ライフサイエンスコーパス: transcription elongation

1 ted that B2 RNA binds stress genes to retard transcription elongation.

2 ults reveal a global requirement for Spt5 in transcription elongation.

3 ow levels of Paf1 on Pol2 are sufficient for transcription elongation.

4 n of pachytene piRNA precursors by promoting transcription elongation.

5 occurs in each nucleotide addition cycle in transcription elongation.

6 lucidate key roles for Rad26 in both TCR and transcription elongation.

7 r and specifically regulates the step of HIV transcription elongation.

8 ranslation initiation, RNA stability, and/or transcription elongation.

9 bsequent release of paused pol II needed for transcription elongation.

10 ndent histone H3 acetylation is required for transcription elongation.

11 Fft3), to overcome the nucleosome barrier to transcription elongation.

12 nd, under cold stress, also in mitochondrial transcription elongation.

13 BET proteins as master regulators of global transcription elongation.

14 n complexes, bind nucleic acids, and promote transcription elongation.

15 how these minor-groove binders affect pol II transcription elongation.

16 lates RNA polymerase II (RNAPII) pausing and transcription elongation.

17 protein transport and localization, and (iv) transcription elongation.

18 xerts its suppressive function by regulating transcription elongation.

19 binding of Tat to CDK9, a process key to HIV transcription elongation.

20 or binding, as well as interfere with pol II transcription elongation.

21 es the ARS gene family through modulation of transcription elongation.

22 a complex with Spt4 and regulates processive transcription elongation.

23 ex is a critical step for P-TEFb to activate transcription elongation.

24 the incorporation of 2'-fluoro dNMPs during transcription elongation.

25 looped enhancer contacts during synchronous transcription elongation.

26 specific and direct epigenetic sensor during transcription elongation.

27 r the transcription start site and promoting transcription elongation.

28 x with RNA polymerase II (and I) to regulate transcription elongation.

29 is may be a general pathway of regulation of transcription elongation.

30 y and disassembly of nucleosomes, as well as transcription elongation.

31 nfer robustness on processes associated with transcription elongation.

32 sense variant in an ELL2 domain required for transcription elongation.

33 vivo influence of positioned nucleosomes on transcription elongation.

34 e mechano-chemical coupling mechanism of the transcription elongation.

35 ide, suggesting a role for RSC in regulating transcription elongation.

36 s to interrogate mechanisms of regulation of transcription elongation.

37 nd facilitate Pol II transition during early transcription elongation.

38 (CycT1) or T2 (CycT2), activates eukaryotic transcription elongation.

39 FIIS) and IIF (TFIIF) are known to stimulate transcription elongation.

40 DCP1A controls Tsix half-life and transcription elongation.

41 ry mechanisms responsive to reduced rates of transcription elongation.

42 t the most common and troublesome barrier to transcription elongation.

43 removes polySUMO chains and promotes RNAPII transcription elongation.

44 NA polymerase II to promoters for productive transcription elongation.

45 ion of nascent rRNA processing events during transcription elongation.

46 e mechanism and regulation of the on-pathway transcription elongation.

47 resulting in a consistent protein barrier to transcription elongation.

48 (P-TEFb) activity, a key factor in promoting transcription elongation.

49 12 inhibition causes a genome-wide defect in transcription elongation and a global reduction of CTD S

50 Ser2 residues in the cat-3 ORF region during transcription elongation and deletion of CTK-1 led to dr

51 Deletion of Spt5 KOW4-5 domains decreases transcription elongation and derepresses TCR.

52 osome assembly and H2A-H2B deposition during transcription elongation and DNA replication.

53 romatin engagement of two central players in transcription elongation and emphasize the importance of

54 Broad H3K4me3 is associated with increased transcription elongation and enhancer activity, which to

55 on a DNA segment by transcription slows down transcription elongation and eventually stops transcript

56 he expressome structure can only form during transcription elongation and explains how translation ca

57 ctional role of TOP2A cleavage in regulating transcription elongation and gene activation.

58 that CDK12 is a general activator of pol II transcription elongation and indicate that it targets bo

59 ription but does enhance the overall rate of transcription elongation and maintains transcription rei

60 sential splicing factors; and associate with transcription elongation and mRNA export complexes.

61 ts by overexpression) complex is involved in transcription elongation and mRNA export.

62 The transcription elongation and pre-mRNA splicing factor Ta

63 teins, implicate TFII-I in the regulation of transcription elongation and provide insight into the ro

64 The core role of NusG is to enhance transcription elongation and RNA polymerase processivity

65 standing of the complex relationship between transcription elongation and rRNA processing.

66 the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, ha

67 le for H2A.Z in coordinating the kinetics of transcription elongation and splicing.

68 ase binds to RNA-polymerase (RNAP) II during transcription elongation and suppresses transcription-as

69 p1 is a protein phosphatase that facilitates transcription elongation and termination by dephosphoryl

70 for Thr4 in engaging the machinery used for transcription elongation and termination.

71 It was found that UV light inhibited transcription elongation and that recovery of RNA synthe

72 he linear Brownian ratchet kinetic model for transcription elongation and the backtracking model for

73 in remodelers has been broadly implicated in transcription elongation and transcription-coupled DNA d

74 itment of ERalpha and RNAPII, and stimulates transcription elongation and transcription-coupled histo

75 In bacteria, the rates of transcription elongation and translation elongation are

76 richia coli UvrD binds RNA polymerase during transcription elongation and, using its helicase/translo

77 -order multiprotein complexes, which promote transcription, elongation, and splicing of a wide range

78 p to 30-fold, and that inhibitory effects on transcription elongation are also possible.

79 atalytic cores and fundamental mechanisms of transcription elongation are conserved, the initiation s

80 The coliphage HK022 protein Nun transcription elongation arrest factor inhibits RNA poly

81 These data therefore reveal transcription elongation as a point of regulatory contro

82 entially, sigma70 acts at other sites during transcription elongation as well.

83 Using in vitro transcription elongation assays, we show that OGA activi

84 xhibits an increased interaction with active transcription elongation-associated factors in embryonic

85 gamma colocalizes and enhances enrichment of transcription elongation-associated H3K36me3 rather than

86 developing a class of molecules that license transcription elongation at targeted genomic loci.

87 f the PRC1 members or UBR5 alone derepressed transcription elongation at these sites, suggesting that

88 By inhibiting transcription elongation, but not initiation, pre-treatm

89 nscription "roadblocking" approaches inhibit transcription elongation by blocking RNAP with a protein

90 inhibit RNA polymerase II (Pol II)-dependent transcription elongation by inhibiting the positive tran

91 Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-

92 The rate of transcription elongation by Pol I directly influences pr

93 Regulation of transcription elongation by positive transcription elong

94 HIV-1 Tat stimulates transcription elongation by recruiting the P-TEFb (posit

95 these transcription factors enhance overall transcription elongation by reducing the lifetime of tra

96 Regulation of transcription elongation by RNA polymerase II (Pol II) i

97 e elongation factor that directly stimulates transcription elongation by RNA polymerase II.

98 or groove sensor." Prolonged interference of transcription elongation by sequence-specific minor groo

99 n vivo, that DksA/ppGpp increase fidelity of transcription elongation by slowing down misincorporatio

100 and both proteins remain associated with the transcription elongation complex (TEC) as it escapes the

101 factor in vivo by loading directly onto the transcription elongation complex (TEC) in trans.

102 s) Csm (TthCsm) to a nascent transcript in a transcription elongation complex (TEC) promotes tetherin

103 termination factor capable of disrupting the transcription elongation complex (TEC), detail the rate

104 opy, we show that only a complete ops-paused transcription elongation complex activates RfaH, probabl

105 e conclude that changes in properties of the transcription elongation complex closely correlate with

106 We found that several components of the PAF1 transcription elongation complex contribute to Chd1 recr

107 and CRISPR loci, Spt4/5 is recruited to the transcription elongation complex during early elongation

108 CDK9 - a component of the transcription elongation complex P-TEFb - bound to the M

109 Thus, the transcription elongation complex Paf1, the histone methy

110 F4/FMR2 (AFF) family protein AFF3 within the transcription elongation complex SEC-L3.

111 observe changes in dinucleotide production, transcription elongation complex stability, and Pol I pa

112 n binds at the upstream fork junction of the transcription elongation complex, similar to sigma2 in t

113 liable model of the complete NusG-associated transcription elongation complex, suggesting that the NG

114 g an atypical pathway for the formation of a transcription elongation complex.

115 teractions of several DNA lesions within the transcription elongation complex.

116 d signal-induced recruitment of the positive transcription-elongation complex P-TEFb and thereby prev

117 es of essential, multisubunit RNA polymerase transcription elongation complexes (TECs).

118 family bind at the upstream fork junction of transcription elongation complexes and modulate RNA synt

119 Collisions between paused transcription elongation complexes and replication forks

120 Here, we show that stalled Escherichia coli transcription elongation complexes block reconstituted r

121 e we show that DksA/ppGpp do not destabilise transcription elongation complexes or inhibit their back

122 al rearrangement triggered by recruitment to transcription elongation complexes through a specific DN

123 pp contribute to prevention of collisions of transcription elongation complexes with replication fork

124 on, translation is not inhibited by arrested transcription elongation complexes.

125 between RNAP and DNA and dissociates stalled transcription elongation complexes.

126 lso found to be associated with a network of transcription elongation components including the super

127 6me3 that links the histone-variant-mediated transcription elongation control to tumour suppression.

128 initiation, release of RNAPII from pausing, transcription elongation, cotranscriptional pre-mRNA spl

129 f topoisomerase I with RNA polymerase during transcription elongation could efficiently relieve trans

130 no major defect in transcription elongation, transcription elongation defects seen with the super elo

131 particularly large impact on the dynamics of transcription elongation during stationary phase.

132 BRDs, the Mediator complex and the positive transcription elongation factor (Abstract figure).

133 Both screens revealed roles for the positive transcription elongation factor (P-TEFb) component Cycli

134 The positive transcription elongation factor (P-TEFb) is required for

135 myocytes by elevating levels of the positive transcription elongation factor (P-TEFb), instating a la

136 2 (E2f2) and Brain Expressed X-Linked (Bex)/Transcription elongation factor A-like (Tceal) superfami

137 ression through the regulated binding of the transcription elongation factor AFF3 between a DMR and a

138 RNAPII but constitutively evicts Spt5, a key transcription elongation factor and TC-NER repressor, fr

139 ified a blockade in the specialized positive transcription elongation factor b (P-TEFb) activation me

140 ld be rescued by additional loss of positive transcription elongation factor b (P-TEFb) activity, a k

141 CDKC;2 functions in an Arabidopsis positive transcription elongation factor b (P-TEFb) complex and i

142 ator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regu

143 DX21 facilitates the release of the positive transcription elongation factor b (P-TEFb) from the 7SK

144 t (transactivator of transcription)-positive transcription elongation factor b (P-TEFb) interaction a

145 The Positive Transcription Elongation Factor b (P-TEFb) phosphorylate

146 tion of transcription elongation by positive transcription elongation factor b (P-TEFb) plays a centr

147 The positive transcription elongation factor b (P-TEFb) promotes tran

148 virally encoded Tat protein hijacks positive transcription elongation factor b (P-TEFb) to phosphoryl

149 es cell viability by activating the positive transcription elongation factor b (P-TEFb) via its relea

150 Positive transcription elongation factor b (P-TEFb), a complex of

151 RNP) sequesters and inactivates the positive transcription elongation factor b (P-TEFb), an essential

152 AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentia

153 The positive transcription elongation factor b (P-TEFb), composed of

154 The positive transcription elongation factor b (P-TEFb), comprised of

155 hat RBPJ binds CDK9, a component of positive transcription elongation factor b (P-TEFb), to target ge

156 controlling the nuclear activity of positive transcription elongation factor b (P-TEFb).

157 pendent kinases CDK13 and CDK11 and positive transcription elongation factor b (P-TEFb).

158 iption elongation by inhibiting the positive transcription elongation factor b (P-TEFb, a complex of

159 ich motif (ARM) to recruit the host positive transcription elongation factor b (pTEFb) complex onto t

160 its previously reported effects on positive transcription elongation factor b and HMBA inducible pro

161 interactions with both 7SK RNA and positive transcription elongation factor b are critical for HEXIM

162 ogether with CDK9, the component of positive transcription elongation factor b complex responsible fo

163 stablishment of Pol II pausing, and positive transcription elongation factor b releases (P-TEFb) paus

164 ed for interaction with the P-TEFb (positive transcription elongation factor b) kinase complex and fo

165 (CCNT2), the regulatory subunit of positive transcription elongation factor b, a complex that inhibi

166 This general transcription elongation factor binds to RNA polymerase

167 r TEAD4, coactivators BRD4 and MED1, and the transcription elongation factor CDK9 for transcription.

168 elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be

169 EPOP interacts with the transcription elongation factor Elongin BC and the H2B d

170 Transcription elongation factor GreA efficiently blocked

171 This universally conserved transcription elongation factor is known as Spt5 in arch

172 c bypass rate, which is exacerbated by TEFM (transcription elongation factor mitochondrial).

173 e both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis

174 The transcription elongation factor NusG facilitates this te

175 The bacterial transcription elongation factor NusG stimulates the Rho-

176 d termination, it is fully responsive to the transcription elongation factor NusG.

177 oteins LARP7 and MePCE captures the positive transcription elongation factor P-TEFb and prevents phos

178 se II, via its interaction with the positive transcription elongation factor P-TEFb.

179 2nd pause region is independent of positive transcription elongation factor P-TEFb.

180 traightforward as temporary backtracking and transcription elongation factor S-II (TFIIS)-dependent R

181 We found that targeting the transcription elongation factor Spt4 selectively decreas

182 ow TFIIH occupancy and high occupancy of the transcription elongation factor Spt4/Spt5 suppresses TC-

183 The transcription elongation factor Spt5 is conserved from b

184 The transcription elongation factor Spt6 and the H3K36 methy

185 e demonstrate that the histone chaperone and transcription elongation factor Spt6 spatially and tempo

186 rt in Science that targeted reduction in the transcription elongation factor SUPT4H1/SUPT5H reduces b

187 We found that interaction of human transcription elongation factor TEFM with mitochondrial

188 which we here show to be independent of the transcription elongation factor TEFM.

189 Here, we used a mutant version of the transcription elongation factor TFIIS (TFIIS(mut)), aimi

190 NusG/Spt5 is a transcription elongation factor that assists in DNA-temp

191 protein is a universally conserved bacterial transcription elongation factor that binds RNA polymeras

192 ucing factor (DSIF or Spt4/5) is a conserved transcription elongation factor that both inhibits and s

193 Our results establish UvrD as a bona fide transcription elongation factor that contributes to geno

194 nscription) has long been considered to be a transcription elongation factor whose ability to destabi

195 Here, we identify TFIIS.h, a transcription elongation factor, as a new transcriptiona

196 The RNA polymerase II (Pol II) transcription elongation factor, Elongin A (EloA), is me

197 dition to serving as a histone chaperone and transcription elongation factor, Spt6 counteracts repres

198 longation by recruiting the P-TEFb (positive transcription elongation factor-b) (CycT1:CDK9) C-termin

199 d form by activating Ell2 (which encodes the transcription-elongation factor ELL2).

200 tep, we designed sequence-specific synthetic transcription elongation factors (Syn-TEFs).

201 ate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymera

202 Transcription elongation factors dramatically affect RNA

203 disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core compone

204 ain of Pol II-and enrichment of the positive transcription elongation factors MYC, BRD4, PAF1, and th

205 RNA polymerase (RNAP), the ribosome, and the transcription elongation factors NusG and NusA.

206 sful, and the essentiality of both conserved transcription elongation factors suggests that both cons

207 ing study of the interactions of RNAPII with transcription elongation factors TFIIS and TFIIF, which

208 t directly engage and remodel nucleosomes or transcription elongation factors that facilitate Pol II

209 complexes, histone-modification enzymes and transcription elongation factors to aid transcription th

210 erases, bromodomain-containing proteins, and transcription elongation factors to mediate chromatin re

211 The vast majority of organisms possess transcription elongation factors, the functionally simil

212 ethylation at Lys36 (H3K36me3), a marker for transcription elongation, guides m(6)A deposition global

213 usters have been identified, those affecting transcription elongation have not been broadly investiga

214 CDK12 inhibition led to defects in transcription elongation in a gene length- and expressio

215 tute AID-catalyzed deamination during Pol II transcription elongation in conjunction with DSIF transc

216 nt for HP1gamma in faithful establishment of transcription elongation in ESCs, which regulates plurip

217 ion factor that both inhibits and stimulates transcription elongation in metazoans.

218 rovide the first base-pair resolution map of transcription elongation in S. pombe and identify diverg

219 Escherichia coli NusG enhances transcription elongation in vitro by a poorly understood

220 to DNA oligonucleotides to assess RNA Pol II transcription elongation in vitro.

221 lates the rate of RNA polymerase II (Pol II) transcription elongation in vitro.

222 impact on global transcription profiles and transcription elongation in vivo.

223 Pausing by RNA polymerase (RNAP) during transcription elongation, in which a translocating RNAP

224 (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, D

225 r CDK9 inhibitor functionally suppressed RNA transcription elongation, induced apoptosis, and reduced

226 benzimidazole (DRB), an RNA Pol II-dependent transcription elongation inhibitor, and flavopiridol inh

227 e that an attenuation-like mechanism governs transcription elongation into the mgtCBR coding region.

228 RNA polymerase II (RNAPII) transcription elongation is a highly regulated process t

229 Transcription elongation is a key regulatory step in gen

230 Pyrophosphate ion (PPi) release during transcription elongation is a signature step in each nuc

231 Regulation of transcription elongation is based on response of RNA pol

232 interactive looping element and showed that transcription elongation is dispensable for promoter/enh

233 Transcription elongation is frequently interrupted by pa

234 Transcription elongation is interrupted by sequences tha

235 The movement of RNA polymerase (RNAP) during transcription elongation is modulated by DNA-encoded ele

236 it targets one or both nucleic acids during transcription elongation is unknown.

237 rmination, the process that marks the end of transcription elongation, is regulated by proteins that

238 sistent with the role of NuA4 in stimulating transcription elongation, loss of EAF5 or EAF7 resulted

239 raft mouse models, suggesting that targeting transcription elongation machinery may be an effective t

240 increase in the recruitment and activity of transcription elongation machinery that enforces active

241 ethered to a small molecule that engages the transcription elongation machinery.

242 o show that it can enhance the efficiency of transcription elongation of apoptosis-associated bax gen

243 Leflunomide abrogates the effective transcription elongation of genes required for neural cr

244 Fbeta) signaling is elevated due to enhanced transcription elongation of key pathway genes, leading t

245 ly activated by cyclin C and is required for transcription elongation of the serum response genes (im

246 ario of the mechano-chemical coupling in the transcription elongation of the single-subunit polymeras

247 small number of regulatory factors influence transcription elongation on a global scale.

248 n, but also at further control steps such as transcription elongation or RNA processing.

249 thought generally to function by modulating transcription elongation or translation initiation.

250 As nucleotide concentration regulates transcription elongation, our findings argue that RNAPII

251 ivin/SMAD2,3 signaling selectively increases transcription elongation, P-TEFb occupancy, and Ser7P-RN

252 ed by sequence elements similar to those for transcription-elongation pausing.

253 resemble the consensus sequence element for transcription-elongation pausing.

254 activity regulation in the initial and final transcription elongation phases.

255 NA sequence directly impacts the kinetics of transcription elongation prior to the sequence entering

256 ich mimics sigmaR4, is released gradually as transcription elongation proceeds, whereas YvrHa, which

257 trol of H3K36 methylation during the dynamic transcription elongation process.

258 Transcription elongation programs are vital for the prec

259 remains in the 7SK-unbound state to sustain transcription elongation programs remains unknown.

260 the activation and maintenance of inducible transcription elongation programs.

261 cetyltransferases, chromatin remodelers, and transcription elongation promote NIPBL occupancy at acti

262 erases, but the influence of DNA sequence on transcription elongation properties of eukaryotic RNA po

263 tion of the large, widespread NusG family of transcription elongation proteins and found that it incl

264 rsal or fixed and change in response to both transcription elongation rate and frequency as well as r

265 yeast that a RNAPII mutant that reduces the transcription elongation rate causes widespread changes

266 olecules revealed a pronounced defect in the transcription elongation rate in FRDA cells when compare

267 est that some static gene features influence transcription elongation rates and that cells may alter

268 Transcription elongation rates influence RNA processing,

269 understand the impact of local modulation of transcription elongation rates on the dynamic interplay

270 mRNA isoform production, by (i) influencing transcription elongation rates, (ii) binding to pre-mRNA

271 the G2/M cell cycle stage which could affect transcription elongation, rather than an indirect conseq

272 In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor

273 MPA treatment interferes with transcription elongation, resulting in a drastic reducti

274 otranscriptional switching in the context of transcription elongation, RNA folding, and ligand bindin

275 t Paf1 functions: a core general function in transcription elongation, satisfied by the lowest Paf1 l

276 initiation), transcription initiation rate, transcription elongation speed (i.e. mRNA chain-growth s

277 genomic scale, the distinct contributions of transcription elongation speed and rate of RNA polymeras

278 impact of specific transcription factors on transcription elongation speed versus TAE to be studied.

279 Recent studies on transcription elongation suggest different mechanistic r

280 H2A.Z impairs transcription elongation, suggesting that spliceosome re

281 that plays multiple key regulatory roles in transcription elongation, termination and coupling trans

282 at other aspects of gene expression, such as transcription elongation, termination, and polyadenylati

283 ine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elongation that couple this alarmone to DN

284 ling a role of DOT1L in promoting productive transcription elongation that is independent of H3K79 me

285 ulation of RNAPII CTD phosphorylation during transcription elongation that is likely to be highly con

286 ion factors promote pause release leading to transcription elongation, the role of epigenetic modific

287 A polymerase II (Pol II) processivity during transcription elongation through cyclin T1 and Cdk9 recr

288 ortholog of CSB, to study the role of CSB in transcription elongation through nucleosome barriers.

289 iption elongation factor b (P-TEFb) promotes transcription elongation through phosphorylation of the

290 on pathways, which link regulation of RNAPII transcription elongation to suppression of aberrant init

291 mplex with P-TEFb, the kinase that initiates transcription elongation, to inhibit elongation at tumor

292 DOT1L loss by itself has no major defect in transcription elongation, transcription elongation defec

293 nfiguration), where it later engages in full transcription elongation upon major ZGA (production).

294 machineries, plays a key role in maintaining transcription elongation when translation and transcript

295 Moreover, DksA has a substantial effect on transcription elongation where it prevents the collision

296 A and NusG are major regulators of bacterial transcription elongation, which act either in concert or

297 It uses reversible inhibition of transcription elongation with 5,6-dichloro-1-beta-D-ribo

298 ution of mechanisms that functionally couple transcription elongation with diverse events that occur

299 One such factor is Spt6, which couples transcription elongation with histone chaperone activity

300 e architecture requires both translation and transcription elongation within the cell.