ライフサイエンスコーパス: tissue

1 dolinium was detected in human cortical bone tissue.

2 al development of estrogen responses in this tissue.

3 geneity and delineates diseased from healthy tissue.

4 nterface between the electronics and growing tissue.

5 lectively depleting the protein in only this tissue.

6 age the phosphorescence lifetimes within the tissue.

7 ed paw, but not in those innervating healthy tissue.

8 n of monocyte-derived macrophages to infarct tissue.

9 tations in genes not expressed in accessible tissue.

10 e liver, heart, skeletal muscle, and adipose tissue.

11 leads to increased lipid droplet size in fat tissue.

12 rogen receptor- positive (ER+) breast cancer tissue.

13 e, adult cancer tissue, and pediatric cancer tissue.

14 , compressive stiffness and hydration to the tissue.

15 and transformation zone of healthy cervical tissue.

16 e rigidity and the permeability of the brain tissue.

17 nearity in the elastic properties of ex vivo tissue.

18 to measure the degree of order of any packed tissue.

19 dian rhythm were noted in insulin-responsive tissues.

20 nts of the phenotypes seen in various muscle tissues.

21 the total frataxin protein present in mouse tissues.

22 ubiquitously in the body, i.e. in non-target tissues.

23 anges in the water content within biological tissues.

24 ndering efforts to visualize targets in deep tissues.

25 ogels and cultured to generate heterogeneous tissues.

26 rom photosynthetic source tissues to storage tissues.

27 ) TAMs in glioblastoma patient-derived tumor tissues.

28 spatial distribution in normal and cancerous tissues.

29 ed viruses in intestinal and extraintestinal tissues.

30 gulation on postmortem human ALS spinal cord tissues.

31 uantitation of cells in complex multilayered tissues.

32 independently from the surrounding exocrine tissues.

33 increasing HIF-1alpha, even within the same tissues.

34 ycle in three-dimensional (3-D) human airway tissues.

35 agnosis by scanning all around the dissected tissues.

36 types with a focus on neurogenesis and brain tissues.

37 scular nature of cartilage makes it a unique tissue(1-4), but whether and how the absence of nutrient

38 ee large datasets consisting of adult normal tissue, adult cancer tissue, and pediatric cancer tissue

39 velopment of optimal strategies for accurate tissue analysis.

40 astatic subclones at autopsy were present in tissue and blood samples from earlier time points.

41 he hysteresis ratio was related to both lung tissue and gas recruitment (R = 0.266, p = 0.008, R = 0.

42 isease due to its ability to remodel cardiac tissue and generate angiotensin II.

43 or activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-resp

44 cause a scarring response that stiffens the tissue and impairs ocular function.

45 odes a receptor highly expressed in prostate tissue and is related to the B7/CD28 family of T-cell im

46 een the gut and brain monitor the intestinal tissue and its microbial and dietary content(1), regulat

47 nduced inflammation and steatosis of adipose tissue and liver are associated with a variety of seriou

48 Transcriptional activation in both adipose tissue and liver as well as serum levels were strongly a

49 rlie hormonal regulation of genes in uterine tissue and optimal development of estrogen responses in

50 We document matching sCNAs in the NAT tissue and the adjacent tumor, suggesting a shared clona

51 igin, as well as instances in which both NAT tissue and tumor tissue harbor a gain of the same oncoge

52 s (ECs) are widely heterogenous depending on tissue and vascular localization.

53 cohort, truncated STMN2 RNA was confined to tissues and disease subtypes marked by TDP-43 inclusions

54 en consistent with sloughed tracheobronchial tissues and inflammatory cells in a background of dense

55 neumoniae can cause disease in various human tissues and organs, including the ear, the brain, the bl

56 Red blood cells (RBCs) transport oxygen to tissues and remove carbon dioxide.

57 ommensal fungus that colonizes human mucosal tissues and skin, can become pathogenic, clinically mani

58 dence implicates crosstalk between metabolic tissues and the immune system in the inception and progr

59 fect the physiological activities of adipose tissues and their dysfunctions, which lead to several me

60 well compared to manual segmentation in most tissues and will be valuable in future studies.

61 at which naloxone was undetectable in brain tissue) and found that this drug still powerfully attenu

62 e of 3D printed phantoms, ex vivo biological tissue, and in vivo mouse and rat models of cancer with

63 sisting of adult normal tissue, adult cancer tissue, and pediatric cancer tissue.

64 d elastic modulus, is enhanced in DM adipose tissue, and suggest that measures of tissue mechanics ma

65 ed down to 0.50lambda for hard objects, with tissue approximating masses slightly higher at 0.73lambd

66 adjuvant therapies to ablate remaining tumor tissues are needed during surgical resection of prostate

67 Many tissues are produced by specialized progenitor cells ema

68 and adjacent normal pancreatic tissues, PDA tissue array and cell lines were used to determine the l

69 t cancer yet rarely detected in adult normal tissues as reported in previous studies, featuring it as

70 Ms in genes highly expressed in craniofacial tissues, as well as genes associated with known autosoma

71 weight gain and induction of UCP1 in adipose tissues associated with dietary protein restriction.

72 the three-dimensional changes following soft tissue augmentation using free gingival grafts (FGG) at

73 a global cue that coordinates local PCP with tissue axes.

74 same direction of effect in the second brain tissue (BA25, N = 60) from the same individuals and in t

75 thetic pigment and pigmented human cartilage tissue both showed hydroquinone-resembling NMR signals.

76 ass but is constitutively present in healthy tissues bound to resident cells via its high-affinity re

77 reveals that protein stability varied within tissues, but discernible trends in the data suggest that

78 ng epithelial cells and primary human airway tissues by increasing the infectivity and stability of v

79 Remarkably, human lung cancer tissues can only be distinguished from adjacent normal t

80 Loss of KBTBD2 in all tissues causes the teeny phenotype, characterized by ins

81 tive stress might induce senescence in joint tissue cells.

82 Patient demographics, tissue characteristics, intraoperative parameters, and p

83 Tissue collected at 7-12 months post-injury showed no si

84 Tissue microarray (TMA) samples from 415 tissues collected from three cancer centers (UM, USC, an

85 cell survival was observed in the EVLP lung tissue compared with lungs undergoing standard transplan

86 st, metabolite levels were lower in parasite tissues compared to fish matrices.

87 is a lipid mediator of inflammation, and its tissue concentration is elevated in cancer and neurologi

88 morphs may significantly advance organ-scale tissue construction by extending the spatial range of ce

89 The tissue cultures were incubated at 37 degrees C in a 5% C

90 ectively, and peaked in aging, strengthening tissues: CXE in xylem and cells bordering intercellular

91 he primary defensive functions and excessive tissue damage actions.

92 y alter smoking-related lung cancer risk and tissue damage from other inhaled toxins.

93 11b function and reduction of PMN-associated tissue damage in chronic inflammatory diseases.

94 cellular response to microbial infection and tissue damage, but its aberrant activation can lead to a

95 is robust to variations in the extent of ON tissue damage, image quality, and species of mammal.

96 controls) and gene expression levels from 21 tissue datasets (brain; blood; thyroid, adrenal, and pit

97 eater risk of mechanical damage during brain tissue deformation from traumatic brain injury.

98 racted from cell cultures and human AD brain tissues, demonstrating the ability of the Hsp70 machiner

99 lly persists in muscle, and we asked if this tissue-dependent persistence was linked to MHC expressio

100 ch play essential roles in animal evolution, tissue development, and homeostasis, and are disrupted i

101 ogeneous refractive indices inside cells and tissues distort the fluorescent signal emitted from sing

102 membrane permeability resulting in enhanced tissue distribution and intracellular drug delivery of m

103 Rationale: Tissue Doppler imaging (TDI) is an echocardiographic met

104 P. syringae to spread locally to neighboring tissues during infection.

105 is a relatively new technique for measuring tissue elasticity.

106 and driven numerous pivotal advancements in tissue engineering and regenerative medicine.

107 rtantly, our study demonstrated that protein tissue-enrichment information can explain phenotypes of

108 temporal lobe epilepsy or peritumoral cortex tissue expressed P2Y12 receptors.

109 Genotype-Tissue Expression Project (GTEx) RNA-seq data were used

110 fferent types of membrane proteins, CorA and tissue factor (TF).

111 olve disease-specific differences in adipose tissue fibrosis compared with histologic measures.

112 Atrial-tissue fibrosis is a central pathophysiological feature

113 tant roles in allergic diseases, asthma, and tissue fibrosis.

114 specifically expressed genes for each of 53 tissues followed by linkage disequilibrium (LD) score-ba

115 pability of developed microcarriers for bone tissue formation was examined in vivo.

116 erized by the accumulation of excessive scar tissue found throughout the neural retina.

117 roscopy can be used to identify the types of tissues found in a nasal septal biopsy, i.e., hyaline ca

118 Flow cytometry of dispersed tissue fragments and serial immunohistochemistry of para

119 making it possible to obtain pre-symptomatic tissue from eye bank donors to probe how gene expression

120 ingle-cell RNA-sequencing data from multiple tissues from healthy human donors.

121 Using lung tissues from IPF and control subjects, we showed that ex

122 ins involved in autophagy in colonic mucosal tissues from patients with sporadic CRC colonized with v

123 ancer specimens (tumor and adjacent nontumor tissues) from patients who underwent surgery and gemcita

124 for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of t

125 that induce differentiation within a defined tissue geometry.

126 long-term results 20 years after connective tissue grafting (CTG) or guided tissue regeneration (GTR

127 his study was to evaluate the impact of soft tissue grafting procedures conducted over a decade ago o

128 of the RISC; rather, AGO1 controls cell and tissue growth by functioning as a direct transcriptional

129 internal pH upregulation to sustain elevated tissue growth, resulting in a porous and fragile skeleto

130 instances in which both NAT tissue and tumor tissue harbor a gain of the same oncogene arising in par

131 e central nervous system, its use in adipose tissue has been limited.

132 llular redox dynamics of NAD in living plant tissues has been challenging.

133 g perfusable vascular networks in engineered tissues have been constrained in architectural complexit

134 tially resolved proteome measurements across tissues have had limited spatial resolution and proteome

135 lls, halts cancer progression as a result of tissue healing and remodelling of the blood vasculature,

136 Soft tissue healing was uneventful in all patients.

137 d metabolic products in biofluids and living tissues holds great promise.

138 n of neuroimmune interactions in maintaining tissue homeostasis and protection.

139 a population of memory T cells that supports tissue homeostasis and provides protective immunity.

140 a key second messenger in cell signaling and tissue homeostasis.

141 While tissue homogenate showed no changes in tubulin acetylati

142 ngs was confirmed with immunohistochemistry, tissue hydroxyproline content, and tissue mRNA expressio

143 be elevated in patients with CLD due to both tissue hypoperfusion as well as decreased LA clearance.

144 Automated tissue identification and characterization using a singl

145 ine cartilage and perichondrium, for a novel tissue identity assay.

146 role for CEPR1 in the maternal reproductive tissue in determining seed size and yield, likely via th

147 woody plants, whereas roots were the richest tissue in graminoids.

148 motactic transport of bacteria within a leaf tissue in response to photosynthesis occurring within pl

149 , and dendritic cells (DCs) present in every tissue in the body.

150 Stems were the richest tissue in woody plants, whereas roots were the richest t

151 ith cytotoxic gene expression from different tissues in single-cell RNA-sequencing data.

152 m 320 MSI tumor biopsies and matched healthy tissues in The Cancer Genome Atlas database were analyze

153 rgy status of adipocytes to other nonadipose tissues including liver, muscle, and pancreas.

154 olving detrimental myeloid cell responses in tissues, including those occurring in the persistently i

155 ned with age-dependent iron elevation in the tissue, increases pro-oxidant iron burden in AD.

156 ly influence GAS pathophysiology during soft tissue infection.

157 with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation be

158 o 32.9 per 100 000 persons for skin and soft tissue infections.

159 shed new light on GM-CSF biology in sterile tissue inflammation and identify several potential thera

160 utrophil migration, TNF-alpha secretion, and tissue inflammation in mice (female BALB/c strain) with

161 nd pharmacological neuromodulation to reduce tissue inflammation with the aim of preventing respirato

162 ex-hormone-dependent manner to limit adipose tissue inflammation.

163 decontamination and modulating peri-implant tissue inflammation.

164 These implanted scaffolds promote tissue ingrowth, which upon cancer initiation is transfo

165 Whether autosis is involved in tissue injury induced under pathologically relevant cond

166 -specific neutrophilic inflammation preserve tissue integrity during infection.

167 in which we have characterized pathological tissue integrity, barrier function and metabolic stabili

168 which these immune cells converge on target tissues, interact with fibroblasts and promote tissue re

169 ate adolescence.SIGNIFICANCE STATEMENT Brain tissue iron is essential to healthy brain function.

170 nges precede disease; and (iii) The affected tissue is a homogeneous single cell monolayer, facilitat

171 BACKGROUNDBeige adipose tissue is associated with improved glucose homeostasis i

172 ation strategy for free sulfhydryl groups in tissue is known for MALDI MSI.

173 Since the tissue is not disaggregated, the location of cells is re

174 w RNA triggers disease because: (i) Affected tissue is routinely removed during surgery; (ii) The exp

175 ists of the bone morphotype, the keratinized tissue (KT), and gingival thickness (GT).

176 aughter cells may be born displaced from the tissue layer.

177 keleton, extracellular matrix and cells, and tissue-level architectures.

178 essivity emerges from pulsed events, and how tissue-level mechanics are the coordinated output of man

179 Cell- and tissue-level processes often occur across days or weeks,

180 ell supernatants with B cells led to greater tissue like memory B cell frequencies.

181 y, these data suggest that functionality and tissue localization are important determinants of CD8+ T

182 MDCK cells were inoculated with tissue lysates, enabling recovery of one IAV isolate con

183 itors, circulating blood monocytes, resident tissue macrophages, and dendritic cells (DCs) present in

184 If AMs, like most tissue macrophages, are sessile, then this numerical adv

185 restricted to replication in human cells and tissues, making them difficult to study in traditional a

186 nnels and GPCRs are co-expressed in the same tissues, many of these channels can inhibit GPCR desensi

187 ersity of microbes in the mesenteric adipose tissue (MAT) surrounding the GI tract.

188 ity of molecular changes that occur in these tissues may guide the development of more efficacious an

189 egenerating adult zebrafish and provides the tissue mechanical basis for future studies into the role

190 adipose tissue, and suggest that measures of tissue mechanics may better resolve disease-specific dif

191 culties and the challenge of obtaining fresh tissues.METHODSThis observational study evaluated 6 indi

192 Tissue microarray (TMA) samples from 415 tissues collect

193 igratory behaviors of lymphocytes within the tissue microenvironment can provide valuable insight int

194 How extracellular matrix contributes to tissue morphogenesis is still an open question.

195 s on development of the liver, which was the tissue most sensitive to AFFF.

196 hemistry, tissue hydroxyproline content, and tissue mRNA expression of fibrosis-associated genes (Ccl

197 ed candidate proteins for analyzing diseased tissues near or distal to salivary glands using transcri

198 T(reg) cells from VAT are determined by the tissue niche in a sex-hormone-dependent manner to limit

199 ver 10 days following the storm and measured tissue nutrient concentrations and deltaN(15).

200 method that measures the velocity of moving tissue.Objectives: We applied this technique to the diap

201 layer and reside deep within the intestinal tissue of animals.

202 ined a predilection for homing back to their tissue of origin on subsequent reactivation and a height

203 PS populations could be separated based upon tissue of origin.

204 pollen grains, and surrounding the vascular tissues of anthers, suggesting that OsNLA1 is important

205 membrane and in the muscle-derived electric tissues of fish.

206 es in cell-signaling pathways in the uterine tissues of G12D and G12V mice were identified using RNA

207 all life stages and throughout all cells and tissues of this animal, including the immune cells of th

208 we analyzed the transcriptome from multiple tissues of two recently diverged Ficedula flycatcher spe

209 ell as in mitochondria from postmortem brain tissues of unaffected individuals and HD patients, suppo

210 ution maps of chromatin interactions from 10 tissue or cell types with a focus on neurogenesis and br

211 tive selection and may have implications for tissue or cell-specific expression of the virus.

212 of cell-specific targeting methods in brain tissue or living animals.

213 ering the peptides ex vivo (i.e., to excised tissue) or in vivo (in animals), using antagonists of op

214 supports cell polarization and functions and tissue organization and homeostasis.

215 zed on the basis of cellular composition and tissue organization.

216 d for looking into, and making sense of, the tissue origin of HGSC.

217 iloxane (HMDSO) for accurate measurements of tissue oxygen tension (pO(2)) using Proton Imaging of Si

218 2)) using Proton Imaging of Siloxanes to map Tissue Oxygenation Levels (PISTOL) magnetic resonance im

219 non-invasive imaging surrogate biomarker of tissue oxygenation status.

220 Here we introduce an on-tissue ozonization protocol that enables a particular st

221 e, paired PDA and adjacent normal pancreatic tissues, PDA tissue array and cell lines were used to de

222 otential for broad efficacy, convenience and tissue penetrance, and thus often offer important advant

223 se-luciferin pairs emit light that is poorly tissue penetrant, hindering efforts to visualize targets

224 Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mecha

225 an or equal to 65 mm Hg and signs of altered tissue perfusion.

226 because of the extremely fragile intestinal tissue perioperatively, and a conservative approach was

227 e measurement of nitric oxide, endothelin-1, tissue plasminogen activator and plasminogen activator i

228 rom human non-small cell lung cancer (NSCLC) tissue possesses 3'-terminal 2'Ome.

229 The results suggest that the tissue property mismatch at the gray-white matter interf

230 ized by rapid cellular infiltration of brain tissue, raising the possibility that disease progression

231 The high tumour-to-normal tissue ratio offered by TMRET in combination with dual-c

232 s C) and add additional cellular mechanisms (tissue recovery and variable cell susceptibility to infe

233 r connective tissue grafting (CTG) or guided tissue regeneration (GTR) using bioabsorbable barriers f

234 ty and effectiveness of this biomaterial for tissue regeneration and in vivo restoration of organ fun

235 efense, inflammation, organ development, and tissue regeneration.

236 tween early calcium signaling and subsequent tissue regeneration.

237 tokine family, and is critically involved in tissue regeneration.

238 that underpin mutational selection in normal tissues remain poorly understood.

239 We propose a role for Gdf5 in tissue remodelling and repair after injury, which may pa

240 ssues, interact with fibroblasts and promote tissue remodelling are beginning to be understood and wi

241 responses or the balance of inflammation and tissue repair in the resolution of infection.

242 formalin-fixed and paraffin-embedded (FFPE) tissues requires reversal of chemical crosslinking and t

243 enance of the cellular phenotype of injected tissue-resident macrophages.

244 ice supported the population of mature human tissue-resident mast cells and basophils.

245 ol of NK cell development and maintenance as tissue-resident populations, whereas mature, terminally

246 ilis genome by 48- and 154-fold in mucus and tissue, respectively, allowing for high-fidelity compari

247 y grow as compared to neighboring non-neural tissues, resulting in dendrite overgrowth.

248 Microarray analysis of ventricular tissue revealed that miR-21 and miR-221, 2 activators of

249 A new tissue sample embedding and processing method is present

250 ast cancer cell-lines and two patient tumour tissue samples through a qPCR instrument and finally pil

251 s a lack of spatial resolution as either the tissue samples were homogenized or specific proteins wer

252 cal specimens, cell lysates, and mouse liver tissue samples, demonstrating its highly sensitive and s

253 hat previously went undetected in bulk brain tissue samples.

254 three groups contained either recurrent soft-tissue sarcomas or positive postoperative findings (nons

255 Over 26,500 ultrathin tissue sections from the same block were imaged, yieldin

256 arkedly reduced NADPH diaphorase staining in tissue sections subsequently subjected to paraformaldehy

257 ns, developing embryos, and centimeter-scale tissue sections.

258 ward derivatization of unsaturated lipids in tissue sections.

259 sic mechanisms that coordinate cell fate and tissue shape will generate an integrated understanding o

260 ts (FMREs) were ubiquitously active in human tissues, showed long-range chromatin interactions and mR

261 ons were within 2-fold of observed blood and tissue silver concentrations in rats and within the 95%

262 ) and pipecolic acid both in brain and liver tissues, similar to the biochemical picture in ALDH7A1-d

263 al during clinical sepsis, and contribute to tissue-specific cytokine responses that are protective a

264 ed potential angiocrine interactions between tissue-specific ECs and other cell types by analyzing li

265 ntify transcription factors that may mediate tissue-specific effects.

266 We provide new insights into the tissue-specific functions of VDRs in maintaining Paneth

267 s thaliana seedlings were investigated using tissue-specific GA inactivation in wild-type (Col-0) or

268 or post-thymic gammadeltaT17 development and tissue-specific imprinting, which is essential for infec

269 We generated a doxycycline-inducible adipose tissue-specific MMP14 overexpression model to study its

270 n antibody-mediated toxin neutralization and tissue-specific neutrophilic inflammation preserve tissu

271 This work shows that regulation of tissue-specific splicing can influence FXR1 condensates

272 e networks, yet the mechanisms governing how tissue specificity of their function is achieved are poo

273 In the present study, we evaluated tissue SPP1 mRNA and OPN protein expression as markers o

274 PZ effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice

275 of the spatiotemporal changes of spinal cord tissue stiffness in regenerating adult zebrafish and pro

276 Solitary intestinal lymphoid tissues such as cryptopatches (CPs) and isolated lymphoi

277 The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage

278 staining of mouse brain, lung or intestinal tissue surface with minute quantities of NanO2-IR or by

279 ly reorient their divisions depends on local tissue tension.

280 erential DNA methylation signatures in proxy tissues that are associated with reproductive phenotypic

281 to visualize molecular structures in complex tissues that have remained hidden until now.

282 large clonal expansions in older adults and tissues that rivalled, remarkably, the TCRalphabeta repe

283 ssing MMP14 in the early-stage obese adipose tissue, the transgenic mice showed a healthier metabolic

284 d the cellular architecture of breast cancer tissue to be characterized on the basis of cellular comp

285 to process 384 mouse organs from collecting tissues to obtaining raw sequencing data, with additiona

286 hrough the phloem from photosynthetic source tissues to storage tissues.

287 The bone marrow senses distant tissue transformation at premalignant/preinvasive stages

288 vade circulating antibodies and might affect tissue tropism.

289 located in exons highly expressed in cardiac tissue (TTN(LOF)).

290 (PDL), which contains stem cells supporting tissue turnover.

291 The inclusion of several nearby tissue types in this data set also led to our identifica

292 n only be distinguished from adjacent normal tissues using quantitative results of both lipid C=C loc

293 ses several restrictions, especially limited tissue volume due to portal vein pressure.

294 contrast between cancerous and non-cancerous tissue was found ex vivo, potentially due to the lower n

295 were sacrificed at week 12 and the augmented tissues were evaluated by cone-beam computed tomography,

296 Radiometabolites from brain and other tissues were measured ex vivo and in vitro.

297 ults in measurable genomic changes in breast tissue with implications in breast carcinogenesis.

298 The learned factors reflect tissues with known biological similarity and identify tr

299 ter while being retained in cancerous kidney tissues with low P-glycoprotein expression.

300 produced, which allow mapping of O(2) in the tissue within 20 s.