ライフサイエンスコーパス: transcriptional activation

1 on and early embryo development that lead to transcriptional activation.

2 regulatory elements cooperate or compete for transcriptional activation.

3 (RIP1) and c-Jun N-terminal kinase (JNK) by transcriptional activation.

4 the NF-kappaB heterodimer in the nucleus for transcriptional activation.

5 impact, affecting both protein stability and transcriptional activation.

6 dependent upon their catalytic function for transcriptional activation.

7 ressors, we propose that both are capable of transcriptional activation.

8 no-ADP-ribosylation activity is required for transcriptional activation.

9 fective at binding to small MAF proteins and transcriptional activation.

10 methylation are a downstream consequence of transcriptional activation.

11 x2 at T118, leading to its stabilization and transcriptional activation.

12 onist-induced coactivator interaction and NR transcriptional activation.

13 was initiated through EGR1 via ERK-regulated transcriptional activation.

14 tosis, but is increased at certain genes for transcriptional activation.

15 of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.

16 urbation, through analysis of indel rate and transcriptional activation.

17 er of maternal transcripts and inappropriate transcriptional activation.

18 rt cis-regulatory enhancer assembly for gene transcriptional activation.

19 affinity and Ubx concentration required for transcriptional activation.

20 ociated with Smad2/3 binding coincident with transcriptional activation.

21 at overexpression of miR-4443 was not due to transcriptional activation.

22 stimulation and was indispensable for IRAK-M transcriptional activation.

23 must have a mechanism for rapid cessation of transcriptional activation.

24 o viral DNA sequences, which correlates with transcriptional activation.

25 d of mRNAs that extends beyond the region of transcriptional activation.

26 er and activator of transcription 3-mediated transcriptional activation.

27 expression, suggesting a novel mechanism of transcriptional activation.

28 ition of Hdac1 expression and enhanced Runx2 transcriptional activation.

29 air, the replication stress response, and/or transcriptional activation.

30 aration mechanism for efficient and specific transcriptional activation.

31 beta-catenin, promoting HP1gamma removal and transcriptional activation.

32 TRIM21, was unable to increase Nrf2-mediated transcriptional activation.

33 es and their transcription factors for rapid transcriptional activation.

34 taneously to identify optimal conditions for transcriptional activation.

35 ated with active genes do not directly cause transcriptional activation.

36 ogenic activity and mechanosensitive Yap/Taz transcriptional activation.

37 ed TNF-alpha mRNA through NF-kappaB-mediated transcriptional activation.

38 SWI/SNF in evicting promoter nucleosomes and transcriptional activation.

39 iption of the fad genes and cancels fab gene transcriptional activation.

40 ly passive environment suppressing premature transcriptional activation.

41 ted that DSBs at pausing sites contribute to transcriptional activation.

42 t of whether the heart is permissive for Myc transcriptional activation.

43 a SWI/SNF-RNA cooperation to achieve optimal transcriptional activation.

44 and is important for priming genes for rapid transcriptional activation.

45 cription of three possible mechanisms of LXR transcriptional activation.

46 mains in single nuclei change in response to transcriptional activation.

47 landscapes these findings reveal synergistic transcriptional activation across a broad landscape of c

48 of hub promoters, which are correlated with transcriptional activation across cell lines, enriched i

49 nal repression activity while OsVOZ2 confers transcriptional activation activity in planta.

50 known "trans factors" modulate the intrinsic transcriptional activation activity of DNA-bound PIF pro

51 affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTER

52 RH2 has lost transcriptional activation activity, due to a divergent

53 ession of PIF-DTGs through modulation of PIF transcriptional activation activity, thus expanding the

54 that autocrine LPA synthesis promotes NFAT1 transcriptional activation and ATX secretion in a positi

55 trome and a genome-wide loss of ERG-mediated transcriptional activation and cell migration.

56 unexpected causal relationship between Foxp3-transcriptional activation and CNS2 demethylation in mic

57 Fusion with E2A confers potent transcriptional activation and constitutive nuclear loca

58 expression strongly inhibits STAT3-dependent transcriptional activation and disrupts STAT3 interactio

59 on by aberrantly inducing both AEP-dependent transcriptional activation and DOT1L-dependent transcrip

60 Thus, transcriptional activation and epigenetic remodeling of

61 In particular, we observed H2A.Z loss upon transcriptional activation and H2A.Z gain upon repressio

62 rol morphogenesis by promoting GLI-dependent transcriptional activation and inhibiting the formation

63 indicates the deubiquitinase USP22 regulates transcriptional activation and modification of target su

64 including modulation of chromatin structure, transcriptional activation and post-transcriptional proc

65 expression is modulated by a balance between transcriptional activation and repression during animal

66 The transcriptional activation and repression during NK cell

67 The mutations affected transcriptional activation and repression in a variegate

68 critical role for complementary PRMT5-MEP50 transcriptional activation and repression in cancer inva

69 These findings suggest that controlling transcriptional activation and repression mechanisms by

70 elopment is a complex process involving both transcriptional activation and repression mechanisms.

71 ly control function by simultaneously tuning transcriptional activation and repression, using a novel

72 and Smad1 binding were associated with both transcriptional activation and repression, with Wnt-repr

73 on plays a key role in NF-kappaBeta-mediated transcriptional activation and repression.

74 d a nearly uniform temporal pattern of rapid transcriptional activation and subsequent shutdown for t

75 binders of the E-box DNA engaged by Myc for transcriptional activation and that this 90-amino acid m

76 g the association of p65-p50 co-binding with transcriptional activation and the association of p50 bi

77 Finally, we show that transcriptional activation and the loss of PRC1-mediated

78 I2DeltaN enhanced the beta-catenin-dependent transcriptional activation and the subsequent activation

79 cantly reduced binding to ChlR1 but retained transcriptional activation and viral origin-dependent re

80 GPC2 expression in neuroblastoma due to MYCN transcriptional activation and/or somatic gain of the GP

81 i during embryogenesis (hours prior to major transcriptional activation) and, by doing so, regulates

82 ers is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known

83 migration, invasion, angiogenesis, stemness, transcriptional activation, and epigenetic programming v

84 e tested multiple strategies for dCas9-based transcriptional activation, and found that simultaneous

85 in beta-catenin/T-cell factor (TCF)-mediated transcriptional activation, and target gene expression,

86 e of events that occur from SMAD2 binding to transcriptional activation, and the mechanisms underlyin

87 enous genes are more amenable than others to transcriptional activation, and tightly regulated genes

88 The pattern of transcriptional activation appears to support a transcri

89 ay cloning strategies, which will facilitate transcriptional activation applications in both dicots a

90 H2AZ regulates transcriptional activation as well as the maintenance of

91 m of IFN regulatory factor 1 (IRF1)-mediated transcriptional activation at cooccupied promoter elemen

92 with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes meg

93 The accumulation of m6dA is associated with transcriptional activation at the brain-derived neurotro

94 egantly demonstrate that DNA methylation and transcriptional activation at the HDAC9 promoter by DNMT

95 f nuclear enrichment and point to a model of transcriptional activation based on nucleocytoplasmic ex

96 Auxin regulates LR organogenesis via transcriptional activation by an auxin complex receptor.

97 increased the ability of estrogen to enhance transcriptional activation by ER-alpha of endogenous est

98 nd transcriptional attenuation due to weaker transcriptional activation by ETS2 compared to ETS1.

99 ement has a distinct role in bursting during transcriptional activation by gamma-interferon.

100 In conclusion, the differences in transcriptional activation by gmAhr's with various agoni

101 s (STING) pathway to induce inflammation via transcriptional activation by IRF3 and nuclear factor ka

102 -distortion and RNAP-non-contact paradigm of transcriptional activation by MerR TFs.

103 This augments transcriptional activation by ORE1 of its downstream tar

104 Transcriptional activation by p53 provides powerful, org

105 associated with YUCCA8, allowing binding and transcriptional activation by PHYTOCHROME INTERACTING FA

106 y genes exhibit evidence for allele-specific transcriptional activation by PrCa master-regulators (in

107 PRMT5 methylation of histone H3R2me1 induced transcriptional activation by recruitment of WDR5 and co

108 nding sites were identified and examined for transcriptional activation by stress-induced transcripti

109 Thus, we identify a mechanism of transcriptional activation by TAZ and demonstrate that p

110 ER-alpha is required for estrogen-stimulated transcriptional activation by the receptor.

111 ATG5 represses transcriptional activation by the TGFbeta-SMAD gene regu

112 e that we designated as the Clock-Associated Transcriptional Activation Cassette or 'CATAC'.

113 l lines and bound directly to the core Notch transcriptional activation complex (NTC), requiring both

114 In the SAM, they form a transcriptional activation complex with the bZIP transcr

115 The system relies on recruitment of Cas9 and transcriptional activation complexes to target loci by m

116 In bacterial systems, CRISPR-Cas transcriptional activation (CRISPRa) has the potential t

117 context, they acquire different patterns of transcriptional activation, cytokine expression and cell

118 ic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants.

119 ivity mediated through its unique C-terminal transcriptional activation domain (TAD).

120 155, and (R)-UT-155) bind the amino-terminal transcriptional activation domain AF-1, which has not be

121 usly defined CE2 site in the Hsf1 C-terminal transcriptional activation domain and with an additional

122 ng experiments indicated that the C-terminal transcriptional activation domain of GLI1 and SMARCA2's

123 essing a HMR22 mutant protein fused with the transcriptional activation domain of VP16, suggesting a

124 s a loss-of-function D516N mutation in HMR's transcriptional activation domain, fails to induce the t

125 r enhanced Klotho's activation using p65-Rta transcriptional activation domains in addition to VP64.

126 ly, we report that Hsp70 interacts with both transcriptional activation domains of Hsf1 in the relate

127 atalytically inactive Cpf1 nuclease fused to transcriptional activation domains to tune the expressio

128 Evolutionary conservation of the EDC and the transcriptional activation during epidermal differentiat

129 Here, we investigated its transcriptional activation during myeloid differentiatio

130 We tested the transcriptional activation effects of these ZFPs in a du

131 CRISPR/dCas9-mediated Foxp3-transcriptional activation elicits CNS2 demethylation.

132 s with higher mRNA stability, which augments transcriptional activation, especially for genes involve

133 he mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the up/down-re

134 st beta-arrestin activation as determined by transcriptional activation following arrestin translocat

135 ge segregation from WT RAM sharply decreases transcriptional activation for all permutants.

136 Its transcriptional activation function requires phosphoryla

137 sted by Relish-dependent attenuation of Foxo transcriptional activation function, a critical metaboli

138 e also demonstrate dose-dependent control of transcriptional activation, function across multiple div

139 cts (e.g. neurite projection) do not require transcriptional activation, further suggesting biologica

140 Knowledge about enhancer-centered transcriptional activation has advanced considerably, bu

141 Transcriptional activation in both adipose tissue and li

142 re, PAX7, but not MLL1, is required for Myf5 transcriptional activation in committed myoblasts.

143 fferent role for AGO1 in estradiol-triggered transcriptional activation in human cells.

144 contributes to improve our understanding of transcriptional activation in human.

145 Sustaining Foxp3-transcriptional activation in induced Tregs also promote

146 editing, as well as small molecule-dependent transcriptional activation in mammalian cells.

147 nd generation of vector systems for enhanced transcriptional activation in plants.

148 Synthetic Notch (synNotch) receptors induce transcriptional activation in response to recognition of

149 n Caulobacter crescentus mediates widespread transcriptional activation in response to the metals U,

150 man cultured cells; the LZA element-mediated transcriptional activation in response to zinc deficienc

151 orter mice demonstrated reduced beta-catenin transcriptional activation in the presence of LPA1 antag

152 flanking NDRs; however, Ino80C's function in transcriptional activation in vivo is not well understoo

153 on plays an important role in the control of transcriptional activation in vivo.

154 r of distinct damages induced during diverse transcriptional activation is a universal prerequisite f

155 degradation is essential, while RA-triggered transcriptional activation is dispensable for APL eradic

156 We find that Notch-dependent transcriptional activation is indeed "bursty"; that wild

157 duced, Sty1-mediated Atf1 phosphorylation in transcriptional activation is unclear.

158 allows RUNX1 to antagonize AML1-ETO-mediated transcriptional activation is unclear.

159 understood, the mechanism of SIRT6-mediated transcriptional activation is unknown.

160 epidermis, associated with a switch from p63 transcriptional activation isoforms to DeltaNp63 isoform

161 Here, by mapping a dopamine-dependent transcriptional activation marker in large ensembles of

162 These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L an

163 of flavan-3-ols constitutively via the same transcriptional activation mechanism.

164 PGAM5 and ME1 upregulation occur via direct transcriptional activation mediated by beta-catenin/TCF1

165 However, ligand-independent transcriptional activation occurring during heat shock (

166 e, which is consistent with recent models of transcriptional activation occurring in non-membrane bou

167 ctivate the tumor suppressor p53, triggering transcriptional activation of a myriad of target genes.

168 y results in propionate accumulation and the transcriptional activation of a propionate shunt pathway

169 strated negative effects of these alleles on transcriptional activation of a reporter with a FOXP2-de

170 eptor (AhR) target genes, and stimulates the transcriptional activation of AhR.

171 gg2Sp ) that conferred pheromone-independent transcriptional activation of an Rgg2-stimulated promote

172 ation and ultimately increased Nrf2-mediated transcriptional activation of antioxidant genes, includi

173 Sexual commitment requires the transcriptional activation of ap2-g (PF3D7_1222600), the

174 CDK11 increased transcriptional activation of AR gene in osteosarcoma ce

175 1 and Hey1, and a reciprocal increase in the transcriptional activation of ATF4 and NFATc1 genes.

176 lyzed its direct targetome and revealed GLI2 transcriptional activation of atypical cadherin and plan

177 Blockade of BRAFi-induced transcriptional activation of autophagy-lysosomal functi

178 oxic strain, cytotoxicity is correlated with transcriptional activation of axoU and T3SS genes, demon

179 These findings uncover MLL-dependent transcriptional activation of BCL6 as a previously unrec

180 tary genomic alterations associated with the transcriptional activation of beta-catenin and NRF2, MEK

181 For example, transcriptional activation of both the T-cell receptor a

182 Jun acetylation site at lysine 273 increased transcriptional activation of c-Jun in melanoma cells an

183 nce, however, suggests that Yap5-independent transcriptional activation of CCC1 also contributes to i

184 evidence of a novel pathway controlling the transcriptional activation of CD40L in bone marrow-deriv

185 of metabolism is largely driven by rhythmic transcriptional activation of clock-controlled genes.

186 which both A- and B-sites were required for transcriptional activation of czcD expression, with the

187 genes involved in neuronal transmission and transcriptional activation of developmental genes, has p

188 but not its enzymatic activity, enhanced the transcriptional activation of distinct LPS-induced genes

189 P response element binding protein-triggered transcriptional activation of Dnmt1 gene.

190 User-friendly tools for robust transcriptional activation of endogenous genes are highl

191 onal activator VP16 (VP64) could be used for transcriptional activation of endogenous genes in plants

192 of ESR1 and ESR2, consistent with sustained transcriptional activation of ERalpha and ERbeta.

193 nts of polycomb repressive complex 2 (PRC2), transcriptional activation of ERG target genes, and incr

194 short palindromic repeats (CRISPR)-mediated transcriptional activation of ESR1 in biliary epithelial

195 The results suggest that SP1 transcriptional activation of Fbxl2 is required for skel

196 in ECM remodeling in the diseased heart via transcriptional activation of focal adhesion assembly.

197 petiole growth by antagonizing PIF-mediated transcriptional activation of genes associated with grow

198 35S::SbMyb60 was associated with the transcriptional activation of genes involved in aromatic

199 ng over bdH3K4me3, resulting in insufficient transcriptional activation of genes, endogenous retrovir

200 transcription factors, was essential for the transcriptional activation of GSDMD.

201 t accumulation of HIF1alpha protein via both transcriptional activation of HIF1alpha mRNA and the pho

202 l genes and the silent mating type loci, and transcriptional activation of hundreds of mRNA-encoding

203 DNA) followed by IFNalpha/beta secretion and transcriptional activation of IFN-stimulated genes (ISG)

204 h dFOXO in vitro and in vivo to regulate the transcriptional activation of insulin receptor (InR) and

205 protectively immunized mice exhibit enhanced transcriptional activation of interferon and immune sign

206 Whereas transcriptional activation of kdpFABC expression is well

207 Fatty liver development was associated with transcriptional activation of lipogenesis, FXR-RXR, PPAR

208 TFEB proteins, this does not translate into transcriptional activation of lysosomal genes, suggestin

209 By day 5, we observed transcriptional activation of mitochondrial biogenesis a

210 get that can provide additional benefits via transcriptional activation of mitochondrial genes.

211 get that can provide additional benefits via transcriptional activation of mitochondrial genes.

212 ultiprotein complex has an important role in transcriptional activation of mitotic genes.

213 rate that SET1A/COMPASS is required for full transcriptional activation of multiple Hox genes but fun

214 We demonstrated that Sox17 TF regulates the transcriptional activation of Nestin's enhancer in devel

215 of HIV-1 with expression of miR-34c-5p, and transcriptional activation of NFkappaB, CREB and NFAT1.

216 Driven by the transcriptional activation of nuclear factor (erythroid-

217 t in wild-type Arabidopsis plants as well as transcriptional activation of P5CS1 and PRO DEHYDROGENAS

218 cascade, resulting in the stabilization and transcriptional activation of phosphorylated Sox2.

219 Stamen development thus appears to involve transcriptional activation of physically clustered genes

220 ng, CTCF-dependent chromatin remodeling, and transcriptional activation of PPARgamma and CEBPalpha to

221 retinoic acid response elements and leads to transcriptional activation of RA target genes.

222 ted meiosis in budding yeast and noted early transcriptional activation of RiBi genes, followed by th

223 RNR activity is greatly stimulated by transcriptional activation of RRM2 during S/G2 phase to

224 e demonstrate that GLIS3 is critical for the transcriptional activation of several genes required for

225 obacter DNA mediates the temporal control of transcriptional activation of several key regulatory pro

226 Point mutation (G239C) of Rrp2 abolishes the transcriptional activation of sigma(54) -dependent rpoS.

227 dCas9-TV confers far stronger transcriptional activation of single or multiple target

228 1, H3K9me2 and sustains H3K4me3 to prime the transcriptional activation of SNAI1 by TGF-beta signalin

229 all forms of RdDM are deficient, leading to transcriptional activation of some transposable elements

230 overcome shape-mediated changes observed in transcriptional activation of SRF or TEAD.

231 domain, which promotes the dimerization and transcriptional activation of STAT3.

232 ysis suggests that MED16 is required for the transcriptional activation of STOP1 targets, including t

233 DOT1L as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblas

234 ion, Nrf2-dependent luciferase activity, and transcriptional activation of target genes.

235 g RNA (ncRNA) to mRNA production accompanies transcriptional activation of TE-related sequences and v

236 he Arntl gene, and a luciferase assay showed transcriptional activation of the Arntl gene upon FLRL2

237 Furthermore, transcriptional activation of the C19MC cistron induced

238 escence in situ hybridization confirmed that transcriptional activation of the clustered genes was co

239 -PCR and 5'-RACE, we observed that following transcriptional activation of the co-transcribed hasRAp,

240 region to enhancer-promoter interactions and transcriptional activation of the corresponding neighbor

241 asing the levels of Tnc, via CRISPR-mediated transcriptional activation of the endogenous gene, enhan

242 Mediator (SAM) system, which induced robust transcriptional activation of the entire C19MC cistron a

243 Here, we show that during transcriptional activation of the fission yeast fbp1 gen

244 we found a significant deterioration in the transcriptional activation of the heat shock response in

245 Transcriptional activation of the human telomerase rever

246 ivation of the unfolded protein response and transcriptional activation of the main KSHV transcriptio

247 ediated senescence rescue was accompanied by transcriptional activation of the melanocyte-lineage sur

248 ting that both IHF and LuxR are required for transcriptional activation of the osmotic stress respons

249 homeostasis through PHR1- and PHL1-mediated transcriptional activation of the P5CS1 gene.

250 e pathological form of hypertrophy devoid of transcriptional activation of the physiological cardiac

251 Oncogenic MLL fusions strongly induced transcriptional activation of the proapoptotic BH3-only

252 invasive phenotype of MCC cells through the transcriptional activation of the sheddase molecule, ADA

253 e requirement of Forkhead box A1 (Foxa1) for transcriptional activation of the Upk2-promoter to tempo

254 g, partly through promoter demethylation and transcriptional activation of the Wnt inhibitor secreted

255 s in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs

256 t, in turn, beta-catenin triggers the direct transcriptional activation of Tspan8 expression, leading

257 We demonstrate that the transcriptional activation of Ty3/Gypsy retrotransposons

258 -PK1), where we detected an early and robust transcriptional activation of type I and type III IFNs.

259 This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogen

260 epeats, mediate through their processing the transcriptional activation of various genes in response

261 Lastly, we confirmed that the transcriptional activation of WNT by AP-1 is conserved i

262 a defect in its previously described role in transcriptional activation of Wnt signalling.

263 modulates OA cartilage degeneration through transcriptional activation of Wnt target genes.

264 tes the association of YAP and TEAD, induces transcriptional activation of YAP target genes and promo

265 phosphorylation of RD26 is required for RD26 transcriptional activation on drought-responsive genes.

266 versible epigenetic changes occurring during transcriptional activation, only demethylation of histon

267 Here, we show that Hd3a and RFT1 can form transcriptional activation or repression complexes also

268 difications (PTMs) have been associated with transcriptional activation or repression under steady-st

269 essing mutational impacts on DNA binding and transcriptional activation or repression.

270 scription but instead compromised subsequent transcriptional activation or transcriptional memory.

271 y and can lead to transcriptional silencing, transcriptional activation, or modulation of alternative

272 However, an efficient dCas9-based transcriptional activation platform is still lacking for

273 vator EIN3 (Ethylene Insensitive 3)-mediated transcriptional activation plays vital roles.

274 The novel finding that Foxp3-transcriptional activation promotes CNS2 demethylation m

275 ARNT knockdown dramatically impaired the transcriptional activation properties of the ligand-acti

276 hat regulation of SLC2A3 is mediated through transcriptional activation rather than posttranscription

277 However, the mechanism of Rap1 transcriptional activation remains poorly understood bec

278 We developed a novel in planta transcriptional activation/repression assay and suggest

279 ion, lignin deposition, proteolysis process, transcriptional activation/repression, and phosphorylati

280 candidate, termed EMICERI, revealed that its transcriptional activation resulted in dosage-dependent

281 MYC-binding sites, validating an additional transcriptional activation role of MYC in cancer metabol

282 ibe a protocol for genome-scale knockout and transcriptional activation screening using the CRISPR-Ca

283 In addition to the synergistic transcriptional activation, selected compounds were eval

284 Many genes exhibited strong levels of transcriptional activation, sometimes only transiently a

285 that heme induces transcription of HAP4, the transcriptional activation subunit of the Hap2/3/4/5p co

286 Simultaneous editing or transcriptional activation/suppression of different gene

287 Recently, three potent dCas9-based transcriptional activation systems, namely VPR, SAM and

288 (designated CRISPR-Act2.0) yielded stronger transcriptional activation than the dCas9-VP64 system.

289 stradiol elicits similar genomic binding and transcriptional activation through estrogen receptor alp

290 Instead, GABP provided transcriptional activation through the Lbr promoter in t

291 te for lineage-specific differences in egl-1 transcriptional activation, thus ensuring that EGL-1 act

292 ntegration site, thereby tightly linking its transcriptional activation to meiotic progression.

293 From their transcriptional activation to their regulatory capabilit

294 RNA/shRNA gene knockdown and CRISPR-mediated transcriptional activation) to test these interactions i

295 l tri-functional CRISPR system that combines transcriptional activation, transcriptional interference

296 The transcriptional activation was associated with structura

297 stribution of proteins, as well as inducible transcriptional activation when coupled with the CRISPR

298 provide a novel mechanism for SIRT6-mediated transcriptional activation, where SIRT6 mono-ADP-ribosyl

299 abled a screen combining gene knockouts with transcriptional activation, which revealed genetic inter

300 d suggests that these factors may coordinate transcriptional activation with other developmental chan