ライフサイエンスコーパス: transcription

1 so best reflects the cell's investments into transcription.

2 s and play critical roles in regulating gene transcription.

3 ociation between these resets and downstream transcription.

4 A (tRNA) accumulation activated ISR reporter transcription.

5 these loci contribute to the fine-tuning of transcription.

6 ased Homologous Recombination (HR) and TERRA transcription.

7 wed by linear amplification through in vitro transcription.

8 ments of the RNAP active site in translesion transcription.

9 e its inhibitory and enhancing activities in transcription.

10 to the nucleus, collectively leading to cMyc transcription.

11 vation of E2F1, a known repressor of miR-223 transcription.

12 pression in human cells by repressing BCL11A transcription.

13 tion-6 (STAT6)-dependent inhibition of Tgfb1 transcription.

14 istone methylation acts as a memory of prior transcription.

15 hylation of the TET2 gene down-regulated its transcription.

16 nscription factors and activates ADGRB1 gene transcription.

17 germination, even before the requirement of transcription.

18 emethylation takes place to allow for active transcription.

19 ssociable PAF subunit critical for chromatin transcription.

20 lation of signal transducer and activator of transcription 5, a downstream molecule of PL signaling,

21 RUNX1 functions as a bona fide repressor of transcription activated by AML1-ETO.

22 the NF-kappaB pathway through the NF-kappaB transcription-activating group P65 by phosphorylation an

23 Transcription activation is enhanced by elongating the c

24 Full-length AR and AR-V7 transcription activation required both PRMT5 and pICln b

25 tive to well-characterized sigmaA4-dependent transcription activators.

26 irst, a long RNA generated by rolling circle transcription acts as both the "smart zipper lock" and t

27 er of cytosolic AGPase and enhanced both the transcription and activity of the latter.

28 ulation was related to both decreased Klotho transcription and diminished protein half-life, whereas

29 H2AX and CHK1, suggesting the modulation of transcription and DNA damage that may be mediated by the

30 a mechanism for how CsMAF1 represses Pol III transcription and how phosphorylation controls this proc

31 into a higher-order structure that regulates transcription and maintains genomic stability.

32 e of PC4-like proteins, which plays roles in transcription and maintenance of genome stability.

33 as a 5.5-kb Xist transgene robustly silenced transcription and read through its polyadenylation seque

34 resource for the analysis of LAD rewiring by transcription and reveal a remarkable flexibility of int

35 ndicate that BCL11A lies at the interface of transcription and splicing and promotes aggressive TNBC

36 lar processes such as the regulation of gene transcription and the enhancement or inhibition of prote

37 henotype and that both viral replication and transcription are affected.

38 and the molecular mechanisms controlling its transcription are likely divergent between them.

39 Ensemble in vitro transcription assays indicate that PQS in the non-templa

40 turnover, and thereby reduce Notch-dependent transcription at other loci and sensitize tissues to gen

41 canonical complexes that may promote RNAPII-transcription at these GC-rich microsatellites: the DSIF

42 igate H2A.Z turnover, we propose that global transcription at yeast promoters is responsible for evic

43 r-order DNA secondary structures to regulate transcription beyond its well-established role in safegu

44 , IL-15, and IL-18 not only upregulate PDCD1 transcription, but also activate a previously unrecogniz

45 We show that SP rapidly inhibits HIV-1 transcription by reducing RNAPII recruitment to the HIV-

46 w that enCRISPRa and enCRISPRi modulate gene transcription by remodeling local epigenetic landscapes

47 Several essential conditions for in vitro transcription by T7 RNAP were confirmed with this assay,

48 on regulation of Hsp70 activities by altered transcription, co-chaperone "helper" proteins, and ATP b

49 transcription factors, needed to assemble a transcription-competent preinitiation complex at the pro

50 fined by the release of product RNA from the transcription complex, the subsequent retention of RNAP

51 Spt4/5 association with transcription complexes was slowly reversible, with DNA-

52 ng humans, and may play an important role in transcription-coupled homologous recombination and DNA r

53 t Gh and Sp lesions are potential targets of transcription-coupled repair.

54 Pol II and accessory factors helps order the transcription cycle.

55 tified several compounds that interfere with transcription, DNA damage repair and the cell cycle.

56 n/proteasome degradation process involved in transcription, DNA repair, and cell division.

57 visualization of native YAP and target gene transcription dynamics, we show that a cycle of fast exo

58 e elongation factor that directly stimulates transcription elongation by RNA polymerase II.

59 The positive transcription elongation factor b (P-TEFb), composed of

60 ted that B2 RNA binds stress genes to retard transcription elongation.

61 a complex with Spt4 and regulates processive transcription elongation.

62 resemble the consensus sequence element for transcription-elongation pausing.

63 ted dominant negative form of the human TCF4 transcription factor (dnTCF4) that specifically abrogate

64 ously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pathway that amp

65 inked the transcription factor RE1-silencing transcription factor (REST) to PD and also Alzheimer's d

66 tinct positions of enrichment at the central transcription factor (TF) binding regions and at the fla

67 through association with the prohypertrophic transcription factor (TF) myocyte enhancer factor-2 (MEF

68 r Factor of Activated T cells 5 (NFAT5) is a transcription factor (TF) that mediates protection from

69 ted with CCAAT/enhancer-binding protein beta transcription factor (TF), while the T allele did not sh

70 The Arabidopsis thaliana zinc finger transcription factor (ZF-TF), S-nitrosothiol (SNO) Regul

71 atterns of paired box 2a (pax2a) and SRY-box transcription factor 10 (sox10) expression in the midbra

72 lood, Huang et al have identified activating transcription factor 4 (ATF4) as a novel regulator of fe

73 f intracellular mediators that eventuates in transcription factor activation.

74 h and viability and activating p53-dependent transcription factor activity in a reporter cell assay.

75 DSIF is a versatile transcription factor and has been implicated in both gen

76 ylation-mediated molecular clutch that tunes transcription factor availability via genome-wide redist

77 HIM integrates transcription factor binding and 3D genome structure to

78 kews through biases in CpG enrichment of the transcription factor binding motif.

79 improved nucleosome positioning, heightened transcription factor binding, and increased expression o

80 that long photoperiods induce the circadian transcription factor BMAL2, in the pars tuberalis of the

81 ferentiation are critically dependent on the transcription factor c-Myc (Myc).

82 Multiple kinases converge on the transcription factor cAMP response element-binding prote

83 tress regulated in part by a BMPR2 dependent transcription factor complex between PPARgamma and p53.

84 on is abolished when the function of the FOS transcription factor complex is disrupted.

85 e window) respond in different ways to input transcription factor concentrations, suggesting that the

86 is a lethal disease caused by mutations in a transcription factor critical for the function of thymus

87 regulate autophagy via dephosphorylation of transcription factor EB (TFEB), a master regulator of ly

88 Here we show that transcription factor EB (TFEB), a master regulator of ly

89 antagonist of estrogen receptor (ERalpha), a transcription factor expressed in over 50% of breast can

90 mber of the ETHYLENE-INSENSITIVE3-LIKE (EIL) transcription factor family.

91 Mutations in the transcription factor FOXC2 are predominately associated

92 elium expression of repressive cldn5-related transcription factor foxo1 are associated with stress re

93 idopsis (Arabidopsis thaliana), the MADS-box transcription factor FRUITFULL induces GPA by directly r

94 mHtt) vis-a-vis the pathogenicity of mHtt on transcription factor function and cell survival.

95 The transcription factor GRHL3 regulates IFE differentiation

96 A transcription factor helps young flies to sleep longer b

97 This transition relies on the transcription factor HY5 controlling a complex downstrea

98 ing a knockout mouse model, we show that the transcription factor hypoxia-inducible factor 2 alpha (H

99 Nrf2 transcription factor is crucial for cytoprotective respo

100 The transcription factor JUN is highly expressed in pulmonar

101 ccessibility changes, we have implicated the transcription factor KLF5 in the transition from BO to O

102 This revealed that Myo6 and the transcription factor Knot regulate transient surges of m

103 Transcription factor Mrr1, best known for its regulation

104 partially melted initiation complex (PmIC), transcription factor MTF1 makes base-specific interactio

105 -opts binding sites of the essential meiotic transcription factor Ndt80 upstream of the integration s

106 MNT is a member of the MYC transcription factor network of proteins that must heter

107 A heterotrimeric transcription factor NF-Y is crucial for cell-cycle prog

108 in in single cells by sequencing defined the transcription factor NFE2L2/NRF2 as a critical driver of

109 N1 and GluN2A as well as KEAP1 (regulator of transcription factor NRF2).

110 duction by pharmacological activation of the transcription factor nuclear erythroid 2-related factor

111 migatus and construction of a library of 484 transcription factor null mutants.

112 NR4A3 is a transcription factor of the orphan nuclear receptor fami

113 n the absence of four SPA genes, the pivotal transcription factor PIF4 fails to accumulate, indicatin

114 ity is modulated by genetic depletion of the transcription factor Prrx1.

115 Emerging evidence has linked the transcription factor RE1-silencing transcription factor

116 The Myc transcription factor represents an "undruggable" target

117 IkappaBzeta, which is a key proinflammatory transcription factor required for cytokine synthesis in

118 system, we found that high expression of the transcription factor SLUG was indispensable for the esta

119 Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal

120 umor suppressor protein p53 or the oncogenic transcription factor TAZ.

121 ementing protein (XPB), a component of human transcription factor TFIIH, in both B lymphocytes and ep

122 ce the bZIP60 mRNA that produces a truncated transcription factor that activates gene expression in t

123 p53 is a tetrameric transcription factor that binds DNA response elements to

124 Furthermore, we identified AP2IX-1 as a transcription factor that controls the switching from th

125 Kruppel-like factor 1 (KLF1/EKLF) is a transcription factor that globally activates genes invol

126 e-dimensional culture and expressed Hoxb7, a transcription factor that is part of a developmental reg

127 Runx1 is a transcription factor that plays a key role in determinin

128 y inform approaches targeting this oncogenic transcription factor to manage malignancies.

129 tein response (UPR) under the control of the transcription factor Xbp1.

130 nase-endoribonuclease module to activate the transcription factor XBP1s, which facilitates ER-mediate

131 The dual protein kinase-transcription factor, ERK5, is an emerging drug target i

132 actor 1 (PBX1) is an essential developmental transcription factor, mutations in which have recently b

133 the ERK serine/threonine kinase and the Fos transcription factor, thereby enhancing neurite outgrowt

134 onships between inherited epigenetic states, transcription factor-DNA binding affinity thresholds and

135 d an 'upstream' cascade of three consecutive transcription factor-nodes, which controls transfer comp

136 ry for indelible expression of this critical transcription factor.

137 53 is an intensely studied tumor-suppressive transcription factor.

138 X also dimerizes with MYC, an oncogenic bHLH transcription factor.

139 uronal dendritic growth mediated by the CREB transcription factor.

140 we identified bHLH121 as an ILR3-interacting transcription factor.

141 tudy the regulatory interactions between the transcription factors (TFs) and the target genes.

142 ssue is modeling the complex crosstalk among transcription factors (TFs) and their target genes, with

143 entries from the most recent collections of transcription factors (TFs) from the JASPAR and UniPROBE

144 rate the activity of signaling effectors and transcription factors (TFs) on enhancers.

145 Stp1 and Stp2 are paralogous transcription factors (TFs) regulated by the Ssy1-Ptr3-S

146 Gene regulatory networks (GRNs) link transcription factors (TFs) to their target genes and re

147 trehalose metabolism and various families of transcription factors (TFs) were differentially expresse

148 ed by accessibility of regulatory regions to transcription factors (TFs).

149 y validate a CRC 'trio' constituted by three transcription factors (TFs): KLF15, TCF4 and NKX2-2, in

150 nts caused further declines of photoreceptor transcription factors accompanied by marked decreases of

151 IRT1 modulates its interactions with various transcription factors and a nodal cytosolic kinase invol

152 the C/EBPbeta (CREB-binding protein) and CBP transcription factors and activates ADGRB1 gene transcri

153 lve gene expression programs orchestrated by transcription factors and epigenetic regulators.

154 very of CD4(+) T cell subset-defining master transcription factors and framing of the Th1/Th2 paradig

155 in motifs belonging to PU.1, TCF3, and OCT2 transcription factors and involved elevated MYD88/TLR pa

156 ocessive RNA polymerases, allosteric protein transcription factors and synthetic DNA transcription te

157 The signaling events activate the transcription factors AP-1 and NF-kappaB, leading to the

158 Members of the NF-kappaB family of transcription factors are key drivers of inflammation th

159 s a competitive reservoir in vivo from which transcription factors are released by mitogen-activated

160 Although it is well-established that transcription factors bind to specific DNA sequences usi

161 the BARLEY B RECOMBINANT/BASIC PENTACYSTEINE transcription factors BPC1/BPC2 positively regulate plan

162 In the developing spinal cord, Onecut transcription factors control the diversification of mot

163 d HMG-box-containing (SOX) genes that encode transcription factors controlling cell fate and differen

164 These transcription factors cooperated to regulate expression

165 ent downregulated expression of a network of transcription factors critical for chordoma survival and

166 n the other hand, CpGs at sites not bound by transcription factors during the global re-methylation p

167 upstream regulatory axis of FcepsilonRI) and transcription factors Elf-1 and YY1.

168 dentity through fine-tuned regulation of key transcription factors ensures beta-cell function.

169 , chemokine receptors CCR4 and CCR6, and the transcription factors GATA-3 and RORgammaT.

170 Here, we demonstrate that transcription factors GLK1 and GLK2 interact with and ar

171 (PRC2) silences expression of developmental transcription factors in pluripotent stem cells by methy

172 text-dependent functions of lineage-defining transcription factors in regulating specification progra

173 filing shows differential expression of many transcription factors in response to 5,8-diHODE.

174 to epithelial-mesenchymal transition driver transcription factors in stem cell-specific accessible r

175 t in the co-expression of these antagonistic transcription factors in the majority of haematopoietic

176 ng this cell type patterning is a network of transcription factors including a central MYB-basic heli

177 ence the ESR through general stress response transcription factors Msn2/4.

178 affinity thresholds and influences of given transcription factors on the activities of other factors

179 ific NFR were enriched for binding motifs of transcription factors related to tissue-specific functio

180 tegrative analyses revealed that the HOXA5-9 transcription factors repress the Ealpha enhancer at ear

181 We show that Hox5 transcription factors shape phrenic MN output by connect

182 ere targeted to Ct-Smad2/3 and Ct-Smad1/5/8, transcription factors specific to the Activin/Nodal and

183 and describe motifs that correspond to other transcription factors that are co-enriched with the prim

184 We also classified families of transcription factors that are increasingly enriched at

185 FOXO proteins are transcription factors that are involved in numerous phys

186 (PIFs) are a group of basic helix-loop-helix transcription factors that can physically interact with

187 identify transcription factors that define one subtype of neural

188 ith known biological similarity and identify transcription factors that may mediate tissue-specific e

189 hlight PGC1alpha, SRF and the MEF2 family as transcription factors that may potentially mediate this

190 Finally, we identified transcription factors that regulate stimulation-dependen

191 rks by linking enhancers and predicted bound transcription factors to their target promoters using a

192 he relevance of high-affinity binding of ARF transcription factors to uniquely spaced DNA elements in

193 Metazoan transcription factors typically regulate large numbers o

194 nt-binding proteins (SREBPs), membrane-bound transcription factors whose proteolytic activation requi

195 tors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metaboli

196 gulated transport of nuclear proteins (e.g., transcription factors) between myonuclei represents a po

197 current catalogue of DNA sequence motifs for transcription factors, and describe motifs that correspo

198 plex interplay between chromatin remodeling, transcription factors, and signaling molecules.

199 Our data show temporal transcription factors, as a group of molecules, are pote

200 cyte development system, we identified eight transcription factors, each of which was essential for t

201 vious research has identified four conserved transcription factors, fos-1 (Fos), egl-43 (EVI1/MEL), h

202 increased expression of a set of homeodomain transcription factors, including homeobox A9 (HOXA9) and

203 bably associated with recruitment of general transcription factors, needed to assemble a transcriptio

204 Pioneer factors subsequently enable other transcription factors, nucleosome remodeling complexes,

205 ve-feedback regulator for multiple oncogenic transcription factors, provides insights into the functi

206 (Samd14-Enh), occupied by GATA2 and SCL/TAL1 transcription factors, reduces SAMD14 expression in bone

207 al Notch ligand and other secretory-specific transcription factors.

208 rough the recruitment of proteins, including transcription factors.

209 Rs, a group of basic helix-loop-helix (bHLH) transcription factors.

210 ell and are often controlled by pre-existing transcription factors.

211 r only a minority of the numerous associated transcription factors.

212 nd invasion, and transcriptional activity of transcription factors.

213 terial RNA polymerase engaged in reiterative transcription from the pyrG promoter, which contains eig

214 Epigenetic regulation of gene transcription has been shown to coordinate with nutrient

215 Recent investigations focusing on GGGGCC-transcription have identified specific, canonical comple

216 is closely correlated with the level of iCGI transcription in a DNA-methylation independent manner.

217 he MAPK signaling pathway, and regulates its transcription in cis.

218 ) functions as an epigenetic activator of AR transcription in CRPC, requiring cooperation with a meth

219 acetylation, and CTCF in anaphase/telophase, transcription in cytokinesis, and long-range chromatin i

220 cific histone demethylase for lipogenic gene transcription in liver.

221 t the processes and factors mediating LILRB1 transcription in NK cells.

222 mark of the initiation step of HIV-1 reverse transcription, in which viral RNA genome is converted in

223 R loops arising during transcription induce genomic instability, but how cells

224 rder to simultaneously measure the shifts in transcription induced by thousands of genetic variants.

225 Transcription infidelity (TI) is a mechanism that increa

226 The process of transcription initiation and elongation are primary poin

227 e restored by fusion with the 100 bp minimum transcription initiation element (TIE) of Klk1b21, sugge

228 wever, the mechanism by which FlrC regulates transcription is not fully elucidated.

229 g recombinantly expressed proteins, in vitro transcription, kinetic analyses, and in vivo cell viabil

230 es that dynamic crowding nontrivially alters transcription kinetics and presents dynamic crowding wit

231 receptor (GR) and KLF15 form a feed-forward transcription loop that cooperatively transactivates the

232 complex stoichiometry and regulation of SHR transcription modulate the division timing of two differ

233 ults demonstrate that the effects of ASOs on transcription must be considered for appropriate experim

234 lled by (pp)pGpp, including DNA replication, transcription, nucleotide synthesis, ribosome biogenesis

235 We show that Rho can prematurely terminate transcription of bacterial CRISPR arrays, and we identif

236 As in the mouse, human A-MYB drives transcription of both pachytene piRNA precursor transcri

237 MRX restricts transcription of coding and noncoding DNA by a mechanism

238 that antagonizes Rho to facilitate complete transcription of CRISPR arrays.

239 the majority of these regulators repress the transcription of genes encoding class A ARFs.

240 how that loss of both Trp53 and Rb1 disables transcription of genes in the autophagic machinery neces

241 PSC-CM) demonstrated that ERRgamma activates transcription of genes involved in virtually all aspects

242 verse effects of hypertonicity by increasing transcription of genes, including those that lead to cel

243 ltransferase (HAT) activities that activates transcription of key protooncogenes, including MYC We re

244 revealed that CDK8 positively regulates the transcription of several ABA-responsive genes, probably

245 hat SM utilizes XPB to specifically activate transcription of SM target promoters.

246 hereby serving to either activate or repress transcription of specific genes involved in nickel homeo

247 otein can disrupt EBV latency by driving the transcription of target genes and by interacting with th

248 that binds DNA response elements to regulate transcription of target genes.

249 not DNA methylation, underlie exon-specific transcription of the Bdnf gene induced by leptin.

250 naling cascade also positively regulates the transcription of the MCM6 gene that is involved in DNA r

251 Zygotic transcription of these genes largely retained features o

252 tion is marked by the general attenuation of transcription on chromosome arms, yet how the cell regul

253 with pol II or by modulating the activity of transcription or RNA processing factors, these regulator

254 h assesses the effects of defined alleles on transcription or splicing when introduced in their endog

255 r in each nucleotide addition during initial transcription, particularly the first 4 to 5 nucleotide

256 The results show initial-transcription pausing can occur in each nucleotide addit

257 The results further show initial-transcription pausing occurs at sequences that resemble

258 swabs and evaluated by quantitative reverse transcription-PCR (qRT-PCR) subsequently confirmed QS up

259 y, polychromatic flow cytometry, and reverse transcription-PCR.

260 had testing for influenza viruses by reverse-transcription polymerase chain reaction (RT-PCR) in Aust

261 ed in acute-phase serum by real-time reverse transcription polymerase chain reaction and analyzed in

262 Swabs were tested for PeV by reverse-transcription polymerase chain reaction and genotypes de

263 expression profiles (by quantitative reverse transcription polymerase chain reaction and RNAscope) of

264 ith vs without CoPEC by quantitative reverse-transcription polymerase chain reaction.

265 l signaling pathways cooperate to change the transcription program through chromatin regulation to re

266 ents using Western blot analysis and reverse transcription quantitative polymerase chain reaction (RT

267 cific interactions controlled the promoters' transcription rates.

268 However, whether and how CRC contributes to transcription regulation in Ewing sarcoma is unknown.

269 a nuclear enzyme involved in DNA repair and transcription regulation, among other processes.

270 diverse processes, including cell division, transcription regulation, and cell signaling.

271 otate a set of genomic intervals in terms of transcription regulation.

272 lic mutations within the leucine zipper-like transcription regulator 1 (LZTR1).

273 ceptor alpha (ERalpha) is a ligand-dependent transcription regulator, containing two transactivation

274 ted by consolidating information relating to transcription, regulatory activity, chromatin accessibil

275 n were predictive of increased and decreased transcription relative to control, respectively, in the

276 Mtb infection supported more efficient HIV-1 transcription, release, and replication.

277 By regulating DNA access for transcription, replication, DNA repair, and epigenetic m

278 Transcription-replication (T-R) conflicts are profound t

279 Using nascent-transcription reporter knock-ins of YAP target genes, we

280 uld directly or indirectly contribute to the transcription repression of these genes.

281 This study identifies a transcription repressor responsible for awn inhibition a

282 results demonstrate that rapid and extensive transcription reprogramming associated with hematopoieti

283 e find that infrequent, stochastic bursts of transcription result in the co-expression of these antag

284 obust, reliable, and highly specific reverse transcription-RPA technique coupled with a lateral flow

285 Use of alternative transcription start sites located within the Arabidopsis

286 , 453 accessible TEs are found to create the transcription start sites of downstream genes in mouse,

287 cer units are precisely delineated by active transcription start sites, validate that these boundarie

288 naling to signal transducer and activator of transcription (STAT) (ruxolitinib) or mitogen-activated

289 tein transcription factors and synthetic DNA transcription templates regulates the synthesis of a flu

290 In addition to negatively regulating CycB transcription, the Fzr-ubiquitinated H2B (H2Bub)-Myc sig

291 Mechanistically, MAOA enhances IL-6 transcription through direct Twist1 binding to a conserv

292 licated in both gene-specific regulation and transcription through nucleosomes.

293 repressive complex 2 (PRC2), which silences transcription through trimethylation of histone H3 lysin

294 course of the day, observed at cellular (eg, transcription, translation, and signaling), organ (eg, c

295 ly transactivates the BoHV-1 immediate early transcription unit 1 (IEtu1) promoter that drives bovine

296 Some negative-sense RNA viruses prime mRNA transcription using host 5' cap sequences, usurping host

297 We find that JAK1 transcription was predominantly restricted to a single a

298 hat master the two intertwined and transient transcription waves defining competence in Streptococcus

299 chromatin, Xist-2kb did not robustly silence transcription, whereas a 5.5-kb Xist transgene robustly

300 vities, and corresponding regulation on gene transcription, which it models as a sparse network of fu