ライフサイエンスコーパス: toxicological

1 itivity of parameters on the model output of toxicological activity was examined across possible rang

2 HVO showed significant toxicological advantages over all other fuels.

3 thods should be more suitable for systematic toxicological analysis (STA).

4 es of three proficiency tests for systematic toxicological analysis and of 103 authentic human urine

5 Of great relevance, our preliminary toxicological analysis indicates that GEBR-32a is not cy

6 racteristics, which allows a more systematic toxicological analysis.

7 bes a sudden death with negative autopsy and toxicological analysis.

8 Biochemical, toxicological and biophysical methods enable the deconvo

9 structure-activity relationships by linking toxicological and chemical mechanistic insights to the i

10 ight major polymer types, according to their toxicological and chemical signatures using in vitro bio

11 Since toxicological and cytological measurements did not highl

12 their fate, as well as their (still unknown) toxicological and ecotoxicological properties.

13 ied by awareness about their related adverse toxicological and environmental impacts.

14 impact of engineered nanoparticles (NPs) in toxicological and environmental media are driven by comp

15 ty-adjusted life years lost, using available toxicological and epidemiological information.

16 tends beyond sample storage for analysis, as toxicological and exposure studies conducted at room tem

17 The toxicological and mutagenic properties as well as the fa

18 stances across multiple media, including non-toxicological and non-chemically deleterious effects.

19 s of PoP and PoPx, further investigations in toxicological and sensory aspects of PoP and PoPx should

20 We showed that in a toxicological application, metabolic monitoring yields q

21 Further research included studies on GSH, toxicological aspects (the concept of "redox cycling"),

22 identified the following physicochemical and toxicological aspects as well as knowledge gaps that sho

23 One of the toxicological aspects of food additives is evaluation of

24 o nutritional quality, shelf-life extension, toxicological aspects, legislation pertaining to food ir

25 Incorporating C. elegans toxicological assays as part of a battery of in vitro an

26 iated with these models pose a challenge for toxicological assays to accurately report treatment outc

27 uctures of an arsenolipid is pivotal for its toxicological assessment and in understanding the arseni

28 that ATS were already viable approaches, for toxicological assessment of one or more end points in th

29 A toxicological assessment was performed with fathead minn

30 usually performed as a part of a traditional toxicological assessment; however, it often requires add

31 modified plants is explained, and aspects of toxicological assessments are discussed, especially the

32 pports further quantification approaches and toxicological assessments compared to nontarget investig

33 However, in toxicological assessments, controversies and uncertainti

34 ons of airborne microplastics guiding future toxicological assessments.

35 In the field of toxicological bioassays, the latest progress in Raman sp

36 Moreover, the putative toxicological burden is unknown.

37 c role of soluble p17 species in HAND, their toxicological capability was evaluated in vivo.

38 in order to link their chemical evolution to toxicological changes.

39 el (ULSD) fuel on the physical, chemical and toxicological characteristics of diesel particulate matt

40 and 4% oxygen levels on physicochemical and toxicological characteristics of particulate emissions f

41 This can be problematic because toxicological characterization is lacking for many emerg

42 etabolites is a sensible alternative for the toxicological characterization of parent molecules vs. m

43 gen detection methods in order to guide post-toxicological chemical assessments.

44 r, is now detrimental as it enhances risk to toxicological compounds harbored by modern carrion resou

45 s of 56 and 29 ng/g, which are equivalent to toxicological concentrations of 123 and 18 ng WHO-TEQDL-

46 etables was estimated using the threshold of toxicological concern (TTC) approach.

47 itude below the long-term daily threshold of toxicological concern (TTC) of 1.5 mug/g and the potenti

48 pecific migration limits (SML) and threshold toxicological concern (TTC) recommended values according

49 n the marine environment and OH-PBDEs are of toxicological concern and are therefore of interest to m

50 ficult to identify which compounds may be of toxicological concern and should be prioritized for furt

51 No toxicological concern was associated to mycotoxins expos

52 ed international guidelines, DBPs of greater toxicological concern were observed in high concentratio

53 seabird eggs from the Canadian Arctic are of toxicological concern.

54 nariol may contaminate food and feed raising toxicological concerns due to their estrogenicity.

55 centrations, many of them raise considerable toxicological concerns, particularly when present as com

56 n Se-Hg interactions, considers not only the toxicological consequences of Hg exposure but also the b

57 ation of action), concerns over the possible toxicological consequences of protein haptenization have

58 sponse in the context of pharmacological and toxicological constraints.

59 and lead should play an important role in a toxicological context.

60 enated byproducts of PPCPs that have limited toxicological data and significant uncertainty with rega

61 city of oil has generally relied on existing toxicological data for a relatively few standard test sp

62 It is shown in this essay how some specific toxicological data has been misused by those aiming to d

63 Given the lack of toxicological data on palytoxins by inhalation exposure,

64 A correlation of the toxicological data with physicochemical parameters of MO

65 re still to be set due to the lack of proper toxicological data.

66 g metabolites and pathways, governmental and toxicological databases, pharmacology resources, and bio

67 also compared to known in vitro and in vivo toxicological effect concentrations.

68 However, considering the toxicological effect of arsenic and the oxidative instab

69 The substrate was used for probing toxicological effect of herbicide atrazine on the algae'

70 life-history trait interactions underlying a toxicological effect on population growth rate, should b

71 The toxicological effects of arsenicals depend on their oxid

72 Hypotheses for toxicological effects of cadmium (Cd), arsenic (As), and

73 volatiles, antimicrobials, as well as on the toxicological effects of durian fruit consumption.

74 In addition to the direct toxicological effects of elevated metals and reduced pH,

75 ase, coastal food webs may be at risk to the toxicological effects of increased methylmercury burdens

76 odel to characterise the pharmacological and toxicological effects of LiCl and VPA using gene express

77 in metallodrug development and beyond to the toxicological effects of metal ions more generally.

78 nteractions between nanoparticles change the toxicological effects of single ENMs in unexpected ways.

79 hroughput examination of the therapeutic and toxicological effects of target compounds in realistic t

80 odel for studying the cellular and molecular toxicological effects on the liver after chronic exposur

81 Toxicological effects related to uranium (natural, enric

82 more, evaluation of potential off-target and toxicological effects, as well as relevant in vitro ADME

83 etabolic vulnerability, as well as potential toxicological effects, inherent in the more potent prima

84 t water quality and introduce potential (eco)toxicological effects.

85 o correlate these with uptake efficiency and toxicological effects.

86 he environment and might then jointly elicit toxicological effects.

87 ing new testing methods to better understand toxicological effects.

88 ounds that are implicated in a wide range of toxicological effects.

89 with SWCNTs as well as suppress their known toxicological effects.

90 hensive screen, 5-HTP SR was devoid of overt toxicological effects.

91 c (S)-NFL leads to much higher than presumed toxicological effects.

92 de novel insights into identifying potential toxicological end points and molecular mechanisms, often

93 Toxicological end points, including mortality, hatching

94 rtebrate model in conjunction with assessing toxicological end points.

95 AA); this rank order was observed with other toxicological end points.

96 ly uninformative and potentially insensitive toxicological end points.

97 er the interaction of essential nutrients on toxicological end points.

98 tem cell-derived hepatocytes demonstrate all toxicological endpoints examined, including steatosis, a

99 ate the potential general toxicity (based on toxicological endpoints selected) and toxicokinetics of

100 er guidelines for PFAAs, including choice of toxicological endpoints, uncertainty factors, and exposu

101 was also confirmed during in vitro cellular toxicological evaluation of LCPM for the case of polyure

102 a correct identification, quantification and toxicological evaluation of the respective metabolites,

103 The toxicological evaluation performed on rats did not show

104 w of migration of monomers and additives and toxicological evaluation.

105 Our findings indicated that rigorous toxicological evaluations must be carried out prior to c

106 safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase

107 t it can be used to propose THDCs for future toxicological evaluations.

108 o can be a valuable complement to inhalation toxicological evaluations.

109 ection in indoor environments and increasing toxicological evidence suggesting a potential for advers

110 Recent toxicological evidence suggests that FM550 may be endocr

111 transparency, efficiency, and acceptance of toxicological evidence, with benefits in terms of reduci

112 evaluated by investigating the oxidative and toxicological evolution of TiO(2) and SiO(2) nanoparticl

113 netics, degradation chemical mechanisms, and toxicological evolution of two OPFRs (2-ethylhexyl diphe

114 Further epidemiological and toxicological examinations of likely biological pathways

115 ure to susceptible populations; and e) using toxicological findings for risk assessment and remediati

116 United States, we have established that the toxicological footprint (TF) increased by 3.3% (88.4 Mt)

117 re-cast predefined molecular pathways into a toxicological framework and (2) provide a data-driven, u

118 ydes and possess important physiological and toxicological functions in areas such as CNS, metabolic

119 RA focuses on management of a toxicological hazard in a specific exposure scenario, wh

120 We also address the toxicological impact and the limitations in translating

121 temperature and mechanical stress affect the toxicological impact of tire leachates.

122 rning specific studies on bare NPs and their toxicological impact on cells.

123 30%, <450 nm) has the potential for stronger toxicological impacts relative to those of other Cu mine

124 However, little is known about their toxicological impacts.

125 This investigation assessed the aquatic toxicological implications of copper oxide (CuO) nanosph

126 required to fully understand the levels and toxicological implications of the identified metabolites

127 tribromoethene has been demonstrated to show toxicological implications.

128 srepresent exposure concentrations and their toxicological implications.

129 hemical property, usage characteristics, and toxicological information are available.

130 There is a lack of publically available toxicological information for the main contaminant 4-met

131 cts (DBPs) in drinking water; however, their toxicological information is scarce.

132 als were entered into commercial use without toxicological information.

133 r of assays to be performed to gain required toxicological insight.

134 Hence, the toxicological interaction between OA and contaminants co

135 ore this scenario, we probe the chemical and toxicological interactions of nanosilver (n-Ag) and nano

136 As part of forensic toxicological investigation of cases involving unexpecte

137 e formed in HepG2 cells that warrant further toxicological investigation, particularly since catechol

138 death despite comprehensive pathological and toxicological investigation.

139 neurological manifestations was subjected to toxicological investigations but was found to have no sp

140 ication of free nanoparticle release and the toxicological investigations of the released particles f

141 Yet, traditional toxicological investigations resolve only recent Se expo

142 of concept, our workflow was applied to the toxicological issue of the oxidation of dietary polyunsa

143 show that NgR1-Fc does not have preclinical toxicological issues in healthy animals or safety concer

144 g an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhib

145 al tool to systematically integrate existing toxicological knowledge from a mechanistic perspective t

146 ts should strategically attempt to fill this toxicological knowledge gap so human health risk assessm

147 l drugs were below typical physiological and toxicological levels.

148 lls can identify potential chemical targets, toxicological liabilities and mechanisms useful for eluc

149 (Al and probably As), without reaching their toxicological limits.

150 ividual PAHs, and we describe the paucity of toxicological literature for many of these compounds.

151 , but biological evidence is lacking and its toxicological mechanism remains unclear for the disease

152 eplete antioxidants in vivo, is a prevailing toxicological mechanism underlying the adverse health ef

153 Despite vast research, the toxicological mechanisms relating to adverse human healt

154 lular perturbations associated with relevant toxicological mechanisms.

155 tes, enzymes, hormones, and blood cells) and toxicological (metals and minerals) variables.

156 ncy Center for the Evaluation of Alternative Toxicological Methods developed the Integrated Chemical

157 Daphnia pulex is a widely used toxicological model and is known for its sensitivity to

158 elegans is used extensively as a medical and toxicological model organism.

159 We present a simple toxicological model that can explain t(2) scaling.

160 e models of ion speciation (WHAM VI) and eco-toxicological models such as the biotic ligand model (BL

161 t reliable cell sources for pharmacological, toxicological or metabolic studies.

162 mechanistic and cellular events underlying a toxicological outcome allows the prediction of impact of

163 s as a tool to identify mechanisms affecting toxicological outcomes among related compounds.

164 covery of compound 41, which showed improved toxicological outcomes at similar exposure levels to com

165 ystems creates complex mixtures with unknown toxicological outcomes.

166 antifying the trend of the physiological and toxicological parameters of the model.

167 Following treatment, toxicological parameters reflecting distinct mechanisms

168 bolic and lipidomics datasets with classical toxicological parameters we developed a hypotheses free,

169 Standard toxicological parameters were assessed.

170 A "toxicological pathway color code model" is introduced to

171 Efforts in many countries have focused on a toxicological pathway-based vision for human health asse

172 PAHs usually elicit similar toxicological pathways but do so with varying levels of

173 logical processes involved in the underlying toxicological pathways can be implemented in a tiered sc

174 ve transcriptomic evaluation across multiple toxicological pathways following exposure to the SPMD ex

175 plied technology allowing many insights into toxicological pathways of environmental contaminants.

176 From a toxicological perspective, the linkages between maternal

177 This work provides a toxicological platform to study mammalian aging and sugg

178 dynamic cell state trajectories and estimate toxicological points of departure.

179 a great importance from the nutritional and toxicological points of view.

180 The Toxicological Prioritization Index (ToxPi) was developed

181 The agency also developed a toxicological prioritization tool, ToxPi, to facilitate

182 ngineer a pharmacophore in order to overcome toxicological problems while maintaining iron clearing e

183 Compound 27 stands out due to its favorable toxicological profile and physicochemical properties, wh

184 ss the recent knowledge regarding thebaine's toxicological profile available for the assessment of po

185 receptor agonists with a pharmacological and toxicological profile compatible with clinical developme

186 non-human primate spinal cord injury and its toxicological profile have not been described.

187 ay a role in the overall pharmacological and toxicological profile of metallodrugs.

188 has been paid to the studies describing the toxicological profile of PtNPs with an attempt to draw c

189 on by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation.

190 h solubility in aqueous media, an acceptable toxicological profile, and oral efficacy.

191 es demonstrate excellent pharmacokinetic and toxicological profiles and dramatic antitumour efficacy

192 notechnology research community and produced toxicological profiles for selected ENMs, as well as imp

193 microarrays and RNA-sequencing technologies, toxicological profiles of contaminants could be identifi

194 In this review, we summarize the in vivo toxicological profiles of different nanomaterials, inclu

195 ge of the mechanism of formation, levels and toxicological profiles of the chemical products in the a

196 ut remains limited due to uncertainty in the toxicological profiles of the nanoparticles (NPs).

197 = 140 nM) and favorable pharmacokinetic and toxicological profiles.

198 targeted potency, pharmacokinetic (PK), and toxicological profiles.

199 macological properties and their preliminary toxicological profiles.

200 ifferences which may explain their different toxicological profiles.

201 ols both in terms of biological activity and toxicological profiling in vitro and in vivo.

202 /A1 to -5 have distinct in vitro and in vivo toxicological properties and that, unlike those for BoNT

203 fining the compounds to improve efficacy and toxicological properties for efficient blocking of malar

204 formation on the complex physicochemical and toxicological properties of both toner powders and print

205 pomers could improve the pharmacological and toxicological properties of drugs and provide mechanisti

206 vers which determine the pharmacological and toxicological properties of gapmer ASOs.

207 significantly affect the physicochemical and toxicological properties of LCPM released during thermal

208 to study the phytochemical constituents and toxicological properties of seagrasses when considering

209 This may affect the physiological or toxicological properties of the treated food.

210 armacokinetic, in vivo efficacy, safety, and toxicological properties, compound 37 was selected for f

211 However, some NPs have toxicological properties, making these materials potenti

212 A metabolic and toxicological re-evaluation was performed after 6 and 12

213 The toxicological relevance and widespread occurrence of fat

214 antioxidants to an aquatic species and imply toxicological relevance for dissipated tire rubber resid

215 nal bioanalysis might reveal an even greater toxicological relevance of HPCs.

216 To understand the toxicological relevance of the OH-HBQs, we studied the i

217 Toxicological research in the 1930s gave the first indic

218 that this new biosensor is suitable for lead toxicological research in vitro and in vivo, and will pa

219 ted in the United States National Center for Toxicological Research Liver Toxicity Knowledge Base (NC

220 g development stage, the National Center for Toxicological Research of the US Food and Drug Administr

221 Toxicological research suggests that coarse particles (P

222 This advance is critical for biomedical and toxicological research, as well as in fundamental studie

223 cell population in the overall governance of toxicological response following exposure to a panel of

224 ts were visualized in radar charts to assess toxicological response patterns allowing the comparison

225 In vitro toxicological response to As varies substantially, deter

226 SCs) enable the study of pharmacological and toxicological responses in patient-specific cardiomyocyt

227 s, but its contribution toward heterogeneous toxicological responses is poorly understood.

228 formation System (IRIS) completed an updated toxicological review of dichloromethane in November 2011

229 onmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in Septe

230 uman health effects of TCE in the U.S. EPA's toxicological review.

231 umption of these waters does not represent a toxicological risk for an adult.

232 Our investigation suggests a toxicological risk of metal oxide NP pollution in the aq

233 rrogates to investigate the aqueous fate and toxicological risk of metal oxide NPs associated with wa

234 tion of toxic As species by plants suggested toxicological risk to higher organisms known to utilize

235 chemicals in their overall human and animal toxicological risk.

236 l value of the mushroom, as well as possible toxicological risks associated with its consumption.

237 However, little is known about the toxicological risks of the ingredients used.

238 echanisms against pathogens, incurring lower toxicological risks than conventional agrochemicals.

239 kinetic modeling aided in characterizing the toxicological role of the complex metabolism and multipl

240 ogy of kidney and liver, providing the first toxicological safety data.

241 on human leukaemic U937 cells and sufficient toxicological safety on normal human white blood cells w

242 adverse outcome pathway (AOP) concept in the toxicological sciences.

243 bstacle to the development of cost-effective toxicological screening methods for engineered nanomater

244 t laboratories to facilitate high-throughput toxicological screening of pharmaceutical agents and tre

245 NBP assays are used in the toxicological screening of pharmaceutical compounds, det

246 Forensic and clinical toxicological screening procedures are employing liquid

247 Despite their widespread use for toxicological screening, biomedical research and pharmac

248 a novel Bayesian probabilistic algorithm for toxicological screening.

249 s in the aquatic environment differ in their toxicological sensitivity to the various chemicals they

250 y systems indicating activation of different toxicological signaling pathways is one of the paramount

251 interdependent effects for the activation of toxicological signaling pathways.

252 Assessing the toxicological significance of complex environmental mixt

253 aw attention to the ubiquity, diversity, and toxicological significance of fungal VOCs as well as som

254 th broad coverage of chemical and biological/toxicological space.

255 ing, selection of appropriate in vivo model, toxicological studies (including toxin production) and d

256 New epidemiological and toxicological studies addressing the potential health im

257 Classical toxicological studies are effective for characterizing p

258 nsortia, intramural research activities, and toxicological studies being conducted by the National To

259 extrapolating synergy observations from (eco)toxicological studies done at high exposure levels.

260 omaterials for various applications, in vivo toxicological studies for evaluating the potential hazar

261 ted particles (PEPs) continues to grow, most toxicological studies have not used the actual PEPs but

262 Toxicological studies have reported that linuron acts as

263 e, making it more suitable for molecular and toxicological studies in C. elegans.

264 s from metal devices as well as guidance for toxicological studies in humans.

265 n the removal of these lesions and for human toxicological studies in the future.

266 urther profiling, but, unfortunately, in GLP toxicological studies it showed liver findings in rat an

267 Toxicological studies must also be carried out because t

268 gn and interpretation of pharmacological and toxicological studies on the effects and disposition of

269 Publicly available toxicological studies on wastewaters associated with unc

270 Detailed preclinical pharmacokinetic and toxicological studies reveal no observable drawbacks.

271 Toxicological studies revealed that repetitive injection

272 und dental implants and will help in guiding toxicological studies to determine the biological signif

273 ing models for assessing epidemiological and toxicological studies to reach consensus on probabilitie

274 to measure concentrations typically used in toxicological studies, and uses inexpensive, commerciall

275 are increasingly used in pharmacological and toxicological studies, but it is often overlooked that i

276 ish (Danio rerio) is a widely used model for toxicological studies, in particular those related to in

277 omedical applications, and for metabolic and toxicological studies, is a cutting-edge research topic.

278 Polychaetes are frequented in toxicological studies, one reason being that some member

279 sed therapeutics and for pharmacological and toxicological studies.

280 cies place considerable reliance on nonhuman toxicological studies.

281 gical advance with potential applications in toxicological studies.

282 ular redox changes induced by xenobiotics in toxicological studies.

283 spensable quantitative tool for clinical and toxicological studies.

284 icator of PM toxicity in epidemiological and toxicological studies.

285 This assay was successfully applied to a toxicological study.

286 these results, prior studies, and extensive toxicological support, the association between PM2.5 and

287 An emerging body of evidence points to the toxicological susceptibility of aquatic reptiles to Hg e

288 opment of reliable and efficient methods for toxicological testing and investigation of nano-bio inte

289 and West Virginia) that routinely performed toxicological testing on drivers involved in such crashe

290 and used in prioritization for more in-depth toxicological testing.

291 at elevated Se concentrations are also known toxicological threats to aquatic animals, we performed a

292 s are existing for the analytes, both EFSA's toxicological threshold of concern (TTC) and sum of olig

293 the total sum of migrating oligomers and on toxicological threshold-of-concern.

294 tions are declining and how levels relate to toxicological thresholds and indices of health like infe

295 tant when exposure values were compared with toxicological thresholds in a risk characterization stud

296 ioaccumulation of Hg to levels that approach toxicological thresholds in at least one apex predator.

297 of reconciling multiple available values of toxicological thresholds into a single outcome.

298 data on IHs with publicly available data on toxicological transcriptomics from propranolol exposure,

299 ther, for substances for which there is good toxicological understanding, a regulatory approach based

300 a great importance from the nutritional and toxicological view.