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1 impaired awareness versus focal to bilateral tonic-clonic.
2 rognostic consequences of focal to bilateral tonic-clonic.
5 approximately half of patients, and include tonic-clonic, absence, and myoclonic seizures, including
6 ss was also associated with more prehospital tonic-clonic activity (22.7% vs 4.2%; P < .001) and card
7 e that physiological sparse and pathological tonic-clonic activity may coexist in the same cortical n
8 ified differences between focal to bilateral tonic-clonic and focal impaired awareness for a marker v
9 al impaired awareness and focal to bilateral tonic-clonic and may account for the more negative progn
10 pentylenetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic seizure incidence and severit
11 sorder or learning difficulty, occurrence of tonic-clonic and non-tonic-clonic seizures in the 3 mont
13 n developed seizures (primarily generalized, tonic-clonic, and atonic) that began on average at 6.8 m
14 eizure types, including absence, generalised tonic-clonic, and complex partial seizures, converge on
15 ic, tonic, clonic, tonic-atonic, generalised tonic-clonic, and focal with clearly observable motor si
17 epsy characterized by myoclonic, generalized tonic-clonic, and in 30% of patients, absence seizures.
18 ffect clonic but decreases susceptibility to tonic-clonic bicuculline seizures in intact male rats.
19 res (defined as bilateral tonic, generalised tonic-clonic, bilateral clonic, atonic, or focal to bila
20 ting multiple forms of epilepsy (generalized tonic-clonic, complex partial, absence seizures), includ
21 with TBC1D24 mutations included generalised tonic-clonic, complex partial, focal clonic, and infanti
22 stem, perhaps contributing to the limbic and tonic-clonic components of the observed epileptic phenot
23 s of consciousness during focal to bilateral tonic-clonic consist of paradoxical increases in cortica
25 ABAB receptor antagonist CGP 35348 prevented tonic-clonic convulsions and significantly enhanced surv
27 1 through mice toxicity studies, we observed tonic-clonic convulsions in several mice at high doses.
30 aged 2-18 years with partial and generalised tonic-clonic epilepsy were identified by population scre
34 Afebrile seizures consisted of generalized tonic-clonic, generalized tonic, generalized atonic, sim
36 Neocortical and entorhinal networks show tonic-clonic-like events, but the main hippocampal terri
37 ateral clonic, atonic, or focal to bilateral tonic-clonic) per 28 days in each 4-week period of an 8-
38 unit activity analysis of focal to bilateral tonic-clonic revealed sustained increases in cortical fi
39 E injection alone while there was a reduced tonic--clonic seizure threshold in the presence of both
41 t responsive to fenfluramine was generalized tonic-clonic seizure (120 of 263 [46%]), with a decrease
43 as high risk of SUDEP (with >=1 generalised tonic-clonic seizure [GTCS] per year), low risk of SUDEP
46 eters can provide notification of an ongoing tonic-clonic seizure, or peace of mind in the absence of
54 ding childhood absence epilepsy, generalized tonic clonic seizures and the epileptic encephalopathy,
55 juvenile absence epilepsy, and epilepsy with tonic clonic seizures only under the sole heading of idi
56 mice increased latencies to forelimb clonus, tonic clonic seizures, hindlimb extension, and death com
57 ), febrile seizures (7/29, 25%), generalized tonic-clonic seizures (5/29, 17%), and focal-onset seizu
58 ythmic myoclonus (all patients), generalized tonic-clonic seizures (all patients) and complex partial
59 osition to sound stimuli-induced generalized tonic-clonic seizures (audiogenic reflex seizures) and i
60 mmon focal epilepsy, with focal to bilateral tonic-clonic seizures (FBTCS+) a more severe form of the
61 lepsy (JME), one predisposing to generalized tonic-clonic seizures (GTCS) and a second to myoclonic s
62 analyzed with the algorithm: 25 generalized tonic-clonic seizures (GTCSs) from 11 patients, and 19 e
63 BPD), partial seizures (PSZ) and generalized tonic-clonic seizures (GTSZ) with and without structural
64 ractable childhood epilepsy with generalized tonic-clonic seizures (ICEGTC), which bears similarity t
66 474S mice) exhibited spontaneous generalized tonic-clonic seizures (which occurred in the absence of
69 seizures, and 1 had 4 witnessed generalized tonic-clonic seizures and approximately 30 suspected gen
72 the estimated lifetime number of generalized tonic-clonic seizures and functional cluster membership
73 evere epilepsy with early onset, generalized tonic-clonic seizures and juvenile lethality by 3 weeks
79 sorders of GABA metabolism, and one in which tonic-clonic seizures associate with increased central n
80 ilepsy, neurological insult, total number of tonic-clonic seizures before randomisation, seizure type
81 CI) 2.7-11.1], history of focal to bilateral tonic-clonic seizures before surgery (aHR 1.6, 95% CI 0.
82 The difference in occurrence of generalized tonic-clonic seizures between groups was 0.3% (95% CI =
84 tanding the networks involved in generalized tonic-clonic seizures can provide insights into mechanis
85 xhibited early onset spontaneous generalized tonic-clonic seizures concurrent with a significant redu
87 f those with EEG abnormality were at risk of tonic-clonic seizures during follow-up compared with 16%
89 presented with afebrile focal or generalized tonic-clonic seizures during the first to second year of
90 istration, decreased spontaneous generalized tonic-clonic seizures in a model of temporal lobe epilep
91 pathetic hyperactivity immediately following tonic-clonic seizures in DS mice, which leads to lethal
93 fficulty, occurrence of tonic-clonic and non-tonic-clonic seizures in the 3 months before pregnancy,
94 on of miR-335-5p increased susceptibility to tonic-clonic seizures in the pentylenetetrazol seizure m
95 rtial seizures are at low risk of subsequent tonic-clonic seizures in the period of time to which the
96 al activation after focal motor to bilateral tonic-clonic seizures in the striatum, globus pallidus e
97 the effects of treatment on the frequency of tonic-clonic seizures in those patients with such pre-ra
98 had a greater latency and lower incidence of tonic-clonic seizures induced by pentylenetetrazol (PTZ;
99 recurrent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneo
100 recurrent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneo
101 al impaired awareness and focal to bilateral tonic-clonic seizures may also help us to understand the
102 ictal SPECT from 59 secondarily generalized tonic-clonic seizures obtained during epilepsy surgery e
103 ilepsy (JME), epilepsy with only generalized tonic-clonic seizures occurring either randomly during t
104 uvenile absence epilepsy, five patients with tonic-clonic seizures on awakening and 30 control subjec
105 e epilepsy and two out of five patients with tonic-clonic seizures on awakening, but in none of the 3
108 of GCaMP6s but not GCaMP6f in the DG induces tonic-clonic seizures several weeks after viral injectio
109 Two of six patients experiencing generalized tonic-clonic seizures showed marked improvement, three s
111 drugs used in the MESS study are greater for tonic-clonic seizures than they are for partial seizures
112 for refractory partial-onset and generalized tonic-clonic seizures that acts as a selective negative
114 nd increasing latency of pilocarpine-induced tonic-clonic seizures upon in vivo coelenterazine admini
115 e strain is unusually sensitive to recurrent tonic-clonic seizures upon routine handling and to seizu
117 as mitigated by metabolic sources of carbon; tonic-clonic seizures were also suppressed by alpha-amin
118 focal impaired awareness, focal to bilateral tonic-clonic seizures were characterized by deeper loss
122 ut 25% of aged apoE4 TR mice had more severe tonic-clonic seizures which occasionally progressed to t
124 zed by normal early development, generalized tonic-clonic seizures with onset at 5-10 years of age, a
126 al impaired awareness, or focal to bilateral tonic-clonic seizures) from baseline analysed in the mod
127 exhibits acoustically triggered generalized tonic-clonic seizures, and often times the EEG, recorded
128 LN8 disease patients present with myoclonus, tonic-clonic seizures, and progressive declines in cogni
129 etion died prematurely following generalized tonic-clonic seizures, and they were equally susceptible
130 f350, caused low seizure threshold, sporadic tonic-clonic seizures, brain enlargement and ectopic neu
131 pendent paradigm, pentylenetetrazole-induced tonic-clonic seizures, exclude the possibility that the
132 ith positive histories of focal to bilateral tonic-clonic seizures, including both remote (none for >
133 rs indicate that the higher the frequency of tonic-clonic seizures, the higher the risk of SUDEP; fur
161 including hemiclonic, hemitonic, generalized tonic-clonic, simple partial (stereotyped episodes of ep
163 vulsive seizures were defined as hemiclonic, tonic, clonic, tonic-atonic, generalised tonic-clonic, a
165 s (hypoactivity, myoclonic jerks, continuous tonic-clonic), which correlated with regional cFOS expre