ライフサイエンスコーパス: tissue stem cell

1 of a decline in the restorative capacity of tissue stem cells.

2 nd germ cells are continuously maintained by tissue stem cells.

3 believed to originate from transformation of tissue stem cells.

4 s and in its possible derivation from normal tissue stem cells.

5 ce for unprecedented transdifferentiation of tissue stem cells.

6 d the potential plasticity of HSCs and other tissue stem cells.

7 about the possible totipotency of some adult tissue stem cells.

8 ritical for the proper regulation of various tissue stem cells.

9 type, characteristic of development-involved tissue stem cells.

10 ells that have molecular programs resembling tissue stem cells.

11 ce of cancer cells with properties of normal tissue stem cells.

12 ing that these cells have features of normal tissue stem cells.

13 ons, with a focus on the regulation of adult tissue stem cells.

14 ial in part through its rejuvenation of aged tissue stem cells.

15 arguably the most extensively characterized tissue stem cells.

16 ypes are transcriptionally similar to normal tissue stem cells.

17 research in cell adhesion, inflammation, and tissue stem cells.

18 s have been shown to originate in epithelial tissue stem cells.

19 rine cells in vivo, suggesting that they are tissue stem cells.

20 t or by endogenous DNA-replication errors in tissue stem cells.

21 least some BCCs can arise from hair follicle tissue stem cells.

22 ion or infection usually first occurs in the tissue stem cells.

23 nd tissue because they do not develop ground tissue stem cells.

24 ing and plasticity, features associated with tissue stem cells.

25 are slow cycling in vivo, a known feature of tissue stem cells.

26 he early oncologic processes and the role of tissue stem cells.

27 nt spheroids previously shown to derive from tissue stem cells.

28 agenic events that generate cancers in human tissue stem cells.

29 ise attributed to an intrinsic plasticity of tissue stem cells 9.

30 orting gases and nutrients and by regulating tissue stem cell activity via signaling.

31 Adult tissue stem cells adjust to environmental changes.

32 enchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells.

33 similarities and differences between normal tissue stem cells and cancer stem cells (CSCs) have been

34 nts have excess cell divisions in the ground tissue stem cells and endodermis, indicating IRK functio

35 vely kill SCs holds promise for rejuvenating tissue stem cells and extending health span.

36 with the strongest correlation found between tissue stem cells and macrophages in COAD.

37 prime instigators of a functional decline of tissue stem cells and of mitochondrial dysfunction that

38 along with the distinctive scarcity of adult tissue stem cells and the complexities of their niches i

39 We proposed that epithelial tissue stem cells and their cancer stem cell (CSC) count

40 are postembryonic determinants of the ground tissue stem cells and their lineage.

41 utrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and canc

42 Cancers are thought to arise in tissue stem cells, and similar to healthy tissue, are th

43 mming, and hematopoietic and skeletal muscle tissue stem cells, and we discuss the implications for r

44 Although tissue stem cells are central to organ homeostasis and r

45 Tissue stem cells are generated from a population of emb

46 Tissue stem cells are responsible for replenishing and m

47 ent lineage-tracing studies, we propose that tissue stem cells are routinely lost and replaced in a s

48 The cardinal properties of adult tissue stem cells are self-renewal and the ability to ge

49 Tissue stem cells are the cell of origin for many malign

50 ived stem cells (BMDC) and not from resident tissue stem cells as previously believed.

51 om bone marrow stem cells (BMSC) and adipose tissue stem cells (ASC) of humans and rhesus macaques we

52 arabiosis rejuvenates the performance of old tissue stem cells at some expense to the young, but whet

53 atogonial stem cells (SSCs) are unique among tissue-stem cells because they undergo ROS-dependent sel

54 Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory pat

55 Tissue stem cells can be expanded and functionally diffe

56 ave challenged this paradigm by showing that tissue stem cells can differentiate to unexpected cell l

57 Differentiating tissue stem cells can self-assemble into structures that

58 Adult tissue stem cells can serve two broad functions: to part

59 ze regulation rheostat safeguarding multiple tissue stem cell compartments.

60 In proliferative human tissues, stem cells compete for dominance, and those wit

61 Tissue stem cells contribute to tissue regeneration and

62 function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology

63 elopment, the vascular precursors and ground tissue stem cells divide to renew themselves and produce

64 Tissue stem cells divide to self-renew and generate diff

65 In many tissues, stem cells divide less often than their progeny

66 These findings introduce LNP-enabled tissue stem cell editing for disease-modifying genome co

67 al organoids-3D spheroids derived from adult tissue stem cells-enable investigation of epithelial phy

68 Tissue stem cell exhaustion is a key hallmark of aging,

69 During organ development, tissue stem cells first expand via symmetric divisions a

70 Adult organisms rely on tissue stem cells for maintenance and repair.

71 Tissue stem cells form the cellular base for organ homeo

72 named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses-including Zika virus

73 a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating th

74 A temporal decline in tissue stem cell functionality may be a key component of

75 The detailed understanding of adult tissue stem cells has significance for both regenerative

76 have some phenotypic similarities with adult tissue stem cells, has been suggested to contribute to t

77 Local tissue stem cells have been described in airways of the

78 Analogies between TICs and normal tissue stem cells have led to the proposal that activati

79 the past decades, studies of pluripotent and tissue stem cells have uncovered a range of metabolic pr

80 for its complete function in DNA repair and tissue stem cell homeostasis.

81 ntegral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis.

82 Distinctive from other tissue stem cells, HSCs transition through multiple hema

83 Wnts are also key drivers of most types of tissue stem cells in adult mammals.

84 m1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and

85 indicating that a similar process occurs in tissue stem cells in dyskeratosis congenita patients.

86 yos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally

87 or the maintenance of diverse populations of tissue stem cells in mice.

88 s an alternative for region-restricted adult tissue stem cells in regenerative medicine.

89 lls to send mitogenic signals to neighboring tissue stem cells in response to estrogen and progestero

90 ayed the ability of mTert-driven GFP to mark tissue stem cells in testis, bone marrow (BM), and intes

91 gr5 are known markers of adult and embryonic tissue stem cells in various organs.

92 tophagy genes in the regulation of different tissue stem cells, including neural stem/progenitor cell

93 hown to promote self-renewal in a variety of tissue stem cells, including neuronal stem cells and hem

94 at lncRNAs exert critical functions in adult tissue stem cells, including skin, brain, and muscle, as

95 nfection, mutation, or epigenetic change-the tissue stem cell is involved in the generation of cancer

96 t to which cancer stem cells resemble normal tissue stem cells is a critical issue if targeted therap

97 sue renewal and repair due to alterations in tissue stem cells is a hallmark of aging.

98 rentiation of specific cell types from adult tissue stem cells is a major challenge in developmental

99 tion in stem cell biology is how the fate of tissue stem cells is initially determined during develop

100 t to test because the identity of most adult tissue stem cells is not known.

101 A remarkable feature of tissue stem cells is their ability to regenerate the str

102 The literature on isolation of adult tissue stem cells is vast and disparate.

103 that supports expansion of several types of tissue stem cells, is a candidate therapeutic target for

104 n patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, du

105 governing embryonic organogenesis and adult tissue stem cell maintenance.

106 us essential roles in animal development and tissue/stem cell maintenance.

107 Adult tissue stem cells mediate organ homeostasis and regenera

108 In tissue stem cells, NIBR-LTSi promotes proliferation, mai

109 ly reprograms and splits into a mixed ground tissue/stem cell niche fate and a vascular precursor fat

110 pled receptor-5 (LGR5) is expressed in adult tissue stem cells of many epithelia, and its overexpress

111 esis are that (a) tumors originate in either tissue stem cells or their immediate progeny through dys

112 lls must be phenotypically similar to normal tissue stem cells or whether they can retain the identit

113 wever, it is unclear whether it functions in tissue stem cells other than blood.

114 arises from the transformation of a resident tissue stem cell, our results show that EMT can produce

115 Thus, there is no "one size fits all" adult tissue stem cell paradigm.

116 Tissue stem cells play a key role in tissue maintenance.

117 mportantly, in contrast to its role in other tissue stem cells, PRC1 negatively regulates the cell cy

118 illustrate immunologic regulation of a core tissue stem cell program after damage and support a role

119 , estradiol, and progesterone, via increased tissue stem cell proliferation to prepare for impending

120 rate subphyla, collectively demonstrate that tissue stem cells rather than pluripotent blastema cells

121 hich aging is caused in part by a decline in tissue stem cell regenerative function.

122 AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Run

123 em cells, but their roles in development and tissue stem cells remain unclear.

124 The role of the immune system in regulating tissue stem cells remains poorly understood, as does the

125 These observations establish that adult tissue stem cells reside within the CD62L(+) Tcm cell co

126 Immune and tissue stem cells retain an epigenetic memory of inflamm

127 Mechanisms of tissue stem cell (SC) quiescence control are important f

128 Malignant transformation of tissue stem cells (SC) may be the root of most cancer.

129 However, whether tissue stem cells (SCs) and progenitors located within S

130 Adult tissue stem cells (SCs) reside in niches, which orchestr

131 Adult tissue stem cells (SCs) reside in niches, which, through

132 Cancers and tissue stem cells (SCs) share similar molecular pathways

133 Adult tissue stem cells self-renew and differentiate in a way

134 The possibility that other adult tissue stem cells show similar heterogeneity and mechani

135 evealed substantial upregulation of an adult tissue stem-cell signature, activated Wnt signalling, an

136 ese results indicate that, similar to normal tissue stem cells, subsets of CSCs in some tumours conta

137 echanistic insight into the dynamics between tissue stem cell subtypes and demonstrates that p63 regu

138 le is known about how growth factors control tissue stem cell survival and proliferation.

139 Tissue stem cells temporally change intrinsic mechanisms

140 Moreover, as cancers often arise from tissue stem cells that acquired oncogenic mutations, we

141 ogenase (15-PGDH) is a negative regulator of tissue stem cells that acts via enzymatic activity of ox

142 s whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in

143 dult mammalian tissues, could regulate adult tissue stem cells through modulating niche signaling and

144 tudies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tumorigen

145 Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting

146 Tissue stem cell (TSC)-derived epithelial organoids are

147 acquired oncogenic mutations, we discuss how tissue stem cells undergoing malignant transformation ac

148 ssue-resident and recruited immune cells and tissue stem cells underlying tissue adaptation to enviro

149 rns, which separated them clearly from other tissue stem cells with lower developmental potency.