ライフサイエンスコーパス: toxic shock syndrome

1 ections, including necrotizing fasciitis and toxic shock syndrome.

2 nes, ultimately causing a condition known as toxic shock syndrome.

3 n humans including necrotizing fasciitis and toxic shock syndrome.

4 arious diseases including food poisoning and toxic shock syndrome.

5 ins (SEs) that cause both food poisoning and toxic shock syndrome.

6 se ranging from pharyngitis to streptococcal toxic shock syndrome.

7 rotoxins (SEs) that cause food poisoning and toxic shock syndrome.

8 m isolated from a patient with streptococcal toxic shock syndrome.

9 h as necrotizing fasciitis and streptococcal toxic shock syndrome.

10 llin-resistant strains and organisms causing toxic shock syndrome.

11 ing food poisoning, bacterial arthritis, and toxic shock syndrome.

12 profound shock associated with streptococcal toxic shock syndrome.

13 me identified in patients with streptococcal toxic shock syndrome.

14 produce disease, such as food poisoning and toxic shock syndrome.

15 d as major virulence factors responsible for toxic shock syndrome.

16 sponses in the pathogenesis of streptococcal toxic shock syndrome.

17 ed with the recently described streptococcal toxic shock syndrome.

18 multiorgan failure define the streptococcal toxic shock syndrome.

19 with necrotizing fasciitis or streptococcal toxic shock syndrome.

20 l bacteremia that mimics human Streptococcal toxic shock syndrome.

21 with necrotizing fasciitis or streptococcal toxic shock syndrome.

22 ections, including necrotizing fasciitis and toxic shock syndrome.

23 ildren, which resembles superantigen-induced toxic shock syndrome.

24 tion of T cells and inflammation, leading to toxic shock syndrome.

25 e outcomes such as necrotizing fasciitis and toxic shock syndrome.

26 m localized skin abscess to life-threatening toxic shock syndrome.

27 rldwide, including necrotizing fasciitis and toxic shock syndrome.

28 ditions, including necrotizing fasciitis and toxic shock syndrome.

29 an penetrate the vaginal epithelium to cause toxic shock syndrome.

30 o life-threatening necrotizing fasciitis and toxic shock syndrome.

31 comes of death, limb loss, and streptococcal toxic shock syndrome.

32 alleles significantly increase the risk for toxic shock syndrome.

33 indings that death was due to tampon-related toxic shock syndrome.

34 7-year-old female who died of tampon-related toxic shock syndrome.

35 o mediate the symptoms collectively known as toxic shock syndrome.

36 inal mucosa, induce interleukin-8, and cause toxic shock syndrome.

37 rwhelming cytokine production, which lead to toxic shock syndrome.

38 ections to life-threatening endocarditis and toxic shock syndrome.

39 ndrome toxin-1 is a major cause of menstrual toxic shock syndrome.

40 teract with underlying immune cells to cause toxic shock syndrome.

41 class II allelic variation in streptococcal toxic shock syndrome.

42 th GAS myonecrosis who died of streptococcal toxic shock syndrome.

43 ion of CD14 by LPS can cause the often fatal toxic-shock syndrome.

44 evere systemic conditions such as septic and toxic shock syndromes.

45 on of bacterial superantigens, most commonly toxic shock syndrome-1 (TSST-1), to specific TCR Vbeta-b

46 was 11% but was much higher in patients with toxic shock syndrome (55%) and necrotizing fasciitis (58

47 with but distinct from Kawasaki disease and toxic shock syndrome admitted to a New York City hospita

48 obic, Gram-positive bacterium that can cause toxic shock syndrome after gynecological procedures.

49 nts (three with hydronephrosis), and five of toxic shock syndrome after use of the menstrual cup.

50 tellation of symptoms that strongly resemble toxic shock syndrome, an escalation of the cytotoxic ada

51 nkeys manifested a T cell activation-related toxic shock syndrome and a profound depletion of CD4+ ly

52 xin B (SEB) is a potent toxin that can cause toxic shock syndrome and act as a lethal and incapacitat

53 ens (SAg) as dangerous toxins that may cause toxic shock syndrome and death.

54 This cascade can ultimately result in toxic shock syndrome and death.

55 e of inflammatory cytokines that can lead to toxic shock syndrome and death.

56 d underlying medical conditions; 4 developed toxic shock syndrome and died (case fatality, 57%).

57 SAGs have been implicated in toxic shock syndrome and food poisoning, and they may al

58 important causative agents in staphylococcal toxic shock syndrome and food poisoning.

59 aureus group-III strains are responsible for toxic shock syndrome and have been underestimated in oth

60 auses a variety of human diseases, including toxic shock syndrome and necrotizing fasciitis, which ar

61 e disease in humans, including streptococcal toxic shock syndrome and necrotizing fasciitis.

62 rom pharyngitis to severe infections such as toxic shock syndrome and necrotizing fasciitis.

63 irulence factors and are responsible for the toxic shock syndrome and other superantigen-related dise

64 duce a massive release of cytokines, causing toxic shock syndrome and possibly death.

65 has features that overlap with myocarditis, toxic-shock syndrome and Kawasaki disease.

66 bacteremia, septic arthritis, streptococcal toxic shock syndrome, and necrotizing fasciitis) caused

67 TNF release during acute TSST1-precipitated toxic shock syndrome, and the C-terminal domain to stimu

68 rious diseases, including food poisoning and toxic shock syndrome, are termed superantigens (SAgs).

69 describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that o

70 Endometritis and toxic shock syndrome associated with Clostridium sordell

71 with necrotizing fasciitis or streptococcal toxic shock syndrome between January 1, 2013, and Decemb

72 e GAS infections, including 11 streptococcal toxic shock syndrome cases and one necrotizing fasciitis

73 he 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise.

74 ted in a number of human diseases, including toxic shock syndrome, diabetes mellitus and multiple scl

75 ylococcus aureus is a causative agent of the toxic shock syndrome disease.

76 Most strains causing toxic shock syndrome, however, produce and secrete very

77 ria that cause fatal ehrlichiosis, mimicking toxic shock syndrome in humans and mice.

78 en exotoxins that mediate food poisoning and toxic shock syndrome in humans.

79 The cause of death is a syndrome much like toxic shock syndrome in humans.

80 partial thromboplastin time in streptococcal toxic shock syndrome is associated with activation of th

81 the intensive care unit (ICU) for menstrual toxic shock syndrome (m-TSS) are lacking.

82 disease in epidemics and its resemblance to toxic-shock syndrome make an infectious etiology seem mo

83 known virulence factors in scarlet fever and toxic shock syndrome, mechanisms by how SAgs contribute

84 Menstrual toxic shock syndrome (mTSS) is a life-threatening diseas

85 Menstrual toxic shock syndrome (mTSS) is a rare but severe disorde

86 Menstrual toxic shock syndrome (mTSS) is thought to be associated

87 State reported cases of Kawasaki's disease, toxic shock syndrome, myocarditis, and potential MIS-C i

88 (n = 1132), KD shock syndrome (n = 45), and toxic shock syndrome (n = 37) who had been admitted to h

89 itis, impetigo, scarlet fever, streptococcal toxic shock syndrome, necrotizing fasciitis and myositis

90 ases of severe iGAS infection (streptococcal toxic shock syndrome, necrotizing fasciitis, septic shoc

91 Streptococcal toxic shock syndrome occurred in 29 children (5.8%), nec

92 ease that can have manifestations similar to toxic shock syndrome or Kawasaki disease.

93 igens (PTSAgs) that can cause illness, e.g., toxic shock syndrome, or synergize with a number of othe

94 um sordellii, causes a rarer but often fatal toxic shock syndrome, particularly in gynecological and

95 (GAS) necrotizing soft tissue infections and toxic shock syndrome remain high-mortality conditions.

96 sis of necrotizing soft-tissue infection and toxic shock syndrome resulting from Streptococcus pyogen

97 Streptococcal toxic shock syndrome (strep TSS) with associated necroti

98 Streptococcal toxic shock syndrome (StrepTSS) is an invasive infection

99 tic cases have been defined as streptococcal toxic shock syndrome (StrepTSS).

100 e from severe cases, including streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (N

101 S) isolates from patients with streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (N

102 Streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis ar

103 n A) is highly associated with streptococcal toxic shock syndrome (STSS) and other invasive streptoco

104 s associated with outbreaks of streptococcal toxic shock syndrome (STSS) in the United States and Eur

105 Streptococcal toxic shock syndrome (STSS) is a highly lethal, acute-on

106 Streptococcal toxic shock syndrome (STSS) is a rapidly progressing, li

107 nd is strongly associated with streptococcal toxic shock syndrome (STSS), a severe and often fatal il

108 sult in the recently described streptococcal toxic shock syndrome (STSS), which is characterized by r

109 ave been implicated in causing streptococcal toxic shock syndrome (STSS).

110 necrotizing fasciitis (NF) or streptococcal toxic shock syndrome (STSS).

111 OR, 8.64; 95% CI, 5.50-13.55), streptococcal toxic shock syndrome (STSS; OR, 11.71; 95% CI, 4.39-31.1

112 The epidemic of toxic shock syndrome that occurred in the 1970s was caus

113 een implicated in serious disease, including toxic shock syndrome, the specific pathological mechanis

114 s described that specifically promote either toxic shock syndrome toxin (TSST) 1 or staphylococcal en

115 (lukMF) genes, while 44.4% were positive for toxic shock syndrome toxin (tsst) gene.

116 on of staphylococcal enterotoxin A (SEA) and toxic shock syndrome toxin (TSST) in neat milk without s

117 us, staphylococcal enterotoxins (SE) A-E and toxic shock syndrome toxin (TSST)-1, which are associate

118 ncluding the staphylococcal enterotoxins and toxic shock syndrome toxin (TSST).

119 nicity island SaPI1 carries the gene for the toxic shock syndrome toxin (TSST-1) and can be mobilized

120 IPs to S. aureus inhibited the production of toxic shock syndrome toxin (TSST-1) and enterotoxin C3,

121 dose-dependent transcytosis in vitro, while toxic shock syndrome toxin (TSST-1) exhibited increased

122 the gram-positive model of shock mediated by toxic shock syndrome toxin (TSST-1), Mif(-/-) mice succu

123 .g., carriage of the enterotoxin A (sea) and toxic shock syndrome toxin (tst) genes and production of

124 of oxygen is necessary for the production of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus

125 The production of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus

126 he effect of O(2) and CO(2) on expression of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus

127 Toxic shock syndrome toxin 1 (TSST-1) contains a long ce

128 The superantigenic function of toxic shock syndrome toxin 1 (TSST-1) is generally regar

129 s with staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 (TSST-1) resulted in enhanc

130 Administration of the superantigen toxic shock syndrome toxin 1 (TSST-1) results in the spe

131 T2-I-A(b), is very inefficient at presenting toxic shock syndrome toxin 1 (TSST-1) to T cells, sugges

132 ne monoclonal antibodies (MAbs) specific for toxic shock syndrome toxin 1 (TSST-1), a bacterial super

133 there have been reports of the production of toxic shock syndrome toxin 1 (TSST-1), enterotoxin, and

134 Superantigens, such as toxic shock syndrome toxin 1 (TSST-1), have been implica

135 tes production of agr RNAIII, protein A, and toxic shock syndrome toxin 1 (TSST-1), particularly unde

136 r, unlike the classical enterotoxins SEB and toxic shock syndrome toxin 1 (TSST-1), the gene for SEl-

137 ught to be associated with colonization with toxic shock syndrome toxin 1 (TSST-1)-producing Staphylo

138 tigens staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 (TSST-1).

139 strain and presence of the gene encoding for toxic shock syndrome toxin 1 (TSST-1).

140 tum or pharynx of patients with KD, secretes toxic shock syndrome toxin 1 (TSST-1).

141 g., staphylococcal enterotoxin A [SEA], SEB, toxic shock syndrome toxin 1 [TSST-1]) which act both as

142 ococcal enterotoxin A (SEA), SEB, or SEC3 or toxic shock syndrome toxin 1 and a potentiating dose of

143 study the activity of superantigens such as toxic shock syndrome toxin 1 and also found that despite

144 ant Staphylococcus aureus and genes encoding toxic shock syndrome toxin 1 and Panton-Valentine leukoc

145 ode and disseminate the superantigen toxins, toxic shock syndrome toxin 1 and superantigen enterotoxi

146 ttenuated staphylococcal enterotoxin (SE) or toxic shock syndrome toxin 1 develop protective antibodi

147 mec type II, the enterotoxin A gene, and the toxic shock syndrome toxin 1 gene.

148 taphylococcal clone or structural variant of toxic shock syndrome toxin 1 is associated with Kawasaki

149 replication, and suboptimal stimulation with toxic shock syndrome toxin 1 leads to viral replication

150 staphylococcal enterotoxin B and C negative, toxic shock syndrome toxin 1 positive, and staphylococca

151 al samples positive for S. aureus (83%), and toxic shock syndrome toxin 1 was isolated from 66 strain

152 nced portions of the regions encoding mature toxic shock syndrome toxin 1 were identical in all six s

153 f staphylococcal enterotoxin A (SEA) to SEH, toxic shock syndrome toxin 1, and Panton-Valentine leuko

154 roliferation in response to the superantigen toxic shock syndrome toxin 1, as well as the proliferati

155 erum) against combinations of superantigens (toxic shock syndrome toxin 1, enterotoxins B and C, and

156 eukocidins (eg, Panton-Valentine leukocidin, toxic shock syndrome toxin 1, exfoliative toxins, and va

157 eus toxins (the enterotoxins A and B and the toxic shock syndrome toxin).

158 ere capable of attenuating the production of toxic shock syndrome toxin-1 (also under the control of

159 Responses to toxic shock syndrome toxin-1 (TSST-1) and pokeweed mitog

160 as well as the staphylococcal superantigens toxic shock syndrome toxin-1 (TSST-1) and staphylococcus

161 fine the interface between the bacterial SAG toxic shock syndrome toxin-1 (TSST-1) and the TCR, we pe

162 ee-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determin

163 The staphylococcal superantigen toxic shock syndrome toxin-1 (TSST-1) is a causative age

164 aphylococcus aureus strains that produce the toxic shock syndrome toxin-1 (TSST-1) superantigen.

165 superantigens [staphylococcal enterotoxins, toxic shock syndrome toxin-1 (TSST-1), and streptococcal

166 Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main caus

167 nical cases of TSS arise due to an exotoxin, toxic shock syndrome toxin-1 (TSST-1), elaborated by tox

168 Tst, the gene for toxic shock syndrome toxin-1 (TSST-1), is part of a 15.2

169 ram quantities of topically applied purified toxic shock syndrome toxin-1 (TSST-1), staphylococcal en

170 A major causative agent of TSS is toxic shock syndrome toxin-1 (TSST-1), which is unique r

171 teins although they elaborate high levels of toxic shock syndrome toxin-1 (TSST-1).

172 EB), staphylococcal enterotoxin C (SEC), and toxic shock syndrome toxin-1 (TSST-1).

173 We investigated whether the superantigen toxic shock syndrome toxin-1 (TSST1) could induce an ant

174 Toxic shock syndrome toxin-1 (TSST1) is a superantigenic

175 Panton-Valentine Leukocidin toxin (PVL), and toxic shock syndrome toxin-1 (tst) genes.

176 nine mutations were constructed in S. aureus toxic shock syndrome toxin-1 amino acids D120 to D130.

177 A dodecapeptide region (toxic shock syndrome toxin-1 amino acids F119-D130), rel

178 lysin streptolysin O enhanced penetration of toxic shock syndrome toxin-1 and streptococcal pyrogenic

179 The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus

180 d theories of Kawasaki disease etiology, the toxic shock syndrome toxin-1 hypothesis and the coronavi

181 Toxic shock syndrome toxin-1 induces interleukin-8 from

182 Staphylococcus aureus superantigen toxic shock syndrome toxin-1 is a major cause of menstru

183 r, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural fe

184 Toxic shock syndrome toxin-1 producing S. aureus was int

185 bond affects S. aureus biofilm formation and toxic shock syndrome toxin-1 production.

186 Toxic shock syndrome toxin-1 residue D130 may contribute

187 e, 96% of the lesional isolates produced the toxic shock syndrome toxin-1 superantigen, and most of t

188 ly express BP107 conformational epitopes and toxic shock syndrome toxin-1 superantigen-binding capabi

189 ells were stimulated with the staphylococcal toxic shock syndrome toxin-1, enterotoxin A, or enteroto

190 - and beta-toxins, but not enterotoxin A and toxic shock syndrome toxin-1, rapidly potentiated sheddi

191 The superantigenic toxins toxic shock syndrome toxin-1, staphylococcal enterotoxin

192 enough to allow for enhanced penetration of toxic shock syndrome toxin-1, whereas streptolysin O dir

193 trains of S. aureus produce the superantigen toxic shock syndrome toxin-1, which can penetrate the va

194 Toxic shock syndrome toxin-1-neutralizing antibodies wer

195 This study shows that toxic shock syndrome toxin-1-positive S. aureus is preva

196 irements similar to that for presentation of toxic shock syndrome toxin-1.

197 is, and Neisseria gonorrhoeae, as well as to toxic shock syndrome toxin-1.

198 as inhibition of T cell proliferation due to toxic shock syndrome toxin-1.

199 era toxin, staphylococcal enterotoxin A, and toxic shock syndrome toxin.

200 es (both MSSA and MRSA) carried the gene for toxic shock syndrome toxin; however, carriage of the gen

201 One isolate possessed the gene for toxic shock syndrome toxin; none had genes for exfoliati

202 anton-Valentine leukocidin, alpha-toxin, and toxic-shock syndrome toxin 1 and increased toxin product

203 Immunoblot analysis of the enterotoxins, toxic-shock syndrome toxin 1, and SpeA with antiserum pr

204 n-Valentine leukocidin, alpha-hemolysin, and toxic-shock syndrome toxin 1, in both methicillin-sensit

205 lococcus aureus enterotoxins (S.E.) A-I, and toxic-shock syndrome toxin TSST-1 act as superantigens t

206 e of inflammatory cytokines that can lead to toxic shock syndrome (TSS) and death.

207 Toxic shock syndrome (TSS) and other superantigen-mediat

208 erantigens (PTSAgs) that are associated with toxic shock syndrome (TSS) and staphylococcal food poiso

209 creted virulence factors sufficient to cause toxic shock syndrome (TSS) in the animals.

210 Toxic shock syndrome (TSS) is a clinical consequence of

211 Toxic shock syndrome (TSS) is a multi system disorder re

212 Toxic shock syndrome (TSS) is an acute onset illness cha

213 Toxic shock syndrome (TSS) is caused by staphylococcal a

214 Toxic shock syndrome (TSS) may be mediated by superantig

215 Lethal toxic shock syndrome (TSS) results from the MHC class II

216 uced by concentrations of the staphylococcal toxic shock syndrome (TSS) toxin 1 (TSST-1) and the stre

217 Despite knowledge of the effects of toxic shock syndrome (TSS) toxin 1 (TSST-1) on the adapt

218 During toxic shock syndrome (TSS), bacterial superantigens trig

219 G) is sometimes administered for presumptive toxic shock syndrome (TSS), but its frequency of use and

220 icated in several serious diseases including toxic shock syndrome (TSS), Kawasaki disease, and sepsis

221 Many cases of neonatal toxic shock syndrome (TSS)-like exanthematous disease bu

222 nd compared with isolates from patients with toxic shock syndrome (TSS).

223 eins compared to isolates from patients with toxic shock syndrome (TSS).

224 tening consequences typically encountered in toxic shock syndrome (TSS).

225 egs) might be beneficial in diseases such as toxic shock syndrome (TSS).

226 rome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS).

227 olonizer of the nose and is a major cause of toxic shock syndrome (TSS).

228 of inflammatory molecules and potentially to toxic shock syndrome (TSS).

229 ium or serum or in vivo in a rabbit model of toxic shock syndrome using DNA microarrays.

230 esis, a strain recovered from a patient with toxic shock syndrome was serially passaged for 6 weeks,

231 iseases, including necrotizing fasciitis and toxic shock syndrome, were analyzed.

232 Staphylococcal superantigens cause toxic shock syndrome, which is characterized by massive

233 V-2 infection, shares clinical features with toxic shock syndrome, which is triggered by bacterial su

234 ained from seven patients with streptococcal toxic shock syndrome who received IVIG therapy, and the

235 g high-risk or protection from streptococcal toxic shock syndrome with a strong protection conferred