ライフサイエンスコーパス: tissue specificity

1 cuss potential explanations for the observed tissue specificity.

2 concepts such as gene dosage-sensitivity and tissue specificity.

3 genomic background and then predicting their tissue specificity.

4 temic side effects due to the drugs' lack of tissue specificity.

5 s, pilRNA expression is dynamic and displays tissue specificity.

6 on genes in mouse than in human, which poses tissue specificity.

7 ted 84,301 developmental enhancers and their tissue specificity.

8 e loss of hCD79b transcriptional activity or tissue specificity.

9 nous hormonal homeostasis, again with strong tissue specificity.

10 n about their transcriptional regulation and tissue specificity.

11 effectors of omega-3 fatty acids with marked tissue specificity.

12 stly change 3' UTR isoform ratios to achieve tissue specificity.

13 gineering to improve receptor retargeting or tissue specificity.

14 ing and tissue-specific genes based on their tissue specificity.

15 ing regulatory nucleotide sequence determine tissue specificity.

16 ht into the genetic determinants of host and tissue specificity.

17 as transcripts with low expression and high tissue specificity.

18 f mice expressing human SLAM with human-like tissue specificity.

19 ation molecule (SLAM, CD150) with human-like tissue specificity.

20 ost different in skew if they have different tissue specificity.

21 al step in defining the viral host-range and tissue specificity.

22 these genes as candidates for biomarkers for tissue specificity.

23 o striking, we considered the possibility of tissue specificity.

24 d a distinct pattern of genomic location and tissue specificity.

25 aracterize them and determine their cell and tissue specificity.

26 tage of an organism, and often show striking tissue specificity.

27 chromosomal location, biological pathway or tissue specificity.

28 a quantitative role but was not required for tissue specificity.

29 Multiple TFs work in concert to achieve tissue specificity.

30 s of a given species, such as host range and tissue specificity.

31 the alternative polyadenylation signals has tissue specificity.

32 of epidermal genes, thus exerting intrinsic tissue specificity.

33 volutionary rates are highly correlated with tissue specificity.

34 oupled sequences that unambiguously modulate tissue specificity.

35 rtner for BRD4 that can direct its locus and tissue specificity.

36 anges are associated with tumorigenesis, not tissue specificity.

37 pressor elements led to the apparent loss of tissue specificity.

38 ility, and localization, and exhibits strong tissue specificity.

39 iew current hypotheses for the basis of this tissue specificity.

40 on network analysis supports its subtype and tissue specificity.

41 onstrated signatures of selection and floral tissue specificity.

42 increase promoter activity at the expense of tissue specificity.

43 ers and are dependent on genomic context and tissue specificity.

44 been complicated by their strict species and tissue specificity.

45 es G-protein activity and may provide unique tissue specificity.

46 l to PFA's efficacy and safety, particularly tissue specificity.

47 luminal progenitor cells to oncogenesis and tissue specificity.

48 CR, which expressed in a network manner with tissue specificity.

49 d key transcription factors controlling this tissue specificity.

50 , their phylogenetic similarities, and their tissue specificity.

51 sociation analysis approaches by considering tissue specificity.

52 ilitate fine-tuning of receptor activity and tissue specificity.

53 is implicated in transcription activity and tissue specificity.

54 ied in all tissues, there are clear cases of tissue specificity.

55 lncRNA properties such as low abundance and tissue specificity.

56 clusters, some of which showed tumor and/or tissue specificity.

57 actors initiate disease and what directs its tissue specificity.

58 d the roles that AS may play in diseases and tissue specificity.

59 ble levels, 162 microRNAs exhibited striking tissue-specificity.

60 ciation analysis approaches fail to consider tissue-specificity.

61 s, anther tapetum, and seed coat with unique tissue-specificity.

62 ntrinsic properties rather than merely their tissue specificities.

63 HBV infection has both host and tissue specificities.

64 und known and novel cancer drivers with high tissue-specificities.

65 as illustrated by their excessive degree of tissue specificity (80%).

66 establish ablative methods that provide the tissue specificity afforded by cis-regulatory elements a

67 o detect T2DM complications, but the lack of tissue specificity, among other reasons, has hampered th

68 Tissue specificity analysis of associated eQTLs provide

69 y linked genes with three mutually exclusive tissue specificities and interdigitated control elements

70 These data are evidence for divergent tissue specificities and targeting of multigene families

71 ed AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to exter

72 This significant tissue specificity and broad tumor type coverage suggest

73 us ovarian and breast cancer, confirming the tissue specificity and cell surface localization.

74 organ structure is essential in maintaining tissue specificity and cellular differentiation.

75 sms using mouse models that recapitulate the tissue specificity and developmental timing of an STR ex

76 Both tissue specificity and electrophysiological studies stro

77 -II splice variants were compiled with their tissue specificity and exon usage.

78 We define tissue specificity and expression-pattern specificity ac

79 igher similarity to the promoter in terms of tissue specificity and higher enrichment of loop factors

80 ny interesting phenotypes such as virulence, tissue specificity and host range, for which it would be

81 ngs provide insights into both the basis for tissue specificity and into possible therapeutic opportu

82 10 targets, that overrides developmental and tissue specificity and is conserved between H3.3K27M-mut

83 ation pathway impacts on current concepts of tissue specificity and models of active chromatin domain

84 ggesting that adaptive immunity controls the tissue specificity and persistence of CHIKV infection.

85 ng noncoding RNAs (ncRNAs) show considerable tissue specificity and play important roles during devel

86 an lead to suboptimal performance, a lack of tissue specificity and potential toxicity.

87 ic pain and inflammation relief by enhancing tissue specificity and prolonging intra-cartilage reside

88 ate transporters showed a complex pattern of tissue specificity and regulation by sulfur nutritional

89 ses (ACs), a group of enzymes with different tissue specificity and regulation.

90 gene expression and to diagnose the probable tissue specificity and role of transcription factors.

91 approach can be broadly applied to increase tissue specificity and sensitivity of differential expre

92 alleles are necessary but not sufficient for tissue specificity and the clinical syndrome.

93 cell biology but often with debate over the tissue specificity and the efficacy of inactivation.

94 c1 and tps26 maize orthologs differ in their tissue specificity and their induction by insect herbivo

95 splantation, with the aim of identifying the tissue specificity and types of immunogenic non-HLA anti

96 ation, expression, processing, conservation, tissue-specificity and other biological features for all

97 s have provided mechanistic understanding of tissue-specificity and potential treatment options for m

98 on-biased, and likely contributes toward the tissue-specificity and progressive nature of the symptom

99 s may enable channel inhibition with greater tissue-specificity and versatility than is achievable wi

100 ith vastly different clinical presentations, tissue specificities, and ages of onset.

101 tion, greater expression, a lesser degree of tissue specificity, and a higher frequency of transcript

102 ict both the presence of enhancers and their tissue specificity, and are thus a feature that can be e

103 are expressed with overlapping cellular and tissue specificity, and coding region mutations can caus

104 nsequences at enhancers depend on cell type, tissue specificity, and constraints at associated promot

105 tliers test for ranking genes based on their tissue specificity, and correlated this ranking with NXS

106 Our study highlights the gender differences, tissue specificity, and potential gut-liver-microbiome a

107 a treatment modality with targeted delivery, tissue specificity, and therapy tailored to address mech

108 ociated eQTLs and sQTLs show a high level of tissue specificity, and these pMEIs are enriched in the

109 This tissue specificity appears to be governed by the relativ

110 mplex differences in expression profiles and tissue specificities are encoded in a single DNA sequenc

111 terms of sequence and expression levels, but tissue specificities are often conserved.

112 rol of the process of mineralization and its tissue specificity are important steps in the search for

113 However, the mechanisms underlying such tissue specificity are unknown.

114 However, these networks do not account for tissue specificity, are limited to protein-coding genes,

115 g a score test-based approach where we model tissue-specificity as a random effect and investigate an

116 ique in not only its structure, but also its tissue specificity, as it is the first member to be foun

117 Here, we present a method for predicting tissue specificity based on quantitative deregulation of

118 romoters by adapting a quantitative index of tissue-specificity based on Polr2a occupancy.

119 ing elements (CNEs) likely to have a desired tissue-specificity based on the expression of nearby gen

120 in peripheral blood studies, but because of tissue specificity, blood-based studies may not detect b

121 controlled by multiple enhancers have higher tissue specificity, but the regulating enhancers are les

122 tested for antigen specificity by ELISA, for tissue specificity by immunohistochemistry, for affinity

123 A new study sheds light on this tissue specificity by showing that binding of clock acti

124 Analysis for tissue specificity by using the Northern blot and revers

125 roid membrane receptor: plausible structure, tissue specificity, cellular distribution, steroid bindi

126 genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, an

127 why inherited mutations often have different tissue specificities compared with spontaneous mutations

128 ODDI provides higher sensitivity and greater tissue specificity compared with conventional DTI for id

129 to solid tumor development and indicate that tissue specificity defines functional significance for t

130 e exists that the intronic promoter provides tissue specificity different from that of the primary pr

131 r-infrared (NIR) fluorophores with different tissue specificities driven by their inherent chemical s

132 ontaining ncRNA transcripts with substantial tissue specificity during gastrulation and early organog

133 ue tumor-specific cell surface antigen whose tissue specificity enables the development of novel ther

134 hat they have evolved different functions or tissue specificities following duplications.

135 degradation in the nucleus to ensure narrow tissue specificity for a gene (e.g., that for FR-alpha)

136 thelial lineage, could provide the locus and tissue specificity for histone methylation and chromatin

137 the genus contrasts with stringent host and tissue specificity for individual species and pathovars.

138 nsplantation, donor exosomes with respective tissue specificity for islet beta cells and renal epithe

139 umulates in the liver, suggesting a striking tissue specificity for ribose metabolism.

140 o influence the level of expression bias and tissue specificity for some allelic combinations.

141 nfounding effects (e.g. temporal regulation, tissue specificity, genetic background) are not consider

142 rely on axonal transport showed the greatest tissue specificity; however, neurovascular dyes already

143 r smoking over a LASSO model, with age-, and tissue-specificity, implying associations are a phenotyp

144 n of at least nine enhancers with individual tissue specificities in the digit anlagen, growth plates

145 al conditions including the mechanism of its tissue specificity in any organism.

146 the MFN1/MFN2 ratio is a key determinant of tissue specificity in CMT2A and indicate that augmentati

147 These sites showed tissue specificity in degree of hydroxylation and a patt

148 y show that individual TFs can contribute to tissue specificity in different tissues by interacting w

149 We discovered that tissue specificity in ER activation was due to differenc

150 Accounting for tissue specificity in global integration of functional g

151 (Xenopus laevis) and has the most restricted tissue specificity in mammals, whereas beta, gamma, and

152 t PGR-dependent genes showed almost complete tissue specificity in PGR target gene profiles.

153 ocal" immune cells play a role in regulating tissue specificity in relation to disease heterogeneity

154 action of the genome is expressed with great tissue specificity in the adult, demonstrating the need

155 Tissue specificity in the distribution of AMPK subtypes

156 ed or divergent B lineage characteristics or tissue specificity in these animals.

157 osity in the BRCA1 locus could contribute to tissue specificity in tumor development.

158 therapeutics in their lack of pharmacologic tissue specificity in vivo.

159 ar and membrane proteins are associated with tissue specificity, indicating a potential role for them

160 publicly available samples, we show that the tissue specificity inherent in splicing signatures is ma

161 Additional analysis shows that tissue specificity is due to abnormal activation of the

162 This higher tissue specificity is strongly associated with having le

163 ific COX deficiency, but the reason for such tissue specificity is unknown.

164 owever, in both cases, the basis of neuronal tissue specificity is unknown.

165 Tissue-specificity is an important aspect of many geneti

166 but not airway epithelium; we conclude that tissue specificity likely contributes to the effect of n

167 k centrality measures, protein essentiality, tissue specificity, localization and solvent accessibili

168 Recently, studies have suggested this tissue specificity may be linked to inhibition of estrog

169 es of torsinA dysfunction, demonstrating how tissue specificity may result from differential suscepti

170 Tissue specificity may result from the presence of more

171 een transcriptional and post-transcriptional tissue specificity mechanisms in cereal globulin genes.

172 numerous tumors, we sought to understand how tissue specificity might factor into their functional si

173 DNase I hypersensitive site (DHS) peaks with tissue specificity negatively correlated with the expres

174 This may help to explain the tissue specificity observed for many viruses.

175 in preputial gland to 97% in testes, and the tissue-specificity observed in vivo was retained in cult

176 Notably, the tissue specificities of these genes include known target

177 he results show a strong correlation between tissue specificity of a gene and the propensity of its p

178 Our finding highlights the tissue specificity of a gene network regulated by a miRN

179 onses at high temperature, suggesting either tissue specificity of ABA signaling or a role of ABA in

180 remains controversial partly because of the tissue specificity of ACAD9 expression: high in liver an

181 Advantage has been taken of the relative tissue specificity of adenovirus for liver, and the gene

182 exon-intron structure, alternative splicing, tissue specificity of alternative splice forms, and prot

183 The molecular basis for tissue specificity of beta-catenin-dependent oncogenesis

184 ed their additional exons, as well as tested tissue specificity of both previously reported and novel

185 Here, we investigate the tissue specificity of both the global levels and locus-s

186 Here, we highlight the tissue specificity of BRAF and EGFR alterations and impl

187 The reason for this tissue specificity of BRCA1 carcinomas must be found if

188 , these results provide important aspects of tissue specificity of BRCA1-mediated suppression of brea

189 Our work elucidates the basis of the tissue specificity of BRCA1-related tumor predisposition

190 The tissue specificity of cancers that arise from malfunctio

191 bryonic stem (ES) cells, we investigated the tissue specificity of CTCF binding sites.

192 matically characterize the global extent and tissue specificity of developmental expression programs

193 r, this simple hypothesis cannot explain the tissue specificity of disorders caused by homoplasmic mt

194 e I hypersensitive sites (DHSs) with similar tissue specificity of DNase-seq signal patterns.

195 Tissue specificity of embryonic Fpn1 dysregulation was e

196 Indeed, we show that (i) tissue specificity of enhancers and nearby gene expressi

197 h in PTSD, important limitations include the tissue specificity of epigenetic modifications, the phen

198 ce of nearby transposable elements (TEs) and tissue specificity of expression increased the odds of A

199 hydroxybenzaldehyde, than with tricetin, the tissue specificity of expression suggests it may be a ca

200 Marked tissue specificity of expression was observed in Zn-depl

201 immunotherapeutic agents because of unusual tissue specificity of expression, uniquely safe profile

202 in-like and CDK-like proteins showing strong tissue specificity of expression.

203 However, this does not account for the tissue specificity of FSHD pathology, which requires sta

204 To better understand the tissue specificity of FV replication and host immunologi

205 and second, it yields information about the tissue specificity of gene expression by the use of nati

206 The tissue specificity of gene expression is imparted by an

207 built a comprehensive gene atlas and studied tissue specificity of genes in cattle.

208 The tissue specificity of genes is known to correlate positi

209 ortant implications for our understanding of tissue specificity of glucocorticoid action including th

210 The molecular factors that govern tissue specificity of glucocorticoids, however, are poor

211 dentifies critical elements required for the tissue specificity of hEPCR and suggests a mechanism for

212 We present evidence that tissue specificity of Hh targets depends on transcriptio

213 interplay of these components may determine tissue specificity of hormone action.

214 ease genes alone cannot explain the observed tissue specificity of human diseases.

215 rkers by analyzing numeric approximations of tissue specificity of human genes.

216 robust platform for deciphering the complex tissue specificity of human mitochondrial-based disorder

217 lly characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression

218 Tissue specificity of imprinting is widespread, and gend

219 izing the infection process, determining the tissue specificity of infection, the spatial migration o

220 -ras(LA2) allele, we have uncovered dramatic tissue specificity of K-ras(G12D)-dependent p19(Arf) up-

221 elationship and the basis for the pronounced tissue specificity of laminopathies are poorly understoo

222 The relevance of tissue specificity of microvascular endothelial cells (M

223 that miRNA expression broadly contributes to tissue specificity of mRNA expression in many human tiss

224 Tissue specificity of NECI-CAT expression demonstrated t

225 We examined the tissue specificity of nine BK alpha alternative exons an

226 isms may explain the variable penetrance and tissue specificity of other mtDNA mutations and highligh

227 tion in these families may shed light on the tissue specificity of oxidative phosphorylation disorder

228 n of Ppp1cc2, and recapitulate the wild-type tissue specificity of PPP1CC2 in transgenic mice.

229 ntal in primary function is unknown, and the tissue specificity of recapitulated gene expression rema

230 Analysis of the tissue specificity of reflectin subtypes reveals that tu

231 To study the timing and tissue specificity of retrotransposition, we created tra

232 a previously unknown factor involved in the tissue specificity of SCA7 and that trichostatin A may a

233 n to identify factors that contribute to the tissue specificity of SCA7.

234 intergenerational repeat instability and the tissue specificity of somatic repeat instability.

235 h the gene and pathway levels, we eliminated tissue specificity of the "host" organs where tumors are

236 framework to explain the age dependence and tissue specificity of the ADLD disease phenotype.

237 at auxin may be responsible for the observed tissue specificity of the AtPGM promoter.

238 Tissue specificity of the bullfrog rem2 gene showed that

239 islet allograft rejection and highlights the tissue specificity of the chemokine/chemokine receptor s

240 in GWAS (higher -log(10)p) regardless of the tissue specificity of the eQTL.

241 branes selectively in neurons, mimicking the tissue specificity of the human disease and providing a

242 hophysiological mechanisms that underlie the tissue specificity of the m.3243A > G mutation, and impo

243 ndependent apoptotic effects and mechanisms, tissue specificity of the p53 response, a molecular unde

244 evolution, together with the redundancy and tissue specificity of their components, provides opportu

245 e networks, yet the mechanisms governing how tissue specificity of their function is achieved are poo

246 The tissue specificity of these DHSs mirrored the activity o

247 ribosomopathies and attempt to reconcile the tissue specificity of these disorders with the ubiquitou

248 To explore the tissue specificity of these eQTLs and hence to quantify

249 on factor-binding sites, which determine the tissue specificity of these genomic assays.

250 Tissue specificity of these linkages was examined in mic

251 To test tissue specificity of this nongenomic signaling mechanis

252 the pathway genes was perturbed, whereby the tissue specificity of transcripts was altered.

253 ting that factors other than Env mediate the tissue specificity of tumor induction by ENTV.

254 oteins Lkb1 and Tsc1/Tsc2 may underlie their tissue specificity of tumor suppressor action.

255 idespread implications for understanding the tissue specificity of tumor suppressor gene phenotypes.

256 A2BP1 play an important role in determining tissue specificity of UGCAUG-mediated alternative splici

257 ression Atlas 2 data allow the cataloging of tissue-specificities of the predicted SREs.

258 The results indicate that tissue-specificity of an isolated enhancer may be quite

259 Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting

260 Tissue-specificity of enhancer candidates is defined bas

261 Our results show RNAs of varying tissue-specificity of expression, speed of RNA polymeras

262 model by measuring the number, identity, and tissue-specificity of functional regulatory targets for

263 we investigate the relationship between the tissue-specificity of gene expression and the type of pr

264 estigated the relative expression levels and tissue-specificity of NCF2 5'-UTR variant mRNAs and thei

265 f taxoids across the whole stem and the stem tissue-specificity of paclitaxel biosynthesis-related en

266 by sub-optimal expression levels or improper tissue-specificity of particular promoters, or rely on t

267 ontributes toward the progressive nature and tissue-specificity of the symptoms.

268 hen used in vivo reporter assays to test the tissue-specificity of these enhancers, chromatin configu

269 tire collections of enhancers with a defined tissue specificity or conservation depth.

270 differences in isoform dependence arise from tissue specificity or from the nature of the oncogenic s

271 We found that tissue-specificity plays a crucial part in the function

272 Neuropsychiatric side effects and lack of tissue specificity precluded clinical use of first-gener

273 ed real time PCR (rtPCR) to characterize its tissue specificity, regional brain expression, and brain

274 The reasons for this tissue specificity remain unknown, although biliary epit

275 Although some of these show tissue specificity (roots or leaves), none exhibit recip

276 iated with mitochondrial dysfunction and the tissue specificity seen in many mitochondrial disorders.

277 Furthermore, complex indels display strong tissue specificity (such as VHL in kidney cancer samples

278 cRNAs show remarkably strong conservation of tissue specificity, suggesting that it is selectively ma

279 ncreases promoter activity at the expense of tissue specificity, suggesting that specificity of expre

280 ion QTLs (eQTLs) provide finer resolution to tissue specificity than bulk tissue cis-eQTLs.

281 is more strongly correlated with measures of tissue specificity than nonreproductive genes, suggestin

282 w avenues of research into toxic effects and tissue specificity that are necessary to allow their suc

283 ropose a categorization of diseases based on tissue specificity that highlights emerging patterns.

284 Despite this high level of tissue specificity, the cis-regulatory elements that con

285 Tissue specificity, the traditional predictor of gene fu

286 other neurodegenerative disorders exhibiting tissue-specificity, thereby guiding the search for effec

287 ving both basal transcriptional activity and tissue specificity to cone photoreceptors and pinealocyt

288 ms may be important in conferring target and tissue specificity to its transcriptional activity.

289 l mouse small intestine tissues and a strong tissue-specificity to the process.

290 Although noteworthy findings on tissue specificity, toxicity, and route of administratio

291 Tissue-specificity values facilitated high-throughput an

292 mental and cell-type-specific functions, yet tissue specificity was established for only a small frac

293 This tissue specificity was greatly altered via alternative s

294 To understand this tissue specificity, we compared early mutant huntingtin-

295 ntigens with broad subtype coverage and high tissue specificity, we have previously selected phage an

296 Expression strength and tissue specificity were maintained over five transgenic

297 s in transcriptional factors/regulators show tissue specificity, whereas histone modifiers are often

298 There was striking tissue-specificity, with predominantly amino acids affec

299 sence of alternative promoters with distinct tissue specificity within many protein-coding genes.

300 ron 5/intron 6 ship1 genomic segment and its tissue specificity within transgenic mice expressing GFP