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1 ing ZSCAN4, a master transcription factor of totipotency.
2 ights into reprogramming cells to a state of totipotency.
3 ajor regulators of plant embryo identity and totipotency.
4 pigenetic pathways or kinetics can establish totipotency.
5  P granules is to maintain germline fate and totipotency.
6 ce of germ cell identity and preparation for totipotency.
7 hanisms underlying plant cell plasticity and totipotency.
8 DNA demethylation to reset the epigenome for totipotency.
9  ability to reprogram somatic nuclei back to totipotency.
10 enomic basal state that is the foundation of totipotency.
11 allows the reprogramming of somatic cells to totipotency.
12 f the germ cell lineage is the generation of totipotency.
13 ineages whose workers have lost reproductive totipotency.
14 nd/or in maintaining germ cell and stem cell totipotency.
15 o epigenetic reorganisation and re-establish totipotency.
16 differentiation had lost their developmental totipotency.
17 actors that reprogram somatic cell nuclei to totipotency.
18 oducts and, for plant systems, expression of totipotency.
19  in both sexes, defining a basis for nuclear totipotency.
20         Here, we describe criteria to define totipotency.
21 hromatin across Zscan4, to promote exit from totipotency.
22  that are based on the principle of inducing totipotency.
23 ing of the epigenome to prime the zygote for totipotency.
24  and its importance for preserving germ cell totipotency.
25  in maintaining germline gene expression and totipotency after heat stress.
26 cell cycle and be reprogrammed to a state of totipotency after nuclear transfer.
27 ty of at least some somatic cells to acquire totipotency after somatic-cell nuclear transfer.
28 ion is important to ensure compatibility for totipotency and development thereafter.
29 ith important implications for understanding totipotency and early lineage bias.
30 s dual role in regulating germline stem cell totipotency and embryonic cell fate specification.
31 ections, suggesting that P granules maintain totipotency and germline identity by antagonizing somati
32 gated whether this causes germ cells to lose totipotency and initiate somatic reprogramming.
33 ile in the cleavage-stage embryo establishes totipotency and is required for further development.
34 e of embryonic stem (ES) cells affects their totipotency and may give rise to fetal abnormalities.
35                                       Though totipotency and pluripotency are transient during early
36 tural as well as experimental acquisition of totipotency and pluripotency, control of transposons, an
37 a distinctive state in E3.5 ICM that bridges totipotency and pluripotency.
38        Early vertebrate embryos must achieve totipotency and prepare for zygotic genome activation (Z
39  into other cell types, resulting in loss of totipotency and reproductive potential.
40 e key players in the acquisition of cellular totipotency and the establishment of specific cellular s
41 ng of the epigenome in hPGCLCs and hPGCs for totipotency and the transmission of genetic and epigenet
42       Reprogramming is essential for zygotic totipotency and to prevent transgenerational inheritance
43 nct from somatic cells in their immortality, totipotency, and ability to undergo meiosis.
44 sms-such as unusual reproductive strategies, totipotency, and cell competition-while developmental bi
45 which lays the foundation for gametogenesis, totipotency, and embryonic development.
46 eptional genomic plasticity and the state of totipotency are being unravelled, and will enhance our a
47 e molecular mechanisms underlying plant cell totipotency are largely unknown.
48 o understanding how cellular immortality and totipotency are retained, gained, and lost.
49 ion factors are key regulators of plant cell totipotency, as ectopic overexpression of either transcr
50 y, suggest that multiple mechanisms maintain totipotency at different stages of germline development,
51 o model in order to understand mouse ZGA and totipotency because of their expression of a group of tw
52 ells is critical toward the establishment of totipotency, but investigations of the germline events a
53 f increasing stringency can be used to judge totipotency by evaluating candidate totipotent cell type
54  germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, inc
55 tic reprogramming is likely to be needed for totipotency, correct initiation of embryonic gene expres
56                                 Regenerating totipotency during development of germ cells entails re-
57 e chromatin structure capable of maintaining totipotency during embryogenesis and leading to differen
58 mechanisms that mediate the establishment of totipotency during the egg-to-embryo transition in mamma
59                                              Totipotency emerges in early embryogenesis, but its mole
60 dentifies DUXBL as an essential regulator of totipotency exit enabling the first divergence of cell f
61 m more advanced blastocysts no longer retain totipotency, failing to form TE and generating PE on the
62 t for expanded fate potential, but not other totipotency features.
63 fic functions and to retain the capacity for totipotency, germ cells repress somatic differentiation,
64 e of giving rise to a new organism, and this totipotency hinges on their ability to assemble membrane
65 molecular condensates that promote germ cell totipotency in animals.
66                 Understanding the process of totipotency in human cells would have broad applications
67  have a crucial role in establishing nuclear totipotency in normal development and in cloned animals,
68 of reprogramming factors capable of inducing totipotency in somatic cell nuclei.
69 X-3 and GLD-1, are essential for maintaining totipotency in the Caenorhabditis elegans germline.
70 chromosome dynamics, and re-establishment of totipotency in the next generation.
71 hanges in gene expression, the transition to totipotency in the plant zygote is accompanied by resett
72  a unique gene expression program and regain totipotency in the zygote.
73 hich these cells are specified and how their totipotency is established and maintained has important
74                  During mouse embryogenesis, totipotency is gradually lost, and, at the 16-cell stage
75 , which is conserved in metazoans, transient totipotency is induced and zygotic transcription is init
76    Unlike pluripotency, the establishment of totipotency is poorly understood.
77                                              Totipotency is the ability of a single cell to give rise
78 s (PGCs), which reprograms the epigenome for totipotency, is linked to changes in nuclear architectur
79 truct TE during in vitro culture, confirming totipotency of ICM cells at this stage.
80                                 The presumed totipotency of plant cells leads to questions about how
81       This result confirms the developmental totipotency of prespore amoebae.
82 are now beginning to talk about the possible totipotency of some adult tissue stem cells.
83       The molecular mechanisms that maintain totipotency of the germline are not well understood.
84                          We propose that the totipotency of the male gametophyte is kept in check by
85 ouse and human pluripotent stem cells toward totipotency or primed human embryonic cells toward the g
86 n on H1 abrogates its ability to repress the totipotency program in ESCs.
87 s de-compacted and H1 is evicted, leading to totipotency reactivation.
88                                              Totipotency refers to the ability of a cell to generate
89                                     Defining totipotency relies on a variety of assays of variable st
90 g direct lineage conversion, pluripotency-to-totipotency reversion and cancer.
91 plicate RNA regulation in the maintenance of totipotency, suggest that multiple mechanisms maintain t
92 c cells are generally acknowledged to retain totipotency, the potential to develop into any cell type
93 , zygotic depletion of Zmym2 compromises the totipotency-to-pluripotency transition during early deve
94                            Specifically, the totipotency-to-pluripotency transition marks one of the
95 ling to mature nucleoli is essential for the totipotency-to-pluripotency transition.
96 aution should be taken when studying ZGA and totipotency using 2C-like cells as the model system.
97 ify the early events in the establishment of totipotency, we monitored the genome-wide transcript pro
98 ryogenesis is an example of induced cellular totipotency, where embryos develop from vegetative cells
99 cell can potentially be reprogrammed back to totipotency, which in turn results in re-differentiation
100 find that the repression of Dyrk1a activates totipotency, which is a possible reason for TE specifica
101 the natural prototype for the acquisition of totipotency, which is the potential of a cell to produce
102 ty, which likely participates in restricting totipotency while preventing extensive organogenesis.
103         Germ cells are unique in engendering totipotency, yet the mechanisms underlying this capacity

 
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