ライフサイエンスコーパス: transcriptional

1 expression strongly inhibits STAT3-dependent transcriptional activation and disrupts STAT3 interactio

2 binders of the E-box DNA engaged by Myc for transcriptional activation and that this 90-amino acid m

3 We tested the transcriptional activation effects of these ZFPs in a du

4 CRISPR/dCas9-mediated Foxp3-transcriptional activation elicits CNS2 demethylation.

5 Transcriptional activation in both adipose tissue and li

6 of metabolism is largely driven by rhythmic transcriptional activation of clock-controlled genes.

7 ng over bdH3K4me3, resulting in insufficient transcriptional activation of genes, endogenous retrovir

8 DNA) followed by IFNalpha/beta secretion and transcriptional activation of IFN-stimulated genes (ISG)

9 get that can provide additional benefits via transcriptional activation of mitochondrial genes.

10 ntegration site, thereby tightly linking its transcriptional activation to meiotic progression.

11 migration, invasion, angiogenesis, stemness, transcriptional activation, and epigenetic programming v

12 versible epigenetic changes occurring during transcriptional activation, only demethylation of histon

13 tochondria and functions in the nucleus as a transcriptional activator for hundreds of genes.

14 We find that PfAP2-G is a transcriptional activator of early gametocyte genes, and

15 bHLH121 acts as a direct transcriptional activator of key genes involved in the F

16 inhibited miR-210 expression by repressing a transcriptional activator, Kruppel-like factor-4 (KLF4).

17 ome-editing platforms: zinc-finger proteins, transcriptional activator-like effectors and clustered r

18 meostasis as controlled by the PGC family of transcriptional activators is required for angiogenic re

19 es carrying TP53 mutations with predicted 0% transcriptional activity (HR = 1.53, 95% CI: 1.21-1.94).

20 d that B12/FA deficiency in mice induces AhR transcriptional activity and accumulation of erythroid p

21 nd that TRIM27 alone is necessary for ZNF165 transcriptional activity and is required for TNBC tumor

22 Tc3 nuclear accumulation and NFAT-luciferase transcriptional activity in skin microvessels, resulting

23 wn halophilic viruses, many of which exhibit transcriptional activity indicative of host infection.

24 r assays revealed that analogues inhibit the transcriptional activity of EWS-FLI1.

25 The transcriptional activity of these iCGIs is tissue- and d

26 g activity, cell migration and invasion, and transcriptional activity of transcription factors.

27 function for NEK10 in the regulation of p53 transcriptional activity through tyrosine phosphorylatio

28 nal variants from 14 loci displaying allelic transcriptional activity, a subset of which corroborates

29 sed K310 NF-kappaB acetylation and NF-kappaB transcriptional activity.

30 Here we report transcriptional adaptation in C. elegans, and find that

31 These findings highlight agents that target transcriptional addiction in cancer cells and suggest co

32 et of mCG sites resulting in more widespread transcriptional alterations and severe neurological dysf

33 ess their joint activities on physiology and transcriptional alterations of steroid-specific target g

34 se but also interact extensively, leading to transcriptional and epigenetic heterogeneity of macropha

35 The bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator with intrinsic

36 from dysplastic lesions facilitated genomic, transcriptional and functional evaluation of gastric pre

37 rogression are likely to be coordinated with transcriptional and metabolic changes, these processes r

38 or up to 1 month failed to fully reverse the transcriptional and phenotypic effects of prolonged trea

39 Complex networks of transcriptional and post-transcriptional regulators, inc

40 Previously, multiple transcriptional and post-translational mechanisms are re

41 ther, our findings demonstrate that distinct transcriptional and signaling mechanisms control peri-we

42 , phloem tissues are a source of significant transcriptional and translational alterations, with the

43 R stress, the homeostatic UPR sets in motion transcriptional and translational changes that promote c

44 eraction of MNT and MYC goes further, beyond transcriptional antagonism, and governs a multitude of d

45 computational approaches, we found that the transcriptional burst frequency is modulated across the

46 ffects of many gene regulatory mechanisms on transcriptional bursting have been studied, it remains u

47 rve a critical role in establishing baseline transcriptional capacity through the recruitment of prot

48 The nature of this transcriptional cascade suggests that drug synergy may e

49 Currently, key transcriptional changes during this developmental window

50 ith high throughput sequencing to assess key transcriptional changes in inflammatory and lysosomal pa

51 to what extent innate cues from DCs dictate transcriptional changes in T cells remains elusive.

52 cond major mechanism-RNA editing due to post-transcriptional changes of individual nucleotides-remain

53 Quantification of global transcriptional changes revealed that although VS induce

54 e RNA polymerase mutations cause large-scale transcriptional changes without altering susceptibility

55 development, and persistent diet-responsive transcriptional changes.

56 ubset at baseline, cells with phenotypic and transcriptional characteristics of follicular T helper c

57 portant role for Hhex-Tle3 in regulating the transcriptional circuitry governing MBC differentiation.

58 growth-promoting genes is coordinated by the transcriptional co-activator Yorkie with its major regul

59 The underlying mechanism of transcriptional co-repressor ETO2 during early erythropo

60 -binding factor alpha1, mediator subunit 12, transcriptional coactivator CBP and TATA-box binding pro

61 gamma coactivator 1-alpha (PGC-1alpha) is a transcriptional coactivator that controls expression of

62 that MYB125 is involved in the control of a transcriptional coexpression network of lignin biosynthe

63 Finally, we find that transcriptional cofactor HOPX is upregulated in mouse mo

64 Interestingly, transcriptional compensation is most prominent in non-pr

65 chanism regulated by the oncogenic SOX2-GLI1 transcriptional complex driving melanoma invasion throug

66 HR and ARNT, demonstrating that the AHR-ARNT transcriptional complex is necessary for expression of M

67 component of the Wnt/beta-catenin-dependent transcriptional complex.

68 ur results unveil the function of a critical transcriptional component, MED16, in the root adaptive r

69 Here, we define transcriptional consequences of reduced dosage of the CH

70 udy reveals unrecognized roles of LXR in the transcriptional control of the tumor microenvironment an

71 y adversity during puberty can enact lasting transcriptional control that manifests only during a uni

72 tion with in vivo neuroimaging, we find that transcriptional correlates of depression imaging phenoty

73 e develop a strategy to simulate single-cell transcriptional data from synthetic and Boolean networks

74 of human adult bulk and single-cell retinal transcriptional datasets revealed predominant expression

75 s will further elucidate the role of DSIF in transcriptional dynamics and disentangle its inhibitory

76 psis thaliana, but little is known about how transcriptional dynamics change over the course of these

77 ally assume specialized fates via changes of transcriptional dynamics, sometimes even within the same

78 development and underscore the risk of post-transcriptional dysregulation in co-occurring neurodevel

79 enic risk is plausibly manifested by complex transcriptional dysregulation in the brain, involving ne

80 is associated with increased cell death and transcriptional dysregulation indicative of an inflammat

81 ssion in healthy human brains as well as the transcriptional E/I (tE/I) ratio.

82 ive element binding protein 1 (RREB1), a RAS transcriptional effector(20,21), as a key partner of TGF

83 s; however, it remains unclear which contain transcriptional effectors.

84 erimentally calibrated in silico analysis of transcriptional effects yielded inferences of high confi

85 ), composed of CDK9 and cyclin T, stimulates transcriptional elongation by RNA polymerase (Pol) II an

86 ated factor that has been shown to stimulate transcriptional elongation in vitro.

87 NIPBL occupancy at enhancers and that active transcriptional elongation is essential to maintain H3K2

88 protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it fu

89 cascades, in concert with NF-kappaB-mediated transcriptional events, control the metabolism at severa

90 ial overlap with H3K9me3, H3K27me3, and E2F1 transcriptional factor binding.

91 Notably ERG, a transcriptional factor downstream from MEK/ERK, binds to

92 w Kruppel-like factor 5 (Klf5), an essential transcriptional factor of cardiovascular remodeling, med

93 Consistently, mice deficient in the transcriptional factor T-bet only delayed the clearance

94 ionally induced by RIPENING INHIBITOR master transcriptional factor, as well as by PHY-mediated signa

95 roteins, RNA structure-changing variants and transcriptional features.

96 Constant dynamic transcriptional fluctuations result in a highly adaptabl

97 nfection outcome, the data point to putative transcriptional genetic markers of susceptibility.

98 etal hemoglobin (HPFH) mutations, editing of transcriptional HbF repressors or their binding sites an

99 -sequencing (scRNA-seq) allows us to dissect transcriptional heterogeneity arising from cellular type

100 By condensing transcriptional information encoded in large datasets, H

101 An inhibitor targeting beta-catenin transcriptional interactions hindered both NF-kappaB DNA

102 epigenetic state, 3D genome architecture and transcriptional landscape of engram cells over the lifes

103 e potential and located them on a continuous transcriptional landscape.

104 Our work provides multi-tissue single-cell transcriptional landscapes associated with aging and CR

105 d compare them in the context of genome-wide transcriptional landscapes.

106 On the transcriptional level, this response is controlled by SU

107 se core TFs form interconnected feed-forward transcriptional loops to establish and reinforce the cel

108 ever, how low phosphate sensing links to the transcriptional machinery remains unknown.

109 ption factor is sufficient to co-opt somatic transcriptional machinery to drive a pro-tumorigenic gen

110 NAs in enhancer-promoter looping, recruiting transcriptional machinery, and facilitating RNA polymera

111 Post-transcriptional mechanisms regulate the stability and, h

112 how following the wrong breadcrumb trail of transcriptional memory provides a framework for understa

113 MS) is classically used to characterize post-transcriptional modifications of ribonucleic acids (RNAs

114 n of MAFG and MAT2alpha and pro-inflammatory transcriptional modules, contributing to CNS pathology i

115 solution analysis of cell-type diversity and transcriptional networks controlling cell-fate specifica

116 ed by the Tabula Muris consortium to uncover transcriptional networks that maintain tissue-specific E

117 including metabolic and transport pathways, transcriptional networks, hormone signaling pathways, an

118 ork, in order to learn and model large-scale transcriptional networks.

119 binding and 3D genome structure to reflect "transcriptional niche" in the nucleus.

120 of carbon-5 of cytosines (m(5) C) is a post-transcriptional nucleotide modification of RNA found in

121 Notably, the transcriptional output of most other genes was largely u

122 umber amplification correlates with enhanced transcriptional output of UBR5.

123 PARG inhibition alters AR transcriptional output without changing AR protein level

124 ts, we show that the SE ensures robust Atoh7 transcriptional output.

125 llel reporter assays to directly measure the transcriptional outputs of thousands of individual regul

126 rs and uncover degenerative and regenerative transcriptional pathways underlying DMD pathogenesis.

127 cally defined by the Fos- or Npas4-dependent transcriptional pathways.

128 have been widely adopted to define specific transcriptional perturbations from gene expression signa

129 and a few key studies demonstrate increased transcriptional plasticity associated with generalist co

130 sregulation, thereby establishing a state of transcriptional plasticity that enables the emergence of

131 dulates divergent infection profiles through transcriptional plasticity.

132 s in the nucleus and cytoplasm indicate post-transcriptional processes enable cells to conserve energ

133 tous on eukaryotic mRNAs, essential for post-transcriptional processing, translation initiation and s

134 Here, we explore the transcriptional profile and DNA replication timing (RT)

135 acological sensitivities; and more recently, transcriptional profile differentiation.

136 ation of CF sputum.Objectives: To define the transcriptional profile of sputum cells and its implicat

137 To define the transcriptional profile of this airway immune dysfunctio

138 chondrial function, and the acquisition of a transcriptional profile that is closer to PHHs.

139 Here, we identify corresponding transcriptional profiles in human glioblastoma and descr

140 the HIV-specific T cell immune responses and transcriptional profiles of PBMC, reinforcing the import

141 Transcriptional profiling coupled with T cell receptor (

142 Unbiased transcriptional profiling in an adult-onset Pkd2 mouse m

143 Transcriptional profiling of HSPCs from mTOR(ECKO) mice

144 Transcriptional profiling of oxidative stress-producing

145 ys showed that multicolor flow cytometry and transcriptional profiling successfully predict the bipot

146 Transcriptional profiling, functional assays, and acute

147 This aberrant transcriptional program caused impairment in self-renewa

148 common epigenetic configuration that primes transcriptional program for embryonic development.

149 yses revealed that ROCK2 controlled a unique transcriptional program in GC B cells that promoted opti

150 but also activate a previously unrecognized transcriptional program leading to enhanced mRNA transla

151 The AP-1 transcriptional program modulates the expression of key

152 ases E2F transcription factors, activating a transcriptional program that initiates S phase.

153 activated an integrated stress response-like transcriptional program to induce ABCB1 through remodeli

154 ZBED2 can repress the pancreatic progenitor transcriptional program, enhance motility, and promote i

155 a subset of ER enhancers to drive a distinct transcriptional program.

156 tress causes a massive reorganization of the transcriptional program.

157 to chemotherapy and inducing a prometastatic transcriptional program; inhibition of TRIM37 increases

158 c programs arising from oncogenic events and transcriptional programs and epigenomic events are impor

159 ploited by tumor cells to aberrantly sustain transcriptional programs commonly dysregulated in cancer

160 To decipher transcriptional programs controlled by diverse NUP98-fus

161 The cell type specific sequences of transcriptional programs during lung regeneration have r

162 lishes BETs as novel determinants of induced transcriptional programs in vascular cells, like endothe

163 Inducible transcriptional programs mediate the regulation of key b

164 The genome-scale transcriptional programs that specify the mammalian trac

165 EBV nuclear proteins usurp normal transcriptional programs to activate the expression of k

166 s are monocots and little is known about the transcriptional programs underlying cell-type specificat

167 ha), inhibited both distinct and overlapping transcriptional programs.

168 ndent and occurs via modulation of metabolic transcriptional programs.

169 actors that induce or suppress large dynamic transcriptional programs.

170 design principles for generating stochastic transcriptional pulses without feedback.

171 s critical for preventing accumulation of co-transcriptional R-loops and DNA damage to avert genomic

172 on of macroH2A by siRNA interference mimicks transcriptional reactivation.

173 ecombinant A4G (rA4G) RSV mutant resulted in transcriptional readthrough and lower G and fusion (F) p

174 ation of CPSF73, which causes very extensive transcriptional readthrough genome-wide.

175 to couple nutrient conditions to the cell's transcriptional regime.

176 Both complexes are necessary for transcriptional regulation but through different mechani

177 me-wide analyses of roles for minimal G4s in transcriptional regulation have been reported, Long G4-c

178 is unclear which motifs are prone to impact transcriptional regulation if mutated.

179 ynamic models of gene regulation can predict transcriptional regulation in bacteria, but in eukaryote

180 Whereas the majority of transcriptional regulation is mediated by DNA-binding tr

181 s and allow reliable constructions of global transcriptional regulation networks encoded in a specifi

182 Transcriptional regulation of AZ development appears to

183 ivation of DUX requires GRSF1-dependent post-transcriptional regulation of Dux mRNA.

184 g a KIP-related protein, was found to be the transcriptional regulation of genes responsible for cell

185 d LATE4 and show that they contribute to the transcriptional regulation of key flowering genes, inclu

186 ing, CEFCIG reveals unique histone codes for transcriptional regulation of reported CIGs, and utilize

187 cultivar-specific mechanisms of cold-induced transcriptional regulation of ripening in European pear,

188 These findings indicate that post-transcriptional regulation of tankyrase serves as a liga

189 x differences in subcutaneous adipose tissue transcriptional regulation using omic-scale data from ~3

190 including genome-wide histone modification, transcriptional regulation, and RNA processing, and ther

191 , due to either variations in copy number or transcriptional regulation, have also been linked to Alz

192 e functional impact of context-specific post-transcriptional regulation.

193 target genes and represent maps of potential transcriptional regulation.

194 go truncatula, a homeotic mutation in the co-transcriptional regulator gene NODULE ROOT1 (MtNOOT1) co

195 lar, a Y585C mutation in the sorbitol operon transcriptional regulator gutR was associated with incre

196 ment but reduced in adulthood, including the transcriptional regulator Hmga1.

197 as well as eilA, a gene encoding a putative transcriptional regulator of ETT2 associated genes.

198 40-containing E3 ligase by Egr2, the central transcriptional regulator of peripheral myelination, to

199 receptor alpha-subunit and activation of the transcriptional regulator STAT5.

200 d by the reduced activity of the prosurvival transcriptional regulator Yes-associated protein.

201 LysR-type transcriptional regulators (LTTRs) are the most common t

202 cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible fact

203 croglia activation and downregulation of the transcriptional regulators CEBPD and IkappaBalpha.

204 Here we report a genome-wide annotation of transcriptional regulators in A. fumigatus and construct

205 gulators (LTTRs) are the most common type of transcriptional regulators in prokaryotes and function b

206 studies focused on the immune receptors and transcriptional regulators involved in T cell quiescence

207 MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression.

208 gen-related receptor) alpha and gamma, known transcriptional regulators of postnatal mitochondrial bi

209 We identify a quartet of transcriptional regulators promoting hPSC self-renewal i

210 ration and organ size through control of the transcriptional regulators YAP (yes-associated protein)

211 nes encoding transporters, surface proteins, transcriptional regulators, and metabolic pathways.

212 Complex networks of transcriptional and post-transcriptional regulators, including microRNAs (miRNAs)

213 tion in situ hybridization to identify novel transcriptional regulators, we show that chromatin remod

214 interactors and their post-translational and transcriptional regulators.

215 promoters that drive expression of key viral transcriptional regulators.

216 l noncoding (nc)RNAs also function as global transcriptional regulators.

217 and their regulatory loops constitutes core transcriptional regulatory circuitry (CRC).

218 We find that the HBV post-transcriptional regulatory element (PRE), specifically t

219 allows for straightforward identification of transcriptional regulatory elements out of combinatorial

220 In addition, brain transcriptional regulatory network analysis revealed a p

221 In this review, we discuss a transcriptional regulatory network model for AF defined

222 Analysis of the topology of transcriptional regulatory networks (TRNs) is an effecti

223 We constructed developmental stage-specific transcriptional regulatory networks by linking enhancers

224 type composition, gene expression, and core transcriptional regulatory networks.

225 Comparisons among the transcriptional regulatory responses of these six ERalph

226 ntified a subset of genes with apparent post-transcriptional repression in young adult mouse HSCs.

227 n K562 cells caused loss of CTCF binding and transcriptional repression of genes with changed CTCF bi

228 Pax5 mediates the transcriptional repression of Wapl through a single Pax5

229 istone-modifying activities are required for transcriptional repression remains controversial.

230 se 1 (TREE1) interacts with EIN3 to regulate transcriptional repression that leads to an inhibition o

231 move 8-oxoG lesions that are associated with transcriptional repression.

232 racting RNAs (piRNAs) to identify targets of transcriptional repression.

233 We report here that a Transcriptional Repressor of EIN3-dependent Ethylene-res

234 LHP1 is a transcriptional repressor of flowering-related genes, su

235 dy provides new insights into YAP as a broad transcriptional repressor of key regulators of the cell

236 and tissue growth by functioning as a direct transcriptional repressor of the master regulator of gro

237 have recently been identified, including the transcriptional repressor SPEN(1-3), the loss of which h

238 Capicua (CIC) is a highly conserved transcriptional repressor that is differentially regulat

239 man HES4, is a basic helix-loop-helix-orange transcriptional repressor that regulates neurogenesis in

240 induction of several adipogenic genes during transcriptional reprograming.

241 ulation in med15b.D mutants, suggesting that transcriptional reprogramming at this time point is not

242 We assess the impact of transcriptional reprogramming of nuclear-encoded chlorop

243 iation in chorismate metabolism explained by transcriptional reprogramming of specific structural gen

244 All these stimuli induce not only a specific transcriptional response but also interact extensively,

245 seq reveals both shared and context-specific transcriptional response components that can identify dr

246 in mice primary macrophages, showed that the transcriptional response downstream of TLR4 was intact i

247 rved protein in eutherian mammals, elicits a transcriptional response in the endometrial epithelium i

248 for anautogenous mosquito reproduction, the transcriptional response to blood-ingestion remains unde

249 HY5 was found to mediate a subset of the transcriptional response to cytokinin.

250 ypomorph, causing an attenuated p53-mediated transcriptional response.

251 uggests that drug synergy may ensue when the transcriptional responses elicited by two unrelated indi

252 The initial legitimate transcriptional responses of TFs to OSKM reprogramming w

253 of evidence are TF binding locations and the transcriptional responses to direct TF perturbations.

254 of long-term cell viability from short-term transcriptional responses to treatment.

255 tiplicative or super-multiplicative combined transcriptional responses, while sub-additivity of acces

256 ty of accessibility associated with additive transcriptional responses.

257 d-messenger generation, and JAK/STAT or NFAT transcriptional responses.

258 h a dedicated MED subunit to induce specific transcriptional responses.

259 cardiomyocytes and interrogated whole genome transcriptional responses.

260 as myonuclear numbers increase, the range of transcriptional return on a per nuclear basis in myofibe

261 e1, all (1)O(2)-induced responses, including transcriptional rewiring of nuclear gene expression, ret

262 vant antifungal resistance could derive from transcriptional rewiring, promoting drug resistance with

263 The role of post-transcriptional RNA modification is of growing interest.

264 2'-O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays important bi

265 and DNA damage depend on the presence of co-transcriptional RNA/DNA hybrids (R-loops) that form in i

266 tterning of the usually carefully programmed transcriptional signals.

267 nsilico analyses identified a 3491-gene MMC9 transcriptional signature and identified 2 transcription

268 he identification of a baseline intrahepatic transcriptional signature associated with response to GS

269 The consensus across tissues provided a transcriptional signature of 248 genes.

270 egulatory elements uncover a core mRNA-ncRNA transcriptional signature shared by IgG(+) and IgA(+) sw

271 Lack of P2X7 promoted a transcriptional signature that correlated with enhanced

272 s and a strong negative correlation with Myc transcriptional signature.

273 We identified transcriptional signatures in the lymph nodes associated

274 We resolve the developmental trajectory and transcriptional signatures of the epiblast, primitive en

275 and myelination, functionally confirming OL transcriptional signatures.

276 Almost all of the transcriptional silencers that we identified were also a

277 re classic epigenetic phenomena that involve transcriptional silencing of one parental allele.

278 that Mkt1 is required for RNAi-mediated post-transcriptional silencing, downstream of small RNA produ

279 es located ~60 nucleotides downstream of the transcriptional start site, while beta genes bore Pol II

280 stone H3, with increased accumulation around transcriptional start sites.

281 led changes in cell population structure and transcriptional states that cannot be discerned from bul

282 of cells to generate and inherit epigenetic transcriptional states.

283 these was identified to be deficient in post-transcriptional steps of chloroplast gene expression.

284 tor inducible gene up-regulation is a common transcriptional stress response in RTECs to ischemia-, c

285 In genome-wide transcriptional studies, we found that ZIKV infection tr

286 ERG repressed PI3K signaling through direct transcriptional suppression of IRS2, leading to reduced

287 support the model that dERR contributes to a transcriptional switch during pupal development that est

288 The Yap/Taz transcriptional target Axl was found to be essential for

289 mall non-coding molecules that regulate post-transcriptional target gene expression.

290 we sought to discover a druggable downstream transcriptional target of LIN9.

291 Finally, we showed that ALDH1A1 is a direct transcriptional target of SOX9, based on chromatin immun

292 V16 E7-expressing cells, and as it is a TP53 transcriptional target, DINO levels further increase.

293 ormation of their expression, regulation and transcriptional targets in human PH and the therapeutic

294 zymes involved in carbohydrate metabolism as transcriptional targets of CRZ1/GnRHL1 signaling.

295 tifier (DR) potassium currents, two putative transcriptional targets of Foxp2, were not affected by t

296 y identified specific metabolites that exert transcriptional, translational, and posttranslational co

297 a-driven primary transcript annotations with transcriptional unit coordinates identified in an unbias

298 used these inferred coordinates to annotate transcriptional units identified de novo.

299 We report extreme transcriptional variability between individual monocytes

300 ultimately leads to activation of mesodermal transcriptional WNT targets and specification of the par