ライフサイエンスコーパス: tractable

1 (the largest number for which computation is tractable).

2 advancement toward making squid genetically tractable.

3 make life cycle progression and parasite sex tractable.

4 ivergent populations that are experimentally tractable.

5 king these pioneering drug discovery efforts tractable.

6 logical molecules in all-atom representation tractable.

7 help make highly diverse sequence data more tractable.

8 cognition, makes this problem experimentally tractable.

9 olate the classical assumptions that make RL tractable.

10 ng key resources in the published literature tractable.

11 nable design variables, to make optimization tractable.

12 ck of realistic models that are analytically tractable.

13 rget microbiome can make these analyses more tractable.

14 Here, we develop a computationally tractable 3D model (implemented as a simulation in the C

15 e-body problem(5) prevents the derivation of tractable(6) analytic formulae that deterministically ma

16 llochthonous populations were detectable and tractable across the river after 1-2 days of (downstream

17 We provide a fixed-parameter tractable algorithm for computing Pareto-optimal reconci

18 We have realized practical, tractable algorithms for each of these models.

19 Our debiased estimators are tractable algorithms that provably achieve full statisti

20 e levels, while presenting an experimentally tractable alternative to animal studies.

21 terest, but their complexity often precludes tractable analytical expressions for messenger RNA (mRNA

22 The model is extremely tractable and applies to a multiregion world but with gl

23 consumption within young ocean crust that is tractable and can be iteratively improved upon as new da

24 till ensuring that the computations would be tractable and capable of delivering nearly efficient out

25 ese challenges, including use of genetically tractable and environmentally responsive in vitro system

26 By providing a computationally tractable and numerically consistent framework to evalua

27 matters promises to deliver modelers with a tractable and reliable mechanistic model of stomatal res

28 Both parasite and host are genetically tractable and this in vivo model will facilitate mechani

29 hlight that while PDXs and PDOs may serve as tractable and transplantable systems for probing the mol

30 function of cuticular inflations in the most tractable and widely-used model of trichuriasis, Trichur

31 ing methods to be computationally efficient, tractable, and equipped with scalable features.

32 circuitry is well characterized, genetically tractable, and rapidly developing, and thus ideally suit

33 period, that the microgels are mechanically tractable, and that, for microscale cell assemblages of

34 us to study its biological significance in a tractable animal model of human inflammatory disease, na

35 icap to achieving this goal is the lack of a tractable animal model to study PML pathogenesis.

36 n large part to an absence of experimentally-tractable animals models of this intervention.

37 intriguing synthetic biological chassis with tractable applications in development, chemotaxis, bacte

38 Here we demonstrate a tractable approach for fully reprogramming adult mouse e

39 nalling contribute to disease, and suggest a tractable approach for therapeutic intervention in PAH.

40 refore, disrupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity.

41 presented here indicate a pharmacologically tractable approach to drive MYC degradation by using SMA

42 tic syndromes represents a more biologically tractable approach to identify neural circuit disruption

43 eta-analyses of experimental infections as a tractable approach to quantify the complex interactions

44 In our novel, computationally tractable approach to RNA-ligand kinetics, we overcome t

45 enges in leveraging these tools into a novel tractable approach to treat cancer.

46 acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite l

47 t evolutionary models for indels that are as tractable as the analogous models for substitution event

48 coccus caseolyticus str 115 in a genetically tractable Bacillus subtilis strain to parse the processi

49 limiting systematic gene surveys to the most tractable bacterial hosts.

50 es data for the evolution of an analytically tractable bead-spring model.

51 ether, we propose that CCAT1 is a clinically tractable biomarker for identifying patients who are lik

52 from the efficiency with a more genetically tractable but vocal nonlearning species, the chicken (a

53 To exceed the level of complexity tractable by classical computers the main challenge is t

54 Our system is made tractable by constraining the number and depth of hierar

55 This approach remains computationally tractable by tracking the genotype and fitness of lineag

56 ieve that the utilization of the genetically tractable C. elegans model will provide a key resource f

57 In this study, a tractable C29S variant of hPAH (C29S) yielded a 3.06 ang

58 Moreover, in genetically tractable Caenorhabditis elegans models, expression of a

59 lle size scaling in the cell provides a more tractable case for testing Huxley's model.

60 om two different retinal images represents a tractable challenge in sensory neuroscience that has so

61 These asymmetric responses pose a tractable challenge to process-based models attempting t

62 smoother contact pattern and more precisely tractable chromosome conformations, and the large-scale

63 Among the tractable complexes identified, we then performed single

64 city assays, proved that we have a series of tractable compounds that can be categorized into structu

65 ndependent random variables, leading to more tractable computation.

66 ave function can reduce this complexity to a tractable computational form for some notable cases of p

67 nization and entrainment, are experimentally tractable constructs that may be analyzed and compared b

68 essful human performance but also, provide a tractable control architecture for computerized agents.

69 ome-default target morphology, and provide a tractable control point for investigating cryptic phenot

70 e levels, we formulated ECM as a numerically tractable, convex optimization problem.

71 We develop tractable count-based models, which are amenable to effi

72 fragment hits; one series of low-reactivity, tractable covalent fragments were progressed to discover

73 carbohydrases concurrent with the unique and tractable dietary resources of their hosts.

74 the onset of disease, and permit the use of tractable disease models.

75 ts suggest that the PH domain of P-Rex1 is a tractable drug target and that these compounds might be

76 -protein-coupled receptors (GPCRs) have been tractable drug targets for decades with over one-third o

77 The intensively studied, genetically tractable endospore-former, Bacillus subtilis, is an ide

78 r structure should enable the formulation of tractable epidemiological models that account for parasi

79 Using the genetically tractable euryarchaeon Haloferax volcanii as a model sys

80 data, LD score regression is computationally tractable even for very large sample sizes.

81 , operons and gene blocks provide a model of tractable evolutionary complexity at the genomic level.

82 LDHA is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates

83 granulomas has been hindered by a paucity of tractable experimental animal models.

84 uman tropism of the virus and the paucity of tractable experimental models.

85 ding of how resistance emerges and a lack of tractable experimental systems hinder progress.

86 e future is rich with potential to integrate tractable experimental systems like theirs with hypothes

87 suggested as a genetically and agronomically tractable feedstock species to augment near-term cellulo

88 this process, we made use of the genetically tractable fly retina, with a focus on the mechanisms tha

89 hat makes the computation of chemical shifts tractable for a large number of conformationally flexibl

90 tics make this method highly predictable and tractable for generation of programmable allelic series

91 ies with electron microscopy, this method is tractable for imaging large fields of view.

92 In addition, this model is tractable for investigation and testing of therapeutic i

93 thods are widely applicable, computationally tractable for many conditions and available online.

94 e emphasis is on signaling pathways that are tractable for therapeutic manipulation.

95 ot require prephasing and is computationally tractable for whole-genome imputation.

96 In the present paper, we provide a tractable formula for the value of competitive stochasti

97 e jointly analyzed through a computationally tractable formulation of partial least squares regressio

98 Here, we show that the genetically tractable frog Xenopus tropicalis, paired with optical c

99 an orbital crossing in a system chosen to be tractable from both sides: Pr[Formula: see text].

100 Our technique is computationally tractable, generally outperforms other methods, is exten

101 Generalizing beyond the most tractable genetic diseases will require modulation of ce

102 Here we utilize a tractable genetic model organism, Caenorhabditis elegans

103 Combining two tractable genetic models, the bacterium E. coli and the

104 Combining two tractable genetic models, the bacterium E. coli and the

105 iota and pathogens at all body sites and the tractable genetics of C57BL/6 mice.

106 n DNA abnormalities, but not all tumors have tractable genomic alterations.

107 One of the more tractable goals of quantitative neuroscience is to devel

108 -inducible cspD2 promoter in the genetically tractable Haloarchaeon, Halobacterium sp.

109 me complex affective phenomena theoretically tractable, help refine accounts of social perception, an

110 ogether, this study establishes E. coli as a tractable host for P450 chemistry, highlights the potent

111 f study of the readily cultured, genetically tractable human gut Bacteroides has revealed important i

112 sparse regression are currently enabling the tractable identification of both the structure and param

113 in human evolutionary genetics would become tractable if we were able to directly measure evolutiona

114 mor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowi

115 They are also numerous and, in many cases, tractable in an experimental and field setting.

116 ariant-set tests are needed to make analyses tractable in large-scale WGS studies with complex study

117 ves are slow, complex, and not recombinantly tractable in traditional industrial hosts.

118 es and xenotransplantation studies with this tractable in vitro system of CD44L to CD44H cell convers

119 ast cancer research is hampered by a lack of tractable in vivo model systems that accurately recapitu

120 five IAPs using heterologous expression in a tractable in vivo model, the Drosophila melanogaster dev

121 m-level environmental exposures to provide a tractable influence on subcellular phenotypes, such as g

122 One arena where this might be tractable is by studying the dynamics and dissemination

123 robacter litoralis DSM 8509 as a genetically tractable lab strain and use it to both directly and ind

124 to make the mathematical models analytically tractable limit the search space of possible treatment r

125 fy alpha-defs as a potentially important and tractable link between innate immunity and thrombosis.

126 circuits and related escape behavior in the tractable locust system.

127 form used to identify and modify genetically tractable mammalian microbiota by engineering community-

128 nabinoid signaling pathways in a genetically tractable, mammalian predictive model, where cannabinoid

129 midgut tissues, and potentially serves as a tractable, manipulatable and easily accessible model for

130 flow for identification of pharmacologically tractable markers of behaviourally characterized cell po

131 nterest because they are the most chemically tractable materials for synthetic exploration.

132 emergent pattern of cell sizes, we propose a tractable mathematical model that depends on intercellul

133 menological model of motor unit fatigue as a tractable means to predict muscle fatigue for a variety

134 ces of ATRX deficiency remain unclear, as do tractable mechanisms for its therapeutic targeting.

135 s-assay validation to define therapeutically tractable MET pathway dysregulation in EGFR-mutant-posit

136 The availability of computationally tractable metadata is especially important for the effec

137 Inspired by effective yet tractable methods of population-level analysis using flo

138 ctory communication is hampered by a lack of tractable methods.

139 This work makes Spizellomyces a genetically tractable model for comparative cell biology and underst

140 alian neural stem cell (NSC) lines provide a tractable model for discovery across stem cell and devel

141 In particular we introduce a tractable model for embedding one network (A) into anoth

142 est that vitiligo may provide a particularly tractable model for investigation of complex disease gen

143 itiligo has thus proved to be a particularly tractable model for investigation of complex disease gen

144 blish the zebrafish as a facile, genetically tractable model for leprosy and reveal the interplay bet

145 istant pathogens, with S. sonnei acting as a tractable model for studying how antimicrobial-resistant

146 PRQ represents a simple, tractable model for studying how neuromodulatory states

147 r lateral line primordium, an experimentally tractable model of complex self-organized organogenesis.

148 organization, which motivates their use as a tractable model of early human embryogenesis.

149 Here, in the mouse retina, a tractable model of the CNS, we evaluated distinct classe

150 a potential game, our formulation provides a tractable model on behavioural dynamics in social networ

151 sive stress on the growth of the genetically tractable model organism Saccharomyces cerevisiae We use

152 bility to study phenotypic trait variance in tractable model organisms using unbiased mutagenesis scr

153 g unbiased forward genetics in even the most tractable model organisms.

154 We show how a tractable model species combined with integrative studie

155 biotic lifestyles and provides a genetically tractable model system for advancing understanding of th

156 be both an important microbial habitat and a tractable model system for asking questions in microbial

157 opment of organoid technology has provided a tractable model system for assessing the detailed mechan

158 tuf genes in Salmonella as a quantitatively tractable model system for gene conversion.

159 agellar length control in Chlamydomonas is a tractable model system for studying the general question

160 lian tissues and describes an experimentally tractable model system representing the snake venom glan

161 Our study represents an experimentally tractable model system to reveal and examine human-speci

162 se genetic reference population, serves as a tractable model system to study how pathogens interact w

163 produced gokushoviruses in an experimentally tractable model system, allowing us to investigate their

164 Using a tractable model system, Dictyostelium, we show that deca

165 died the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), add

166 y contours perception in mice, a genetically tractable model system.

167 We introduce an analytically tractable model that enables one to connect two layers i

168 The Drosophila egg chamber provides a tractable model to dissect such contributions during mor

169 thering within a single species, providing a tractable model to investigate the molecular basis of sk

170 The larva provides a tractable model to investigate the regulation and conseq

171 This tractable model will enable biophysical evaluation of mu

172 The tractable model yeast, Saccharomyces cerevisiae, relocat

173 By considering a simplified tractable model, we identify different homology testing

174 Combining tractable modelling frameworks with multiple data source

175 utrition, with an emphasis on experimentally tractable models and hypothesis-driven mechanistic work.

176 es implicated in human disease that serve as tractable models for studies of pathogen-host interactio

177 agents, which poses challenges for creating tractable models of behavior.

178 However, the lack of formal analytically tractable models of such coupled infrastructure systems

179 low-complexity communities that can serve as tractable models to understand community dynamics.

180 Using physiologically relevant in vitro tractable models, we found that cocaine-induced hypoacti

181 , and might facilitate the identification of tractable molecular targets to therapeutically promote n

182 nt that were not accessible before, allowing tractable monitoring and assessment of early development

183 mans or conserved in the more experimentally tractable mouse.

184 ions that mediate infection in a genetically tractable multicellular model organism.

185 The tractable nature of dragonflies for physiological experi

186 Here, we take advantage of the tractable nature of vocal learning in songbirds (Lonchur

187 This study illustrates the tractable nature of WGS data and outlines an approach fo

188 Whereas behaviour in the analytically tractable network is a direct but not trivial consequenc

189 Plateletcrit and factor XI are potentially tractable new targets for secondary prevention of ischae

190 ry chimera, with 25% of its phylogenetically tractable nucleus-encoded proteins deriving from green a

191 ococcus elongatus PCC 7942, is a genetically tractable obligate phototroph that is being developed fo

192 classification and gene identification to be tractable on modern large data sets.

193 membrane fusion systems are not genetically tractable, only few such investigations have been report

194 Here we used the genetically tractable organism D. melanogaster to define the neural

195 lasmodium falciparum into a genetically more tractable organism.

196 ment of similar systems in other genetically tractable organisms for multiplexed conditional genome e

197 oton calcium imaging based on experimentally tractable parameters.

198 transport that regulates a pharmacologically tractable pathway necessary for PDAC tumor growth and me

199 ns in purified virus and infected cells, and tractable peptides for monitoring Gag levels were identi

200 ghly resistant to Shigella and the lack of a tractable physiological model of shigellosis has impeded

201 agement mechanisms of plants by using a more tractable platform-the common baker's yeast-to create pl

202 es is the characterization of experimentally-tractable pre-clinical models that exhibit multi-domain

203 rms induce sleep through a pharmacologically tractable Prion Protein (PrP) signaling cascade.

204 llelism improves speed and makes iteration a tractable problem for larger networks.

205 ads (in the nucleotide alphabet) into a more tractable problem of assembling centromeres from transla

206 ective, these disorders offer among the most tractable problems in psychiatry, with a great deal of a

207 gies in chemical assessment is a complex but tractable process with four fundamental steps.

208 n of ATAD2 has proved to be one of the least-tractable proteins within this target class.

209 Using BiRD, we construct a tractable proxy to transportation costs, allowing the fo

210 Thus, fear mechanisms represent a tractable PTSD biomarker in the study of sex differences

211 echanical behavior through a computationally tractable quantity-the electron density-without resortin

212 oincidence, happen to be those that react at tractable rates on laboratory time scales at -78 degrees

213 isplaying muted Lewis acidity and affiliated tractable rates, reveals a rate-limiting complexation vi

214 us emerge as highly portable, evolutionarily tractable regulatory modules through which to create pat

215 Here we partition an experimentally tractable regulatory network-the gap gene system of dipt

216 directly assessed due to the lack of a fully tractable reverse-genetics (RG) system for rotaviruses.

217 tion by taking advantage of a modified fully tractable reverse-genetics system.

218 to the current strategies and established a tractable RG system for the rescue of the simian RRV str

219 g CDK4/6 kinases and identifies MET/FAK as a tractable route to broaden the utility of CDK4/6 inhibit

220 hit-and-run algorithm, enabling reliable and tractable sampling of genome-scale biochemical networks.

221 Thus, MAP4K4 is a plausible, tractable, selective therapeutic target in DOX-induced h

222 es is poorly understood because of a lack of tractable small- animal models.

223 MAV-1 infection of susceptible mice is a tractable small-animal model for encephalitis, and the v

224 proteins with varied functions, were highly tractable small-molecule targets.

225 priority, and women's cancers are not only a tractable socioeconomic policy target in themselves, but

226 al arises from the lack of a computationally tractable solution that can recover these sequences from

227 The method provides a tractable solution to reduce the time complexity and phy

228 These results provide a mechanistically tractable solution to the credit assignment problem.

229 ities of neonatal skin to develop clinically tractable solutions that promote the regeneration of adu

230 ntibiotics are an abundant and synthetically tractable source of molecular diversity, but they are of

231 iversified, secluded and yet microscopically tractable space.

232 Small, genetically tractable species such as larval zebrafish, Drosophila,

233 the Iberian ribbed newt Pleurodeles waltl, a tractable species suitable for laboratory research.

234 nterneurons in both mice and non-genetically tractable species, thus opening the possibility to study

235 If made genetically tractable, squid and other cephalopods offer a wealth of

236 ile Kalman filter (VKF), which is based on a tractable state-space model of uncertainty and extends t

237 Since D(3)E is based on an analytically tractable stochastic model, it provides additional biolo

238 carcinogenesis and suggests therapeutically tractable strategies toward cDC1 repair.

239 quantitative genetics in animal models is a tractable strategy for examining both the genetic basis

240 uisition of full donor T-cell chimerism as a tractable strategy to improve outcomes in patients allog

241 Structural variations led to tractable structure-permeability and structure-efflux re

242 Here, we used a genetically tractable synthetic rice segmental allotetraploid system

243 ds, demonstrating the utility of this highly tractable system for future investigations of HCMV-induc

244 visual trait that has proven to be a highly tractable system for genetic analysis and for studying a

245 motor system and establishes Drosophila as a tractable system for investigating neural mechanisms of

246 e Caenorhabditis elegans germline provides a tractable system for studying the mechanisms that contro

247 have thus established a robust, genetically tractable system for the rapid identification and functi

248 not yet clear, in part due to the lack of a tractable system for their experimental investigation.

249 avian brood parasites provide a particularly tractable system for understanding how uncertainty, driv

250 cialized eggshell structures, has provided a tractable system to ask these questions.

251 Nuclear RNAi provides a highly tractable system to study RNA-mediated chromatin changes

252 gamete (spore)-killing wtf drivers, offers a tractable system to test this hypothesis.

253 We used Drosophila as a genetically tractable system with a simpler gut bacterial population

254 cades as investigators turned to genetically tractable systems.

255 Together these imaging assays constitute a tractable, systems-based platform for studying otherwise

256 naling axis may serve as a pharmacologically tractable target during infection and inflammation.

257 ndings suggest PAR1 may be a therapeutically tractable target for demyelinating disorders of the CNS.

258 or, and suggests that neutral SMase can be a tractable target for developing anti-K-Ras therapeutics.

259 e and are the first to confirm ks-vFLIP as a tractable target for the treatment of PEL and related di

260 s, raising the possibility that these may be tractable targets for miRNA-based therapies for OS.

261 pathways now represent robust and clinically tractable targets for preventing the initiation of delet

262 hese challenges, positioning coregulators as tractable targets in the development of new cancer thera

263 chemical starting points for novel and less-tractable targets.

264 umerically more accurate and computationally tractable than existing approaches.

265 es the study of closed systems now much more tractable than in the past, and we argue that the time h

266 m of study where generalizations may be more tractable than those relying on taxonomic specificity.

267 ng cause of CICI and that PFT-mu may offer a tractable therapeutic strategy to limit this common side

268 Thus, Col VI may represent a tractable therapeutic target across a range of fibrotic

269 vitro and in vivo, thus revealing TRPC5 as a tractable therapeutic target for focal and segmental glo

270 ntification and prioritization of chemically tractable therapeutic targets is a significant challenge

271 nt of heart failure, and represent potential tractable therapeutic targets.

272 in malignant diseases, along with serving as tractable therapeutic targets.

273 present in clinical specimens and the highly tractable three-dimensional (3D) organoid system demonst

274 l lines to identify synergistic combinations tractable to clinical translation.

275 lter bacterial populations, making them more tractable to current therapeutic strategies.

276 urrent studies indicate that this pathway is tractable to pharmacologic intervention.

277 r therapeutic invention in NSCLC that may be tractable to small-molecule inhibitors, as a new point t

278 Combination therapies deemed immediately tractable to translation included ABT-263/crizotinib, AB

279 highlight membrane potential modulation as a tractable tool for modulation of signaling cascades that

280 Our organoid system provides a genetically-tractable tool that will allow these human-specific feat

281 esearchers a powerful set of computationally tractable tools with which to investigate neurodegenerat

282 patiotemporal resolution and the adoption of tractable transformed T cell systems for cell biological

283 : It causes human cancers, and it exhibits a tractable transition from its latent to its productive c

284 , functions, and physiology should make them tractable translational targets in each of these setting

285 ry biomarkers that could potentially provide tractable treatment targets to guide pharmacological int

286 One strategy for reaching a tractable understanding of circuit function is to seek t

287 ationship into a one-dimensional dynamic for tractable understanding, mapping the relationship betwee

288 omposition of the human immune system is now tractable using single-cell multi-omics approaches.

289 This robust, highly tractable vertebrate model can be used in the detection

290 nction analyses and for genetic screens in a tractable vertebrate system.

291 this task, we chose the larval zebrafish, a tractable vertebrate that pursues and captures swimming

292 to 3' blocks indicates that they represent a tractable vulnerability in homologous recombination-defi

293 otein quaternary structure, and to provide a tractable way to study the genotype-phenotype map of suc

294 uncertainty in a physically well-founded and tractable way, and we demonstrate that even modest varia

295 -trait genotype-phenotype maps might only be tractable when jointly considering multiple phenotypes.

296 ns is crucial to make systems biology models tractable while still representative of the underlying b

297 dying cannabinoid signaling in a genetically tractable whole-animal model.SIGNIFICANCE STATEMENTCanna

298 ndent cannabinoid signaling in a genetically tractable, whole-animal model where cannabinoid signalin

299 dying cannabinoid signaling in a genetically tractable, whole-animal model.

300 s, insertions and deletions, have not proved tractable with short-read whole genome sequencing.