ライフサイエンスコーパス: tissue-specific

1 ommonly observed, SPE is highly genotype and tissue specific.

2 ulatory and signaling architecture is highly tissue specific.

3 disc, ASP and myoblasts, whereas others are tissue-specific.

4 Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been show

5 Such tissue-specific ablation is even more critical when the

6 1039-1050) show that the tissue-specific ablation of FOXA1/2/3 in the adult mouse

7 Tissue-specific ablation of integrin beta1 abolishes the

8 the majority of promoters and enhancers have tissue-specific accessibility, and we discover regulator

9 andscape analysis showed differences in stem tissue-specific accumulation of metabolites.

10 However, the mechanisms of these tissue-specific actions remain unclear.

11 The precise signals controlling tissue-specific adaptation and differentiation of cDCs a

12 Tissue-specific aging is presented here and we highlight

13 Activation of local ILC2s by tissue-specific alarmins induced their proliferation, ly

14 e features of adenoviral vectors that enable tissue specific and efficient delivery of the CRISPR-Cas

15 mited conditionally significant results: non-tissue-specific and brain-specific Basenji-H3K4me3 for a

16 he (CTG)n repeat expansion is age-dependent, tissue-specific and expansion-biased.

17 Controlling tissue-specific and organism wide changes in metabolism

18 AKI induced the expression of Sult1e1 in a tissue-specific and sex-specific manner.

19 cating that Sult1e1's effect on AKI was also tissue-specific and sex-specific.

20 functional in zebrafish, allow imputation of tissue-specific and shared patterns of transcription fac

21 transcriptional response to acute hypoxia is tissue-specific and time-of-day-dependent.

22 The tissue-specific and time-specific transcriptional respon

23 ation in peripheral tissues, and exacerbates tissue-specific and whole-body insulin resistance in hig

24 ripheral self-antigen compartment, including tissue-specific antigens (TSAs).

25 iled investigations of our results highlight tissue-specific associations, drug validation opportunit

26 The tissue-specific attributes of this healing response, des

27 Tissue-specific autoimmune diseases are driven by activa

28 Caspian seals Pusa caspica by age, sex, and tissue-specific bioaccumulation, and compared with that

29 issue that are tissue selective and underlie tissue-specific biology.

30 n maternal plasma might serve as a placental tissue specific biomarker for preeclampsia.

31 er establish the utility of breast milk as a tissue-specific biospecimen for investigations of breast

32 gically significant differences were usually tissue specific but not specific to cancer.

33 g inflammation that acts in conjunction with tissue-specific cancer-initiating mutations.

34 on article summarizes the recent advances on tissue-specific carcinogens and their complex crosstalk

35 y transforming GAL4 enhancer-trap lines into tissue-specific Cas9-expressing lines.

36 Tissue-specific CD45(+) immune cell responses occurred a

37 factor, plays a crucial role in determining tissue-specific cell fate, including differentiation of

38 ted microRNA response elements to prioritize tissue-specific ceRNA interactions.

39 resource for chronic social stress-induced, tissue-specific changes in proteins, lipids, and metabol

40 Our findings suggest that tissue-specific chaperone function contributes to the se

41 Endothelial cells adopt tissue-specific characteristics to instruct organ develo

42 of protein shedding kinetics based on tumor tissue-specific characteristics.

43 posed by a biological, tissue-level control; tissue-specific chemical variation is most likely to sur

44 Upstream open reading frames (uORFs) are tissue-specific cis-regulators of protein translation.

45 orms and show that isoform mixing influences tissue-specific clathrin activity in neurons, which requ

46 l effects of different RAS mutations and the tissue-specific clinical implications are complex and nu

47 Distances between tissue-specific codon and codon-pair frequencies were us

48 Here, we propose a tissue-specific collaborative mixed model (TisCoMM) for

49 Collectively these data reveal tissue specific compartmentalisation of the cellular pro

50 Cell fate potential is programmed in tissue-specific configurations of chromatin, which restr

51 single-cell transcriptomics, we identified a tissue-specific core signature of snMacs and two spatial

52 tudies indicating the existence of cell- and tissue-specific cysteine-omes, further emphasizing the n

53 al during clinical sepsis, and contribute to tissue-specific cytokine responses that are protective a

54 ed mortality and bacterial load, and reduced tissue-specific cytokine responses.

55 possibly smoking cessation, although larger, tissue-specific datasets are required to confirm these r

56 se over 15 entities caused by generalized or tissue-specific defects in enzymes of glycogen metabolis

57 By contrast, tissue specific deletion in cap mesenchymal cells abolis

58 Tissue-specific deletion of TRIM71 in the male germline

59 We investigated metabolites from mice with tissue-specific deletion of VDR in intestinal epithelial

60 The tissue-specific deployment of highly extended neural 3'

61 essed factors can have compelling impacts on tissue-specific development.

62 es that suggests a potential role of 5hmC in tissue-specific development; as well as a resource to fa

63 types of autophagy, a clear understanding of tissue-specific differences in their activity and regula

64 vitro plants revealed temperature-dependent, tissue-specific differential distribution of various phe

65 The tissue-specific distribution of proteins also provides a

66 ngle-cell RNA-seq tissue atlas to generate a tissue-specific DNA methylation reference matrix, allowi

67 research is warranted to evaluate how these tissue-specific DNAm markers classify and predict asthma

68 Results: Tissue-specific dose conversion factors for common postt

69 abolic subsequences, we generated an adipose tissue-specific DRP1 knockout model (Adipo-Drp1(flx/flx)

70 standing the biological barriers that hinder tissue-specific drug delivery and strategies to overcome

71 scuss key advances and emerging concepts for tissue-specific drug delivery approaches and their clini

72 ciferase assay (ETSLA) system to investigate tissue-specific dynamics of circadian gene expression.

73 cover transcriptional networks that maintain tissue-specific EC identity and to identify novel angioc

74 We found a strong correlation between tissue-specific EC transcriptomic measurements generated

75 ed potential angiocrine interactions between tissue-specific ECs and other cell types by analyzing li

76 We identified novel markers of tissue-specific ECs and signaling pathways that may be i

77 clustering algorithm, we found that certain tissue-specific ECs cluster strongly by tissue (eg, live

78 iocrine and functional relationships between tissue-specific ECs.

79 ed variability, including either systemic or tissue-specific effects across multiple organ systems, w

80 studies map to non-coding sequence and their tissue-specific effects influence transcriptional regula

81 Simulations of tissue-specific effects of primary acute viral infection

82 t loci (eQTLs), exhibits complex patterns of tissue-specific effects.

83 ntify transcription factors that may mediate tissue-specific effects.

84 We propose a model for tissue-specific enhancer activity in which an HDAC-assoc

85 A higher proportion of immune tissue-specific enhancers are TE-rich compared to enhanc

86 otent cells, they can transition into active tissue-specific enhancers during development, highlighti

87 More broadly, ILC2s emerge as tissue-specific enhancers of cancer immunity that amplif

88 rogression better than others; compared with tissue-specific enhancers, pleiotropic enhancers show st

89 us to predict 461,141 putative developmental tissue-specific enhancers, the human orthologues of whic

90 To this end, we systematically performed a tissue-specific enrichment analysis using our recently d

91 ers to putative target genes and demonstrate tissue-specific enrichments of sequence variants associa

92 Through prioritizing SNPs with tissue-specific epigenetic annotation, T-GEN can better

93 determinants of transcriptional control and tissue-specific epigenetic memory.

94 ative 3' back-splicing, and both of them are tissue-specific, especially enriched in brain tissues.

95 Tissue specific expression of genes contributes substant

96 egulates the chromatin states that establish tissue- specific expression during adipogenesis.

97 Tissue-specific expression clusters indicated that all c

98 ome a crucial component of gene and regulate tissue-specific expression during mouse tissue developme

99 ctions in farm animals by bacteria-inducible tissue-specific expression of PG-1 transgene.

100 Here, we report that tissue-specific expression of RBOHD in phloem or xylem p

101 y is predicted largely by the divergence and tissue-specific expression of the human co-orthologs, i.

102 The tissue-specific expression of these six CsAAPs in leaves

103 on of tissue-specific genes and change their tissue-specific expression patterns during evolution.

104 Although class A ARFs have tissue-specific expression patterns, how their expressio

105 r levels than KWL1 and exhibits differential tissue-specific expression patterns.

106 an orange carrot (genotype DH1) and compared tissue-specific expression profiles and in vitro product

107 operties with TCDD and BNF, and the distinct tissue-specific expression profiles indicate different f

108 ially bound in different tissues to regulate tissue-specific expression programmes.

109 antage of the newly emerged, genome-wide and tissue-specific expression quantitative trait loci (eQTL

110 Analyses of tissue-specific expression using promoter:GUS reporter l

111 family of covalently circularized RNAs with tissue-specific expression, were recently demonstrated t

112 eractors of ULK1 and ULK2 all have different tissue-specific expressions partially contributing to di

113 are widely distributed and may function in a tissue-specific fashion.

114 ting or restraining HH pathway activity in a tissue-specific fashion.

115 w evidence that nutrient availability shapes tissue-specific fate programs via alphaKG-dependent diox

116 g nitrogen deficient and with a reproductive tissue-specific function for CEP-CEPR1 signaling.

117 Our results identify an extraribosomal tissue-specific function to rpl10a in the immune system,

118 ichments of shared high-posterior SNPs in 53 tissue-specific functional categories and find evidence

119 idermis, mesophyll, and vascular bundle, its tissue-specific functions in thermomorphogenesis are not

120 Although the origins and tissue-specific functions of resident macrophages have b

121 We provide new insights into the tissue-specific functions of VDRs in maintaining Paneth

122 portant physiologic processes, synchronizing tissue-specific functions throughout the body.

123 g motifs of transcription factors related to tissue-specific functions, and marked genes functionally

124 ic anatomical size, tissue architecture, and tissue-specific functions.

125 Tissue-specific GA depletion was achieved by ectopic exp

126 s thaliana seedlings were investigated using tissue-specific GA inactivation in wild-type (Col-0) or

127 cal techniques, tissue ablation, microscopy, tissue-specific gene and enzyme activity expression with

128 hat our single blind study using eight liver tissue-specific gene biomarkers (e.g. AMBP and AHSG) is

129 aled that 5hmC is preferentially enriched on tissue-specific gene bodies and enhancers.

130 phenotypic, microscopic, transcriptomic, and tissue-specific gene expression analyses, we demonstrate

131 ge, we developed a framework for integrating tissue-specific gene expression and epigenomic maps to o

132 could have a significant role in regulating tissue-specific gene expression and transcript splicing.

133 position as a common feature associated with tissue-specific gene expression changes in the heart.

134 iated with ubiquitous, germline, and somatic tissue-specific gene expression patterns.

135 s of regulatory element evolution that shape tissue-specific gene expression programs and defines reg

136 Tissue-specific gene expression requires coordinated con

137 his analysis revealed a dramatic increase in tissue-specific gene expression, concurrent with slowed

138 SetDB1-induced H3K9 trimethylation, ensuring tissue-specific gene expression.

139 esent a category, such as tissue-enriched or tissue-specific gene expression.

140 tively, our results indicate a rich layer of tissue-specific gene regulation at the level of alternat

141 t sites are found to drive the expression of tissue-specific genes and change their tissue-specific e

142 The follow-up pathway analysis from tissue-specific genes for asthma shows that the immune s

143 We demonstrated that tissue-specific genes significantly reflected the tissue

144 latory architectures of germline and somatic tissue-specific genes, uncover regulatory rules for gene

145 tigation such as biotherapeutic development, tissue-specific genetic engineering, and genetic disease

146 We observed that tissue-specific genetic manipulation of eya expression i

147 protein levels showed development stage and tissue specific heterogeneity of RP levels.

148 The tissue-specific heterogeneity of the endothelium is main

149 The wide-range spatial mobility and tissue-specific Hg integration times of this planktivoro

150 ciated with regulatory motif alterations and tissue-specific histone marks consistent with these vari

151 stly used mouse models with constitutive and tissue-specific homozygous knockout of Nr2f1.

152 Here, a tissue-specific hybrid bioink is described, composed of

153 However, the nanoscale dynamics of tissue-specific immune cells have been relatively little

154 Although research into the induction of tissue-specific immunity by vaccines and with age is sti

155 ve combinations and severities of global and tissue-specific impairments.

156 arginal mucosal protection in the absence of tissue-specific imprinting signals.

157 or post-thymic gammadeltaT17 development and tissue-specific imprinting, which is essential for infec

158 The cell- and tissue-specific increases in BAFF expression were depend

159 ulated cytokines contribute substantially to tissue-specific inflammation.

160 We further revealed tissue-specific innate immune response patterns to HCMV,

161 Then, it further incorporates tissue-specific inputs to highlight disease-specific var

162 Weights for tissue-specific isoform expression and functional domain

163 ation, gene predictors were trained using 19 tissue-specific J. regia transcriptomes aligned to the g

164 We induced ubiquitous or tissue specific knockdown or overexpression of each sing

165 ed by hierarchical mechanisms that result in tissue-specific levels.

166 bioanalytical signatures to reveal cell- or tissue-specific lipids.

167 that observed in Arabidopsis is reported and tissue-specific localization in the epidermis and mesoph

168 spite growing interest in the development of tissue-specific lymphatics, the cellular origin of bone

169 Despite emerging data on the effect of tissue-specific manipulation of glucocorticoid receptors

170 integrins expressed in parental cells, in a tissue specific manner, as a key step of cancer progress

171 heart development and cardiac function in a tissue specific manner.

172 ers and enhancers towards their targets in a tissue specific manner.

173 Its functional properties are regulated in a tissue-specific manner through co-assembly with beta sub

174 ncRNAs are distributed across the body in a tissue-specific manner with some also being sexually dim

175 To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic mol

176 components (genetic and environmental), in a tissue-specific manner, to trigger or sustain a disease

177 stem/progenitor cells and inflammation in a tissue-specific manner.

178 three genes, all of which are expressed in a tissue-specific manner.

179 the gene is regulated transcriptionally in a tissue-specific manner.

180 m cells, suggesting that PHF7 is acting in a tissue-specific manner.

181 ctor to regulate hundreds of genes-many in a tissue-specific manner.

182 tic, or sensory) abrogates tumor growth in a tissue-specific manner.

183 etained within tissues in both a gene- and a tissue-specific manner.

184 droperoxides to nontoxic lipid alcohols in a tissue-specific manner.

185 ucible Msi1 overexpression in a temporal and tissue-specific manner.

186 and conforms to organoids and tumoroids in a tissue-specific manner.

187 loci (AUC: 0.97) from each optimal subset of tissue-specific markers, respectively.

188 h a dietary trace element to shed light on a tissue-specific mechanism of disease risk based on impai

189 associated with reinfection, suggesting that tissue-specific mechanisms govern the development of imm

190 ians reveals that most fossil specimens show tissue-specific melanosome chemistries that differ from

191 the transcription factor TBX3 as a candidate tissue-specific member of the beta-catenin transcription

192 ders in which CAAs occur and CAAs predicting tissue-specific metastasis.

193 e whether murine CD8alphaalpha binds only to tissue-specific MHC-Ib molecules or also to ubiquitously

194 onserved cnidarian feature, and evidence for tissue-specific microRNA arm switching as found in Bilat

195 es that PUMA consistently captures important tissue-specific miRNA regulatory processes.

196 onsiderably different, PUMA captures similar tissue-specific miRNA-target regulatory interactions in

197 We generated a doxycycline-inducible adipose tissue-specific MMP14 overexpression model to study its

198 ugh the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic,

199 Our findings establish Sox17 as a tissue-specific modifier of Wnt responses and point to a

200 d-elbow gating mechanism elucidates distinct tissue-specific modulations, pharmacology, and disease p

201 ach cell type were then analyzed to retrieve tissue-specific molecular information and to generate cl

202 anner, but also provide a blueprint of how a tissue-specific molecule might be constructed for applic

203 nalyzed single-cell RNA sequencing data from tissue-specific mouse ECs generated by the Tabula Muris

204 Intravenous injection facilitated tissue-specific, multiplexed editing of six genes in mou

205 expression in testis, which illustrates the tissue-specific nature of cis-regulatory evolution bypas

206 A tissue-specific network was subsequently constructed usi

207 Inferred tissue-specific networks reveal general principles for t

208 n antibody-mediated toxin neutralization and tissue-specific neutrophilic inflammation preserve tissu

209 Furthermore, tissue-specific NFR were enriched for binding motifs of

210 l for maintaining stem cell functionality in tissue-specific niches.

211 Tissue-specific or tissue-enriched proteins were identif

212 hese ubiquitously expressed enzymes leads to tissue-specific or tissue-predominant phenotypes.

213 uencing, we identified a large repertoire of tissue-specific p53 genes and a common p53 transcription

214 heral vs. lymphoid organs, revealing a novel tissue-specific paradigm for the reactivation of memory

215 l adenomatous polyposis), by changing only 2 tissue-specific parameters: the number of stem cells in

216 These results suggest a tissue specific pathobiology of the Q141K variant, suppo

217 ht the consequences of chronic infection for tissue-specific pathology and identify open questions in

218 ntify type III IFNs as important factors for tissue-specific pathology in this disease.

219 rush hour regulated by the circadian and/or tissue-specific pathways.

220 issue sites from 60 individuals, we identify tissue-specific patterns of NK cell subset distribution,

221 how that this simple theory predicts complex tissue-specific patterns of segregation in mouse experim

222 Here, we use tissue-specific pharmacology and metabolic tools to clar

223 LMNA variants lead to diverse tissue-specific phenotypes including cardiomyopathy, lip

224 ial molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.

225 The higher-order mutants grew with mild tissue-specific phenotypes.

226 otein targets of ROS modification that drive tissue-specific physiology in vivo are largely unknown.

227 bserved in all organs examined, highlighting tissue-specific prenatal molecular phenotypes in SMA.

228 re microRNA (miRNA), is a highly dynamic and tissue-specific process.

229 r, we failed to reveal biologically relevant tissue-specific processes subjected to miRNA-mediated re

230 MA we identified miRNAs regulating important tissue-specific processes that, when mutated, may result

231 , and marked genes functionally enriched for tissue-specific processes.

232 s in embryogenesis, cell differentiation and tissue-specific processes.

233 gins overlap with a constitutive or a silent tissue-specific promoter.

234 Somatic tissue-specific promoters lack positioned nucleosomes an

235 four transgenic lines that express Cre under tissue-specific promoters of the pancreas, mammary gland

236 This approach depends on the availability of tissue-specific promoters, and it does not allow further

237 om ATP generation by uncoupling protein 1, a tissue-specific protein present in mitochondria of brown

238 demonstrate the important contribution of a tissue-specific protein to the polyQ protein-mediated se

239 y ubiquitous transcripts are found to encode tissue-specific proteins.

240 ially contribute to organogenesis, including tissue-specific regulation between male and female inflo

241 alternative RNA variants contributes to the tissue-specific regulation of gene expression.

242 Evidence for tissue-specific regulation of import into plastids, and

243 findings represent a clear demonstration of tissue-specific regulation of organelle protein import a

244 d-like proteins (MBNL) belong to a family of tissue-specific regulators of RNA metabolism that contro

245 This comprehensive analysis of tissue-specific regulatory elements, transcription facto

246 We report that 42% of the 285 significant tissue-specific regulatory interactions we identify were

247 Finally, we show that genes whose tissue-specific regulatory patterns are consistent with

248 ing private clonotypes, which tended to form tissue-specific repertoires, especially in the periphera

249 In addition, tissue-specific rescue of ga20ox triple and ga3ox double

250 ults demonstrate a mechanism that allows for tissue-specific resistance against stress and could aid

251 erse gene expression patterns, and provide a tissue-specific resource for future studies.

252 es (ROS) are signaling molecules produced by tissue-specific respiratory burst oxidase homolog (RBOH)

253 i) conditions highlight the need to consider tissue-specific responses in strategies targeting regene

254 By overlaying tissue-specific RNA-sequencing data from pancreas, small

255 ing approaches to demonstrate a reproductive tissue-specific role for CEPR1 in controlling yield and

256 ene-trait associations, but also detects the tissue-specific role of candidate target genes in comple

257 trait-associated genes, we can elucidate the tissue-specific role of candidate target genes.

258 These findings illustrate the tissue-specific roles for autophagy and functional depen

259 tely required in spermatogenesis, indicating tissue-specific roles in centriole and basal body format

260 sceral regions may shed new light on adipose tissue-specific roles in systemic metabolic perturbation

261 In this review, we discuss the expression, tissue-specific roles, and substrate specificities of th

262 levels per sample, we find highly consistent tissue specific RP mRNA signatures in normal and tumor s

263 These results not only suggest that a tissue-specific RSPO mimetic protein can stimulate regen

264 , rhizome fortification, stress response and tissue-specific secondary metabolites biosynthesis.

265 st peripherally encountered antigens such as tissue-specific self-antigens that are regionally draine

266 strategy to screen hundreds of sequences for tissue-specific silencer activity in whole Drosophila em

267 Overall, our study demonstrates that tissue-specific silencing is widespread throughout the h

268 as well as k-mer methods in the discovery of tissue-specific sites bound in vivo.

269 This work shows that regulation of tissue-specific splicing can influence FXR1 condensates

270 Here, we show that tissue-specific splicing of fxr1 is required for Xenopus

271 GAL4 GFP enhancer trap system, we describe a tissue-specific split luciferase assay for non-invasive

272 elopment inectodermal and mesodermal-derived tissue-specific stem and progenitor cells and then, foll

273 The horizontal basal cell (HBC) is a dormant tissue-specific stem cell presumed to only be forced int

274 The derivation of tissue-specific stem cells from human induced pluripoten

275 In endodermal-derived tissue-specific stem or progenitor cells, TP53 mutations

276 rectal and LN tissue suggest that different tissue-specific strategies may be required to eliminate

277 ons of clock emergence, its concordance with tissue-specific structure/function, the interdependence

278 Our results pave the way for tissue-specific therapeutic modulation of JunD to preven

279 eogenic peptides are well suited for current tissue-specific therapeutic paradigms to augment the end

280 "core" set of TOP mRNAs, but also identifies tissue-specific TOP mRNAs produced via alternative trans

281 tocyte nuclear factor-1beta (HNF-1beta) is a tissue-specific transcription factor that is required fo

282 oles in different tissues by partnering with tissue-specific transcription factors.

283 In particular, we (a) identify tissue-specific transcription profiles for distinct clas

284 d regions regulating germline, placental and tissue-specific transcription.

285 Developing insight into tissue-specific transcriptional mechanisms can help impr

286 Tissue-specific transcriptome analysis showed that most

287 Core clock genes regulate tissue-specific transcriptome oscillations that synchron

288 scriptional response in vivo, revealing both tissue-specific transcriptomes and a unique signature, w

289 ol in the roots of L. frutescens and compare tissue-specific transcriptomes with existing data from E

290 ative splicing plays a major role in shaping tissue-specific transcriptomes.

291 ion of Drosophila copper homeostasis by ATP7 tissue-specific transgenic expression caused alterations

292 us de novo mutations in EEF1A2, encoding the tissue-specific translation elongation factor eEF1A2, ha

293 ilitate TE survival and rapid proliferation: tissue-specific transposition and minimization of negati

294 The molecular basis of this tissue-specific tumor incidence remains unknown and intr

295 c ductal adenocarcinomas (PDACs) to activate tissue-specific tumour immunity.

296 ceptibility gene type 1 or 2 (BRCA1/2) poses tissue-specific variations in cancer risks and primarily

297 entify DNAm smoking effects that are unique (tissue-specific) vs. shared between tissues (tissue-shar

298 In vivo, this translated into a tissue-specific vulnerability of the bone marrow that ca

299 oth root development by generating different tissue-specific Wnt10a conditional knockout mice.

300 in regulatory sequence can therefore lead to tissue-specific Y-Chromosome-driven sex biases in expres