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1 determine if PKA controls EBNA1's ability to transactivate.
2 ulates MYC and E2F2 and some genes that they transactivate.
4 mobility and binding frequency, and strongly transactivate a luminal androgen-receptor program of pro
5 was unable to translocate to the nucleus or transactivate a NF-kappaB reporter following tumor necro
6 e confirmed p53(420) is able to tetramerize, transactivate a p21 promoter, bind dynein and that the r
7 TDEC from WT expressed VDR and were able to transactivate a reporter gene whereas TDEC from KO mice
8 ional function but shows impaired ability to transactivate a subset of p53 target genes, including tw
10 became activated to the DNA-binding form and transactivated a large number of genes in lymphoid cells
11 mized rats, we established that ligands that transactivated a model promoter 40-80% of an agonist, re
12 5.8-kb fragment consisting of these elements transactivated a reporter gene in vivo recapitulating en
13 o causes melanotic tumors, while in vitro it transactivates a Stat92E-luciferase reporter in the abse
14 te a role for AT-hooks in EBNA1's ability to transactivate, a function necessary for EBV to immortali
15 cated PtrSND1-A2(IR) lacking DNA-binding and transactivating abilities can disrupt the function of fu
16 ine zipper 1 (SPZ1) promotes EMT through its transactivating ability in increasing TWIST1 expression.
18 s that are important for the DNA-binding and transactivating activities of two naturally occurring va
20 BP transcriptional activity (by reducing its transactivating activity but not its nuclear localizatio
21 EBP/OREBP by increasing its phosphorylation, transactivating activity, and localization to the nucleu
31 -regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.
35 -1, in a p53-independent manner, by directly transactivating Bax, and prove that alters the B-cell CL
37 s characterized by inside-out signaling that transactivates beta(2) integrin adhesive activities.
39 ate that in response to TGF-beta1, KLF10 can transactivate both TGF-beta1 and Foxp3 promoters, implic
40 s (SHFV) was identified as a key factor that transactivates both -2 and -1 PRF, and the universally c
43 bly, we now show that both -2 and -1 PRF are transactivated by a protein factor, specifically a PRRSV
48 s identify ALK as a receptor tyrosine kinase transactivated by D2R that promotes its internalization,
49 ated that this gene is posttranscriptionally transactivated by ICP27 in a plasmid cotransfection assa
50 ng that the binding of STAU1 to mRNAs can be transactivated by lncRNAs uncovers an unexpected strateg
51 enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor
55 additional regions in the BoHV-1 genome are transactivated by the GR or stress-induced transcription
62 le of Aurora kinase A (AURKA) in BCSCs, as a transactivating co-factor in the induction of the c-Myc
64 with the native bacterial CRISPR RNA (crRNA)-transactivating crRNA (tracrRNA) duplex and contains a c
65 crRNA), which in combination with unmodified transactivating crRNA (tracrRNA) is shown to functionall
66 receptor (TCR), the TCR associates with and transactivates CXCR4 via phosphorylation of S339-CXCR4 i
69 or of seed development, LEAFY COTYLEDON1, to transactivate DOG1 during maturation and help to establi
70 d in a decrease in the ability of HIF-1alpha transactivating domain to recruit co-activators and dimi
72 ent HPV types to block the ability of p53 to transactivate downstream genes following DNA damage.
77 ay (G(q/11)-coupled phospholipase C) and the transactivated EGFR downstream signaling pathways (phosp
78 xpression by siRNA suppresses p40 effects on transactivating EGFR and Akt, preventing apoptosis, and
79 n of G protein-coupled receptors (GPCRs) can transactivate epidermal growth factor receptors (EGFRs),
81 hat Mesp1 binds to the proximal promoter and transactivates Etv2 gene expression via the CRE motif.
82 ated that the Sp1 mutation both impaired Tat-transactivated expression and also altered basal express
84 ously, we reported that the neurotoxic HIV-1 transactivating factor (Tat) acutely disrupts mitochondr
85 e results illustrate that SARI inhibits AP-1 transactivating factor binding to the cis-element of the
87 Galpha(q) signaling by crossing tetracycline-transactivating factor/V1A mice with transgenic mice tha
89 e; however, by 24 weeks of age, tetracycline-transactivating factor/V1A-TG mouse hearts had reduced c
90 t p53, which previously has been reported to transactivate FBW7, is also targeted by the same E3 liga
93 the FHM nPR, whereas five progestins and P4 transactivated FHM AR, all at environmentally relevant c
95 nase transactivation and discovered that ADP transactivates Fms-like tyrosine kinase 3 (Flt3), a rece
96 ere exposed to MMP-9, EGFR was significantly transactivated, followed by p38 MAPK activation, I-kappa
97 ad box subclass M1 (FOXM1) as a co-factor to transactivate FOXM1 target genes in a kinase-independent
99 localization inhibits this newly discovered transactivating function of AURKA, sensitizing resistant
100 uclear transcription factor, ERalpha has two transactivating functional domains (AF), AF-1 and AF-2.
101 on on DNA-binding activities, alterations in transactivating functions and interactions with cofactor
102 a guanine-nucleotide exchange factor (GEF), transactivates Galpha activity-inhibiting polypeptide 1
106 is, mitosis, adherent junctions, but also to transactivate genes involving in matrix degradation and
107 led that hearts from knockout mice failed to transactivate genes regulated by the transcription facto
111 -inducible factor 1alpha (HIF-1alpha), which transactivates genes governing angiogenesis and metaboli
112 acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle r
113 f HF-SCs in vivo, we show that LHX2 directly transactivates genes that orchestrate cytoskeletal dynam
114 GLI1 undergoes nuclear translocalization and transactivates GLI1-binding sites similar to GLI1, unlik
116 tivity of all transcription factors known to transactivate heat shock protein 27 expression, these fi
119 PCD, GmNAC81 and GmNAC30 bind in vivo to and transactivate hydrolytic enzyme promoters in soybean pro
121 This is the first report to indicate that NT transactivates IGF-1R and that this response is linked t
122 transfection assays, HIF-1alpha was found to transactivate IGFBP3 through a novel hypoxia responsive
123 ient CD4 and CD8 T cells, and c-Maf directly transactivated IL-10 gene expression through binding to
126 s show marked cochlea abnormalities, and the transactivating isoform of p63 (TAp63) protein is normal
129 o SUMOylation that regulates its capacity to transactivate its target genes in normal liver and durin
130 ed that LEF1 binds to the MMP13 promoter and transactivates its expression, but we observed that SIRT
133 roteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and al
135 ha-hgamma(c)OPT vector lacked the ability to transactivate LMO2 protein expression, whereas the CL20i
140 age fluid from inhibitory kappaB kinase beta transactivated mice, Escherichia coli lipopolysaccharide
141 ed transgenic (inhibitory kappaB kinase beta transactivated) mice that conditionally express an activ
142 signaling, a key pathogenic pathway in PKD, transactivated miR-21 promoter in kidney cells and promo
143 y of nuclear factor kappa B (NF-kappaB) that transactivates miR-155 gene was significantly (P = 0.002
144 mutant p53 displayed distinct mechanisms of transactivating mitochondrial transcription factor A (TF
145 growth factor (VEGF) B and D, which in turn transactivate MMP-12 via PI3-K, p38 and JNK signaling pa
147 Furthermore, truncated Gli-1 (tGli-1), which transactivates molecules involved in metastasis, was det
153 2-E47 heterodimers have a reduced ability to transactivate neuronal differentiation genes compared wi
154 uggest that GNA13 drives CXCL5 expression by transactivating NF-kappaB in a Rho-dependent manner in p
155 roinflammatory cytokine/chemokine landscape, transactivated NK cells, increased MHC class II expressi
157 nd has been shown to have two activities: it transactivates Notch in neighbouring cells and cis-inhib
158 lar adhesion with Notch expressing cells and transactivates Notch to promote signaling and nuclear tr
159 r 6 results in a Serrate molecule capable of transactivating Notch but exhibiting little or no Notch
160 cription factor Kruppel-like factor 5 (KLF5) transactivates NOTCH1 in the context of p53 mutation or
162 hat retains the ability to interact with and transactivate nuclear hormone receptors through its N-te
163 ein), which contain CtrA-binding motifs, and transactivated ompA, surE and bolA promoter-lacZ fusions
164 of Rta- and RBP-Jkappa-bound promoters, Rta transactivated only those that also contained POU motifs
165 the YBX1 protein level, which decreased YBX1-transactivated p21 expression and abolished G1 phase cel
166 hermore, we found that mutp53 proteins hyper-transactivate p53-target gene CDKN1A upon glutamine depr
169 ly, the mutation increases JAK1 activity and transactivates partnering JAKs, independent of its catal
172 tonin 5-HT(2C) receptors, in which melatonin transactivates phospholipase C (PLC) through 5-HT(2C) .
173 ws that HKa significantly decreases the bFGF-transactivated phosphorylation of EGFR at Tyr 1173 betwe
176 he induction of tumor suppressor p53 and p53-transactivated proapoptotic genes, (2) delayed progressi
177 is poorly understood, since IE62 efficiently transactivates promoter elements lacking this sequence.
178 TN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and
180 demonstrated that fluctuations in viral Tat-transactivating protein levels generate integration-site
181 blishes latency in part because its tegument-transactivating protein, pp71, remains associated with e
183 istent with the ability of Raf inhibitors to transactivate Raf-1 when a PKA-activated Ras promotes Ra
189 by forming a ribonucleoprotein complex with transactivating responsive (TAR) RNA and P-TEFb, an elon
191 Additional mechanistic dissection finds TR4-transactivated SCD1 promoter activity via direct binding
192 acity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14.
193 se can facilitate their known interaction in transactivating Sirtuin 1 (SIRT1), a NAD(+)-dependent hi
194 variants are unable to bind DNA in vitro and transactivate SOX reporter genes in cultured cells.
195 harboring this motif, whereas TAC and other transactivating SOX proteins feature only remotely relat
197 aled a subset of TP53 target genes that were transactivated specifically in sarcomas that were highly
198 X2 expression during NE-transdifferentiation transactivates SPINK1, a critical-player for maintenance
199 sisting of DNA-binding subunit GABPalpha and transactivating subunit GABPbeta, is essential for lymph
200 t E2, acting through estrogen receptor-beta, transactivates synaptic TrkB and beta1-integrin, and via
201 al of FOXM1 is determined by its capacity to transactivate target genes that are implicated in differ
203 These effects are dependent on HIF-1, which transactivates target genes encoding metabolic enzymes a
209 ciably influence the ability of WT PHOX2B to transactivate the DBH promoter, nor did it alter the dec
210 t AR stably expressed in PCa cells failed to transactivate the endogenous AR-regulated PSA or TMPRSS2
211 uclear import of NSY-7 within AWC neurons to transactivate the expression of the high mobility group
212 Indeed, kinase-dead AURKA can effectively transactivate the FOXM1 promoter through a Forkhead resp
214 require Galphai subunits only as adaptors to transactivate the Gbetagamma heteromers, which then act
215 TSAR1 and TSAR2 are coregulated with and transactivate the genes encoding 3-HYDROXY-3-METHYLGLUTA
222 f the extrinsic pathway of blood coagulation transactivate the MASP matriptase, thus connecting coagu
224 al level, we demonstrated that TAp63 and p53 transactivate the promoter and increased the expression
225 n vitro studies have shown that Foxa1/a2 can transactivate the promoters of Mucin 2 (Muc2), which is
232 doid synthesis 1 (BIS1) transcription factor transactivated the expression of all of the genes encodi
237 ranscription factor 15 (KLF15) cooperatively transactivated the infected cell protein 0 (ICP0) promot
239 ed that N1-ICD (Notch1 intracellular domain) transactivated the mouse Kruppel-like factor 4 (Klf) pro
242 Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major u
244 in localized to the nucleus and specifically transactivated the SlTPS5 promoter in Nicotiana benthami
246 ver, when Sp1 and Sp3 were coexpressed, they transactivated the Tesc promoter in a synergistic manner
247 homeodomain proteins, Six1, LBX1, and HoxA5, transactivated the ZEB1 promoter, in the case of Six1, t
248 phatidylinositol (3,4,5)-triphosphate, which transactivates the Akt/mammalian target of rapamycin pat
249 n luciferase activity, suggesting that c-Jun transactivates the Aldh1a1 promoter as a homodimer and n
250 orward transcription loop that cooperatively transactivates the BoHV-1 immediate early transcription
253 is to determine the mechanisms by which p40 transactivates the EGFR in intestinal epithelial cells.
255 Catharanthus APETALA2-domain 3 (ORCA3) that transactivates the expression of several genes encoding
257 In earlier work, we demonstrated that Sox10 transactivates the nicotinic acetylcholine receptor alph
258 ncodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 locus encoding B
262 e studies support a unique concept that 5-HT transactivates the serine kinase receptor, BMPR 1A, to a
263 transfection experiments establish that NOR1 transactivates the Skp2 promoter through a nerve growth
265 te response element-binding protein (ChREBP) transactivates the txnip promoter, whereas ChREBP knockd
266 the expression of GmNAC81 and GmNAC30 fully transactivates the VPE gene in soybean protoplasts and t
267 e RAS-RAF-MEK-ERK signaling cascade directly transactivates the xCT promoter in synergy with the ATF4
269 nd SRF physically associate and synergize in transactivating the MCK promoter independently of SRF bi
270 t Pax3 synergizes with both Gli2 and Zic1 in transactivating the Myf5 epaxial somite (ES) enhancer in
271 Expression of pUL83 alone is capable of transactivating the promoter in a reporter assay, and pU
276 e (as a prodrug and MMP 2-sensitive moiety), transactivating transcriptional activator peptide-PEG100
277 that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical W
278 proteins, led us to hypothesize that ROS can transactivate TrkB in CNS neurons by a zinc-dependent me
279 in axons of mammalian cortical neurons, can transactivate TrkB in neurons and heterologous cells in
281 cytosolic MT-3, the increased cytosolic zinc transactivates TrkB, and the enhanced Shc signaling down
282 d ECH_1038, which were expressed in DCs, and transactivated trp120 and ECH_1038 promoter-lacZ fusions
284 strate that SPZ1, a newly dscribed molecule, transactivates TWIST1 promoters, and that this SPZ1-TWIS
286 ticulum stress potentiated HIF-1 activity to transactivate VEGF expression as well as another well ch
288 ese transduced viral RNAs, BZLF1 transcripts transactivated viral promoters triggering the prelatent
289 ding frame 61 (ORF61) encodes a protein that transactivates viral and cellular promoters in transient
294 e transactivation response element (TAR) RNA transactivates viral transcription and represents a para
295 uclei, where it initiates VZV replication by transactivating viral immediate early (IE), early (E), a
296 255 residue interacts with STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated
297 e formed in living cells and that Galphai is transactivated within minutes after growth factor stimul
299 vitro the ability of manifold progestins to transactivate zebrafish (zf) and human (h) PRs, using tw