ライフサイエンスコーパス: toxic

1 gnitude, with chloraminated water being more toxic.

2 ewable, easy to obtain, inexpensive, and non-toxic.

3 catechol metabolites are likely reactive and toxic.

4 Human Abeta has higher propensity to form toxic Abeta species, which are considered the main patho

5 a specific encephalopathy that is caused by toxic accumulation of lysine degradation intermediates.

6 d both NADPH and GSH pools, thereby allowing toxic accumulation of reactive oxygen species.

7 Here we repurposed mastoparan-L, the toxic active principle derived from the venom of the was

8 al evolution and potential to exert specific toxic activities.

9 , studies towards understanding granadaene's toxic activity are hindered by its instability and insol

10 iments with (212)Pb-anti-mCD38 established a toxic activity of 277.5 kBq.

11 Autophagy degrades many of the toxic, aggregate-prone proteins responsible for such dis

12 In particular, numerous proteins that form toxic aggregates in neurodegenerative diseases, such as

13 with the aim to promote the emergence of non-toxic aggregates.

14 The Wtf4(poison) protein forms dispersed, toxic aggregates.

15 athways target misfolded proteins to prevent toxic aggregation and neurodegeneration(1).

16 -induced increase in harmful AR metabolites, toxic aldehydes, steatosis, ER stress, apoptosis, and li

17 tains only pristine graphite, water, and non-toxic alkanes formed by an interfacial trapping method i

18 onal antibodies directed against aggregated, toxic alpha-synuclein.as well as anti-aggregation or pro

19 In the search for highly transparent and non-toxic alternative front layers replacing state-of-the-ar

20 HTT and HTTex1 with expanded polyQ are both toxic although full-length HTT remains diffuse while HTT

21 l hepatocytes, where it converts potentially toxic ammonia to the valuable amino acid, glutamine.

22 ntal factors, VZV infection may increase the toxic amyloid burden and contribute to amyloid-associate

23 omeric Abeta, which are known to be the most toxic amyloid species within the brain.

24 log-a water-soluble, non-hallucinogenic, non-toxic analogue of ibogaine that can be prepared in a sin

25 nsitively to low concentrations of bioactive/toxic analytes: statistically relevant impedance changes

26 c excessive ethanol consumption has distinct toxic and adverse effects on a variety of tissues.

27 t of ELT is due to the ability to inactivate toxic and chromophore functional groups, transform impur

28 rial stoichiometry and generally suffer from toxic and complex dopants.

29 This inhibitor was mitochondria toxic and cytotoxic to colorectal cancer cells, but not

30 s such as immune-related, infection-related, toxic and haemodynamic factors and obesity are also impo

31 We engineered split-DddA halves that are non-toxic and inactive until brought together on target DNA

32 They served as non-toxic and low cost photocatalyst.

33 ed adjuvant ipilimumab dose (ipi10) was more toxic and not superior in efficacy to HDI.

34 IAA/DNP treatment (up to 10 uM each) was non-toxic and resulted in a 3 to 16-fold increase in exosome

35 Despite their common use, they are highly toxic, and approximately half of cancer patients have tu

36 ect of the nanoparticles was reversible, non-toxic, and attributable to the binding to integrins on t

37 Yet, excess copper is extremely toxic, and is exploited as a bacteriocide in medical and

38 vailable solid that is non-explosive and non-toxic, and should find broad utility as a replacement fo

39 the sites of human pathogenic mutations and toxic antibody docking.

40 Triclosan is a frequently detected and toxic antimicrobial agent present in many consumer and i

41 composed of DNA complexed with histones and toxic antimicrobial proteins that ensnare pathogens, but

42 Topical fluralaner was 6- to 28-fold as toxic as permethrin in four pyrethroid-resistant strains

43 d synthesis and, in particular, decreases in toxic bile acids.

44 tment for severe neonatal jaundice to remove toxic bilirubin from the blood.

45 re pressure would converge to produce highly toxic blends of secondary metabolites, independent of ph

46 dation (a bile pigment), once believed to be toxic, but recently recognized as a powerful endogenous

47 ncrease in reactive oxygen species (ROS) and toxic by-products of energy metabolism which can lead to

48 These organisms are thought to produce toxic byproducts that stimulate immune-mediated damage o

49 on rate while minimizing the accumulation of toxic byproducts.

50 Gs) with varying abilities to produce highly toxic, carcinogenic aflatoxins.

51 g systemic exposure of nanocarrier delivered toxic cargoes and increasing nanoparticle concentrations

52 cause they use a relatively abundant and non-toxic catalyst to selectively deliver high-value product

53 tate degradation of superfluous, damaged and toxic cellular components.

54 microalgae have been explored for detecting toxic chemicals by employing fluorescence emissions and

55 safe and efficient capture or degradation of toxic chemicals, including chemical warfare agents (CWAs

56 o WWTFs for their efficacy in removing these toxic chemicals.

57 rsons is a priority following the release of toxic chemicals.

58 cts to reduce cholesterol uptake, preventing toxic cholesterol accumulation.

59 tal nanoparticles, which are relatively less toxic compared with those synthesized through physical o

60 ons, such as water-soluble iron (WS-Fe), are toxic components of fine particles (PM(2.5)).

61 rations induced by low levels of a bioactive/toxic compound.

62 Comparative analysis of model bioactive/toxic compounds (ouabain and CdCl(2)) demonstrates that

63 ach from the surface when they die, but some toxic compounds promote cell adhesion.

64 sucralose and the generation of potentially toxic compounds was assessed and comparatively discussed

65 quinone (<0.3 to 19 micrograms per liter) at toxic concentrations (median lethal concentration of 0.8

66 and tissue silver concentrations lower than toxic concentrations.

67 dy identifies the binding site of the highly toxic convulsant tetramethylenedisulfotetramine (TETS),

68 der unabated OW and OA, namely in regulating toxic cyanobacteria blooms on coral reefs.

69 pollution regimes in P-rich lakes will favor toxic cyanobacterial dominance, restricting future N pol

70 cheilus striatus, a specialist grazer of the toxic cyanobacterium Lyngbya majuscula.

71 he release of bioactive compounds, including toxic cyanopeptides.

72 (CDNF) protects dopaminergic neurons against toxic damage in the rodent brain and is in clinical tria

73 ing for quantifying complete classes of most toxic DBPs at sufficiently low quantification limits (ng

74 The release of their less toxic decomposition products into the blood will lead to

75 or the direct repair of the main TMZ-induced toxic DNA adduct, the O6-Methylguanine lesion.

76 e exposure of LRRK2 transgenic mice to a sub-toxic dose of MPTP resulted in severe motor impairment,

77 s stimulated new uptake route, following non-toxic doses of dielectric barrier discharge CAP.

78 ircuit that increases the free fraction of a toxic drug and thereby increases its dialytic removal.

79 soluble prefibrillar aggregates, are highly toxic due to their strong ability to seed tau misfolding

80 OTA has a chronic toxic effect and proved to be mutagenic, nephrotoxic, te

81 for three Antarctic organisms predicted low toxic effects (<5% effect to the growth or development o

82 cal benefits that outweigh treatment-related toxic effects is unknown.

83 ay until progressive disease or unacceptable toxic effects occurred.

84 Cardiovascular toxic effects of cancer therapeutics and radiation thera

85 ting protects tumor-bearing mice against the toxic effects of chemotherapy while enhancing therapeuti

86 ch might further pose a health threat due to toxic effects of free gadolinium.

87 ay is at least 10-fold more sensitive to the toxic effects of glutamate than the MTT assay.

88 This study investigated the toxic effects of polystyrene (PS) beads (0.1-10.0 mum) a

89 ng viral replication by preventing the known toxic effects of Zta overexpression.IMPORTANCE Epstein-B

90 table nature of human seminal plasma and its toxic effects on cells in culture limit the ability to s

91 nd practical concern because of their highly toxic effects on human health and ecosystems.

92 ronments, future research on their potential toxic effects on people and ecosystems is important.

93 the development of therapies that have fewer toxic effects than high-intensity chemotherapeutic regim

94 therapy led to serious and life-threatening toxic effects that were consistent with those reported w

95 Overall survival and toxic effects were also assessed.

96 The most frequent toxic effects were nausea, vomiting, or diarrhea; an asy

97 However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is compl

98 tion but, over the past decade, the arterial toxic effects, which can present as acute vasospasm, acu

99 viral effect is achievable in humans without toxic effects.

100 ral circulation, thereby avoiding off-target toxic effects.

101 ded on the grounds that it may help to avoid toxic effects.

102 asis than placebo with no apparent long-term toxic effects.

103 activity toward diacetyl and methylglyoxal, toxic electrophilic dicarbonyls.

104 ronmental health from adverse effects of the toxic element mercury and its compounds.

105 This toxic element occurs both naturally and as a result of m

106 However, the necessary inclusion of lead, a toxic element, raises a critical concern for future comm

107 Toxic elemental exposure through consumption of contamin

108 Dark:white ratios of the potentially toxic elements (As, Cr, Hg, Ni and Pb) varied from 0.9 t

109 those products with higher concentrations of toxic elements during a weight loss program could pose a

110 il ecosystem and how exposure to potentially toxic elements impact ESs, we developed a quantitative t

111 t-forward implementation to other metals and toxic elements, given the availability of target-specifi

112 ade exclusive use of nanocrystals containing toxic elements, precluding their use in biological or en

113 aily gains (ADG) result when livestock graze toxic endophyte (Epichloe coenophialum)-infected tall fe

114 rmation and maintenance of nutrient-rich/non-toxic environment.

115 gulation in FA processing and storage causes toxic FA accumulation or altered membrane compositions a

116 nsights suggest that non-haemodynamic tubulo-toxic factors, such as endotoxins and bile acids, might

117 ch systems is hindered by the requirement of toxic, flammable organic electrolytes or often costly io

118 to remember the locations of nourishing and toxic food sources for survival, a fact that necessitate

119 Methanol is highly toxic for human, so methanol detection is valuable espec

120 Aromatic compounds are generally toxic for microorganisms, which makes their production i

121 g amino acids, we find that cysteine is most toxic for mitochondria and show that elevated non-vacuol

122 investigation into Cu as both beneficial and toxic for neurobehavioral outcomes.

123 useful when the proteins to be produced are toxic for the expression system or show unusual features

124 ssential for meiotic spindle assembly but is toxic for the mitotic spindle.

125 Interstrand DNA crosslinks (ICLs) are a toxic form of DNA damage that block DNA replication and

126 recursor cells, thereby lowering potentially toxic-free intracellular iron levels and by accelerating

127 and that ALS-linked FUS mutants can cause a toxic gain of function in the cytoplasm by repressing th

128 er, we present molecular insights into a FUS toxic gain-of-function involving direct and aberrant RNA

129 inocerebellar ataxia type 1 (SCA1) through a toxic gain-of-function mechanism in the cerebellum.

130 and avoids the use of explosive reagents or toxic gases, such as CO, as the C1 synthon.

131 d hydrological shifts during MAR can release toxic, geogenic contaminants from sediments to groundwat

132 y HPLC-MS analysis to be essentially free of toxic gossypol.

133 Monitoring of toxic heavy metals in fish samples is a matter of a grea

134 Arsenic is a highly toxic heavy-metal pollutant which poses a significant he

135 rapy for porphyria disorders that accumulate toxic heme intermediates.

136 The serum haptoglobin protein (Hp) scavenges toxic hemoglobin (Hb) leaked into the bloodstream from e

137 National bans of acutely toxic highly hazardous pesticides have led to substantia

138 ns played a key role in purifying water from toxic impurities and, thus, played a role in the formati

139 issue and diffuse cytoplasmic in another but toxic in both).

140 including chemical warfare agents (CWAs) and toxic industrial chemicals (TICs), are critically import

141 Toxic, inflammatory, or hypoxic-insults to RTECs can cau

142 atocytes in response to carbon tetrachloride toxic injury.

143 on degeneration (e.g. developmental pruning, toxic insult from neurodegenerative disorder), Wallerian

144 R) may prevent organ damage from ischemic or toxic insults in animals, but clear evidence in humans i

145 t spatially constrains the metabolism of the toxic intermediate lactaldehyde.

146 Therefore, characterizing the structure of toxic intermediate oligomers plays an essential role in

147 To prevent toxic intracellular accumulation of amyloid precipitate,

148 to-date for many compounds, including highly toxic iodinated, brominated, and nitrogen-containing DBP

149 Na and, to a lesser extent, Cl were the most toxic ions to almond rootstocks.

150 ay contribute to controlling the movement of toxic ions to leaves and, therefore, can be seen as a me

151 FANCJ to suppress incompletely processed and toxic joint DNA molecules during repair of ICL-induced D

152 ping paediatric brain is more susceptible to toxic late effects of the tumour and its treatment.

153 However, the issues raised by the toxic lead element and marginal stability due to the vol

154 f DNA interstrand crosslinks (ICL), a highly toxic lesion that leads to chromosomal instability and p

155 osynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcC

156 f 160-fold higher than the recognised EC(50) toxic levels of copper in soils.

157 Millions of people are exposed to toxic levels of dissolved arsenic in groundwater used fo

158 rget organisms may be exposed to potentially toxic levels of pesticides from beef cattle feed yards.

159 Toxic levels of selenium (Se) shown to cause deformities

160 nase, without which 1-IPPs can accumulate to toxic levels that elicit precocious termination by CPF/R

161 utathione peroxidase 4 (GPX4), reduces these toxic lipid species.

162 ignalling enhances liver recovery from acute toxic liver injuries (APAP and carbon tetrachloride) by

163 nents of the observed changes, we divide bee toxic load into extent (area treated) and intensity (app

164 county-level annual estimates of total 'bee toxic load' (honey bee lethal doses) for insecticides ap

165 5%), drusen (0.8%), nonexudative AMD (0.3%), toxic maculopathy (0.1%), and hereditary dystrophy (0.04

166 pHLIP ICG is non-toxic, marks blood flow for hours after injection, and e

167 and liver disease through a gain-of-function toxic mechanism.

168 to help understand the common and underlying toxic mechanisms induced by metals.

169 that vary in severity from mild diarrhea to toxic megacolon and/or death.

170 ons of proteins and lipids via generation of toxic metabolic intermediates.

171 oHABs are characterized by the production of toxic metabolites known as cyanotoxins.

172 and discuss future directions in exploiting toxic metabolites to kill cancer cells.

173 PSS2242 is responsible for detoxification of toxic metabolites, constituting a protective system agai

174 dietary exposures to mercury (Hg), a highly toxic metal traditionally regarded as a neurotoxin, has

175 Smoking and exposure to toxic metals are risk factors for some subpopulations.

176 s vitamin D also increases the absorption of toxic metals, such as lead and cadmium.

177 tal concerns associated with the presence of toxic metals, these quantum dots are not well suited for

178 l remediation depends on their resistance to toxic metals.

179 The presence of toxic methylmercury (MeHg) in Arctic freshwater ecosyste

180 work an electrochemical immunosensor for the toxic microalgae Alexandrium minutum (A. minutum AL9T) d

181 of these foods have large concentrations of toxic minerals like As, Cd or Pb.

182 Toxic misfolded proteins potentially underly many neurod

183 d of other neurotoxicants that may share its toxic mode of action.

184 phosphorylate zidovudine and ganciclovir to toxic moieties, enabling treatment of KSHV-MCD with thes

185 productive flux, when coupled with a second toxic molecule that is more prone to slippage, the overa

186 ial barrier that also prevents free entry of toxic molecules or drugs from the blood.

187 Immunotherapy offers a potentially less toxic, more tumor-specific treatment for neuroblastoma t

188 There was no toxic mortality.

189 However, toxic MP effects may fundamentally alter ecological scal

190 eloped a new model of PD that combines a sub-toxic MPTP insult to the G2019S-LRRK2 mutation.

191 sease (HD), proteolytic processing generates toxic N-terminal huntingtin (HTT) fragments that prefere

192 n has been shown to induce the production of toxic neuronal amyloid protein and also enhance neurotox

193 ommon garter snakes (Th. sirtalis) and their toxic newt prey exhibiting hotspots of newt tetrodotoxin

194 e sequenced the Na(v) channel gene family in toxic newts and found that newts expressed Na(v) channel

195 ted whether symbiotic bacteria isolated from toxic newts could produce TTX.

196 rs are optimized for fast elimination of the toxic NO molecules.

197 The ideal gene delivery vector must be non-toxic, non-immunogenic, overcome extra- and intra-cellul

198 Controlling greenhouse gas and toxic/odorous emissions from composting offers the great

199 TDS was the most toxic of the constituents tested but could not predict t

200 t transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial oute

201 intermediates, whose structures, potentially toxic oligomerization, and interactions with cellular ch

202 e disadvantages of 1) occasional handling of toxic or pyrophoric P(III) starting materials and 2) a d

203 thesized that lengthy untreated psychosis is toxic or that it reflects a more severe form of schizoph

204 infection may downregulate ACE2, leading to toxic overaccumulation of angiotensin II that induces ac

205 Furthermore, CAR elevated toxic oxysterols in the brain of maternally exposed Dhcr

206 d by assuming equimolar toxicity to the most toxic parent; final analysis excluded degradates with li

207 t-containing RNA that can encode potentially toxic peptides, impacting neuron function and health.

208 etine has been recognized as one of the most toxic pharmaceuticals in the aquatic environment.

209 To date, however, the fate of potentially toxic plastic additives has received comparatively littl

210 yrrolizidine alkaloids (PAs) are found to be toxic pollutants emitted into the environment by numerou

211 yamine uptake deficiency and resistance to a toxic polyamine biosynthesis inhibitor methylglyoxal bis

212 iation of aryl hydrocarbon receptor-mediated toxic potencies among homologues of chrysene with struct

213 r binding is a key to accurate assessment of toxic potencies of environmental pollutants.

214 udies have pinpointed DBPs with the greatest toxic potency, analytical methods have been lacking for

215 ies and what imbues the aggregates with such toxic potential are still not yet understood.

216 Mutant DMPK mRNAs are toxic, present in nuclear RNA foci and correlated with a

217 Rather, pathology may reflect distinct toxic processes triggered by different repeat lengths ac

218 t expansion has been established to generate toxic products, mRNAs encoding the C9ORF72 protein are a

219 for disease progression; 4) assess uniquely toxic properties imparted to alphasyn upon truncation; a

220 Hsp70, are essential in the reactivation of toxic protein aggregates that occur during translation o

221 study the resulting coupled behavior between toxic protein clearance and proteopathic phenomenology.

222 ubresolution molecular complexes, such as in toxic protein oligomers associated with amyloid diseases

223 gy upregulation may help to reduce levels of toxic protein species, and thereby alleviate disease.

224 This study investigates on the presence of toxic proteins in quinoa seeds.

225 amage is often accompanied by the release of toxic proteins such as cytochrome c.

226 upregulation is able to reduce the levels of toxic proteins, ameliorate signs of disease, and delay d

227 ith known RQC pathways to prevent buildup of toxic proteins.

228 he prion-like propagation and aggregation of toxic proteins.

229 cleotide depletion, or accumulation of other toxic purine intermediates, could be more relevant.

230 ting this phenomenon, we identified a highly toxic quinone transformation product of N-(1,3-dimethylb

231 To identify toxic R-loops in the human genome, here, we map RNA:DNA

232 d hemoglobin tests involve the use of highly toxic reagents such as potassium cyanide, the polymeriza

233 tantly, this process can produce potentially toxic repeat-containing RNA that can encode potentially

234 elopment and antibody production and elicits toxic responses in the livers and kidneys of rodents.

235 esults raise concerns about the formation of toxic ring-cleavage products during the initial stage of

236 Toxic RNAs expressed from such repetitive sequences can

237 Pyrrolizidine alkaloids (PAs) are toxic secondary metabolites produced by numerous plant s

238 ode, further work is needed to develop a non-toxic, selective, and stable O(2)-to-H(2)O(2) electrocat

239 solated suppressor mutants that can tolerate toxic serine concentrations by three targeted and non-ta

240 (n = 1132), KD shock syndrome (n = 45), and toxic shock syndrome (n = 37) who had been admitted to h

241 with but distinct from Kawasaki disease and toxic shock syndrome admitted to a New York City hospita

242 ease that can have manifestations similar to toxic shock syndrome or Kawasaki disease.

243 tellation of symptoms that strongly resemble toxic shock syndrome, an escalation of the cytotoxic ada

244 State reported cases of Kawasaki's disease, toxic shock syndrome, myocarditis, and potential MIS-C i

245 with necrotizing fasciitis or streptococcal toxic shock syndrome.

246 m localized skin abscess to life-threatening toxic shock syndrome.

247 comes of death, limb loss, and streptococcal toxic shock syndrome.

248 challenge by chemically functionalizing non-toxic silicon nanocrystals with triplet-accepting anthra

249 gen and then elevate the production of tumor-toxic singlet oxygen to significantly enhance PDT.

250 economy, low E-factor, and no requirement of toxic solvents and chromatographic purification.

251 ion step is time consuming and often employs toxic solvents such as chloroform.

252 loid deposition diseases posit that the most toxic species are oligomers that form either along the p

253 , the SB-OP duo undergoes degradation to non-toxic species in the presence of Zn(2+) ions.

254 hesis that preamyloid oligomers are the most toxic species produced during IAPP amyloid formation.

255 emissions of other greenhouse gases, odorous/toxic species, and reactive compounds can affect net cli

256 lepias) species, with high concentrations of toxic steroids (cardenolides), provide a potent source o

257 glutamatergic system, leading to excessive, toxic stimulation, have been associated with AD.

258 ngal infections as well as a wide variety of toxic substances and drugs and systemic immune-mediated

259 etabolism as it is in charge of transforming toxic substances in the body.

260 nt activities while being substantially less toxic than bilirubin.

261 oxicity to the environment but they are less toxic than ionic liquids.

262 ls that are potentially more stable and less toxic than lead-containing hybrid organic-inorganic pero

263 resistant strains and not significantly less toxic than permethrin in a susceptible strain and a mild

264 d-App rat allele because human-Abeta is more toxic than rodent-Abeta and the pathogenic role of the p

265 eral years, the search toward novel and less-toxic therapeutic strategies for T-ALL/T-LBL patients ha

266 enable delivery of the most effective, least-toxic therapies.

267 Although Noctiluca blooms are non-toxic, they can cause fish mortality by exacerbating oxy

268 nd invasion, and protection against external toxic threats such as antibiotics.

269 s a severe drawback due to the employment of toxic tin hydrides to the point that "flight from the ty

270 ative stress, and m-Tyr has been shown to be toxic to a broad range of biological systems.

271 lls using a drug that would otherwise be too toxic to administer systemically.

272 a ubiquitous environmental stressor that is toxic to all lifeforms.

273 throids as a class were the most potentially toxic to benthic invertebrates, and of the 9 pyrethroids

274 verexpression of the C terminus of Spc110 is toxic to cells and correlates with its localization to t

275 s and could demonstrate that these tRNAs are toxic to cells due to their miscoding capacity in eukary

276 , activating ancillary nucleases that can be toxic to cells, necessitating mechanisms to remove cOA i

277 ective Inhibitors) compounds are selectively toxic to colorectal cancer cells with APC mutations, alt

278 on amylin, but not baboon amylin fibers, are toxic to cultured beta-cells.

279 m symptomatic prion-infected mice are highly toxic to cultured neurons, exceptionally pure intact hig

280 ough a high level of overexpression could be toxic to DA neurons.

281 se domain were replaced by alanine is highly toxic to E. coli cells.

282 sorption of fungal metabolites, which can be toxic to epithelial cells and lead to barrier dysfunctio

283 e contraction in Nematostella polyps and are toxic to fish.

284 AB569 was not toxic to human cell lines at bactericidal concentrations

285 Oxygen is both vital and toxic to life.

286 trast, gossypol and lipopolysaccharides were toxic to macrophages but not adipocytes under high conce

287 acterium and Bacillus-yet are relatively non-toxic to mammalian cells.

288 DNA double-strand breaks (DSBs) are toxic to mammalian cells.

289 rethroid insecticides are known to be highly toxic to most aquatic nontarget organisms, but little is

290 ized that, heat shock may also be especially toxic to myeloma cells by causing protein unfolding, inc

291 diatric cancer cell lines and were minimally toxic to nontumorigenic cells.

292 Inhibition of PIM kinases was toxic to PMBL cells, attenuated protein translation, and

293 erminations showed that solenopsins are more toxic to the parasite than benznidazole, the drug of cho

294 e have validated five of these SASs as being toxic (toxSASs), with neutralization by the protein prod

295 e flux and crustal enrichment factors of the toxic trace metals were augmented by factors of 2 to 4 a

296 selection step avoids the use of potentially toxic treatment procedures, and the brief hands-on time

297 accumulating non-functional and potentially toxic truncated polypeptides.

298 dominate the observed toxicity according to toxic unit (TU) assessments.

299 A new family of robust, non-toxic, water-compatible ruthenium(II) vinyl probes allow

300 in the sequestration of TCBZ and additional toxic xenobiotic metabolites.