ライフサイエンスコーパス: toxin

1 (antitoxin adds three AMPs to Tyr104 of the toxin).

2 (PA), the cell-binding component of anthrax toxin.

3 ecific glycan binding characteristics of the toxin.

4 uce the sensitivity of WCR larvae to a Cry3A toxin.

5 ts with the receptor-binding domain D of the toxin.

6 the protein delivery machinery of diphtheria toxin.

7 c bacterium that can also produce diphtheria toxin.

8 t also not introduce a potential allergen or toxin.

9 th, while the HipB antitoxin neutralizes the toxin.

10 neffective against strains that lack anthrax toxin.

11 om proteolysis, preventing release of active toxin.

12 d the way that the antitoxin inactivates the toxin.

13 e channel functionally arrested by tarantula toxin.

14 as antigenic methods are able to detect free toxin.

15 subtype-selective anti-M(1)AChR snake venom toxin.

16 antitoxin is degraded liberating the active toxin.

17 er risk and tissue damage from other inhaled toxins.

18 hey function as decoys to mitigate bacterial toxins.

19 variants at three key positions against two toxins.

20 e gene mutations, infections, or exposure to toxins.

21 amino acids, lipids, bile acids, and uremic toxins.

22 hat serve as decoys for bacterially produced toxins.

23 ulfate (IS) is one of the most potent uremic toxins.

24 l epithelium due to the production of potent toxins.

25 comparing the structures of lethal and edema toxins.

26 ulence effect of Bacillus thuringiensis (Bt) toxins.

27 ect from cell death induced by mitochondrial toxins.

28 nd the risk of contamination with viruses or toxins.

29 (WTIgP) as a reactibody for organophosphorus toxins.

30 vironments and defence against pathogens and toxins.

31 ys does not explain the lethality of anthrax toxin(1,2).

32 were deoxynivalenol-3-glucoside (63%), HT-2 toxin (15%), and tenuazonic acid (13%).

33 otection against MRSA strains encoding alpha-toxin(4)-a pore-forming toxin that binds the metalloprot

34 The testing algorithm resulted in 34 GDH(+)/toxin(+), 53 GDH(-)/toxin(-), and 124 GDH(+)/toxin(-) sa

35 the secretion of one or more AB-type toxins: toxin A (TcdA), toxin B (TcdB) and the C. difficile tran

36 Serum toxin A- and B-specific neutralizing antibodies were mea

37 greater serum antitoxin IgA and IgG against toxins A (P = .02 for both) and B (P = .009 and .008, re

38 diff Quik Chek Complete (Quik Chek), Premier Toxins A and B, and Clarity.

39 ges of genetically and chemically detoxified toxins A and B.

40 The Singulex Clarity C. diff toxins A/B (Clarity) assay is an automated, ultrasensiti

41 eshold (C(T) ), and Singulex Clarity C. diff toxins A/B (Clarity) concentrations between groups with

42 how neuronal channels are blocked by protein toxins, a uniporter interaction domain on MICU1 binds to

43 The pore binding toxins aconitine and veratridine block peak currents of

44 al conserved lysine residues by co-expressed toxin-activating acyltransferases.

45 spore germination and outgrowth, growth, and toxin activity in a dose-dependent manner in vitro In a

46 The toxin also targets DARC on the endothelium, contributing

47 point an ancestral gene giving rise to a new toxin and functionally characterize both genes in the sa

48 nfants vs term infants, except for pertussis toxin and pneumococcal serotypes 4 and 19F after the pri

49 oth its direct antimicrobial activity (e.g., toxin and viral neutralization) and its ability to enhan

50 gative bacteria confers innate resistance to toxins and antibiotics.

51 ghlights the association and co-evolution of toxins and antitoxins.

52 e in soil habitats contaminated with various toxins and are best characterized for their bioremediati

53 rapidly evolved practical resistance to Cry3 toxins and Cry34/35Ab, the only Bt toxins in commerciall

54 eria use virulence factors, such as secreted toxins and effector proteins, to manipulate host cellula

55 We hypothesized that elevated stool toxins and infection with ribotype 027 associate with se

56 polymers have shown promise as inhibitors of toxins and other pathogens, and they are important compo

57 evolutionary origins of potential allergens, toxins and parasites, and how they might have influenced

58 AB(5) bacterial toxins and polyomaviruses induce membrane curvature as a

59 rate the clearance of drugs, metabolites, or toxins and reverse the decreased expression under diseas

60 hm resulted in 34 GDH(+)/toxin(+), 53 GDH(-)/toxin(-), and 124 GDH(+)/toxin(-) samples, of which 39 w

61 nol, fumonisin B1, zearalanone, T-2 and HT-2 toxin) and emerging mycotoxins (enniatins, beauvericin,

62 ding direct protein output assessment (delta-toxin), and cytotoxicity against human keratinocytes (Ha

63 /TakA (antitoxin phosphorylates Ser78 of the toxin), and HepT/MntA (antitoxin adds three AMPs to Tyr1

64 1 lacks sequence homology to any other known toxin, and the receptor-binding domain 2 is completely a

65 rne particles such as microbes, metabolites, toxins, and fragments of microorganisms are present ubiq

66 serving as scavengers that can bind multiple toxins, and improve the survival of mice infected with M

67 t could be engineered using a combination of toxin-antidote and CRISPR components, each of which are

68 Here, we introduce the Toxin-Antidote Recessive Embryo (TARE) drive.

69 nking of the microelectrode surface and HT-2 toxin antigen binding fragment of antibody (anti-HT2 (10

70 Four commercial real-time PCR tests, toxin antigen detection by enzyme immunoassay (EIA), tox

71 tic elements (MGEs), which encode virulence, toxin, antimicrobial resistance, and other metabolic fun

72 Of the ~80 putative toxin-antitoxin (TA) modules encoded by the bacterial pa

73 t are reminiscent of those typically seen in toxin-antitoxin (TA) operons.

74 ug resistance have previously been linked to toxin-antitoxin (TA) systems.

75 ese questions were investigated for a type I toxin-antitoxin system (AapA1-IsoA1) expressed from the

76 Here, we describe the AtaT2 toxin from a toxin-antitoxin system from Escherichia coli O157:H7.

77 Toxin-antitoxin systems are found in many bacterial chro

78 Using bacterial toxin-antitoxin systems as a model, we screened a combin

79 r detoxification; antimicrobial peptides and toxin-antitoxin systems associated with symbiosis, immun

80 Though thousands of various toxin-antitoxins pairs have been predicted bioinformatic

81 T-2 and its major metabolite HT-2 toxin are naturally occurring contaminants in cereals, w

82 rate that tissue and host specificity of the toxin are related to specific glycan binding characteris

83 Bacteria and their toxins are associated with significant human morbidity a

84 Lethal and edema toxins are critical virulence factors of Bacillus anthra

85 onal autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins that translocat

86 Toxin complex (Tc) toxins are virulence factors of pathogenic bacteria.

87 ool samples were tested by an ultrasensitive toxin assay (clinical cutoff, 20 pg/mL).

88 Pore-forming toxins associated with S. aureus EVs were critical for N

89 on microscopy in a drug-induced (sea anemone toxin, ATXII) Na(+) channel GOF isolated heart model and

90 one or more AB-type toxins: toxin A (TcdA), toxin B (TcdB) and the C. difficile transferase toxin (C

91 innati, OH, USA) for use in detection of the toxin B (tcdB) gene from toxigenic C. difficile The Revo

92 tor-binding site in Clostridioides difficile toxin B (TcdB), which binds the human receptor Frizzled.

93 Binding measurements performed on cholera toxin B subunit homopentamer (CTB(5)) and nanodiscs cont

94 membrane, and nanodomains induced by cholera toxin B.

95 e in mice of either sex either by diphtheria toxin-based ablation of >50% of mature DG granule cells

96 The voltage-sensing domain targeting toxin BDS-I increases Na(V)1.7 but decreases NaChBac pea

97 ric proteins composed of an Fv and a protein toxin being developed for cancer treatment.

98 roadens the known target specificity of GNAT toxins beyond the earlier described isoleucine and formy

99 n mice through the production of B. fragilis toxin (BFT).

100 abolism underlies sensitivity to the biliary toxin biliatresone and may account for the reported asso

101 h sensitivity to the plant-derived BA-linked toxin biliatresone.

102 of-concept toxicity studies with the biliary toxin, biliatresone, and the bile acid, glycochenodeoxyc

103 d side chains, located ~60 angstrom from the toxin binding sites.

104 C/B) has been proposed to also contribute to toxin binding to neurons by interacting with lipid membr

105 f these systems are mostly well defined, the toxins' biological activity and expression conditions ar

106 ons, and, more recently, glabellar botulinum toxin, BoNT, injections.

107 Among these toxins, BoNT/B is one of the two types approved for medi

108 rum IgM and mucosal IgA response against the toxin, but a low serum IgG response, which is associated

109 to the three major classes of secreted SVMP toxins by sequential removal of a membrane-tethering dom

110 we show that ensilication stabilizes tetanus toxin C fragment (TTCF), a component of the tetanus toxo

111 MAPT/tau gene and exposure to environmental toxins can increase the risk of PSP.

112 fe threatening effects of drugs of abuse and toxins can occur either by pharmacodynamic (PD) approach

113 s (TCP), and are able to acquire the cholera toxin-carrying CTX phage.

114 lied for G(i)alpha GTP-loading and pertussis toxin-catalyzed ADP-ribosylation of G(i)alpha, for which

115 (+) samples, and 95.3% agreement with GDH(+)/toxin(-)/CCNA(-) samples.

116 in B (TcdB) and the C. difficile transferase toxin (CDT)(2).

117 d by LF show a greater resistance to anthrax toxin challenge.

118 Toxin complex (Tc) toxins are virulence factors of patho

119 copy (cryo-EM) structure of CDT, a bipartite toxin comprised of the proteins CDTa and CDTb.

120 later with higher cell abundances and higher toxin concentration in the seston (respectively, about 1

121 lly repeated using different contaminant and toxin concentrations, which can make studies prohibitive

122 model, the transmembrane delivery of a split-toxin construct potently inhibits the growth of xenograf

123 N fertilization supply will increase the Bt toxin content in transgenic Bt rice, especially under el

124 sion of the virulence cascade, including the toxin coregulated pilus (TCP), and are able to acquire t

125 Here we analyzed resistance to Bt toxin Cry1Ac in a field-derived strain of pink bollworm

126 resistance to transgenic cotton producing Bt toxin Cry2Ab in India, but not in the United States.

127 the retrograde tracer fragment B of cholera toxin (CTb) were performed in the LP.

128 In adult mice with toxin (cuprizone)-induced demyelination, oral GlcNAc pre

129 caused by Fusarium species that produce food toxins, currently devastates wheat production worldwide,

130 hracis Ames wild-type strain or the isogenic toxin-deficient mutants DeltaEF, DeltaLF, and DeltaPA.

131 biosynthesis) and virulence genes (eg, beta-toxin, delta-toxin) that defined a pathogenic ecology.

132 Cyanobacterial blooms produce hazardous toxins, deplete oxygen, and secrete compounds that confe

133 important novel traits that are comprised of toxins derived from several distinct protein families, b

134 as a targeted treatment approach to deliver toxins directly to cancer cells are one of the fastest g

135 the insidious manner by which interbacterial toxins disarm their targets emphasizes the highly evolve

136 f Quik Chek Complete; Techlab), with GDH-and-toxin discordant samples tested with CCNA.

137 Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behaviora

138 thetic hypo-innervation utilizing a targeted-toxin (dopamine beta-hydroxylase antibody conjugated to

139 , transgenic mice where the human diphtheria toxin (DT) receptor was expressed behind the hair-cell s

140 nd upper airways and the produced diphtheria toxin (DT), which binds to the elongation factor 2 and b

141 mechanisms that can neutralize pore-forming toxins during infection.

142 obacteria in freshwater environments produce toxins (e.g., microcystin) that are harmful to human and

143 entified stool samples tested with a GDH-and-toxin EIA (C.

144 Toxin emissions and legacies are major global issues aff

145 risk for CDI with asymptomatic carriage of a toxin-encoding strain was 9.32 (95% CI=3.25-26.7).

146 The PltB subunit of each toxin exhibits different glycan-binding preferences that

147 ypes after loss due to injury, infection, or toxin exposure in the nose.

148 they are also the target of cellular stress, toxin exposure, and aging-related injury.

149 curs when cells are going to die anyway from toxin exposure.

150 epithelial colonization; and cigarette smoke toxin exposure; as well as to elucidate genes required f

151 t, leading to an imbalance in favor of AapA1 toxin expression.

152 the solute carrier (SLC) human multidrug and toxin extrusion protein 1 (hMATE1, SLC47A1), emerged as

153 s suggest that hOCT2 and human multidrug and toxin extrusion proteins 1 and 2-K are involved in mIBG

154 and OCT2 and MATE1 and MATE2K (multidrug and toxin extrusion proteins) in clinical studies.

155 nom-ome' and this included 139 genes from 33 toxin families.

156 ature, which could reduce N allocation to Bt toxin for transgenic Bt crops (Bt crops), but the N fert

157 d in the secretion of hydrolytic enzymes and toxins for a range of bacteria.

158 Phylogenetically, these two toxins form new groups within their respective families

159 Here, we describe the AtaT2 toxin from a toxin-antitoxin system from Escherichia col

160 smic reconstitution of functional diphtheria toxin from engineered intein-flanked fragments upon rece

161 orter from Lysenin, a sphingomyelin-specific toxin from the earthworm Eisenia fetida [10, 11].

162 like plasminogen activator (Pla) and murine toxin from the OMVs.

163 oxin that influences substrate catalysis and toxin function which may be relevant to specific TA-medi

164 granadaene, which reveal features central to toxin function, namely the polyene chain length.

165 The HipA toxin functions as a serine/threonine kinase that inhibi

166 ure-negative but PCR-positive for diphtheria toxin gene, 1 was culture-positive without further testi

167 en carrying major virulence genes, the Shiga toxin genes stx (1) and stx (2) and the intimin gene eae

168 The C. difficile toxin has an enzymatic component, termed CDTa, and a por

169 As some gating modifier toxins have affinity for model lipid bilayers, a tripart

170 nfections but is protective against malarial toxin hemozoin.

171 tely absent in other well-studied heptameric toxins (i.e., anthrax).

172 Antipertussis toxin IgG seroconversion occurred in 9 out of 19 coloniz

173 These toxin-immunity protein pairs are extraordinarily diverse

174 pylori We show that expression of the AapA1 toxin in H. pylori causes growth arrest associated with

175 , they were shown to capture and eliminate a toxin in live mice.

176 secretion, whereas the secretion of Typhoid toxin in Salmonella enterica serovar Typhi relies on a m

177 ll numbers (ca. 10(5) cells.L(-1)) and total toxin in suspension (4 x 10(6) pg.L(water)(-1)) obtained

178 a possible topology of the membrane-inserted toxin in the different membranes.

179 and C. ulcerans, and use of diphtheria anti-toxin in the United States, 1996-2018.

180 ray crystal structures of both PVL and alpha-toxin in their soluble, monomeric, and oligomeric membra

181 To characterize involvement of uremic toxins in cerebral and neurobehavioral abnormalities in

182 e to Cry3 toxins and Cry34/35Ab, the only Bt toxins in commercially available corn that kill rootworm

183 ptide cyanotoxin, are one of the main marine toxins in continental aquatic ecosystems.

184 peptide receptor A by genetic approaches or toxins in mice significantly attenuated or ablated spina

185 or the detection of Clostridioides difficile toxins in stool.

186 of small peptides to neutralize lethal snake toxins in vitro, establishing a potential route to simpl

187 ination of freshwater supplies with chemical toxins including persistent organic pollutants.

188 ial toxins, which protects mitochondria from toxin-induced damage.

189 aneous pancreatitis (sPanc), both (sDMPanc), toxin-induced DM (iDM) and controls.

190 lic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice.

191 Toxin-induced muscle injury to tibialis anterior muscles

192 Typhoid toxin is a virulence factor of Salmonella enterica serov

193 ase substantially in response to stress, but toxin is not liberated.

194 readily degraded in vivo, antitoxin bound to toxin is protected from proteolysis, preventing release

195 h the antitoxin is an enzyme and the cognate toxin is the direct target of the antitoxin: Hha/TomB (a

196 As predicted, delivery of lytic toxins is highly effective, whereas nonlytic toxins leav

197 Understanding the modes of action of Bt toxins is important for WCR control and resistance manag

198 Domoic acid (DA), a potent marine toxin, is readily oxidized upon reaction with singlet ox

199 toxins is highly effective, whereas nonlytic toxins leave large patches of E. coli alive.

200 fective procedures for reduction of T-2/HT-2 toxin levels is needed.

201 The secreted pore-forming toxin listeriolysin O (LLO) of the intracellular pathoge

202 cuoles requires the presence of pore-forming toxin listeriolysin O.

203 Anthrax lethal toxin (LT) is a protease virulence factor produced by Ba

204 with chimera plus single-mutant heat-labile toxin [LT(R192G)] elicited strong serum anti-CfaE and an

205 Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins t

206 lar-capillary barrier dysfunction, and edema toxin may significantly exacerbate pulmonary pathologies

207 hionine tRNAs, and suggest that various GNAT toxins may have evolved to specificaly target other if n

208 ainst Clostridioides (Clostridium) difficile toxins may protect against recurrence of C. difficile in

209 Respiratory diphtheria is a toxin-mediated disease caused by Corynebacterium diphthe

210 killing by neutrophils or protection against toxin-mediated neutrophil lysis.

211 Muscarinic toxins (MTs) are natural toxins produced by mamba snakes

212 ubgroups in comparisons of toxin-positive to toxin-negative patients.

213 he early synergism between antibody-mediated toxin neutralization and tissue-specific neutrophilic in

214 ntibody-mediated protection was dependent on toxin neutralization rather than on enhanced opsonophago

215 alizing activity and different mechanisms of toxin neutralization.

216 n to cause disease, immunity correlates with toxin neutralization.

217 antibodies with strong in vitro and in vivo toxin-neutralizing activity and different mechanisms of

218 e generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies by immuni

219 proteins in Bpm that share features found in toxins of the TAS and repurposed transcriptional data to

220 of organelles and stimulated with bacterial toxins or Candida albicans to induce NETosis.

221 dels simply damaged the rodent brain through toxins or lesions.

222 riggered by exposure to pathogens, microbial toxins, or endogenous danger signals, EC responses are p

223 vival and increased sensitivity to microbial toxin, osmotic and oxidative stress are seen in both mut

224 efore consumption in order to inactivate the toxin, particularly in sprouts, generally consumed raw.

225 These findings provide evidence that lethal toxin plays a determinative role in bacterial disseminat

226 igher across all subgroups in comparisons of toxin-positive to toxin-negative patients.

227 Toxin positivity by EIA and CCA associated with IDSA sev

228 lysis identified a 3 kDa peptide, Hld (delta-toxin), present in GLP-1 positive supernatants but absen

229 Muscarinic toxins (MTs) are natural toxins produced by mamba snakes that primarily bind to m

230 ha-hemolysin and PVL, but also other related toxins, produced by USA300 and other epidemic MRSA clone

231 This reduced uremic toxin-producing activity and ameliorated progression to

232 frequencies (~94%) at the interface between toxin-producing colonies.

233 Produce-associated outbreaks of Shiga toxin-producing Escherichia coli (STEC) were first ident

234 merging (non-aflatoxin biosynthetic pathway) toxins production in mycelia and yeast extract sucrose (

235 he ability of S. aureus to secrete cytolytic toxins, protect itself from several aspects of the human

236 nsitive assays for detection of C. difficile toxins provide measurements of disease-specific markers

237 Antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertact

238 nity to 14 pneumococcal serotypes, pertussis toxin (PT), tetanus toxoid (TT) and varicella, and immun

239 pretreatment of human islets with pertussis-toxin (PTX) improved GSIS and prevented the inhibitory e

240 LukE-DARC interaction and the role that this toxin-receptor pair plays in S. aureus pathophysiology.

241 t for understanding the role of the stalk in toxin recruitment to the sarcin/ricin loop and may provi

242 Bacterial toxins represent a vast reservoir of biochemical diversi

243 ibosyltransferase PtxS1-subunit of pertussis toxin, respectively.

244 disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac function.

245 The extreme potency of the plant toxin, ricin, is due to its enzymatic subunit, RTA, whic

246 Bacterial repeats in toxin (RTX) cytolysins form a prominent group of protein

247 arG(Mtb) ), functions along with its cognate toxin Rv0059 (DNA ADP-ribosyl transferase, DarT(Mtb) ),

248 samples, 100% positive agreement with GDH(+)/toxin(+) samples, and 95.3% agreement with GDH(+)/toxin(

249 ity had 96.2% negative agreement with GDH(-)/toxin(-) samples, 100% positive agreement with GDH(+)/to

250 toxin(+), 53 GDH(-)/toxin(-), and 124 GDH(+)/toxin(-) samples, of which 39 were CCNA(+) and 85 were C

251 cts ion channels, the known targets of their toxin scaffolds, but binds to four melanocortin receptor

252 show how the barrel pore is primed for CdiA toxin secretion.

253 C and HepG2 drug biotransformation and liver-toxin sensitivity to levels similar to those in PHHs.

254 s, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all been solved for chicken

255 enterohemorrhagic Escherichia coli is Shiga toxin (Stx).

256 The main cellular receptors of Shiga toxins (Stxs), the neutral glycosphingolipids (GSLs), gl

257 ecoveries after the DCL, we injected cholera toxin subunit B into the hand representation in Cu to la

258 rescently tagged retrograde tracers (cholera toxin subunit B) into retinotopically-matched locations

259 equence that is highly conserved in four Luk toxin subunits and is ubiquitous in representation withi

260 orm of cell death instigated by pore-forming toxins such as S. pneumoniae pneumolysin.

261 environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs).

262 transcription of the ToxT-dependent cholera toxin synthesis genes of V. cholerae c2-HDA significantl

263 ation of C. difficile growth and activity of toxins TcdA and TcdB as well as analysis of MBRA bacteri

264 n: Hha/TomB (antitoxin oxidizes Cys18 of the toxin), TglT/TakA (antitoxin phosphorylates Ser78 of the

265 rains encoding alpha-toxin(4)-a pore-forming toxin that binds the metalloprotease ADAM10 on the surfa

266 lts reveal a structural feature of an ICE TA toxin that influences substrate catalysis and toxin func

267 branes in the absence of membrane potential, toxins that bind VSD and modulate the gating behavior of

268 ion, and compete against other bacteria with toxins that disrupt lipid membranes, cell walls and acti

269 The production of pore-forming toxins that disrupt the plasma membrane of host cells is

270 metabolic demands but that is also devoid of toxins that might harm the sensitive neural tissues.

271 roduces an array of bicomponent pore-forming toxins that target and kill leukocytes, known collective

272 in (MARTX) toxins are pore-forming bacterial toxins that translocate multiple functionally independen

273 Snake venoms are mixtures of toxins that vary extensively between and within snake sp

274 ) and virulence genes (eg, beta-toxin, delta-toxin) that defined a pathogenic ecology.

275 ds in directly binding and neutralizing TcdB toxin, the primary determinant of C. difficile disease.

276 Although certain microbial lipids are toxins, the structural features important for cytotoxici

277 olution of host adaptations in Salmonella AB toxins, their cell and tissue tropisms, and the design f

278 thin the human population, exposure to alpha-toxin through skin infection may modulate the establishm

279 TG proteins mediate protection against alpha-toxin through the release of ADAM10 on exosomes-extracel

280 or bacterial pathogens that rely on a single toxin to cause disease, immunity correlates with toxin n

281 thogenesis of ETEC in which the bacteria use toxin to drive up-regulation of cellular targets that en

282 ies may bind to bacterial pathogens or their toxins to control infections, and their effector activit

283 The ability of these toxins to target and bind to motor nerve terminals is a

284 dent on the secretion of one or more AB-type toxins: toxin A (TcdA), toxin B (TcdB) and the C. diffic

285 NLRP1 and/or CARD8, including anthrax lethal toxin, Toxoplasma gondii, Shigella flexneri and the smal

286 eveals that organoids express high levels of toxin transcripts.

287 ond wave follicles were ablated by diptheria toxin treatment of Lgr5-DTR-EGFP mice at E16.5 while fir

288 a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .000

289 bodies conjugated to biotinylated saporin, a toxin unable to cross cell membranes.

290 th resistance to Bacillus thuringiensis (Bt) toxins utilized in commercial transgenic traits have bee

291 ripartite relationship among gating modifier toxins, voltage-gated ion channels, and the lipid membra

292 , our results are relevant for understanding toxin-VSD interaction and gating mechanisms of K(v) chan

293 itive for Clostridium difficile (CD) and its toxin were considered.

294 The B-subunit of the cholera toxin which is a monosynaptic retrograde tracer was used

295 ells using selection for resistance to Shiga toxin, which uses a plasma membrane-associated glycosphi

296 onditions and upon exposure to mitochondrial toxins, which protects mitochondria from toxin-induced d

297 nal epithelial cells (IECs) and uses a MARTX toxin with three effector domains-an actin cross-linking

298 AB toxins with built-in cell targeting and endosomal escape

299 gents, allowing for fast detection of deadly toxins with high clinical relevance.

300 experiments, especially when there are many toxins with redundant function.