ライフサイエンスコーパス: tightly

1 To perform its functions, RPA binds ssDNA tightly.

2 en improved to monitor disease activity more tightly.

3 rbohydrate cores binding elemental iron more tightly allow complete iron replacement within 15-60 min

4 Reagents that bind tightly and specifically to biomolecules of interest rem

5 nt to pack these heterogeneous structures as tightly as possible.

6 omplex rearrangements of domain organization tightly associated with catalysis.

7 These findings suggest that theta is more tightly associated with feedforward processing than gamm

8 Elevated oxidative stress is tightly associated with oral cancer.

9 acts with the docking protein Pex14p that is tightly associated with Pex17p.

10 e identify a rare population of muscle cells tightly associated with photoreceptor axons at stereotyp

11 For soil microbes tightly associated with plant roots, such as arbuscular

12 Drug-induced proarrhythmia is so tightly associated with prolongation of the QT interval

13 small number of cells at the leaf margin is tightly associated with the control of differential grow

14 , and that the evolution of this pathway was tightly associated with the morphological expansion of t

15 Changes to lipid metabolism are tightly associated with the onset and pathology of Alzhe

16 Here, we show that FLD tightly associates with LUMINIDEPENDENS (LD) and SET DOM

17 We demonstrate that TSPN6 tightly associates with SDC4, the SDC4-TSPN6 association

18 hic information, we designed GS-6207 to bind tightly at a conserved interface between capsid protein

19 mulations we show that PIP(2) interacts most tightly at the crystallographic interaction sites, outco

20 peptides obtained via mRNA display bind PHD2 tightly away from the active site.

21 orylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium

22 l fate related function modules and interact tightly based on their functional similarity.

23 of a target protein via two antibodies that tightly bind at least two distinct epitopes of the same

24 e scaffold for the development of selective, tightly binding MMP inhibitors.

25 ort the generation of a highly selective and tightly binding MMP10 inhibitor (K(i) < 2 nm).

26 We found that recombinant mouse MUTYH tightly binds AP sites opposite all four canonical undam

27 m exchange experiments revealed that GS-6207 tightly binds two adjoining capsid subunits and promotes

28 ecanylsulfamoyl)adenosine], which mimics the tightly bound acyl-AMP reaction intermediate, was able t

29 which a self-intercalated c-di-GMP dimer is tightly bound by a network of H bonds and pai-stacking i

30 ing this approach, knob domain peptides that tightly bound Complement component C5 were obtained, at

31 amics 3D folding simulations and Monte Carlo tightly bound ion estimations of ion-mediated electrosta

32 r formed at the N-terminal motif of NUBP1 is tightly bound, while the [4Fe-4S](2+) cluster bound at t

33 pen conformation to a closed state with more tightly-bound Met-tRNAi.

34 formational change in the receptor regulated tightly clearance of fibrillar alphaSN by human monocyte

35 ng the diapedesis pore, keeping this opening tightly closed around the transmigrating neutrophils.

36 We found a tightly closed pore gate in NALCN where the majority of

37 n AChRs expressed in cell lines, rather than tightly clustered by the intracellular scaffolding prote

38 toxin-producing Escherichia Coli (STEC) were tightly clustered in late-July at the national and state

39 histone methylation reader ZCWPW1, which is tightly co-expressed during spermatogenesis with Prdm9,

40 g and repolarizing the action potential were tightly coexpressed, and their absolute expression level

41 mitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagne

42 ceptors and P-type pathway bipolar cells are tightly connected throughout the retina, but that spatia

43 a cytoskeleton, while in keratocytes, it is tightly connected to cytoskeletal dynamics and mechanics

44 g temperature and receding sea-ice cover, is tightly connected to lower latitudes through the North A

45 Notch1 is tightly connected to many signaling pathways that are th

46 It is recognized that cell metabolism is tightly connected to other cellular processes such as re

47 radiodurans, the outermost surface layer is tightly connected with the rest of the cell wall.

48 his study is crucial, since it allows one to tightly control nanoparticle size by tuning the volume o

49 function of chromatin-binding proteins that tightly control the expression of master transcription f

50 The systems facilitate tightly controlled and efficient DSB formation at define

51 ariability in spatial spread observed in our tightly controlled and replicated experimental system an

52 AN), the leading pacemaker of the heart, are tightly controlled by a conserved network of transcripti

53 A-methyltransferase in neurons, DNMT3A1, are tightly controlled by activation of N-methyl-D-aspartate

54 strongly mediated by nicotinic receptors and tightly controlled by autoinhibition via muscarinic M2 r

55 en suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense e

56 These functions are also tightly controlled by inhibitory networks in the PFC, wh

57 npathologic conditions, protein synthesis is tightly controlled by metabolic regulation.

58 in temperature and aridity because they are tightly controlled by moisture availability.

59 The activity of RIPK1 is tightly controlled by multiple posttranslational modific

60 The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin

61 rticular, extracellular glutamate levels are tightly controlled by the astrocytic glutamate transport

62 atalysed protein ubiquitylation(1), which is tightly controlled by the modification of cullin with th

63 complex in metazoans, a highly selective and tightly controlled Ca(2+) channel of the inner mitochond

64 investigated in a single-center study under tightly controlled conditions in healthy controls, pre-d

65 ity of the human serum metabolome under such tightly controlled conditions.

66 Transcription of these sequences is tightly controlled during development to prevent genomic

67 Brain glutamate must be tightly controlled during hyperglycemia because of the r

68 f artificially posed expressions taken under tightly controlled experimental conditions.

69 Plant immune responses need to be tightly controlled for growth-defense balance.

70 and glia that form the brain originate from tightly controlled growth and division of neural stem ce

71 ertain cell types, and telomerase levels are tightly controlled in normal conditions.

72 been implicated in synaptic plasticity, the tightly controlled mechanisms that regulate local quanti

73 The generation of a tightly controlled ObLiGaRe doxycycline inducible SpCas9

74 gical Fe(III) and other transition metals to tightly controlled parts of the body.

75 The complement system is a tightly controlled proteolytic cascade in the innate imm

76 Our data contribute to the evolving model of tightly controlled proteostasis of the TOC159 import rec

77 vity, cellular MYC protein levels need to be tightly controlled so that they do not induce apoptosis.

78 Use of this tightly controlled system revealed a deficiency in diffe

79 The dynamics of ECM signaling are tightly controlled throughout growth and development.

80 homeostasis, stem cell activity needs to be tightly controlled throughout the adult life.

81 This process is tightly controlled to avoid aneuploidy, and we previousl

82 flammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation.

83 pment, WNT/beta-catenin signalling has to be tightly controlled to ensure proliferation and different

84 by which the catalytic activity of OTUD3 is tightly controlled to ensure timely activation of antivi

85 ensuring that cell membrane contractility is tightly controlled to execute proper daughter cell separ

86 nflammation, leukocyte recruitment has to be tightly controlled to prevent overwhelming leukocyte inf

87 , the identities of which are established by tightly controlled transcriptional networks(1).

88 NLRP3 inflammasome activity must be tightly controlled, as its over-activation is involved i

89 Therefore, beta-cell Ca(2+) handling is tightly controlled.

90 of and target recruitment by DUBs need to be tightly controlled.

91 allergic reactions, and their production is tightly controlled.

92 austion; therefore, IFN-I expression must be tightly controlled.

93 ystem, provided that this immune response is tightly controlled.

94 However, this variability is tightly controlled: a given eukaryotic protein type is t

95 tter (PM) can cause in skin is important for tightly controlling the release of air pollutants and pr

96 a balance between the UPS and the chaperones tightly controls neuronal differentiation.

97 Mating and egg laying are tightly cooordinated events in the reproductive life of

98 t cations, presumably because those ions are tightly coordinated by rRNA and deeply buried in the rib

99 l mechanism of action that likely involves a tightly coordinated regulation of CRBN with endothelial

100 These cellular events are tightly coordinated via locally produced regulatory biom

101 that the subcellular localization of Mad1 is tightly coordinated with cell cycle progression by kinet

102 PG biosynthesis is tightly coordinated with cell wall growth and turnover,

103 Astroglial homeostatic responses are tightly coordinated with neuronal activity.

104 Both BB assembly and DNA replication are tightly coordinated with the cell cycle to ensure their

105 moderate shifts in nuclear speckle distances tightly correlate with changes in cell type-specific gen

106 more showed that METTL3 and FOXO3 levels are tightly correlated in HCC patients.

107 hogenic tau accumulation and aggregation are tightly correlated with Abeta42/40 ratio.

108 associated changes in synaptic functions are tightly correlated with altered microRNA (miRNA) express

109 nt growth restriction of the jazD mutant was tightly correlated with upregulation of the Trp biosynth

110 ctors and further analysis also identified a tightly-correlated "core" set whose relational structure

111 ns as well as genomic loops in a manner that tightly correlates with increased accessibility, enhance

112 activity in the primary somatosensory cortex tightly correlates with the onset and speed of locomotio

113 olled through an autoregulated minor intron, tightly correlating Srsf10 with minor spliceosome abunda

114 of Na(+) into cytosol and, if not regulated tightly, could result in a futile cycle.

115 se they are too fast to consist of multiple, tightly coupled 8-nm steps.

116 in which ATP consumption and production are tightly coupled and regulated.

117 t developmental responses to temperature are tightly coupled during thermomorphogenesis and suggest t

118 e transmembrane segments shows that they are tightly coupled in the unliganded and single agonist-bou

119 These tightly coupled reactions are catalyzed by terminase ass

120 Their assembly and disassembly are tightly coupled to cell cycle progression.

121 Bacterial cell division is tightly coupled to the dynamic behavior of FtsZ, a tubul

122 The expression properties are tightly coupled with protein evolutionary rate, dependin

123 aptic vesicle exocytosis and endocytosis are tightly coupled, and their coupling is essential for syn

124 dothelial cells (ECs) within the BRB/BBB are tightly coupled, express high levels of Claudin-5 (CLDN5

125 Larval fish and Oithona distributions were tightly coupled, indicating potential predator-prey inte

126 We show here that the tightly coupled, nonlinear nature of high-latitude ecosy

127 but not neighbor, kinetochore-fibers remain tightly coupled, restricting chromosome stretching.

128 shable, indicating that these structures are tightly coupled.

129 This tightly couples tail binding, hexamerization, and ATPase

130 of precise, high-amplitude oscillation with tightly defined ensemble period and phase.

131 Previously, we observed a loosely and tightly docked state preceding leaflet merger using arre

132 The cross-linkages can lock the payloads tightly, endowing the crosslinked Rososome with better s

133 The response that we observed was tightly entrained to task timing, was spatially extensiv

134 ificantly higher differentiation compared to tightly-fitting models in two of the four disease groups

135 perimental evidence against commonly pursued tightly-fitting models.

136 d the emission profile was consistent with a tightly focussed beam.

137 The IEM is favored for proteins that are tightly folded and highly charged in solution and for dr

138 of the human cerebellar cortex is much more tightly folded than the cerebral cortex.

139 , human bone delta(2)H values are relatively tightly grouped and highly distinct from precipitation d

140 Fur-family metalloregulator Zur binds to DNA tightly in its metallated repressor form to Zur box oper

141 uided DNA endonuclease that binds substrates tightly in vitro but turns over rapidly when used to man

142 We demonstrate the utility of the tightly inducible P(BAD)-riboswitch construct using the

143 As they are tightly integrated into neural networks, label-free tool

144 tational and visualization frameworks can be tightly integrated to facilitate interactive genomic dat

145 ethods to determine structural epitopes with tightly interacting intact antibodies under native condi

146 charged surface supported by a rigid core of tightly intertwined proteins.

147 Our findings support a model in which tightly-intertwined biological dependencies of RNA and p

148 barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, wh

149 domain (RBD) of the viral spike glycoprotein tightly (K(D) of 2 nM), and a 2.6- angstrom-resolution c

150 ion kinetic analyses showed that NADPH binds tightly (K(D) of ~2 mum) to AsFMO and that the hydride t

151 In addition, the tightly knitted beta-bracelet fold, which presumably all

152 the variation statuses of genes and TEs are tightly linked and jointly contribute to the unequal dis

153 nked but separable by recombination from the tightly linked cluster of UAA, TAP, and LMP genes, the s

154 hat the mammalian complex I pumps protons by tightly linked conformational and electrostatic coupling

155 Sleep and DMN function may be tightly linked during adolescence and young adulthood, a

156 nstrated to induce targeted mutations in two tightly linked genes, svDrm1a and svDrm1b, at a frequenc

157 sses within this family are encoded by seven tightly linked genes: MtPRP1, MtPRP2 and MtPRP3, and fou

158 Metabolism and cell death are tightly linked in the phenomenon of ferroptosis, a form

159 Although the development of robust and tightly linked molecular markers on LG10 through chromos

160 sequencing (BSR-Seq) approach in developing tightly linked or co-segregating markers to Pm5e.

161 be explained by pleiotropic QTL or multiple tightly linked QTL.

162 plicated, precluding identification of novel tightly linked species-specific associations.

163 roduct of mutation breeding and the other is tightly linked to a locus that is involved in the expans

164 cer agents, as functions of KAP1 and ATM are tightly linked to cancer.

165 As the Stokes shift is tightly linked to excited-state proton transfer (ESPT) o

166 ormative of co-evolutionary sectors that are tightly linked to functional and/or structural propertie

167 ctors, whereas internal microbiomes are more tightly linked to host factors.

168 nd establishment of S. aureus infections are tightly linked to its ability to modulate host immunity.

169 These assemblies were tightly linked to LTB(4) formation.

170 xosamine Biosynthetic Pathway (HBP) has been tightly linked to PC development.

171 frequency bands, which in wild-type mice are tightly linked to running speed, was invariant in rTg451

172 n of more than half of the induced genes was tightly linked to specific dynamic features of NF-kappaB

173 Although menaquinone levels are known to be tightly linked to the cellular redox/energy status of th

174 Exocytosis in alpha-cells is tightly linked to the opening of voltage-gated P/Q-type

175 ount of visual signal information content is tightly linked to the phase of local gamma-rhythmic acti

176 indicate that a chromosome 9 locus harboring tightly linked variants in FTSJ3 and GH1 reduces growth

177 l phenomena (e.g., particle adhesion) become tightly linked with the microscopic details of ion adsor

178 cause motor neuron and muscle properties are tightly linked, we make predictions on the boundaries of

179 80 upstream of the integration site, thereby tightly linking its transcriptional activation to meioti

180 the higher relative phase speed is much less tightly localized at the interface in the isotropic diel

181 Centriole copy number is tightly maintained by the once-per-cycle duplication of

182 n response to pathogen proteins, and must be tightly modulated to prevent spurious activation in the

183 the monoclonal antibody CR3022 binds the RBD tightly, neutralizing SARS-CoV-2, and report the crystal

184 Ripening of tomato fruit is a complex tightly orchestrated developmental process that involves

185 n vivo during a viral infection, in a manner tightly orchestrated in time and space.

186 extracellular matrix fiber networks, between tightly packed cells, and between blood vessels or nerve

187 Tightly packed complexes of nucleocapsid protein and gen

188 substituted K13-W106 residues to organize a tightly packed core and novel surfaces that may bind add

189 low-contrast overlapping objects that may be tightly packed is a major bottleneck in standard deep le

190 designed systems(9-13) in that they possess tightly packed shells devoid of large apertures.

191 amination under low-energy environments with tightly packed small sediment particles compared with hi

192 e of the Abeta42 sequence, suggesting a more tightly packed structure.

193 Lipid rafts are tightly packed, cholesterol- and sphingolipid-enriched m

194 thin all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro.

195 ranules more severely than 600 MPa; however, tightly-packed complexes of globular starch granules-pro

196 cription factors, yeast Reb1 and Tbf1, and a tightly positioned nucleosome, are strong blocks to the

197 Nucleation-promoting proteins tightly regulate actin polymerization in cells.

198 der photomixotrophy, the cell must therefore tightly regulate electron fluxes from photosynthetic and

199 The colonic mucosa must therefore tightly regulate fluid influx to control absorption of f

200 e existence of sophisticated mechanisms that tightly regulate the specificity and sensitivity of infl

201 The mTOR signaling cascade is tightly regulated and central to normal neuronal develop

202 PrsS and PrpS are tightly regulated and expressed solely in pistil and pol

203 eceptors, and the signaling transduction are tightly regulated and fine-tuned to keep the signaling o

204 Its activation is tightly regulated and involves complex structural rearra

205 highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue

206 Importantly, we demonstrate the design of tightly regulated aptamers with strong target affinity o

207 te domain swapping oligomerization and other tightly regulated association mechanisms relevant in bio

208 eNOS is tightly regulated at various levels, including transcrip

209 Our results show that a tightly regulated autophagic response is triggered upon

210 ability to bind and hydrolyze ATP, which is tightly regulated both by co-chaperone proteins and post

211 Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity.

212 mammalian mRNAs and showed that they can be tightly regulated by a steric-blocking antisense oligonu

213 tructures, and their kinetic transitions are tightly regulated by accessory proteins at the synapse.

214 Furthermore, PCAF activity is tightly regulated by ATR (ataxia telangiectasia and Rad3

215 erilii, a species where sexual maturation is tightly regulated by both metabolic state and lunar cycl

216 Transcription is tightly regulated by cis-regulatory DNA elements where t

217 Their response is tightly regulated by complex signaling pathways that all

218 Intestinal homeostasis is tightly regulated by complex yet poorly understood signa

219 by serine proteases KLK5 and KLK7, which are tightly regulated by lympho-epithelial Kazal-type relate

220 Ca(2+) overload, the activity of MCU must be tightly regulated by MICUs, which sense changes in cytos

221 e at synapses during synaptic plasticity are tightly regulated by neuronal activity.

222 f the cellular response to DNA damage and is tightly regulated by posttranslational modifications.

223 Let-7 biogenesis is tightly regulated by several RNA-binding proteins, inclu

224 Hematopoiesis is tightly regulated by the bone marrow (BM) niche.

225 mental stimuli, gene expression patterns are tightly regulated by the dynamic interplay between trans

226 tical predictions that variations in chi are tightly regulated by the four environmental drivers.

227 e for ROS clearance and their expression are tightly regulated by the growth and environmental condit

228 phagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin

229 t infectious or inflammatory disease, and is tightly regulated by the neurons located in the median p

230 Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC).

231 opoietic stem and progenitor cells (HSPC) is tightly regulated by their bone marrow (BM) microenviron

232 ese ion channels in somatosensory neurons is tightly regulated by u-opioid receptors through the sign

233 sociated Ca(2+) responses, the importance of tightly regulated Ca(2+) dynamics for mitochondrial axon

234 The data further highlight the importance of tightly regulated communication between the IFN-alpha/be

235 e recombination landscape and reinforces the tightly regulated control of crossover numbers without r

236 s the MET receptor tyrosine kinase, which is tightly regulated developmentally in rodents and primate

237 the cytoplasmic level of l-cysteine must be tightly regulated due to its propensity to reduce iron a

238 3 to a tyrosine-directed kinase represents a tightly regulated event that enables a bacterial virulen

239 Each of these activities is tightly regulated in both time and space.

240 Protein synthesis is quickly and tightly regulated in cells to adapt to the ever-changing

241 Glucose metabolism is tightly regulated in healthy hepatocytes.

242 Here, we report that Ndc80 turnover is also tightly regulated in meiosis: Ndc80 degradation is activ

243 Hence, MYCs need to be tightly regulated in order to optimize plant fitness.

244 With the assumption that futile cycles are tightly regulated in reality, the FBA models were manual

245 Expression of mitochondrial proteins is tightly regulated in response to internal and external s

246 carry out a wide range of functions that are tightly regulated in space and time.

247 Tissue pH is tightly regulated in vivo, being a sensitive physiologic

248 This novel, spatio-temporally tightly regulated mechanism relies on the inhibition of

249 einhardtii), chloroplast gene expression is tightly regulated posttranscriptionally by gene-specific

250 ntenance of these stereociliary bundles is a tightly regulated process requiring the involvement of s

251 Cholesterol synthesis is a tightly regulated process, both transcriptionally and po

252 and neuroendocrine systems rely on fast and tightly regulated release of neurotransmitters stored in

253 nd width of these actin-based stereocilia is tightly regulated throughout life to establish and maint

254 mics of excitatory neurotransmission must be tightly regulated to achieve efficient synaptic communic

255 Macrophage-initiated inflammation is tightly regulated to eliminate threats such as infection

256 In plants, iron uptake from the soil is tightly regulated to ensure optimal growth and developme

257 DNA from viruses or transposable elements is tightly regulated to prevent pathogenesis.

258 grammed meiotic double-strand breaks must be tightly regulated to promote accurate homolog segregatio

259 HSF1 is tightly regulated via intramolecular repressive interact

260 IgE is the least abundant immunoglobulin and tightly regulated, and IgE-producing B cells are rare.

261 osis factor receptor superfamily (TNFRSF) is tightly regulated, disruption of which triggers various

262 Thus, calcium-cAMP signaling must be tightly regulated, e.g., by agents that catabolize cAMP

263 exit of BACE1 and APP in primary neurons is tightly regulated, resulting in their segregation along

264 the FA pathway, and its activity needs to be tightly regulated.

265 e ER, the action of atlastin GTPases must be tightly regulated.

266 the labile pool of chelatable "free" iron be tightly regulated.

267 nd levels of this particular FGF protein are tightly regulated.

268 ich the synthesis of membrane lipids must be tightly regulated.

269 nitrogen acquisition and utilization must be tightly regulated.

270 cretion of the major curli subunit, CsgA, is tightly regulated.

271 alance) in neural circuits is believed to be tightly regulated.

272 Our findings demonstrate that Polo tightly regulates the RZZ-Spindly-dynein module during m

273 n vasculature maintains brain homeostasis by tightly regulating ionic, molecular, and cellular transp

274 Two large, tightly related dominant biomarker clusters were found,

275 Halo mass and concentration are tightly related in a way that depends on cosmology and o

276 ve platform studying MR to MS in a pig model tightly related to human MS criteria.

277 ast proteins, we show that ubiquitylation is tightly repressed throughout elongation by the Y-shaped

278 In addition, when a rubber band tightly secures the sensor to the skin, the gap between

279 mers found in oM1000 appearing to be stable, tightly self-associated ensembles that coexist in dynami

280 its cognate transcription regulator HdrR by tightly sequestering HdrR in a membrane-localized hetero

281 ltrafast electrooptical sampling reveals the tightly short-range bound nature of such soliton molecul

282 ces LC11 responses by pooling fast-adapting, tightly size-tuned inputs.

283 investigating the connectivity of dozens of tightly spaced M1 sites, which was the linchpin for unco

284 best known binder and roughly 36 times more tightly than the design starting point (wild-type c-Raf-

285 es this by binding the virus polymerase more tightly than the human version of the protein.

286 is new variant binds roughly five times more tightly than the previous best known binder and roughly

287 dicted that this new variant binds even more tightly than the previous best-binding variant, c-Raf-RB

288 eir target and bind orders of magnitude more tightly than their substrates.

289 d changes and bound to the RBD 170-fold more tightly than wild-type ACE2.

290 The capacity for cognitive control is tightly tied to the prefrontal cortex, whose expansion i

291 The middle protein, MP, binds tightly to CCPol and confers upon it the ability to synt

292 bitor 1 (PAI-1) with its target enzymes bind tightly to low-density lipoprotein (LDL) receptor-relate

293 Sulfono-gamma-AA peptides were shown to bind tightly to MDM2 and MDMX, with K(d) of 19.3 and 66.8 nM,

294 ext of synthetic ligands and drugs that bind tightly to riboswitches without eliciting a biological r

295 d be used to evolve l-RNA aptamers that bind tightly to structured d-RNAs.

296 tions of the water column, and that both are tightly tuned to environmental conditions in the ETNP.

297 g glutamate and tyrosine residues binds more tightly, which is consistent with the known importance o

298 inger produce distinct outputs, but interact tightly with each other and receive similar inputs.

299 nalysis tool that incorporates visualization tightly with state-of-the-art statistical analysis frame

300 of hnRNPK work together to interact with RNA tightly, with the KH3 domain being neither necessary nor