ライフサイエンスコーパス: toxin-neutralizing

1 studies demonstrated that both MAPs elicited toxin-neutralizing Ab in rabbits.

2 V230-Ficoll induced 10-fold higher titers of toxin-neutralizing Abs in cynomolgus monkeys at 2 wk com

3 to induce serum LF-specific IgG2c and lethal toxin-neutralizing Abs was significantly impaired in CD1

4 F-specific serum IgG, IgG subclasses, lethal toxin-neutralizing Abs, and mucosal IgA compared with WT

5 ve established an in vitro assay to test the toxin-neutralizing activities of antimalarial antibodies

6 l antibodies that differ in their respective toxin-neutralizing activities.

7 terized for their binding affinity and their toxin neutralizing activity in vitro and in vivo.

8 Anti-PA IgG levels and serum toxin neutralizing activity were strongly associated (R2

9 topes adjacent to V5E1 but display only weak toxin neutralizing activity, thereby providing structura

10 antibodies with strong in vitro and in vivo toxin-neutralizing activity and different mechanisms of

11 ngineering is a feasible strategy to enhance toxin-neutralizing activity and suggest that engineered

12 a peptide linkers have proven to have potent toxin-neutralizing activity in vivo against Shiga, botul

13 Two mAbs with toxin-neutralizing activity recognized two different epi

14 ity to detoxify BV and also assign efficient toxin-neutralizing activity to MC-derived heparin and pr

15 In some cases, such toxin-neutralizing activity was notably high, indicating

16 odimer D10/B7, a 6-fold increase in in vitro toxin-neutralizing activity.

17 hat any of the BoNT/A binding agents possess toxin-neutralizing activity.

18 e ricin-specific VHHs we identified, six had toxin-neutralizing activity: five specific for RTA and o

19 A single toxin-neutralizing agent consisting of a double-tagged V

20 n be promoted by coadministering a VHH-based toxin-neutralizing agent with an antitag monoclonal anti

21 VHH heterodimer toxin-neutralizing agents containing two linked Stx1-neu

22 b substantially improved the efficacy of Stx toxin-neutralizing agents to prevent death or kidney dam

23 verexpress StxB induced high titers of Shiga toxin neutralizing antibodies.

24 piglets given the toxigenic strain developed toxin-neutralizing antibodies (indicating that toxin is

25 Serologic changes, levels of toxin-neutralizing antibodies (TNAs), and pulmonary and

26 Efforts to develop toxin-neutralizing antibodies as adjunctive therapies ar

27 Toxin-neutralizing antibodies fractionated from egg yolk

28 effective in protecting animals and elicits toxin-neutralizing antibodies in humans, but enthusiasm

29 or CR3 binding and induced formation of CyaA toxin-neutralizing antibodies in mice.

30 rotection was associated with high levels of toxin-neutralizing antibodies in serum.

31 High-affinity toxin-neutralizing antibodies may be of therapeutic valu

32 In previous studies, we demonstrated that toxin-neutralizing antibodies target four spatially dist

33 the RTA-RTB interface is a target of potent toxin-neutralizing antibodies that interfere with both e

34 We have engineered a panel of toxin-neutralizing antibodies, including single-chain va

35 -Asp mutant rPA, as measured by induction of toxin-neutralizing antibodies, was significantly lower t

36 the in vitro and in vivo activity of anthrax toxin-neutralizing antibodies.

37 tigens, including high levels of anti-PA and toxin-neutralizing antibodies.

38 eceived low doses of BL22 or had preexisting toxin-neutralizing antibodies.

39 each toxin was most effective in generating toxin-neutralizing antibodies.

40 que sera from all immunized groups contained toxin-neutralizing antibody and recognized all the domai

41 significant correlation was observed between toxin-neutralizing antibody titer and survival after cha

42 e compared serum immunoglobulin G levels and toxin-neutralizing antibody titers in rabbits following

43 acis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscula

44 gene that suppresses bacterial growth and a toxin-neutralizing antitoxin gene, usually encoded in a

45 FI-29, a serogroup O107/O117 strain, as the toxin-neutralizing component.

46 G format, GC132a showed ~50-fold more potent toxin-neutralizing efficacy than the best class M Ab in

47 Key toxin-neutralizing epitopes have been found within the c

48 l of this reaction, using recombinant Lethal Toxin Neutralizing Factor (rLTNF) as a case study.

49 e generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies by immuni

50 been identified; however, the major anthrax toxin-neutralizing humoral responses to these antigens a

51 Adding plaque toxin-neutralizing MAb 3hE5 blocked the toxic effect of

52 or Sterne spore vaccine, as well as those of toxin-neutralizing monoclonal antibodies (MAbs) produced

53 S. aureus directly with MEDI4893*, an alpha toxin-neutralizing monoclonal antibody, blocked TGF-beta

54 y effects, HNP-1-HNP-3 possess antiviral and toxin-neutralizing properties.

55 ch potent, stable and readily manufacturable toxin-neutralizing proteins could provide the basis for

56 nization also produced high titers of lethal-toxin-neutralizing serum antibodies in both mice and gui

57 l infection, supporting a potential role for toxin-neutralizing therapy.

58 30,000 (range, 5,800 to 157,000) and lethal-toxin-neutralizing titers greater than 16,000.

59 Antibodies with high toxin-neutralizing titers were generated against C. diff

60 neutralizing agent) consisting of two linked toxin-neutralizing VHHs, JMN-D10 and JMO-G1, was fully p