ライフサイエンスコーパス: to date

1 s, this strategy has rarely been implemented to date.

2 old faster than the fastest measured rubisco to date.

3 precise and efficient has not been described to date.

4 No therapies have been shown effective to date.

5 argest dataset of antheridiogen interactions to date.

6 etection have not been published or marketed to date.

7 isease-associated genes having been reported to date.

8 and reporting SRs/MAs than has been the case to date.

9 er, few have been functionally characterized to date.

10 inflexa relative to most bryophytes studied to date.

11 ost, and more than 1 million deaths recorded to date.

12 imilar microbial natural products is limited to date.

13 e for overall survival are poorly elucidated to date.

14 This is the largest GWAS of anxiety traits to date.

15 llosteric P2X1 receptor antagonists reported to date.

16 oaches have not been systematically assessed to date.

17 ch a demonstration, however, remains elusive to date.

18 is available in a pathophysiological context to date.

19 other materials evaluated for patch antennas to date.

20 neuropathy as a common feature in all cases to date.

21 aortic valve replacement has been conducted to date.

22 reatment has not been shown to be beneficial to date.

23 harge distributions have not been accessible to date.

24 mong >3000 Fab crystal structures determined to date.

25 mV and OER overpotential of 5.1 mV reported to date.

26 ediatric low-grade gliomas (pLGGs) published to date.

27 cy of tocilizumab observed in ovarian cancer to date.

28 , the most clinically successful antibiotics to date.

29 cohort studies of ECMO for COVID-19 reported to date.

30 rates of COVID-19 cases and deaths conducted to date.

31 st conversion of benzyl alcohol by oxidation to date.

32 cient nitrene transfer biocatalysts reported to date.

33 and well characterized maps of SVs and STRs to date.

34 nt the most potent V-ATPase inhibitors known to date.

35 LR7 antagonist is available for clinical use to date.

36 ighest resolution EGaIn patterning technique to date.

37 of individual RV strains have been recovered to date.

38 pes of planarian viruses have been described to date.

39 st red-shifted fluorous soluble fluorophores to date.

40 ion of these parameters has been carried out to date.

41 onyl compounds, but none have been developed to-date.

42 a dextran of the highest molar mass reported to date (~10(9) g/mol).

43 largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls).

44 complex experimental lineage tracing dataset to date, 34,557 human cells continuously traced over 15

45 To date, 49 patients have a neuropathological diagnosis.

46 To date, ~50% of patients with bvFTD receive a prior psy

47 t of the surgeries eventually were performed-to-date (64.2%); the mean +/- SD delay in surgery was 63

48 To date, a binding site for P on L had not been describe

49 In most anti-NANP antibodies studied to date, a germline-encoded Trp is used to engage the Pr

50 To date, a similar analysis of yeast colonies has not pr

51 In this Perspective, we have provided an up-to-date account of drug discovery efforts targeting sele

52 However, to date, accurate control over dopant concentration and

53 m is competitive with other methods reported to date, achieving an improved sensitivity (limit of det

54 To date, activation of the sulfur electrophile for prote

55 To date, although a less favorable cardiovascular risk p

56 In this review, we discuss major findings to date and challenges faced when using dirty mice and s

57 valuate every covalent mechanophore reported to date and compare the predicted mechanochemical reacti

58 This Review summarizes the evidence to date and describes novel opportunities for the discov

59 h data on active zeolite catalyst structures to date and enable for the first time the detection of A

60 re the highest seroprevalence rates observed to date and highlight the significant burden of asymptom

61 ence similarity with other PIs characterized to date and is the first PI with CS-alpha/beta motif des

62 number of nonstoichiometric MXenes reported to date and opens avenues for controlling physical prope

63 ghest-resolution images of the motile cilium to date and reveal how BBs template axonemes.

64 a recombinant of any sarbecoviruses detected to date, and its receptor-binding motif, important for s

65 coral reefs have adapted to thermal extremes to date, and may have the ability to adapt to near-term

66 PO availability in the largest patient group to date, and to compare it between patients with recent

67 tous small RNAs in individual murine tissues to date, and we expect that these data will be a resourc

68 To date, approximately one million deaths and over 32 mi

69 has not been performed, and cases described to date are scattered among at least 14 publications.

70 variants observed in at least one individual to date are variants of uncertain significance (VUSs).

71 s with a novel ultrathin drug-eluting stent, to date, are limited.

72 potent and selective UCHL1 probe (IMP-1710) to date based on a covalent inhibitor scaffold and apply

73 To date, binary crystals composed of spherically symmetr

74 To date, both biomolecule-clay and polymer-clay nanocomp

75 entials (ERP) have been used translationally to date but are limited by the significant differences i

76 that stimulus-value associations are kept up to date by constantly comparing the expected value of a

77 gle cohort (n = 262) of BD patients reported to date by harnessing the power of a multi-site, ongoing

78 To date, clinical guidelines recommend a weight loss goa

79 the presynaptic side.SIGNIFICANCE STATEMENT To date, compensatory adaptations which stabilise target

80 he most extensive genome-wide ORF collection to date, covering 90% of human, nonredundant, protein-en

81 demonstrating the need for high-quality, up-to-date data on TB determinants and outcomes.

82 To date, data are limited regarding the trend of liver b

83 Using an up-to-date database of published locational records for An.

84 To date, dementia prediction models have been exclusivel

85 gest non-targeted urinary metabolomics study to date demonstrate the role of the urine metabolome in

86 ) appear to be a pan-CoV RO element, studies to date describe an assortment of additional CoV-induced

87 To date, differences in postoperative prescribing among

88 However, no latency reversal agent (LRA) to date effectively clears viral reservoirs in humans, s

89 However, to date, efforts to rapidly and comprehensively identify

90 ong the closest synthetic mimics constructed to date, enabled by a silyl protection/deprotection stra

91 ompounds assessed as anode materials in SIBs to date exhibit significant degradation issues under fas

92 (Mus), which similar to all mammals studied to date exhibits spinal scarring following SCI.

93 To date, explanatory molecular mechanisms and the influe

94 To date, few CMAGs have been generated, although notably

95 ield of over 84%, the highest value reported to date for biomass derived GQDs.

96 ses the implications of the work carried out to date for theory and research, and points toward next

97 MF59) is the most efficacious vaccine tested to date for this indication.

98 producing the lowest method detection limits to-date for many compounds, including highly toxic iodin

99 me prior that takes into account the most up-to-date fossil stem calibrations, we estimated the mitoc

100 To date, ganglion-to-ganglion cell coupling is thought t

101 Most of these platforms have, to date, generally demonstrated relatively low ion yield

102 d computational biology research and funding to date has been concentrated predominantly on cancer re

103 However, little research to date has been conducted investigating the effects of

104 Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in h

105 But lacking to date has been quantification of spider kinematics, su

106 The literature to date has focused heavily on issues surrounding the qu

107 py), is widespread across Southeast Asia but to date has not been reported in Africa(1-4).

108 However, evidence to date has not reliably distinguished between exposure

109 ependences, yet the vast majority of studies to date have analyzed extremes on a site-by-site basis.

110 us and common condition, but genetic studies to date have been hampered by the small size of the asse

111 Clinical trials to date have been largely unsuccessful in identifying ef

112 However, studies to date have been limited to mouse and rat neurons.

113 ist for all cancer types, and most developed to date have been optimized for individual tumor types.

114 However, studies to date have employed single peptide autoantigens, which

115 Few studies to date have examined urine, the most readily available

116 Most studies to date have focused on overexpressed iRhom1 and -2, so

117 Most studies to date have focused on the potential role of altered re

118 Several studies to date have identified specific forms of homeostatic sy

119 However, these materials to date have made exclusive use of nanocrystals containi

120 Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor alle

121 Most of the enzyme filaments known to date have only been observed in cells, but in a handf

122 Most of the studies published to date have shown that the performance in short-duratio

123 The few studies to date have significant methodological weaknesses.

124 le therapeutics for management of AMR, none, to date, have been universally accepted or obtained Food

125 To date, health organizations and countries around the w

126 To date, however, antioxidant assays require costly inst

127 To date, however, few experiments have successfully demo

128 To date, however, no early biomarkers or effective thera

129 To date, however, no known PSCs have demonstrated dual c

130 To date, however, no known study has examined whether so

131 To date, however, no one has examined how 5-HT influence

132 To date, however, the fate of potentially toxic plastic

133 To date, however, the identity of the affected circuits

134 To date, however, the reported performance of TTA in rig

135 oxy for its photochemically active fraction; to date, however, the validity of this model system has

136 However, to date, ICB monotherapy in such malignancies has been i

137 the most detailed map of the fruit fly brain to date, identifying over 25,000 neurons and 20 million

138 mong the experimental groups and the highest to date in a rabbit model.

139 enicity of leading vaccine candidates tested to date in animals and humans and discuss the outcome an

140 mperature ferroic property has been observed to date in orthorhombic RMnO(3).

141 Additionally, we examine the field's success to date in targeting stressors and stress allostasis in

142 Herein, we provide an update on the progress to date in the clinical development of therapeutics targ

143 erent from other treatment strategies tested to date, in that the drug shows little acute effect, but

144 the simplest bryostatin 1 analogues reported to date, in which bryostatin's A- and B-rings are replac

145 Dental materials to date including calcium hydroxide paste, mineral triox

146 am effectors, the failure of clinical trials to date indicates that the mechanism of KRAS-driven mali

147 To date, intramolecular electrophilic C-H borylation is

148 n working fewer hours than men, but evidence to date is limited by self-report and a lack of detail r

149 Much of the research to date is limited to case series or single-center exper

150 To date, it is unclear if other prenatal steroids also c

151 To date, it remains unknown whether fibrous dysplasia an

152 To date, it remains unknown which cell types are critica

153 he spread of the NRCS-A clone and enabled us to date its emergence in the late 1960s and its expansio

154 However, up to date, its prognostic predictive capability has not be

155 We review up-to-date knowledge on the biogenesis of the RNA m(6)A mod

156 However, the literature available to date lacks a specific review on this subject.

157 An up-to-date list of 34 genes responsible for mt-tRNA modific

158 To date, little attention has been paid to CEF during lo

159 n to play a role in periodontitis, although, to date, little is known about their interaction with th

160 To date, mAb quantification requires time and labor-inte

161 ective of this review is to summarize the up-to-date management of acute and recurrent pericarditis.

162 To date, many computational approaches have been develop

163 t nature of the nutritional psychiatry field to date means that the existing literature identified in

164 To date, members of this family have been reported to be

165 To date, microRNA-1 (miR-1) is the only microRNA known t

166 Up to date, more than 80 pathogenic and likely pathogenic m

167 To date, more than 850 confirmed human cases of H5N1 vir

168 To date, most polymer hexosomes are reportedly rotationa

169 To date, most studies have focused on activators such as

170 To date, mouse, hamster, ferret, guinea pig, and non-hum

171 the largest cohort of Brody disease patients to date (n = 40), consisting of 22 new patients (19 nove

172 To date, no automated open source PFAS data analysis sof

173 To date, no clinical test can reliably diagnose the subt

174 To date, no consensus has been reached regarding these o

175 To date, no consistent evidence for the vertical transmi

176 To date, no drug or vaccine has been approved to treat t

177 uated vaccines or vaccine vectors.IMPORTANCE To date, no Food and Drug Administration (FDA)-approved

178 To date, no licensed vaccine exists for prevention of hu

179 To date, no Ncd-type kinesin-14 has been found to natura

180 To date, no publication has reported any association bet

181 To date, no recipients have developed posttransplant COV

182 To date, no reliable tools have been available for the m

183 To date, no safe allergen-specific immunotherapy for pat

184 n the gene ABCA12, is poorly understood, and to date, no satisfactory treatment has been developed.

185 Despite these findings, to date, no studies have directly examined how O-GlcNAcy

186 To date, no study has examined the association between c

187 otemporal parameters of stimulation employed to date notwithstanding, it is likely that future DBS fo

188 alogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptome

189 ore report the largest feline autopsy cohort to date of 32 cats ranging from 1.5 to 22.1 years of age

190 ntil ~2000 when it reached its highest point to date of 75%; it was slightly lower at 73% in 2018.

191 This study provides the strongest evidence to date of an intellectual sparing advantage with PRT in

192 the present day, estimating the total costs to date of delayed action.

193 ave compiled the most comprehensive data set to date of long-term (1970-2009) summertime vertical tem

194 hesis provides the most comprehensive theory to date of the biological and cultural evolution of musi

195 Approaches reported to date often seek to suppress dendrites formation at th

196 , no consensus exists from studies published to date on a preferred treatment for TON.

197 aterials for photocatalytic water splitting, to date only few reviews have been published providing a

198 Lassa virus-specific T cell responses, but, to date, only a few T cell epitopes within these protein

199 However, to date, only a very few bona fide small molecules have

200 To date, only about 17% of druggable GPCRs have had thei

201 To date, only one T7SS substrate protein, encoded in a s

202 To date, only two MEK1/2 degrader papers have been publi

203 aled phylogeny of lichen-forming fungi (LFF) to date (over 3,300 species), we identified shifts among

204 In this Review we provide an up-to-date overview of the field, outline the optimal manag

205 ne regulatory networks behind DB infestation to date palm by RNA-Seq analysis.

206 To date, pathogen-specific antibody therapy has primaril

207 To date, pathogenetic mutations in 16 distinct genes hav

208 However, to date, pharmacological agents have failed to achieve s

209 est brain structural covariance study of OCD to date, point to a less segregated organization of stru

210 To date, possible interaction of PIP(2) with ENaC primar

211 To date, preclinical studies suggest that it is possible

212 erogeneity of results from studies published to date preclude any definitive characterization of the

213 To date, prior studies have focused on legacy persistent

214 Herein, the most up-to-date progress on TMN-based nanomaterials is comprehen

215 This review provides a background and up-to-date progress that will allow the reader to judge whe

216 oductively isolating behaviors, but examples to date provide evidence that they can have a simple gen

217 on maps of chromosome folding in human cells to date, providing a valuable resource for studies of ch

218 To date, Razumab (Intas Pharmaceuticals Ltd, Ahmedabad,

219 port the largest cutaneous SCC meta-analysis to date, representing six international cohorts and tota

220 rgest cross-sectional cohort of CHIKV-deaths to date reveals that CHIKV-ECSA strains can cause death

221 To date, several molecular-docking protocols have been e

222 To date, small molecule inhibitors of these proteins typ

223 e focus of most radiation protection studies to date, some research suggests that pheomelanin has a b

224 f entry for many infectious agents; however, to date specific strategies to enhance Trm responses at

225 To date, structural studies of mammalian dCTPase have be

226 nsport substrates via an elevator mechanism, to date structures are only available for a single DASS

227 However, to date, studies on protective immunity have been perfor

228 er, attempts at this have had little success to date, suggesting that we need to better understand ho

229 on the most complete Cucurbitaceae phylogeny to date suggests that an annual life cycle may have cont

230 The evidence to date supports the concept that the thrombotic manifes

231 To date, surprisingly little is known about how OR antag

232 This scientific statement provides an up-to-date synthesis of the existing data on the MT and how

233 diseases and considered therapeutic targets. To date, systematic and intensive annotations of ES even

234 to escape the therapeutic options available to date thanks to the presence of a subset of cells endo

235 Pb(4)S(3)Br(2), a chalcohalide phase unknown to date that does not belong to the ambient-pressure PbS

236 These results provide the strongest evidence to date that system-justifying beliefs diminish aversion

237 d the performance of the biggest AWL-reactor to date that was installed at a coal-fired power plant i

238 However, to date the entire repertoire of proteins with targeting

239 Here we used the method to date the exploitation of dairy and carcass products i

240 To date, the acrylamide group remains the predominantly

241 To date, the application of these assays to studies in c

242 In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to sub

243 To date, the building blocks studied have been primarily

244 n in clinical management of cancer; however, to date, the clinical significance and regulatory mechan

245 To date, the consequences of membrane-bound CD40L (mCD40

246 However, to date, the direct preparation of [(18)F]-aryl fluoride

247 To date, the disease has been reported from over 160 fis

248 To date, the effects of numerous recovery modalities hav

249 To date, the enantiospecific analysis of mixtures necess

250 However, to date, the evidence has all been indirect [4-7], and i

251 To date, the field has lacked a simple behavioral paradi

252 To date, the integration of CyTOF datasets remains a cha

253 To date, the metabolic adaptations that occur during the

254 To date, the pathogenic mechanism involved remains poorl

255 mediated C-C sigma-bond activation reported to date, the reaction occurs at the central four-membere

256 To date, the requirement of MELK in cancer remains contr

257 To date, the term SAC mostly refers to late transition m

258 odetection has proven to be challenging and, to date, the true potential of organic semiconductors in

259 Remarkably, to date, the untoward phenotypic consequences of disrupt

260 he most complete GEM that has been developed to date: the E. coli GEM.

261 The World Health Organization has stated "To date there has been no information nor evidence to su

262 To date there have been no studies examining peripheral

263 To date, there are no effective chemotherapeutics despit

264 To date, there are no efficacious drugs and vaccines aga

265 To date, there are no inhibitors that specifically targe

266 However, to date, there are no optical probes able to identify i-

267 But to date, there has been limited quantitative measure of

268 However, to date, there is no clinical diagnostic test for CMS su

269 To date, there is no Food and Drug Administration-approv

270 To date, there is no licensed vaccine or therapeutic int

271 To date, there is no systematic overview of glutamate in

272 To date, there is scant evidence examining relations bet

273 However, to date, there is still the lack of an easy-to-manipulat

274 However, up to date, there were only four studies (conducted on smal

275 To-date, there is no effective cure and disease manageme

276 To date these studies have largely employed reactants in

277 the diversity and abundance of bat viruses, to date they have not been shown to harbor exogenous ret

278 To date, this affinity discrepancy has been attributed t

279 To date, this literature has primarily focused on the ro

280 To date, this represents the first published instance of

281 To date, this research has focused largely on deep neura

282 in Uruguay (spanning 664 species) assembled to date, to identify hotspots of species-richness, endem

283 To date, understanding of the genetic control of puberty

284 est ABCA4-associated disease cohort reported to date, updates the genotype-phenotype model establishe

285 ymer, only limited success has been achieved to date using block copolymers as precursors.

286 To date, vanadium dioxide (VO(2) ) is the only known sim

287 By offering an up-to-date view on these techniques, we identify emerging t

288 To date we know little about natural emotion word repert

289 To date, we are unable to find critical care specific li

290 st multimodal 7 tesla machine learning study to date, we overcome this limitation by capitalizing on

291 n the largest single-molecule R-loop dataset to date, we show that individual R-loops form nonrandoml

292 To characterize research effort to date, we synthesized results from ~600 published stud

293 ned mechanisms, at least in members examined to date, whereas G3 exhibits no sequence-specific insert

294 a handful of derivatives have been developed to date, which are, however, limited to diamino- and dia

295 ns underrepresented in neuroscience research to date, will enlarge and diversify databases and pave t

296 nt the largest CNV investigation in epilepsy to date with 10 712 European epilepsy cases and 6746 anc

297 In this largest genetic study of CC to date with histologically confirmed diagnosis, we stro

298 cohort of patients treated with RVD reported to date with long follow-up and demonstrates the ability

299 This Review canvases these approaches to date, with emphasis placed on the application of elec

300 Here, we review published results to date within the growing field of iPSC-based sarcomeri