ライフサイエンスコーパス: transcript

1 did not modulate the levels of the Httexon1 transcript.

2 the coding, function of the endogenous xbp-1 transcript.

3 represses translation of some of its target transcripts.

4 site of cellular co-expression with PWS gene transcripts.

5 ection feasible down to ~600 individual mRNA transcripts.

6 plemented by WT mRNA but not by SSBP1 mutant transcripts.

7 expression of multiple additional classes of transcripts.

8 r clones expressed both BCOR-WT and BCOR-mut transcripts.

9 itative differential expression of ultralong transcripts.

10 tern, which lacked the metaplasia-associated transcripts.

11 3' processing for viral and a subset of host transcripts.

12 lly predictive of hnRNPK localization within transcripts.

13 RNAs or untranslated regions (UTRs) of mRNA transcripts.

14 ay act in a combinatorial fashion on certain transcripts.

15 pression or expression of Epstein-Barr virus transcripts.

16 entire variable regions of rhesus Ig and TCR transcripts.

17 L54, which also affects the splicing of UL44 transcripts.

18 (ELAVL1) forms complexes with NAFLD-relevant transcripts.

19 NAs in P. vera (Pistacia vera L.) with 53220 transcripts.

20 vidual donors for cfDNA and one of the cfRNA transcripts.

21 that duplicated genes often accumulate more transcripts.

22 ferentially assemble on different classes of transcripts.

23 es in the number of false-positive genes and transcripts.

24 g evidence for the use of dual ORFs in these transcripts.

25 junction that tags the majority of abundant transcripts.

26 tetraphosphate (Np(4)) capping of bacterial transcripts.

27 Few transcripts (28) were differentially expressed when larv

28 hat TRM can induce m(6)A-mediated changes to transcript abundance and alternative splicing.

29 tome studies involve the examination of mRNA transcript abundance and gene expression patterns in the

30 exity, combined with difficulty in measuring transcript abundance and high sequence identity across t

31 By integrating these data with transcript abundance and peptide processing, we develope

32 PgCad1 transcript abundance in midgut tissues did not differ be

33 sion, including systematic underestimates of transcript abundance levels and large increases in the n

34 Transcript abundance of C(4)-CAM signature genes was sho

35 voltage clamp, follows KfSLAC1 and KfALMT12 transcript abundance, declining to near zero by the end

36 get gene transcription without affecting Yap transcript abundance.

37 Gene transcript abundances were determined using RNA sequenci

38 ed cells reporter mRNAs generated from short transcripts accumulate in nuclear speckles and are bound

39 The (Cap)1G transcript adopts a dimeric multihairpin structure that

40 Changes in polysome-bound transcripts after miRNA inhibition were determined using

41 here we show that viral infections affect TE transcript amounts via modulations of the piRNA and siRN

42 Full-length transcript analysis links multiple alternative splicing

43 the extent of ribosomal collisions along the transcript and identify individual codons where ribosoma

44 elihood to estimate the resulting monolignol transcript and protein abundances in transgenic Populus

45 thod that leverages estimates of unprocessed transcript and protein abundances to extrapolate cell st

46 distribution and expression of nAChR subunit transcript and protein across A1 layers in young and age

47 e SEC10 gene on SEC10 expression at both the transcript and protein levels.

48 ariety of potent immune factors, both at the transcript and protein levels.

49 h brain exposed to acrylamide at metabolite, transcript and protein levels.

50 During grain filling, 848 transcripts and 24 metabolites were differentially accum

51 iated with a rapid and selective loss of BBB transcripts and chromatin features, as well as a greatly

52 AB to visualize and quantify nuclear nascent transcripts and cytoplasmic mRNAs as a function of posit

53 Transcripts and episomal DNAs derived from proviral PVCV

54 ncRNAs are distinct from both protein-coding transcripts and genomic background noise in terms of len

55 o reduced translation efficiency of UUG-rich transcripts and impaired fertility, suggesting a role of

56 Syncrip (Syp) binds to msp300 transcripts and is essential for plasticity.

57 nscription of both pachytene piRNA precursor transcripts and messenger RNAs encoding piRNA biogenesis

58 and how exposures alter expression of immune transcripts and pathways.

59 gene functionally and identified ERICH3 mRNA transcripts and protein isoforms that are highly express

60 thaliana) AtSCS gene results in two in-frame transcripts and subsequently two proteins, that differ o

61 GmbH, Berlin, Germany) to process interview transcripts and the framework approach to analyze the qu

62 system relies on highly complex and diverse transcripts and the proteins they encode.

63 crucial for the virus ability to express its transcripts and to eventually reactivate.

64 Here, we show that ASOs act upon nascent transcripts and, consequently, induce premature transcri

65 ss multiple guide RNAs expressed as a single transcript, and subsequently cleave target DNA.

66 vel utility to integrate data-driven primary transcript annotations with transcriptional unit coordin

67 Interestingly, 3' end degraded transcripts are also subject to re-adenylation.

68 Moreover, which transcripts are direct targets of this key posttranscrip

69 that alternatively 5'-edited ND7 5' and CR3 transcripts are present in the transcriptome, providing

70 These transcripts are processed by DICER-LIKE3 into 24-nucleot

71 how long interspersed nuclear repeat (LINE1) transcripts are recruited together with associated genes

72 rol cells by using the endogenous homologous transcript as a template, indicating ATXN3's role in PNK

73 ngs establish that RsmA associates with many transcripts as they are being synthesized in P. aerugino

74 dneys with KDPIs >=85% had very similar gene transcripts as those observed in ECD kidneys, except tha

75 Moreover, the harboring of gene transcripts associated with growth in the nucleus and ma

76 tentially interacting variants that regulate transcripts associated with MDD and demonstrate NPDR's u

77 Transcripts associated with N-glycan processing were dow

78 to identify the causal variant and effector transcripts at T2DM GWAS susceptibility loci.

79 large nuclear bodies, which sequester SRSF7 transcripts at their transcription site, preventing thei

80 can also alter the reading frame in an mRNA transcript because 1,N (6)-erA is incompletely incised b

81 ve mRNA and result in cross-contamination of transcripts between different cell populations.

82 er overall expression levels of the affected transcripts but rather the protein-coding regions.

83 riter METTL3 specifically impacts viral late transcripts by reducing their splicing efficiency.

84 Fusion transcripts can contribute to diversity of molecular net

85 ntibody responses initiated by these variant transcripts can later lead to IgE against the native mol

86 silenced an axis of CDR1as and its antisense transcript, cerebellar degeneration related protein 1 (C

87 Compared to FF, FFPE transcripts coding for nuclear/cytoplasmic proteins invo

88 Although both early and late viral transcripts contain m(6)A, depletion of m(6)A writer MET

89 d that start codons within cap-snatched host transcripts could generate chimeric human-viral mRNAs wi

90 d maintenance of AML, a bias towards mutated transcripts could have a significant impact on disease m

91 methylated regions are detected as peaks in transcript coverage from immunoprecipitated RNA relative

92 s revealed increasingly complex and complete transcript databases that have been used to validate the

93 In developing this tool, we integrated the transcript dataset of plants, several rules governing ge

94 ever, it is unknown how broadly RBPs and ERV transcripts directly interact to provide a posttranscrip

95 In the absence of DXO1 function, transcripts displaying a high proportion of NAD(+) cappi

96 RIPTiDe (Reaction Inclusion by Parsimony and Transcript Distribution) which uses both transcriptomic

97 A) to inosine (I) RNA editing contributes to transcript diversity and modulates gene expression in a

98 The upregulation of late transcripts does not require the primary late-gene-speci

99 g miRNAs, which were predicted regulators of transcripts downregulated in the bone marrow and involve

100 Similarly, loss of ac4C from viral transcripts due to depletion of NAT10 inhibited HIV-1 re

101 wherein BjuA.Galpha1 was the highly abundant transcript during plant growth and developmental stages.

102 ential translation of stress-responsive gene transcripts during hypoxia.

103 mplementary domains: vaccine research, viral transcript editing, T-cell effector response targeting i

104 d increased expression of parenchymal injury transcripts (eg, hypoxia-inducible factor EGLN1).

105 lusive expression of the desired therapeutic transcript (either pol II or pol III but not both).

106 a platform for the biogenesis of the nascent transcripts emanating from these genes.

107 These include transcripts encoding human leukocyte antigen (HLA) recep

108 proper time for their expression, KSHV late transcripts evade PPD through the activity of the host f

109 inostat caused a significant increase in DMD transcript expression in mdx mice.

110 dinucleotides and in the expression of 3,857 transcripts (false discovery rate [FDR] <= 0.1 and absol

111 cytosine-guanine dinucleotide regions for 82 transcripts (false discovery rate [FDR]-P < 0.05).

112 HAX-1) as the most significantly upregulated transcript (FC = +2, P < 0.0006).

113 strongly associated with expression of SNX19 transcript features that tag multiple rare classes of SN

114 Bioinformatic analysis identified transcripts for active (DEFA4, TNFAIP6, FAR2) and chroni

115 In strong hua-pep mutants, functional transcripts for C- and D-function genes are reduced, res

116 most frequently found alternatively spliced transcripts for REA and IF content.

117 CMR) biopsies expressed typical TCMR-related transcripts, for example, intense IFNG-induced effects.

118 A total of 166 alternatively spliced transcripts from 125 genes were significantly differenti

119 ntain a diverse collection of over 70 CaMKII transcripts from all four CaMKII-encoding genes.

120 repurposed to bind and isolate A-to-I edited transcripts from cellular RNA.

121 ed approach and cloned three full-length OSC transcripts from cork (QsOSC1-3).

122 combinatorial indexing(11,12,18) to barcode transcripts from tens of thousands of cells in a single

123 yocytes in vitro to discover hundreds of ERV transcripts from the primate-specific MER41 family, some

124 in cultivated and wild accessions, numerous transcripts had expression patterns unique to particular

125 abundance and high sequence identity across transcripts, has severely limited our collective underst

126 While 12% of the drought-responsive transcripts have similar dynamics in cultivated and wild

127 uencing (8-oxoG RIP-seq) to identify 343 RNA transcripts heavily enriched in oxidations in human bron

128 lerates substantial reduction in full-length transcripts, helping to determine the pathogenicity of B

129 The improved transcript identification and quantification shown by ou

130 sequencing solve inaccuracies in alternative transcript identification of full-length transcripts in

131 on of previously annotated rejection-related transcripts identified 4 groups: normal "R1(normal) " (N

132 ant surface glycoprotein (mVSG) coat protein transcripts identified.

133 required for efficient splicing of the IAV M transcript in nuclear speckles.

134 nalysis of RNase E cleavage of the rimO-crhR transcript in vitro suggested that CrhR plays a role in

135 w data-driven approach for grouping together transcripts in an experiment based on their inferential

136 thods to assemble and quantify the genes and transcripts in an RNA sequencing experiment.

137 s (SLE) and can be tracked via IFN-inducible transcripts in blood.

138 ation induced the accumulation of barley APL transcripts in both the shoots and roots.

139 The fusion transcripts in fetal brain were enriched for genes for l

140 ative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development and

141 These retained introns affect transcripts in multiple cellular pathways predicted to b

142 Downregulated transcripts in our model showed a significant overlap wi

143 y monitor the expression dynamics of nascent transcripts in resting and activated CD4+ T cells.

144 ive transcript identification of full-length transcripts in short-read RNA-Seq data, which encourages

145 We co-detected these transcripts in specific respiratory, corneal and intesti

146 type mice and that knock-down of Chrna3 gene transcripts in the habenula or interpeduncular nucleus (

147 erplay between intronic miRNA and their host transcripts in the modulation of key signaling pathways

148 Here, we report the heterogeneity of CaMKII transcripts in three complex samples of human hippocampu

149 side polyphosphates at the 5' end of nascent transcripts in vitro and the percentage of transcripts t

150 and precise system to deplete specific mRNA transcripts in zebrafish embryos.

151 F1 coregulate the stability of ER-associated transcripts, in particular those associated with the cel

152 nscription termination of non-polyadenylated transcripts including snRNAs and mRNAs encoding replicat

153 During differentiation a large number of transcripts, including many encoding key pluripotency-re

154 nction induced graded regulation of 101 gene transcripts, including MAPK (mitogen-activated protein k

155 ) effect of budesonide on formoterol-induced transcripts, including those encoding many proinflammato

156 une system, autophagy, and apoptosis pathway transcripts, indicating that the DAP1 risk allele mediat

157 enetic diseases, which cannot be obtained by transcript information alone.

158 endogenous retroviral elements and chimeric transcripts initiated from long terminal repeats during

159 In this study, we determined a series of transcript initiation complex structures from the pyrG p

160 ing that intron retention (IR) could lead to transcript instability, in this study, we performed BruC

161 analysis, revealing a striking remodeling of transcripts involved in neuronal signaling.

162 e find that relative expression of MR1A/MR1B transcript is associated with the prevalence of MR1 + CD

163 Here we demonstrate that the PHOSPHO1 transcript is highly enriched in mature brown adipose ti

164 The array transcript is processed by Cas12a itself to release mult

165 The accumulation of these transcripts is accompanied by changes at genic nucleosom

166 ost prominent class of SNX19 risk-associated transcripts is predicted to be overexpressed, defined by

167 Accurate estimation of transcript isoform abundance is critical for downstream

168 Accordingly, SGD has incorporated published transcript isoform data in our instance of JBrowse, a ge

169 ticular, VACV genes produce large numbers of transcript isoforms that vary in their start and termina

170 More than 38 500 novel transcript isoforms were identified, including six categ

171 etect genes with translated ORFs on multiple transcript isoforms, including targets of RNA surveillan

172 Gene annotations, different transcript isoforms, nucleotide sequences and protein in

173 ount for much of the variation between human transcript isoforms.

174 Fusing LLT and SLT transcript leaders to green fluorescent protein indicate

175 oxin promoter and enhanced processing of its transcript, leading to an imbalance in favor of AapA1 to

176 Transcript length (relevant to gene delivery strategies)

177 Gene expression levels measured with full transcript length single-cell RNA sequencing identified

178 correlation between numbers of families and transcript length were 0.20 (P = 0.025) overall and 0.27

179 se mechanism by significantly increasing the transcript level of silicon transporter genes (EcLsi1, E

180 DWARF1 (DWF1) lead to variation of the DWF1 transcript level that contributes to natural variation o

181 LSCs have predominantly been studied at the transcript level, thus information about posttranscripti

182 , even if the data strongly support specific transcript-level effects.

183 width under HNT is a result of differential transcript-level response of Fie1 in grains developing u

184 We determined NPM1mut transcript levels (TLs) by quantitative reverse-transcri

185 so be effectively used for quantification of transcript levels and analysis of differential gene expr

186 onic RNA sequences, some of them controlling transcript levels associated with glucagon action.

187 interaction networks with the differences in transcript levels between control and disease-does not r

188 Here, we show that TA transcript levels can increase substantially in response

189 evident by microglial morphology or cytokine transcript levels in R6/2 mice.

190 reas AtGA2ox10 produces C(19)-GA(9) AtGA2ox9 transcript levels increase after cold treatment and AtGA

191 was lost in the Deltakatms strain, and whose transcript levels increased in M. smegmatis biofilms alo

192 hIP-seq approach, we found that CcpA affects transcript levels of 514 of 1667 GAS genes (31%) whereas

193 Protein and transcript levels of cell cycle regulators were examined

194 Moreover, transcript levels of PYP1, 2 and 6 genes in peel and pul

195 n precursor, vitellogenin, and monitored its transcript levels throughout the entire shrimp life-cycl

196 Here, we present global analyses of viral transcript levels to further understand the roles of the

197 ound that despite the lack of protein, CLASP transcript levels were higher in dark-grown root tips.

198 rogenitors, 5hmC did not correlate with gene transcript levels, however, upon differentiation the glo

199 upregulated muscular and adipose Pgc-1alpha transcript levels, whereas exercise alone was incapable

200 base in gene bodies positively correlated to transcript levels, with more than 2000 genes stably mark

201 ng mechanism in grasses at physiological and transcript levels.

202 ranscriptase to acquire spacers from foreign transcripts, most contain conventional spacer acquisitio

203 Other RNA motifs were also enriched in these transcripts, most with a biological role based on GO ana

204 at FACT and H2Bub globally repress antisense transcripts near the 5' end of genes and inside gene bod

205 oncoding RNA Noncoding Intergenic Co-Induced transcript (NICI) on chromosome 12p13.31 which is regula

206 d a greater number of associations with gene transcripts, not directly associated with lipid metaboli

207 loops from E. coli dnaX mRNA and the gag-pol transcript of Human Immunodeficiency Virus (HIV) perturb

208 The transcript of Rca1beta increased 40-fold in 4 h at eleva

209 y identified RNA thermometer within the ompA transcript of Shigella dysenteriae First identified by i

210 y and specifically binds to and degrades the transcript of TRAILR4, which in turn represses TRAILR4 e

211 We reviewed publicly available transcripts of all DODAC and ODP meetings from February

212 In primary transcripts of eukaryotic nuclear genes, coding sequence

213 Here we discover extensive mixed tailing in transcripts of hepatitis B virus (HBV) and human cytomeg

214 We analyzed workshop evaluations and audio transcripts of postoperative debriefs between coach/coac

215 In upf1-deficient mutants, NMD-susceptible transcripts of ribosomal proteins that are known for the

216 Transcripts of scyl-1 are greatly decreased in adr-1 mut

217 1 promotes SLO-2 function not by editing the transcripts of slo-2 but those of scyl-1, which encodes

218 the stability of spliced and intron-retained transcripts on a genome-wide scale.

219 cell hierarchies, differential expression of transcripts only partially explains protein abundance.

220 fferential expression analysis revealed, 160 transcripts, out of these, 143 transcripts were signific

221 ational workflow to identify high-confidence transcripts, perform differential splicing event analysi

222 Furthermore, we identified the transcript profile of two cell states expressing germ ce

223 Analysis by snRNA-seq identified transcript profiles and inferred functions, cell traject

224 ubstantial differences between the cell-type transcript profiles of Arabidopsis and rice.

225 nies root growth, we generated comprehensive transcript profiles of Brachypodium whole-root system at

226 the epitope from the full latency-associated transcript promoter did not efficiently prime gB-CD8s; h

227 ally on behalf of users during the import of transcript quantification files.

228 g of MIWI2 to a nascent transposable element transcript recruits repressive chromatin remodelling act

229 a significant but limited effect on histone transcript regulation, consistent with multiple mechanis

230 se in M. inflexa, including major changes in transcripts related to metabolism, expression of LEA and

231 n, although the stability of intron-retained transcripts remained relatively constant.

232 ecause the minimal level of full-length (FL) transcripts required for normal function remains to be e

233 Sequencing of gut transcripts revealed PE-fed larvae retain an expression

234 sing cloned eRNAs to study their function as transcripts, revealing roles for eRNAs in enhancer-promo

235 n in translation-elongation kinetics along a transcript's coding sequence plays an important role in

236 cRNA) that we named Stem Cell Inhibitory RNA Transcript (SCIRT), which was markedly upregulated in tu

237 t-based feature selection was applied to the transcript-sequence-derived k-mers.

238 Analysis of Pol I native elongating transcript sequencing data in Saccharomyces cerevisiae s

239 ts influence Pol I in vivo Native elongating transcript sequencing studies reveal that Pol I occupanc

240 n of TP53 protein combined with TP53 and RB1 transcript silencing alleviated induced arrest in TP53+/

241 re we propose SCATS (Single-Cell Analysis of Transcript Splicing) for differential splicing analysis

242 le elements can regulate gene expression and transcript splicing.

243 A significant fraction of VACV transcripts start or end within coding regions of neighb

244 Genome-scale technologies that resolve transcript subpopulations in the nucleus and cytoplasm i

245 lls with spacers targeting a subset of phage transcripts survived the infection, indicating that Type

246 g synthesized in P. aeruginosa, identify the transcripts targeted by RsmA, and suggest that RsmA and

247 (lncRNAs) are defined as non-protein-coding transcripts that are at least 200 nucleotides long.

248 ional approaches, UPF3B-dependent NMD target transcripts that are candidates to mediate the functions

249 Nearly two-thirds of the transcripts that are expressed in anatomically similar t

250 t transcripts in vitro and the percentage of transcripts that are Np(4)-capped in E. coli, clear evid

251 ns that could be generated only from primary transcripts that contain tandemly repeated copies of the

252 entified, including six categories of fusion-transcripts that may result from differential RNA proces

253 perone Hfq targets a subset of those nascent transcripts that RsmA associates with and that the two R

254 rifampicin, we identify hundreds of nascent transcripts that RsmA associates with in P. aeruginosa W

255 ting that cryptic transcription produces the transcripts that then succumb to PPD.

256 Like the functions of lncRNA transcripts, the mechanisms that underlie these genome-b

257 itutive expression of dehydration-associated transcripts, the sequestration of mRNAs in ribonucleopro

258 lncRNAs to function as regulatory noncoding transcripts, there is growing evidence that lncRNAs may

259 ns of nucleic acids that target specific RNA transcripts through several mechanisms.

260 discovered and experimentally validated new transcripts through the application of PRAM to mouse hem

261 nd annotate it using 6.5 million full-length transcripts, thus improving our understanding of gene co

262 or proximal polyadenylation of the antisense transcripts to FLD/LD/SDG26-associated H3K4 demethylatio

263 viral polymerases cleave 5'-m7G-capped host transcripts to prime viral mRNA synthesis ("cap-snatchin

264 messenger RNA (mRNA), which normally commits transcripts to their destruction, has the capacity to dy

265 be an alternative to other methods to assess transcript translation efficiency.

266 that the premature termination of host gene transcripts upstream of iCGIs is closely correlated with

267 We show that most overlapping upstream transcripts use poly(A) sites within the first 2 kb of t

268 he expression of OsNLA1.1, the most abundant transcript variant, is up-regulated in response to incre

269 The expression of Satb1 transcript variants with distinct 5' UTRs occurs in a st

270 However, the spatial distribution of transcripts was eventually resumed, showing that the pre

271 ly unreported subset of small peptide-coding transcripts was identified from these lncRNA loci via ta

272 sions beyond canonical exon-to-exon chimeric transcripts, we develop CICERO, a local assembly-based a

273 s were considerably less stable than spliced transcripts, we found a global stabilization of spliced

274 long reads spanning the full length of mRNA transcripts, we provide support for 23,865 splice isofor

275 All three transcripts were also expressed in the adult brain, main

276 0a When the levels of NMD-susceptible rpl10a transcripts were artificially increased in zebrafish lar

277 Beyond substantiating that intron-retained transcripts were considerably less stable than spliced t

278 Anammox genes and transcripts were detected over a narrow depth range near

279 More than 700 transcripts were differentially expressed in the proxima

280 ed between favorable temperatures, while 614 transcripts were differentially expressed when experienc

281 In humans and mice, sTDP43 transcripts were enriched in vulnerable motor neurons, a

282 These alternate transcripts were expressed at very low levels in the wil

283 The hub transcripts were identified for REA (LRRFIP1, RCAN1 and

284 ficantly decreased, but fatty acid synthesis transcripts were increased, compared with control mice.

285 tected at lower rates and zinc finger family transcripts were of poorer quality.

286 cripts were significantly upregulated and 17 transcripts were repressed under HS conditions.

287 revealed, 160 transcripts, out of these, 143 transcripts were significantly upregulated and 17 transc

288 Sr60 transcripts were transiently upregulated 1 d post-inocul

289 ures that tag multiple rare classes of SNX19 transcripts, whereas they only weakly affected expressio

290 on of a considerable amount of noncoding RNA transcripts, which are increasingly recognized for their

291 ed by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable polyp

292 nificantly more likely spliced into multiple transcripts while they expressed.

293 either solely the normal BCOR-WT or BCOR-mut transcripts, while other clones expressed both BCOR-WT a

294 ith microarray measurements to identify gene transcripts whose translation was up-regulated in respon

295 ranscribing novel unspliced forms of HIV-RNA transcripts with competent open reading frames (ORFs), a

296 long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism.

297 s in which the Opa1 locus no longer produces transcripts with S2 cleavage sites, we generated a simpl

298 el and as yet uncharacterized long noncoding transcripts with unknown function.

299 ivo enables the specific capture of such new transcripts, with 4SU residues being tagged by biotin li

300 correlation of somatostatin and parvalbumin transcripts within human and non-human primates.