ライフサイエンスコーパス: tonotopic

1 of cortical myelination and the strength of tonotopic activation across several auditory cortical re

2 A greater effective separation of tonotopic activity patterns was observed under ALT than

3 ised of three distinct levels: a Peripheral, tonotopic analysis, a Central analysis computing feature

4 ly that the arrangement of vertical cells is tonotopic and aligned to the innervation pattern of the

5 projections participate in the formation of tonotopic and binaural maps in primary auditory cortex.

6 , we proposed that planar neurons provided a tonotopic and narrowly tuned input to the DCN, whereas r

7 In conclusion, the tonotopic and non-tonotopic corticofugal connections of

8 to measure the microstructure of orthogonal tonotopic and periodotopic gradients forming complete au

9 to broad along both the dorsoventral (i.e., tonotopic) and the rostrocaudal dimensions.

10 gests that the auditory core, containing the tonotopic areas A1, R, and RT, constitutes the first sta

11 Projections to tonotopic areas had fewer nuclear origins than those to

12 few areas (e.g., the MGB ventral division to tonotopic areas), and others project to all areas (e.g.,

13 abeled cells were in expected high-frequency tonotopic areas, but some VNLL and INLL labeling appeare

14 ng confirmed the existence of at least three tonotopic areas.

15 challenges this precept, as the traditional tonotopic arrangement appears weakly organized at the le

16 electrode recordings may describe a smoother tonotopic arrangement due to a sampling bias towards neu

17 nt procedures that revealed a systematic and tonotopic arrangement of AN fibers in each subdivision w

18 were observed in the DCIC, and a comparable tonotopic arrangement was observed across the boutons of

19 ing of the temporal pattern of firing in the tonotopic array of auditory nerve fibers.

20 frequencies up to 1 kHz are encoded along a tonotopic array of hair cells and transmitted to afferen

21 The tonotopic array of T-stellate cells enhances the encodin

22 octopus cell spanning about one-third of the tonotopic array.

23 ge of these gradients moved along the future tonotopic axes during the development of all nuclei stud

24 Cell density followed the tonotopic axis and decreased with decreasing best freque

25 ial cells showed wider integration along the tonotopic axis and the amount of L4 input varied with su

26 expression and kinetics can differ along the tonotopic axis as well as in different cell types of the

27 nsformation in temporal processing along the tonotopic axis contributes to efficient extraction of au

28 t, we found that local connections along the tonotopic axis differed from those along the isofrequenc

29 ions exist in gradients corresponding to the tonotopic axis in NM that reflect the characteristic fre

30 Stimulating MGBv along the tonotopic axis in the slice produced an orderly shift of

31 ns that has not been investigated across the tonotopic axis is short-term synaptic plasticity.

32 own-regulation of P2X2/3R currents along the tonotopic axis occurs simultaneously with an increase in

33 own-regulation of P2X2/3R currents along the tonotopic axis occurs simultaneously with an increase in

34 Along the dorsoventral, tonotopic axis of DCN, the mean position of c-fos-positi

35 gradient in Kv3.1 immunoreactivity along the tonotopic axis of the barn owl NM and NL and a less prom

36 ry multiunit spiking activity throughout the tonotopic axis of the central nucleus of the inferior co

37 xpressed in a continuous gradient across the tonotopic axis of the central nucleus of the inferior co

38 Expression profiling along the developing tonotopic axis of the chick basilar papilla (BP) identif

39 ce variants of KCNQ4 (KCNQ4_v1-v4) along the tonotopic axis of the cochlea.

40 the distribution of sensory cells along the tonotopic axis of the cochlea.

41 n reverberation is comparable throughout the tonotopic axis of the IC.

42 The AMI will be implanted along the tonotopic axis of the ICC to achieve frequency-specific

43 nctional differences and gradients along the tonotopic axis of the LSO relate to qualitative and/or q

44 variation in sensory transduction along the tonotopic axis of the mammalian cochlea.

45 3 immunostaining along the lateral to medial tonotopic axis of the MNTB was detected.

46 gradient in Kv3.1b protein levels across the tonotopic axis of the MNTB, and are consistent with a ro

47 ressed in gradients along the medial-lateral tonotopic axis of the nuclei.

48 x, thus reconciling historical accounts of a tonotopic axis oriented medial to lateral along Heschl's

49 e expression of prestin and MAP1S across the tonotopic axis that may partially contribute to a previo

50 e, but the spread of these neurons along the tonotopic axis was 35% greater for ephrin-B2(lacZ/+) mic

51 ong the isofrequency axis (orthogonal to the tonotopic axis) arose predominantly within a column.

52 spread across approximately one-third of the tonotopic axis, a click evokes a soma-directed sweep of

53 was a decrease in CREB expression along the tonotopic axis, and the pattern of pCREB labeling appear

54 age-sensitive dye (VSD) signals along the AI tonotopic axis, demonstrating topography in the mouse th

55 ed by local maxima in firing rates along the tonotopic axis, has been characterized in the auditory n

56 tic frequency discontinuities along the main tonotopic axis, in combination with a smooth frequency g

57 specific hair cell characteristics along the tonotopic axis.

58 different hair cells and along the cochlea's tonotopic axis.

59 d preferred frequencies adhered tightly to a tonotopic axis.

60 redictably with position along the so-called tonotopic axis.

61 rogeneity was superimposed orthogonal to the tonotopic axis.

62 ce comparably segregated responses along the tonotopic axis.

63 dient in dendritic length along the presumed tonotopic axis.

64 e clusters of pCREB-positive cells along the tonotopic axis.

65 uped together in distinct clusters along the tonotopic axis.

66 ber of clusters between hair cells along the tonotopic axis.

67 Both were oriented orthogonally to the tonotopic axis.

68 cell response frequency along the cochlea's tonotopic axis.

69 tuning of mechanosensory hair cells along a tonotopic axis.

70 their birthdates, which are aligned with the tonotopic axis.

71 laminae of the ICC and perpendicular to the tonotopic axis.

72 al processing properties across the presumed tonotopic axis; neurons in the MSO and the low-frequency

73 fferent positions on an elongated frequency (tonotopic) axis.

74 These findings suggest that large-scale tonotopic-based FC does not require sensory experience t

75 an noise to reveal pronounced distortions in tonotopic coding of TFS and ENV following permanent, noi

76 rons may play a central role in formation of tonotopic connections in the auditory system.

77 topographic, most likely frequency-matched (tonotopic) connections as well as non-topographic (non-t

78 connections as well as non-topographic (non-tonotopic) connections.

79 We recorded from neurons in two tonotopic cortical belt areas in the dorsal posterior ec

80 e closest auditory affiliations are with non-tonotopic cortical regions involved in higher order audi

81 In conclusion, the tonotopic and non-tonotopic corticofugal connections of AI can potentially

82 time points (P10, P15, and P20) spanning the tonotopic critical period.

83 ring pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway.

84 leus, nucleus magnocellularis (NM), exhibits tonotopic distribution of both input and membrane proper

85 specific to stimulus frequency and that the tonotopic distribution of input number and membrane exci

86 nd the inflammatory response in the CSF, the tonotopic distribution of neurosensory pathologies in th

87 amics are sufficient to explain the observed tonotopic distribution of STD.

88 nglion neurons (SGNs), with a focus on their tonotopic distribution.

89 order cells of the rat organ of Corti with a tonotopic expression gradient.

90 in the auditory system, we investigated the tonotopic expression of several Eph receptors and ephrin

91 igate the excitation patterns throughout the tonotopic field determined by acoustic stimulation.

92 anization of AI is characterized by a robust tonotopic frequency gradient overlaid with spatially clu

93 and the number of channels accessible to the tonotopic frequency gradients of the CN, ABIs improve sp

94 Here we show that, whereas tonotopic frequency representation develops normally in

95 the sensory dendrites are best correlated to tonotopic frequency representation.

96 ency modulation (dispersion), in addition to tonotopic gain and active amplification.

97 along the chicken basilar papilla revealed 'tonotopic' gradations in calcium sensitivity and deactiv

98 The model reveals that a limited tonotopic gradient could be achieved simply by altering

99 rent in these mutants was attenuated and the tonotopic gradient in amplitude was also lost, although

100 s was reduced relative to wild type, and the tonotopic gradient in conductance, where channels from t

101 The finding of a tonotopic gradient in presynaptic terminals suggests tha

102 Using confocal imaging, we observed a tonotopic gradient in the concentration of proteinaceous

103 Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps

104 pe (WT) animals, Kv3.1b is expressed along a tonotopic gradient in the MNTB, with highest levels in n

105 These results argue that the tonotopic gradient is not established by the selective i

106 e channels are thought to play a role in the tonotopic gradient observed in the mammalian cochlea.

107 Kv3.1 is expressed in a tonotopic gradient within the medial nucleus of the trap

108 This arrangement, which is termed a tonotopic gradient, results from the coordination of man

109 proximately perpendicular to the axis of the tonotopic gradient, suggesting an orthogonal organisatio

110 at orchestrate those features and govern the tonotopic gradient, we used expression microarrays to id

111 , a large number of axons diverge across the tonotopic gradient.

112 on of DCN for spectral edge coding along the tonotopic gradient.

113 s in the core auditory cortex, its extending tonotopic gradients in the belt and even beyond that.

114 aps (AFMs) are defined by the combination of tonotopic gradients, representing the spectral aspects o

115 hearing organs that are needed to establish tonotopic gradients.

116 AI receives tonotopic inputs from MGv and MGd.

117 AI receives non-tonotopic inputs from the ipsilateral MGm, SG, and bic.

118 In the present study of a tonotopic insect hearing organ, we combine mechanical me

119 bindin and calretinin were found within each tonotopic location and neuronal type, some distinct subd

120 used to predict tuning frequencies and thus tonotopic location if hair cells were endowed with each

121 of the trapezoid body (MNTB) specific to the tonotopic location within the nucleus.

122 d that predicted from the originating cell's tonotopic location.

123 NM axons in XDCT are organized in a precise tonotopic manner along the rostrocaudal axis, spanning t

124 ic tufts target the CNIC in a less dense but tonotopic manner.

125 king activity has been proposed to shape the tonotopic map along the ascending auditory pathway.

126 induce targeted expansions in the adult rat tonotopic map and find that these bottom-up changes unex

127 re distributed oppositely in relation to the tonotopic map and that they are equally distributed in e

128 ion of the target frequency range within the tonotopic map but no change in sound intensity encoding

129 the mouse auditory cortex, where an orderly tonotopic map can arise from heterogeneous frequency tun

130 Thus, changes in the DCN tonotopic map can be explained by peripheral modificatio

131 al plasticity due to hearing loss results in tonotopic map changes.

132 corresponded to the regions of the auditory tonotopic map devoted to these frequencies.

133 is thought to instruct the formation of the tonotopic map during the differentiation of sensory hair

134 We found that the tonotopic map emerged during the third postnatal week in

135 , this pretarget axon sorting contributes to tonotopic map formation in NL.

136 of Kv3.1 immunoreactivity varied across the tonotopic map in the medial nucleus of the trapezoid bod

137 nct characteristic frequency (CF) gap in the tonotopic map in which responses were either extremely w

138 eorganization of the mouse auditory midbrain tonotopic map is induced by a specific sound-rearing env

139 The structural correlates underlying tonotopic map maturation and reorganization during devel

140 In the thalamus, the tonotopic map matured with an expanded range of frequenc

141 By 3 weeks, the midbrain tonotopic map of control mice was established, and manga

142 are cochleotopically organized, providing a tonotopic map of sound frequencies.

143 The rat auditory cortex is organized as a tonotopic map of sound frequency.

144 f the present study was to determine how the tonotopic map of the DCN appears in animals with severe

145 bited spatial covariation that reflected the tonotopic map of the STP.

146 the target intensity range but no change in tonotopic map organization relative to controls.

147 low- and high-frequency regions of a single tonotopic map receive dominant inputs from different tha

148 sly shown to correspond to auditory cortical tonotopic map refinement (P11-P14), providing a structur

149 echanism linking spontaneous spike bursts to tonotopic map refinement and further highlight the impor

150 ng and silencing of synapses which underlies tonotopic map refinement.

151 However, the potential for tonotopic map reorganization after more severe lesions i

152 capacity for receptive field plasticity and tonotopic map reorganization and that locally correlated

153 Its auditory cortex contains a tonotopic map representing frequencies from 6 to 70 kHz.

154 use changes in a corresponding region of the tonotopic map which reflect primarily changes in the sha

155 d/or their high-affinity receptors along the tonotopic map, and they suggest that a combination of ne

156 l and structural sharpening of an inhibitory tonotopic map, as evidenced by deficits in synaptic stre

157 requency-selective responses, organized in a tonotopic map, for all subjects.

158 ver-representation of 7 kHz within the adult tonotopic map.

159 he cochlea coil, commonly referred to as the tonotopic map.

160 ech occupy the low-frequency portions of the tonotopic map.

161 tatory input and are organized into the same tonotopic map.

162 lting in a large-scale reorganization of the tonotopic map.

163 is essential for the formation of a precise tonotopic map.

164 ificial stimuli, resulting in a nonclassical tonotopic map.

165 ibutions of cSlo variants help determine the tonotopic map.

166 of each hair cell and thus help establish a tonotopic map.

167 ontaneous and may indicate irregularities of tonotopic mapping in cochlear mechanics.

168 ayers responsible for the frequency-to-place tonotopic mapping in the cochlea, which together form a

169 hought to determine the local stiffness, and tonotopic mapping in turn, change little along the cochl

170 along the basilar papilla, foreshadowing the tonotopic mapping observed between NM and the basilar pa

171 A1 are best delineated by combining in vivo tonotopic mapping with postmortem cyto- or myeloarchitec

172 cochlear efferent innervation, which refines tonotopic mapping, improves sound discrimination, and mi

173 re loading the model accurately predicts the tonotopic mapping.

174 rior colliculus (IC), which are important in tonotopic mapping.

175 llowing auditory stimulation; (ii) wide-area tonotopic mapping; (iii) EEG-synchronized imaging during

176 Both tonotopic maps and response amplitudes of tinnitus parti

177 ne tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB

178 Similarly, the tonotopic maps for the hearing loss without tinnitus gro

179 luding the experience-dependent expansion of tonotopic maps in A1 and the acquisition of acoustic pre

180 The formation of tonotopic maps in A1 was specifically influenced by a ra

181 ated that this topography is consistent with tonotopic maps in SON and NL.

182 as well as the refinement and maintenance of tonotopic maps in the brain.

183 ring inner hair cells, which may help refine tonotopic maps in the brain.

184 ctivity of adjacent hair cells to refine the tonotopic maps in the cochlear nucleus.

185 uring a brief, 3-d window, but did not alter tonotopic maps in the thalamus.

186 Tonotopic maps in voice-modified monkeys were not distor

187 ased neural synchrony, and reorganization of tonotopic maps of auditory nuclei.

188 We observed precisely organized tonotopic maps of best frequency (BF) in the middle laye

189 nganese-enhanced MRI to analyze the midbrain tonotopic maps of control mice during normal development

190 The core region contains two "mirror-image" tonotopic maps oriented along the same axis as observed

191 In contrast, frequency-selective tonotopic maps were similar between the two species.

192 s study demonstrates that the adult form of 'tonotopic maps' of sound frequency in the rat primary au

193 4 weeks broadened spectral tuning, disrupted tonotopic maps, and reduced spontaneous discharge correl

194 We identified three distinct tonotopic maps, corresponding to primary (A1), rostral (

195 MD distorted tonotopic maps, weakened the deprived ear's representati

196 e has confirmed the presence of these global tonotopic maps, while uncovering an unexpected local var

197 ibutes little to the construction of precise tonotopic maps.

198 x resulting from the overlap of binaural and tonotopic maps.

199 quantitative T(1) mapping with phase-encoded tonotopic methods to map primary auditory areas (A1 and

200 n for bimodal listening; IE was sensitive to tonotopic mismatch for EAS, but not for bimodal listenin

201 ned within rather than across ears, and that tonotopic mismatch should be minimized to maximize the b

202 increasing amounts of speech information and tonotopic mismatch.

203 functionally distinct cortical regions: the tonotopic, narrowly frequency-tuned module [central narr

204 as of the same functional type (tonotopic to tonotopic, nontonotopic to nontonotopic, limbic-related

205 d by their putative functional affiliations: tonotopic, nontonotopic, multisensory, and limbic.

206 us but without redirection of retinal axons, tonotopic order and sharp tuning curves were seen, indic

207 ere increased, their tuning was broader, and tonotopic order in their frequency maps was disturbed.

208 eas and demonstrate their shapes, sizes, and tonotopic order.

209 We first mapped tonotopic organization across 96 electrodes spanning app

210 s gyrus and more recent findings emphasizing tonotopic organization along the anterior-posterior axis

211 cell morphologies consistent with a loss of tonotopic organization and the formation of an organ wit

212 l three subdivisions of the CN exhibit clear tonotopic organization at or before birth, but the topog

213 Here, we explicitly compared the strength of tonotopic organization at various depths within core and

214 cortical areas; 5) cortical areas devoid of tonotopic organization have topographic projections to c

215 ined receptive fields revealed an equivalent tonotopic organization in all layers of the cortical col

216 he middle cortical layers revealed a precise tonotopic organization in core, but not belt, regions of

217 Frequency-mapping studies have revealed tonotopic organization in primary auditory cortex, but t

218 dress a debate surrounding the robustness of tonotopic organization in the auditory cortex that has p

219 evelopment of tone frequency selectivity and tonotopic organization is influenced by patterns of neur

220 o ventral (high frequencies) in SON; 2) this tonotopic organization is less precise than the organiza

221 o ventral (high frequencies) in SON; 2) this tonotopic organization is less precise than the organiza

222 s, single-unit studies support the classical tonotopic organization of A1 defined by the spectral com

223 ent frequency components is reflected in the tonotopic organization of auditory cortical fields.

224 al division (MGv) of the MGC, reflecting the tonotopic organization of both core areas.

225 th frequency gradient orthogonal to the main tonotopic organization of cat ICC, reflect a layering of

226 A quantitative examination of the tonotopic organization of primary afferent projections t

227 These data indicate that the tonotopic organization of spiral ganglion projections to

228 BD latency or amplitude, indicating that the tonotopic organization of the auditory brainstem is unde

229 We provide an overall view of the functional tonotopic organization of the auditory cortex in the rat

230 The tonotopic organization of the auditory portion of the VI

231 ional theories of auditory streaming rely on tonotopic organization of the auditory system to explain

232 Finally, we propose that the tonotopic organization of the cochlea plays a crucial ro

233 nd coordinate hair cell innervation with the tonotopic organization of the cochlea.

234 ir cell innervation are coordinated with the tonotopic organization of the cochlea.

235 om) brain mapping, we used MEMRI to show the tonotopic organization of the mouse inferior colliculus.

236 related well with hair cell position and the tonotopic organization of the papilla.

237 In the avian auditory brainstem, the tonotopic organization of the second- and third-order au

238 KCa channel properties needed to explain the tonotopic organization of the turtle cochlea.

239 and non-overlapping, consistent with the non-tonotopic organization of this field.

240 Clear tonotopic organization was only observed in the IC of th

241 Tonotopic organization was retained to some extent as ev

242 Neural population thresholds and tonotopic organization were mapped over the surface of t

243 t least three distinct areas with fine-scale tonotopic organization, as well as at least one addition

244 areas, induced expression manifested a clear tonotopic organization, i.e., in dorsal, posteroventral,

245 propose that beyond the well known cortical tonotopic organization, multipeaked spectral tuning ampl

246 files of single neurons or changes in global tonotopic organization.

247 hlea that may be an important element of its tonotopic organization.

248 rspersed throughout the SON and show similar tonotopic organizations.

249 rspersed throughout the SON and show similar tonotopic organizations.

250 The analysis begins in the tonotopic pathway, where these cues are processed in par

251 ific purinergic modulation follows a precise tonotopic pattern in the ventral cochlear nucleus of dev

252 These data suggest that while intrinsic tonotopic patterning of auditory cortical circuitry occu

253 latencies in more rostral sites and possible tonotopic patterns parallel to core and belt areas, sugg

254 platform with which to identify mediators of tonotopic plasticity.

255 dentifying a primary locus of change for the tonotopic plasticity.

256 s well as candidate genes that might execute tonotopic plasticity.

257 ically regulated with respect to the nuclear tonotopic position (i.e. sound frequency selectivity).

258 located along the axis must determine their tonotopic position in order to generate frequency-specif

259 ce date of birth of a neuron correlates with tonotopic position in the cochlea, we investigated if it

260 , we investigated if it also correlates with tonotopic position in the cochlear nucleus (CN).

261 The correlation between birthdate and tonotopic position suggests testable mechanisms for spec

262 cell's tuning varied in accordance with its tonotopic position.

263 sts testable mechanisms for specification of tonotopic position.

264 ype I spiral ganglion neurons (SGNs) at each tonotopic position.

265 lity of physiological processes to restore a tonotopic presentation of sound in the midbrain.

266 Noise exposure altered the tonotopic profile of SA in the direct pathway by causing

267 Noise-induced changes in the tonotopic profile of SA may represent a neural correlate

268 as characterized by an anterior-to-posterior tonotopic progression from high to low frequencies (rang

269 orsal cochlear nucleus (DCN) receives direct tonotopic projections from the auditory nerve (AN) as we

270 This study examines the development of the tonotopic projections from the spiral ganglion to the co

271 border of AI marked entry into a second core tonotopic region, P, with progressively higher frequenci

272 sensitive regions were localized to specific tonotopic regions of anterior auditory cortex, extending

273 tinylated dextran amine (BDA) into different tonotopic regions of the LSO of albino rats and analyzed

274 tical in all cases, thus indicating that all tonotopic regions of the LSO receive a similar combinati

275 basal pole) of the polarized cells from the tonotopic relationships.

276 sted a relation between hearing loss-induced tonotopic reorganization and tinnitus.

277 elations between hearing loss, tinnitus, and tonotopic reorganization.

278 f the IC is needed to specify how the single tonotopic representation in the IC central nucleus leads

279 similar response type compared to the single tonotopic representation in the ICc.

280 The experiments demonstrate that tonotopic representation is crucial to complex pitch per

281 A presumably normal tonotopic representation may have been maintained within

282 e these distortions degrade and diminish the tonotopic representation of temporal acoustic features,

283 Eliminating tonotopic representation to auditory nuclei demonstrates

284 the IC central nucleus leads to the multiple tonotopic representations in core areas of the auditory

285 a predominantly linear mechanism to transmit tonotopic representations of spectra, type IV neurons us

286 The inferior colliculus exhibited multiple tonotopic representations.

287 ounds entails the transformation of sensory (tonotopic) representations of incoming acoustic waveform

288 attention in a manner that recapitulates its tonotopic sensory organization.

289 ictions of the PS model, a greater effective tonotopic separation of A and B tone responses was obser

290 The results argue against tonotopic separation per se as a neural correlate of str

291 ns may be efficiently encoded by a cascading tonotopic sequence of neural synchronization patterns wi

292 ylate treatment can induce hyperactivity and tonotopic shift in the amygdala and infusion of salicyla

293 egree of myelination and the strength of the tonotopic signal across a number of regions in auditory

294 e, similar at apex and base, and lacking the tonotopic size gradient seen in wild type.

295 processing step for transforming a sensory (tonotopic) sound image into higher level neural represen

296 ally from areas of the same functional type (tonotopic to tonotopic, nontonotopic to nontonotopic, li

297 d P15, during which tone exposure alters the tonotopic topography of A1.

298 understood, they are generally attributed to tonotopic variations in the constituent hair cells or cy

299 ifferent BF regions of AI terminate in a non-tonotopic way in the ipsilateral medial division of the

300 AI projects in a tonotopic way to the ipsilateral ventral (MGv) and dorsa