (SMRT) serves as a platform fo

187 sor silencing mediator for retinoic acid and thyroid hormone receptors (SMRT) suppressed AP-1 activit

188 el termed silencing mediator of retinoid and thyroid hormone receptors (SMRT)(mRID1) in which targete

189 epressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plet

190 uced silencing mediator of retinoic acid and thyroid hormone receptors (SMRT)-receptor interaction.

191 ) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT).

192 the silencing mediator of retinoic acid and thyroid hormone receptors (SMRT).

193 epressor silencing mediator for retinoid and thyroid hormone receptors (SMRT).

194 y by the silencing mediator for retinoid and thyroid hormone receptors (SMRT).

195 CoR1) and silencing mediator for retinoid or thyroid-hormone receptors (SMRT) are the best characteri

196 1 (NCoR1)/silencing mediator for retinoid or thyroid-hormone receptors (SMRT) corepressors in skin ke

197 1 (NCoR1)/silencing mediator for retinoid or thyroid-hormone receptors (SMRT) corepressors or histone

198 is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily.

199 Nuclear hormone receptors, such as the thyroid hormone receptors (T3Rs) and retinoid X receptor

200 Two NRs are homologues of the thyroid hormone receptor that previously were thought to

201 (VDR) belongs to the superfamily of steroid/thyroid hormone receptors that is activated by 1alpha,25

202 restingly, EBI was found to be a very potent thyroid hormone receptor (THR) agonist, while NH-3 is an

203 rofile in maternal serum for activity at the thyroid hormone receptor (THR) and ryanodine receptor (R

204 H expression, presumably by interacting with thyroid hormone receptors (THRs) bound to TSH subunit ge

205 otein and silencing mediator of retinoid and thyroid hormone receptors to a newly identified putative

206 For most target genes, the thyroid hormone receptor (TR) activates gene expression

207 Unliganded thyroid hormone receptor (TR) actively represses transcr

208 g four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering

209 The use of thyroid hormone receptor (TR) agonists for the treatment

210 Phosphonic acid (PA) thyroid hormone receptor (TR) agonists were synthesized

211 Thyroid hormone receptor (TR) alpha and beta mediate thy

212 to elevated expression of genes regulated by thyroid hormone receptor (TR) and liver X receptor (LXR)

213 oduct (Hr) acts as a corepressor of both the thyroid hormone receptor (TR) and the orphan nuclear rec

214 ed that a knock-in mouse harboring a mutated thyroid hormone receptor (TR) beta (PV; TRbeta(PV/PV) mo

215 We used a thyroid hormone receptor (TR) beta mutant mouse (TRbetaP

216 wth and metastatic progression in vivo using thyroid hormone receptor (TR) beta(PV/PV) knock-in (PV)

217 We have shown that the thyroid hormone receptor (TR) binds to a thyroid hormone

218 t mediates ligand-independent actions of the thyroid hormone receptor (TR) during development and in

219 potency and efficacy of different ligands of thyroid hormone receptor (TR) for regulating the recruit

220 multimeric complex that copurifies with the thyroid hormone receptor (TR) from HeLa cells and marked

221 It is well documented that unliganded thyroid hormone receptor (TR) functions as a transcripti

222 The thyroid hormone receptor (TR) has been proposed to regul

223 triiodo-l-thyronine, T3) inhibits binding of thyroid hormone receptor (TR) homodimers, but not TR-ret

224 g an unrecognized and essential role for the thyroid hormone receptor (TR) in lung development.

225 r coactivator 3 (SRC3) in gene activation by thyroid hormone receptor (TR) in vivo.

226 ivators implicated in gene activation by the thyroid hormone receptor (TR) include members of the p16

227 Thyroid hormone receptor (TR) is a member of the nuclear

228 ransporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform-specific action; a

229 When triiodothyronine (T3) binds the thyroid hormone receptor (TR) it indirectly contacts hel

230 Whereas thyroid hormone receptor (TR) knockout and transgenic st

231 We built a computer model of the thyroid hormone receptor (TR) ligand-binding domain in i

232 The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiol

233 e only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of the

234 ors, including nuclear receptors such as the thyroid hormone receptor (TR) that targets the TRAP220 s

235 The response to the liganded thyroid hormone receptor (TR) was mediated by an unusual

236 formed malignant hepatic cell lines in which thyroid hormone receptor (TR) was over-expressed by co-t

237 cute response of the Xenopus TRbetaA gene to thyroid hormone receptor (TR), an extensively studied me

238 d of the VDR DBD resembles that found in the thyroid hormone receptor (TR), and suggests a mechanism

239 show that another nuclear hormone receptor, thyroid hormone receptor (TR), can suppress ABCA1 transc

240 (COUP-TF1), retinoid X receptor (RXR)-gamma, thyroid hormone receptor (TR)-beta2, and guanylyl cyclas

241 gene through this interaction, and enhances thyroid hormone receptor (TR)-driven transcription in a

242 nuclear receptor corepressor (NCoR) enhances thyroid hormone receptor (TR)-mediated basal transactiva

243 eceptors (SMRT) have both been implicated in thyroid hormone receptor (TR)-mediated repression.

244 ligand and coactivator or corepressor to the thyroid hormone receptor (TR).

245 preference for binding the beta form of the thyroid hormone receptor (TR).

246 so involved in transcriptional regulation by thyroid hormone receptor (TR).

247 o describe transcriptional regulation by the thyroid hormone receptor (TR).

248 nd differentiation by binding to the nuclear thyroid hormone receptor (TR).

249 ator-1) has been previously shown to enhance thyroid hormone receptor (TR)/retinoid X receptor-mediat

250 In contrast, the thyroid hormone receptor (TR)/RXR heterodimer is believe

251 a nonpermissive heterodimer, such as that of thyroid hormone receptor (TR)/RXR, where it has been ref

252 Loss of thyroid hormone receptor (TR)alpha1 abolishes T(3) signa

253 is alternatively spliced to generate either thyroid hormone receptor (TR)alpha1 or a non-hormone-bin

254 The beta isoform of thyroid hormone receptor (TR-beta) has a key role in the

255 Thyroid hormone receptors (TR) act as activators of tran

256 are mediated by their respective receptors: thyroid hormone receptors (TR) and peroxisome proliferat

257 for transcriptional repression by unliganded thyroid hormone receptors (TR) but not essential for tra

258 We found that the thyroid hormone receptor (TRalpha 3) has a differential

259 ed a direct interaction of cytosol-localized thyroid hormone receptor TRalpha1 and the p85alpha subun

260 Thyroid hormone (T(3)) signaling through the thyroid hormone receptor (TRalpha1) regulates hepatoma c

261 oD, myocyte enhancer factor-2 (MEF2) and the thyroid hormone receptor (TRalpha1) that takes place in

262 mitogen-activated protein kinase (MAPK) and thyroid hormone receptor TRbeta1 (TR) in the cell nucleu

263 ells transfected with wild-type (wt) nuclear thyroid hormone receptor TRbeta1 (TR), L-thyroxine (T(4)

264 metabolic processes in the liver through the thyroid hormone receptor, TRbeta1.

265 that express a dominant negative form of the thyroid hormone receptor (TRDN) controlled by the cardia

266 xpression of a dominant negative form of the thyroid hormone receptor (TRDN) driven by the elastase p

267 xpression of a dominant negative form of the thyroid hormone receptor (TRDNalpha) was restricted to t

268 T3 binds to the thyroid hormone receptors (TRs) and controls their regul

269 entified in humans as a coactivator bound to thyroid hormone receptors (TRs) and essential for thyroi

270 hyroid hormone action is mediated by nuclear thyroid hormone receptors (TRs) and is dependent upon th

271 Although thyroid hormone receptors (TRs) are a prerequisite for t

272 Thyroid hormone receptors (TRs) are critical endocrine r

273 Thyroid hormone receptors (TRs) are critical regulators

274 Aberrant thyroid hormone receptors (TRs) are found in over 70% of

275 Thyroid hormone receptors (TRs) are hormone-regulated tr

276 Thyroid hormone receptors (TRs) are hormone-regulated tr

277 The nuclear thyroid hormone receptors (TRs) are ligand-activated tra

278 The thyroid hormone receptors (TRs) are ligand-dependent tra

279 Thyroid hormone receptors (TRs) are ligand-dependent tra

280 Thyroid hormone receptors (TRs) are ligand-regulatable t

281 Thyroid hormone receptors (TRs) are members of the nucle

282 The functions of thyroid hormone receptors (TRs) are regulated by a host

283 Thyroid hormone receptors (TRs) bind as homodimers or he

284 Thyroid hormone receptors (TRs) can repress or activate

285 Unliganded thyroid hormone receptors (TRs) interact with corepresso

286 orm-selective agonists or antagonists of the thyroid hormone receptors (TRs) might be therapeutically

287 these T(3) -induced changes are mediated via thyroid hormone receptors (TRs) or by non-genomic mechan

288 Thyroid hormone receptors (TRs) regulate both body weigh

289 pite the well documented broad expression of thyroid hormone receptors (TRs), analysis of different T

290 with the transcription activity of wild-type thyroid hormone receptors (TRs), leading to dysregulatio

291 Thyroid hormone action is mediated by thyroid hormone receptors (TRs), which are members of th

292 '-tri-iodothyronine (T3) binds and activates thyroid hormone receptors (TRs).

293 iation, and metabolism by binding to nuclear thyroid hormone receptors (TRs).

294 ns of such hormones are mediated by specific thyroid hormone receptors (TRs).

295 II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors

296 By inducing a dominant negative form of the thyroid hormone receptor under the control of doxycyclin

297 criptional regulator of MyHC expression, the thyroid hormone receptor, was pharmacologically manipula

298 T3 binds to thyroid hormone receptor, which heterodimerizes with ret

299 metabolic homeostasis by binding to nuclear thyroid hormone receptors, which regulate target gene ex

300 effect is mediated via the genomic action of thyroid hormone receptors, with little evidence for non-