ライフサイエンスコーパス: transcriptional network

1 ession (although they couple functionally to transcriptional networks).

2 uencing (RNA-seq), including the BMP-induced transcriptional network.

3 AX variants converge to modulate the MAX-MYC transcriptional network.

4 rlapped with downregulation of the HNF-1beta transcriptional network.

5 e systems have been integrated into a common transcriptional network.

6 f LHX1 and a largely separable VIP-dependent transcriptional network.

7 y to dampen the metabolic stress-induced UPR transcriptional network.

8 t conditions and that may act as hubs in the transcriptional network.

9 MT-mediated disruption of a lineage-specific transcriptional network.

10 tic matrix stiffness inhibited the HNF4alpha transcriptional network.

11 on or whether it triggers a broadly targeted transcriptional network.

12 of canalization and gene regulation in this transcriptional network.

13 egulated processes orchestrated by a complex transcriptional network.

14 , led to dramatic reprogramming of the liver transcriptional network.

15 ting that ANT and AIL6/PLT3 influence a vast transcriptional network.

16 organellar motility, cellular signaling, and transcriptional network.

17 nucleus, where it drives a daughter-specific transcriptional network.

18 f crucial endosperm regulators into a single transcriptional network.

19 t may act to stabilize rather than drive the transcriptional network.

20 PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks.

21 c alterations that result in deregulation of transcriptional networks.

22 ssion also counteracts aging changes in gene transcriptional networks.

23 ugh the activation or repression of distinct transcriptional networks.

24 ell pluripotency is governed by OCT4-centric transcriptional networks.

25 ases are associated with the deregulation of transcriptional networks.

26 t 3,5-diiodothyronine (T2) can also regulate transcriptional networks.

27 E2F, and BET pathways, which converge on key transcriptional networks.

28 les in governing metabolic and developmental transcriptional networks.

29 tion factors (crisprTFs) to globally perturb transcriptional networks.

30 to improved modelling and prediction of post-transcriptional networks.

31 s an important genetic model for elucidating transcriptional networks.

32 guide this process by controlling downstream transcriptional networks.

33 ganisms that did not co-evolve its regulated transcriptional networks.

34 on the temporal and spatial dynamics of the transcriptional networks.

35 ork, in order to learn and model large-scale transcriptional networks.

36 ds the functionality of cell-type-specifying transcriptional networks.

37 rch to obtain large-scale datasets and model transcriptional networks.

38 genomic programs direct partially convergent transcriptional networks.

39 and biochemical responses driven by complex transcriptional networks.

40 which are established by tightly controlled transcriptional networks(1).

41 INCR is a newly identified player in the MYC transcriptional network able to control the expression o

42 The transcriptional network acting downstream of LIF, WNT an

43 mental signals in complex but poorly defined transcriptional networks, allowing trees to produce wood

44 us far, the extent to which genital and limb transcriptional networks also share cis-regulatory eleme

45 ystem, underscoring the power of genome-wide transcriptional-network analyses.

46 Transcriptional network analysis on these cells identifi

47 research into genetic algorithms, genetics, transcriptional network analysis, and genomics.

48 his is accompanied by changes across a broad transcriptional network and by significant VIP-directed

49 We also construct a simple synthetic transcriptional network and demonstrate using experiment

50 omprehensive insight on early human germline transcriptional network and epigenetic reprogramming tha

51 loss and long-term responses to remodel the transcriptional network and physiological and developmen

52 an primordial germ cells, revealing a unique transcriptional network and progressive and conserved gl

53 plex regulatory loops including an MYCN core transcriptional network and super-enhancers resulting fr

54 TAZ with TEAD, as a tool to characterize the transcriptional networks and biological effects regulate

55 ural stem cell biology and converge in human transcriptional networks and cell types pertinent for fe

56 Changes in transcriptional networks and chromatin state lie at the

57 sults reveal how the cell cycle orchestrates transcriptional networks and epigenetic modifiers to ins

58 ally, the link between super enhancer-driven transcriptional networks and essential metabolic pathway

59 ransients for understanding morphogen-driven transcriptional networks and indicates that gene express

60 PRi-based approach can be applied to dissect transcriptional networks and interpret the contributions

61 grative network biology approach to identify transcriptional networks and key driver genes that regul

62 identified guide RNAs (gRNAs) that modulate transcriptional networks and protect cells from alpha-sy

63 These receptors activate transcriptional networks and signaling cascades controll

64 changes in TF binding intensity in mammalian transcriptional networks and suggest that some TF-depend

65 de insights into the complex interplay of NR transcriptional networks and their contribution to the d

66 nd ChIP-seq data to enhance the inference of transcriptional networks and their functional interpreta

67 Transcriptional networks and upstream regulator analyses

68 en delivered by XgDeltaavrHah1 By perturbing transcriptional networks and/or modifying the plant cell

69 immune cell subsets, activation of specific transcriptional networks, and upregulation of immune che

70 ic multipotent progenitors, lineage-specific transcriptional networks are activated or repressed to o

71 Transcriptional networks are critical for the establishm

72 Transcriptional networks are models that allow the biolo

73 Transcriptional networks are reconfigured by changes in

74 chromatin structure, dedicated enhancers and transcriptional networks are regulated in a context-spec

75 Pluripotent-specific transcriptional networks are sequentially reactivated as

76 vascular expansion and define the FOXO1-MYC transcriptional network as a novel metabolic checkpoint

77 lasma cell fates are controlled by different transcriptional networks, as exemplified by the mutually

78 plant transcription factor in modulating the transcriptional network associated with plant immunity.

79 eage transcription factor Thpok, we inferred transcriptional networks associated with CD4(+)- or CD8(

80 counteracts breast tumorigenesis by opposing transcriptional networks associated with cell cycle and

81 offers a basis for discovering the potential transcriptional network behind one of the most abundant

82 une cells, searching for gene expression and transcriptional networks belonging to specific cellular

83 major differences in pathway activation and transcriptional networks between PMA and DAG-lactones.

84 Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements

85 through this mechanism, they repress the GR transcriptional network both in cultured cells and in th

86 These results reveal new features of the ANT transcriptional network by linking ANT to previously unk

87 Inferring a transcriptional network can be a helpful initial step in

88 In mouse embryonic stem cells (mESCs), the transcriptional network can be divided into three functi

89 amatically improve the efficiency with which transcriptional networks can be analyzed, making genomic

90 In addition to biochemical gradients and transcriptional networks, cell behavior is regulated by

91 Consistently, a transcriptional network centered on the ZBTB16 transcrip

92 tor GLK1, a key regulator of a light-induced transcriptional network central to photomorphogenesis.

93 TEAD1 is a core component of the cardiac transcriptional network, co-occupying cardiac regulatory

94 extracellular signals and dynamic control of transcriptional networks contribute to the correct spati

95 Transcriptional networks control the differentiation of

96 tudy provides comprehensive profiling of the transcriptional network controlled by C/EBPepsilon durin

97 tributable to disruption of a BPDCN-specific transcriptional network controlled by TCF4-dependent sup

98 pathway analysis revealed that FZD3 inhibits transcriptional networks controlled by CREB5, FOXD1, and

99 ctively, our work provides insights into the transcriptional networks controlled by WT1 and identifie

100 there is an enrichment of these motifs in a transcriptional network controlling the early T cell dev

101 solution analysis of cell-type diversity and transcriptional networks controlling cell-fate specifica

102 accessibility data allowed us to reconstruct transcriptional networks controlling photoreceptor diffe

103 n cereals will enable to further unravel the transcriptional networks controlling this important yiel

104 eproductive structures require Cu, and which transcriptional networks coordinate Cu delivery to repro

105 insic signals are required to understand how transcriptional networks coordinate fate specification a

106 n parallel with cognitive processes, a novel transcriptional network coordinating brain structural or

107 1alpha co-activator that regulates the HIF-1 transcriptional network, crucial for cancer development.

108 Here we identify major transcriptional networks deregulated in DFUs that result

109 revealed that more complex lineage-defining transcriptional networks direct CD4(+) T cell differenti

110 act genomic localization of ER-alpha and the transcriptional network downstream of ER-alpha and FOXA1

111 tions of LHX1, we mapped the VIP-independent transcriptional network downstream of LHX1 and a largely

112 Further, TCP4 modulates the common transcriptional network downstream to auxin-BR signaling

113 his suggests that AGL22 uniquely regulates a transcriptional network during drought stress, linking c

114 on-coding somatic mutations disrupt the PAX8 transcriptional network during OC development.

115 xymethylated DNA is associated with specific transcriptional networks during heart development and fa

116 While the transcriptional networks during hemato-endothelial devel

117 associated with the degradation of coherent transcriptional networks during stem cell ageing.

118 lineage segregation, miR-337-3p controls the transcriptional network dynamics of developing hepatocyt

119 We performed an integrated analysis of transcriptional network evolution by examining mRNA expr

120 Strikingly, we found that transcriptional networks evolve at a common rate across

121 ays puberty by impairing the transition of a transcriptional network from an immature repressive epig

122 esis that FKBP1b also can protect downstream transcriptional networks from aging-induced dysregulatio

123 Thus, we identify ATF5 as a member of the transcriptional network governing pancreatic beta-cell s

124 To identify the transcriptional networks governing human retinal develop

125 proach provides a foundation for elucidating transcriptional networks guiding the development of the

126 This transcriptional network has significant overlap with the

127 ure of experimental information on bacterial transcriptional networks have prevented their systematic

128 ising direct link between two major cellular transcriptional networks, highlighting a previously unre

129 yotube formation, partially via the myogenin transcriptional network, highlights the importance of me

130 including metabolic and transport pathways, transcriptional networks, hormone signaling pathways, an

131 d KDM6A mutations, upregulation of the TP63N transcriptional network, hypermethylation of pancreatic

132 r cell including the rapid mobilization of a transcriptional network implicated in accelerated growth

133 n function leads to the down-regulation of a transcriptional network important for ILC2 differentiati

134 ll as alterations in cis-regulatory loci and transcriptional network in a mouse model system.

135 rt the rapid expansion and divergence of the transcriptional network in a polyploid crop and offer a

136 particular, we identified an AP-1 regulated transcriptional network in dlPFC neurons associated with

137 r the repressive branch of the sugar sensing transcriptional network in Drosophila.

138 results reveal novel roles for PBX1 and its transcriptional network in mDAn development and PD, open

139 ings reveal that a large part of the complex transcriptional network in metastasis can be controlled

140 y Eya1 and Six1 as key components of the Shh transcriptional network in normal development and in onc

141 ish the landscape of SE-associated oncogenic transcriptional network in NPC, which can be exploited f

142 omprehensive analysis of the genome-wide WT1 transcriptional network in podocytes in vivo using chrom

143 nterruption of the reading frame affects the transcriptional network in the oviducts at a specific st

144 and malignant lymphoid cells reveals a novel transcriptional network in transformed lymphoid cells ex

145 in testis cell types originate from modified transcriptional network in undifferentiated spermatogoni

146 nd that lncRNA knockdown can perturb complex transcriptional networks in a cell type-specific manner.

147 t-A-iTreg cells dampened crucial TH2-skewing transcriptional networks in DCs.

148 used to predict regulatory components of the transcriptional networks in M. capitata.

149 cyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive.

150 , our study provides a comprehensive view of transcriptional networks in response to a nutrient signa

151 a systems biology approach to identify host transcriptional networks in such cells and study the con

152 While the role of transcriptional networks in these processes is increasin

153 on of flavonoid decorating enzymes and their transcriptional networks in various plant species.

154 alytical advances can reveal the topology of transcriptional networks in which hundreds of genes are

155 data we define a comprehensive human breast transcriptional network, including a set of myoepithelia

156 gene expression profiling characterized the transcriptional networks induced in tolerogenic DCs by A

157 The proposed pipeline for transcriptional network inference and comparison is high

158 improvement of high-throughput profiling and transcriptional network inference methods: from activiti

159 Starting from chemical-specific transcriptional networks inferred from these data, we sh

160 To this end, we characterized the transcriptional network initiated by the type-B ARABIDOP

161 proliferative organoids (i.e. ribosome) and transcriptional networks involved in differentiation, in

162 This suggests that the GATA3 transcriptional network is a promising target for novel

163 Core regulatory circuitry (CRC)-dependent transcriptional network is critical for developmental tu

164 and survival, and implicated that the c-Myc transcriptional network is deregulated following JMJD1A

165 GRACE can improve our understanding of how a transcriptional network is re-wired in cancer.

166 The regulation of cell-specific transcriptional networks is accomplished by an epigeneti

167 terize the impact of KLF15-dependent cardiac transcriptional networks leading to HF progression, amen

168 Thus, SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppres

169 We illustrate how altered transcriptional networks may impact cardiomyocyte functi

170 differentiation, these poorly characterized transcriptional networks may underlie the etiology and b

171 ggesting differential signaling pathways and transcriptional network mechanisms that lead to the acti

172 unctions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-ass

173 is; however, a detailed understanding of the transcriptional network mediating this process is unclea

174 GIGANTEA (GI) as a genome-wide regulator of transcriptional networks mediating growth and adaptive p

175 The enormous divergence of signalling and transcriptional networks mediating the crosstalk between

176 pulation-specific gene regulation as well as transcriptional network modification.

177 This activity results in blocking the core transcriptional network necessary for endoderm specifica

178 e cells, ZEBs function to regulate important transcriptional networks necessary for cell differentiat

179 While the transcriptional network of human embryonic stem cells (h

180 Thus, we position Tshz1 in the transcriptional network of maturing beta-cells and sugge

181 However, the mode of action and transcriptional network of nuclear AURKA in BCSCs remain

182 B-Zfp189 interactions in mediating a central transcriptional network of resilience.

183 4 at the Bcl-6 promoter, Bach2 regulates the transcriptional network of Tfh cells in a different way,

184 LI1 target genes, contribute to the aberrant transcriptional network of the disease, and mediate the

185 tion involves the dramatic upregulation of a transcriptional network of thousands of genes whose expr

186 gnificance, immunosuppressive potential, and transcriptional network of well-defined neutrophil subse

187 TF mutant library provides key insights into transcriptional networks of basidiomycetous fungi and hu

188 To resolve the underlying transcriptional networks of follicular B-cell lymphomas,

189 e network function, here we deconvoluted the transcriptional networks on the same datasets using ARAC

190 s derived from the hPSC-epi delivered a core transcriptional network organised around WT1, TCF21 and

191 tiation was defined more subtly by nonrandom transcriptional network organization, with roles in thes

192 e package extends the RTN (Reconstruction of Transcriptional Networks) package, and uses RTN transcri

193 Finally, our reconstructed transcriptional networks pinpointed the precise timing f

194 We show that, when coupled to a downstream transcriptional network, pre-steady-state measurement of

195 vertebrate neural tube, a morphogen-induced transcriptional network produces multiple molecularly di

196 The GATA and PAX-SIX-EYA-DACH transcriptional networks (PSEDNs) are essential for prop

197 y signaling pathways and a core pluripotency transcriptional network (PTN) comprising Nanog, Oct4, an

198 t calculates regulon activity profiles using transcriptional networks reconstructed by the RTN packag

199 c chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via m

200 Using a genomics approach, we identified the transcriptional networks regulated by Foxp1 in the devel

201 lysis of The Cancer Genome Atlas to identify transcriptional networks regulated by TAp63 and DeltaNp6

202 Transcriptional networks, regulated by extracellular sig

203 our results indicate that an LMO4-regulated transcriptional network regulates alcohol consumption in

204 dentified deficiencies in a STAT3-controlled transcriptional network regulating extracellular matrix

205 However, the WT1-dependent transcriptional network regulating podocyte development

206 Elucidation of the transcriptional networks regulating HC fate determinatio

207 surfactant proteins, lipid transporters, and transcriptional networks regulating their expression has

208 Here, we show that PBX1 controls a novel transcriptional network required for mDAn specification

209 ese findings reveal the presence of a robust transcriptional network required to produce functional M

210 Transcriptional networks revealed that the dominant phot

211 The generation of rewired transcriptional networks, selection for specific phenoty

212 ditionally, identification of protumorigenic transcriptional networks specific to RB loss that were v

213 reported that a tissue-environment-dependent transcriptional network specifies human microglia identi

214 ese findings reveal an environment-dependent transcriptional network specifying microglia-specific pr

215 However, the transcriptional network sustaining the Tfh cell phenotyp

216 main transcription factor complex controls a transcriptional network that balances reproduction versu

217 Thus, CEH-60 governs an elaborate transcriptional network that balances stress responses a

218 Our data shows identification of a transcriptional network that controls barrier resistance

219 d is therefore critical for establishing the transcriptional network that controls GC B cell and plas

220 result, great progress in understanding the transcriptional network that controls photoreceptor spec

221 ng sets of target genes generate the complex transcriptional network that controls the Plasmodium lif

222 ene regulation in the chambers, the complete transcriptional network that controls these patterns rem

223 sclerotome are specified appropriately, the transcriptional network that drives early chondrogenesis

224 Our findings delineate a post-transcriptional network that governs breast cancer metas

225 of disease, delineation of the AR-dependent transcriptional network that governs disease progression

226 r with genetic perturbations, this reveals a transcriptional network that integrates opposing retinoi

227 adipokines that can regulate UCP1 through a transcriptional network that is dissociated from brown a

228 growth to defense but rather by a conserved transcriptional network that is hardwired to attenuate g

229 have been extensively studied, the upstream transcriptional network that modulates their levels and

230 Oral mucosa contains a unique transcriptional network that primes oral wounds for rapi

231 a novel role for Mef2c/d in coordinating the transcriptional network that promotes early B-cell devel

232 We reverse-engineered a transcriptional network that provides a mechanistic basi

233 cription factors positioned at the apex of a transcriptional network that regulates a diversity of do

234 ude that BCL11A is a critical component of a transcriptional network that regulates B cell fate by co

235 ndings reveal a novel role of HNF-1beta in a transcriptional network that regulates intrarenal choles

236 Little is known about the transcriptional network that regulates PD duplication.

237 nt of the DRA-specific factor Hth alters the transcriptional network that regulates Rhodopsin express

238 ctor independence 1 (Gfi-1) is a part of the transcriptional network that regulates the development o

239 ights into the multifactorial Tbx3-dependent transcriptional network that regulates the structure and

240 ic physiology, but little is known about the transcriptional network that regulates their development

241 ring 26S proteasome capacity, we defined the transcriptional network that responds to this stress in

242 rs, CEH-60/PBX and UNC-62/MEIS, coordinate a transcriptional network that supports reproduction while

243 nase, and by the activation of an intestinal transcriptional network that upregulates delta-9 fatty a

244 , many essential components of the beta cell transcriptional network that were down-regulated in the

245 We identify transcriptional networks that are controlled by Arid1a a

246 xpression analysis was conducted to identify transcriptional networks that are responsive to the cons

247 ysis of the extrinsic signals and downstream transcriptional networks that assign cell fates in the c

248 the global regulator Hfq contributes to post-transcriptional networks that control expression of nume

249 The mechanisms of root iron uptake and the transcriptional networks that control root-level regulat

250 Our study reveals novel transcriptional networks that control stress susceptibil

251 provide novel insight on the nonoverlapping transcriptional networks that control the differentiatio

252 nes is known, little is understood about the transcriptional networks that coordinate their expressio

253 13 and postnatal day 5 in order to identify transcriptional networks that diversify neuron cell fate

254 every cell is maintained by highly specific transcriptional networks that establish a coherent molec

255 a set of conserved organizing principles and transcriptional networks that govern PR subtype differen

256 Transcriptional networks that govern secretory cell spec

257 orted, the underlying molecular pathways and transcriptional networks that govern the maintenance of

258 A-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, inv

259 Second, gradients initiate transcriptional networks that integrate broadly distribu

260 ed by the Tabula Muris consortium to uncover transcriptional networks that maintain tissue-specific E

261 ent goal of molecular biology is to identify transcriptional networks that regulate cell differentiat

262 To uncover the transcriptional networks that regulate Cux2 expression i

263 ivo several key drivers and their associated transcriptional networks that regulate depression suscep

264 sition of the ENS, little is known about the transcriptional networks that regulate the diversificati

265 me maps are critical for elucidating complex transcriptional networks that underlie growth, behavior,

266 To unravel the transcriptional networks that underlie the development o

267 programmed in vitro by forced changes to the transcriptional network, the most dramatic example of wh

268 ilitate their genome-wide incorporation into transcriptional networks, thereby contributing to human

269 However, the transcriptional network through which BZR1 regulates fru

270 s in inaccessible chromatin to establish new transcriptional networks throughout development and cell

271 We generated a transcriptional network to explore how transcription fac

272 tivation triggers the noncanonical NF-kappaB transcriptional network to induce genes identified in hu

273 d environmental signals converge on a common transcriptional network to promote cell elongation.

274 dr5, Pask integrates signaling cues with the transcriptional network to regulate the differentiation

275 However, the response of the transcriptional network to RUNX1-ETO expression is devel

276 ave evolved adaptive strategies that involve transcriptional networks to cope with and survive enviro

277 e their multifunctional nature to alter host transcriptional networks to elicit a diverse set of cell

278 nscriptional Networks) package, and uses RTN transcriptional networks to identify significant co-regu

279 ng pathways that trigger distinct downstream transcriptional networks to regulate the diversity of ne

280 acts at the intersection of the p53 and Myc transcriptional networks to reinforce the anti-prolifera

281 nized into 11 modules, provided insight into transcriptional network topology as well as grouping gen

282 It remains unknown whether divergent transcriptional networks underlie these cortical wiring

283 l benefit from improved understanding of the transcriptional network underlying cambial growth and wo

284 ator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular re

285 und that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN)

286 have contributed to our understanding of the transcriptional networks underlying Arabidopsis root end

287 r target genes is essential for modeling the transcriptional networks underlying developmental proces

288 nal binding sites and reconstructing dynamic transcriptional networks underlying pluripotency progres

289 f genes for maintaining homeostasis, but the transcriptional networks underlying their expression rem

290 loyed in computational analyses to model the transcriptional networks underlying wood formation, incl

291 Reverse engineering of transcriptional networks using gene expression data enab

292 high-throughput and unbiased perturbation of transcriptional networks via randomized crisprTFs can re

293 nt regulators establish AML subtype-specific transcriptional networks, we performed a comprehensive g

294 5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular sw

295 F4-aryl hydrocarbon receptor (AhR)-dependent transcriptional network, which generates suppressive hum

296 Metazoan development is regulated by transcriptional networks, which must respond to extracel

297 The genome-wide perturbation of transcriptional networks with CRISPR-Cas technology has

298 lper (T(FH)) cells is regulated by a complex transcriptional network, with mutually antagonistic Bcl6

299 ments (TEs) influence the evolution of novel transcriptional networks yet the specific and meaningful

300 quires changes to chromatin architecture and transcriptional networks, yet whether other regulatory e