ライフサイエンスコーパス: transcriptional repression

1 rative cell division by opposing TCF-related transcriptional repression.

2 ctive Cas9 (dCas9) to target loci for stable transcriptional repression.

3 H4, marks that are generally associated with transcriptional repression.

4 (miRNAs) to identify mRNAs targeted for post-transcriptional repression.

5 association of p50 binding lacking p65 with transcriptional repression.

6 ed for recruiting the co-repressor CtBP1 and transcriptional repression.

7 Histone deacetylation occurred after transcriptional repression.

8 nes, leading to H3K4me2 demethylation and to transcriptional repression.

9 that regulate stem cell differentiation via transcriptional repression.

10 on of transcription, usually associated with transcriptional repression.

11 enetic signal for chromatin condensation and transcriptional repression.

12 n and recognition required for XIST-mediated transcriptional repression.

13 n, resulting in condensed chromatin and gene transcriptional repression.

14 assembly, resulting in decreased H3K4me3 and transcriptional repression.

15 s and other transcription factors leading to transcriptional repression.

16 ssociated with host-antiviral resistance and transcriptional repression.

17 requirement of MDM4 to promote p53-mediated transcriptional repression.

18 if was identified that is important for this transcriptional repression.

19 V selectively degrades IFI16, thus relieving transcriptional repression.

20 ts of VAL1, acting through epigenetic and/or transcriptional repression.

21 mechanism based on DNA methylation-mediated transcriptional repression.

22 richia coli can be co-opted for programmable transcriptional repression.

23 ification, which is strongly associated with transcriptional repression.

24 showed that these mutations compromise REST transcriptional repression.

25 he IL-2 promoter permissive to Foxp3-induced transcriptional repression.

26 lar, Xrn1 catalytic activity is required for transcriptional repression.

27 specific gene loci, which is associated with transcriptional repression.

28 use of an alteration of PcG protein-mediated transcriptional repression.

29 repressors and release of MYC proteins from transcriptional repression.

30 acetylation of lysine 9/14 of histone 3 and transcriptional repression.

31 yoR interacts directly with Gata4 to mediate transcriptional repression.

32 encing machinery that it recruits to enforce transcriptional repression.

33 er of the genome is thought to contribute to transcriptional repression.

34 ing of the mechanisms underlying AR-mediated transcriptional repression.

35 ers at HML and HMR, the critical targets for transcriptional repression.

36 2A, a chromatin modification associated with transcriptional repression.

37 Ankrd1 deletion additionally relieved MMP10 transcriptional repression.

38 ulatory loop, whereas Jmjd2c assists PRC2 in transcriptional repression.

39 ome, macroH2A1 was thought to play a role in transcriptional repression.

40 ins are dominant targets of EWS/FLI-mediated transcriptional repression.

41 ization, interactions with co-regulators and transcriptional repression.

42 move 8-oxoG lesions that are associated with transcriptional repression.

43 cription factor genes, coinciding with their transcriptional repression.

44 D1/HDAC corepressor complex to MERVL LTR for transcriptional repression.

45 , to form the BAH-PHD-CPL2 complex (BPC) for transcriptional repression.

46 molecules capable of relieving utrophin post-transcriptional repression.

47 ort a mechanism for H3K27me3 recognition and transcriptional repression.

48 GTACAA-3' palindromic sequence, resulting in transcriptional repression.

49 mode of virus-mediated host shutoff through transcriptional repression.

50 s critical for maintenance of the associated transcriptional repression.

51 racting RNAs (piRNAs) to identify targets of transcriptional repression.

52 hile ectopic expression of ZFP708 results in transcriptional repression.

53 rary screening and the extent of the induced transcriptional repression.

54 3) at differentiation genes leading to their transcriptional repression.

55 this effect was modified by Kaiso-dependent transcriptional repression.

56 A antitoxin is required for dimerization and transcriptional repression.

57 rs of genes critical for brain function, and transcriptional repression.

58 se temporal window and results in reinforced transcriptional repression.

59 w functional link of the nuclear lamina with transcriptional repression.

60 at Znf703 requires the Buttonhead domain for transcriptional repression.

61 ation of this site prevented Gli binding and transcriptional repression.

62 ct histone signatures including two modes of transcriptional repression, active repression (hypoacety

63 nged protein half life and exhibited reduced transcriptional repression activity compared to wild-typ

64 globally its critical role in mediating the transcriptional repression activity of AR.

65 OsVOZ1 displays transcriptional repression activity while OsVOZ2 confers

66 determined by in vivo promoter occupancy and transcriptional repression activity.

67 Our findings together suggest that transcriptional repression and activation mediated by th

68 t both cooperatively and antagonistically in transcriptional repression and activation of genes invol

69 ion of mutant and endogenous ETV6, decreased transcriptional repression and altered megakaryocyte mat

70 Salt stress triggers a simultaneous transcriptional repression and aquaporin internalization

71 These data suggest that PIP transcriptional repression and channel internalization a

72 racterizes heterochromatin and mediates both transcriptional repression and chromatin anchoring at th

73 , Elba1 and Elba2 that possess activities in transcriptional repression and chromatin insulation.

74 analyses of mutant alleles that separate the transcriptional repression and clustering functions of S

75 comb RING finger homologs that are linked to transcriptional repression and developmental gene regula

76 d C-terminal ZF domains of Gfi1, but not its transcriptional repression and DNA binding activities, w

77 f action facilitates rapid switching between transcriptional repression and gene activation through t

78 repressive complex 2 (PRC2) mainly mediates transcriptional repression and has essential roles in va

79 ion of c-Fos, Egr-1 and Egr-2 through direct transcriptional repression and indirect inhibition of Er

80 ly, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the

81 regulating genes, and reveals a link between transcriptional repression and mitophagy, which is also

82 effects on NNMT were caused by PAX3-mediated transcriptional repression and overexpression of NNMT bl

83 em cells, here we show that PRC1 can trigger transcriptional repression and Polycomb-dependent chroma

84 Tethering of LSH induces transcriptional repression and silencing is dependent on

85 , a conserved eukaryotic protein involved in transcriptional repression and splicing in animals.

86 al C-terminal domain, which is necessary for transcriptional repression and sufficient for toxin neut

87 hylase-independent role for KDM2 proteins in transcriptional repression and uncovers a new function f

88 , which in cooperation with AR causes SPINK1 transcriptional-repression and impedes SPINK1-mediated o

89 nervous system, where it is associated with transcriptional repression, and at CAG trinucleotides in

90 on the mechanisms involved in STAT3-mediated transcriptional repression, and more importantly, identi

91 ed with enhancers, transcription initiation, transcriptional repression, and others.

92 er repressed mRNAs and the mechanism of post-transcriptional repression are currently unknown.

93 anscriptional activation) and negative (i.e. transcriptional repression) arms of the circadian regula

94 ur study identifies DNA-methylation-mediated transcriptional repression as a backup system for post-t

95 These results implicate transcriptional repression as a means to deliver essenti

96 ring roles for SF1 in pre-mRNA retention and transcriptional repression, as well as in splicing, futu

97 The tumor-specific shift to transcriptional repression associated with DNA methylati

98 e repressor complex architecture maintaining transcriptional repression at theSUC2gene.

99 For its role in transcriptional repression, BCL11A was found to interact

100 Transcriptional repression by B1 is the major determinan

101 hemokines such as CCL3 through enhancing the transcriptional repression by beta-catenin.

102 We identified a NEAT1-dependent mechanism of transcriptional repression by H3K9me2 at the c-Fos promo

103 nt enhancers and reveal a new mode of active transcriptional repression by HNF-1beta.

104 hese findings highlight a novel mechanism of transcriptional repression by HNF6 and demonstrate how o

105 ls in dispersed MCL cells were due to direct transcriptional repression by hypoxia-induced factor 1al

106 stabilization of RP(o) by CarD could lead to transcriptional repression by inhibiting promoter escape

107 As Sin3b is also required for transcriptional repression by Mxd-Max complexes, our res

108 ell appreciated, physiological importance of transcriptional repression by NF-kappaB in cancer has re

109 n PPARgamma is abundant, PPARgamma abrogated transcriptional repression by Sp1 at the Atgl promoter a

110 Transcriptional repression by uSTAT5 reflects restricted

111 es cluster into the functional categories of transcriptional repression, chromatin modification, or D

112 n (Rb) was required to strengthen the E2F-Rb transcriptional repression complex.

113 epressor prohibitin is part of the WT1-BASP1 transcriptional repression complex.

114 form the catalytic subunit of several large transcriptional repression complexes.

115 s) for targeting nuclease-dead Cas9-mediated transcriptional repression (CRISPRi) and activation (CRI

116 RISPRi libraries produced varying degrees of transcriptional repression critical for uncovering novel

117 DSB-mediated transcriptional repression depends on DDR signaling but

118 tes numerous biological functions, including transcriptional repression, DNA repair, and telomere mai

119 tifact was accounted for, we determined that transcriptional repression does not require local GR occ

120 r the methyl-CpG binding domain (MBD) or the transcriptional repression domain (TRD).

121 facultative heterochromatin which maintains transcriptional repression established during early deve

122 prisingly, very low levels of PTMs linked to transcriptional repression even at silent HBV promoters.

123 For archaea currently no tools for transcriptional repression exist.

124 and the mutational pathomechanisms included transcriptional repression, exon skipping, and intron in

125 Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in

126 ks-H3K27me3, which is associated with stable transcriptional repression-for genes known to promote re

127 f its promoter by OsGATA12, which suggests a transcriptional repression function for a GATA transcrip

128 FoxM1b also possesses transcriptional repression function.

129 Although their mechanism of transcriptional repression has been well studied for ove

130 ponents of this complex and the mechanism of transcriptional repression have not been characterized.

131 ns of Rap1 to telomere length regulation and transcriptional repression have yielded significant mech

132 between H3K9me3, chromatin architecture, and transcriptional repression, how H3K9me3 regulates genome

133 ng, alter subcellular localization, decrease transcriptional repression in a dominant-negative fashio

134 e repurposed AsCpf1 and LbCpf1 for efficient transcriptional repression in Arabidopsis, and demonstra

135 get genes suggested that SRC-1 also mediates transcriptional repression in breast cancer cells.

136 hanistic analysis of dynamics and control of transcriptional repression in development.

137 However, the EIN3-mediated transcriptional repression in ethylene response is unkno

138 specific lysine methylation promote AML1-ETO transcriptional repression in leukemia.

139 ltransferase that is critical for regulating transcriptional repression in mammals.

140 Transcriptional repression in multicellular organisms or

141 We consistently observe transcriptional repression in proximity to DSBs.

142 this, we observe no evidence for persistent transcriptional repression in response to a multi-day co

143 eracts with EIN3 to inhibit shoot growth via transcriptional repression in response to ethylene.

144 zinc homeostasis and showed that it mediates transcriptional repression in response to zinc.

145 rules that determine gRNA effectiveness for transcriptional repression in Saccharomyces cerevisiae.

146 ell imaging to detect and track nuclear RNAi transcriptional repression in single living human cells.

147 ents led to a repressed epigenetic state and transcriptional repression in the ventricular zone.

148 ntified a subset of genes with apparent post-transcriptional repression in young adult mouse HSCs.

149 ght to primarily regulate gene expression by transcriptional repression, in this study, we discover t

150 Transcriptional repression includes the 5-Htr2a serotoni

151 promoters in a CG context is associated with transcriptional repression, including at genes silenced

152 for most of the Fur regulon, Fur binding and transcriptional repression increase under anaerobic cond

153 echanism mediating pathogenesis is excessive transcriptional repression induced by the expanded ATXN-

154 Transcriptional repression involves a class of proteins

155 ry, these studies suggest that E2F8-mediated transcriptional repression is a critical tumor suppresso

156 Transcriptional repression is a fundamental function tha

157 Transcriptional repression is a pervasive feature of ani

158 xin (FXN) protein and evidence suggests that transcriptional repression is caused by an R-loop that f

159 We show that MLH1 transcriptional repression is dependent on DNA methylati

160 In quiescent cells, where strong transcriptional repression is induced by physiological s

161 fications to enforce gene silencing, but how transcriptional repression is propagated through mitotic

162 stone modification typically associated with transcriptional repression-is more enriched at the promo

163 EZH2 is involved in global transcriptional repression, mainly targeting tumor-suppr

164 d with increased gene promoter levels of the transcriptional repression mark H3K27me3 (histone 3 lysi

165 to decreased H3K27 trimethylation, a histone transcriptional repression mark.

166 gical effectors controls eEF2 activity via a transcriptional repression mechanism that reduces eEF2K

167 However, the H3K27me3 recognition and transcriptional repression mechanisms are only partially

168 the sequence and functional contribution of transcriptional repression mechanisms at high temporal r

169 However, post-transcriptional repression mechanisms targeting the 5' a

170 e authors identified a sequential, postnatal transcriptional repression mediated by KLF15 of pathways

171 on of these cell cycle genes by antagonizing transcriptional repression mediated by p53.

172 Here we show that transcriptional repression, mediated by the zinc-finger

173 Transcriptional repression needs to be rapidly reversibl

174 r studies indicate that equivalent levels of transcriptional repression occur by direct interaction o

175 own synthesis in stromal cells by signaling transcriptional repression of 15-PGDH elucidates long so

176 Mechanistically, we noticed transcriptional repression of 5-LO by proto-oncogene c-M

177 roto-oncogene c-Myb in TAMs induced a stable transcriptional repression of 5-LO.

178 Mechanistically, CLSY1 mediates the transcriptional repression of a negative regulator of ro

179 ts constitutive acetylation accounts for the transcriptional repression of a number of tumor suppress

180 Furthermore, we demonstrated that transcriptional repression of AFP gene by ZBTB20 was liv

181 The transcriptional repression of alternative lineage genes

182 Transcriptional repression of any one of these lncRNAs r

183 n the 1.5 kb ATX promoter which demonstrated transcriptional repression of ATX expression.

184 , that is early down-regulated and induces a transcriptional repression of ATZ expression.

185 ancy in the CLV1 clade is in fact due to the transcriptional repression of BAM genes by CLV1 signalin

186 These include regulation of telomere length, transcriptional repression of both telomere-proximal gen

187 de fashion on the basis of silencer-mediated transcriptional repression of caspase 9.

188 erates sensitivity to PARPi via Myc-mediated transcriptional repression of CDK18, while most tumors w

189 Fs act as tumor suppressors, most likely via transcriptional repression of cell cycle genes in respon

190 E2F-mediated transcriptional repression of cell cycle-dependent gene

191 t 91-R flies and observed both a significant transcriptional repression of computationally-predicted

192 IL-10-induced transcriptional repression of CXCL8 and TNFA genes consi

193 These events resulted in transcriptional repression of DDIT4L and, in turn, in in

194 Transcriptional repression of Dnmt1 by REMOTE-control wa

195 icated by histone modifications resulting in transcriptional repression of eight of nine genes invest

196 eloped efficient and stable CRISPRi-mediated transcriptional repression of exogenous and endogenous g

197 ed binding of Dax1 to Sf1 to further enhance transcriptional repression of FAdE.

198 peats in intron 1 of the FXN gene leading to transcriptional repression of frataxin expression.

199 for mammalian development and implicated in transcriptional repression of genes and transposons.

200 dysregulation of innate immune responses and transcriptional repression of genes associated with memo

201 enhancers and super-enhancers, and leads to transcriptional repression of genes critical for myeloid

202 n K562 cells caused loss of CTCF binding and transcriptional repression of genes with changed CTCF bi

203 EC) in an in vitro coculture system revealed transcriptional repression of GJA1 (encoding the gap jun

204 , we identify a novel B-lymphoid program for transcriptional repression of glucose and energy supply.

205 boundaries depends on high transcription, as transcriptional repression of HERV-H elements prevents t

206 HCT116 colon cancer cells and NME2-mediated transcriptional repression of hTERT in these cells.

207 n with chemotherapies relieves ATF2-mediated transcriptional repression of IFNbeta1, resulting in imp

208 cell expansion and effector function through transcriptional repression of Irf4.

209 nd function of CD8(+) T cells through direct transcriptional repression of Irf4.

210 nsducer and activator of transcription 5 and transcriptional repression of its negative regulators.

211 Thus G9a has a dominant function in transcriptional repression of K(+) channels and in acute

212 The transcriptional repression of key genes, induced by TCF1

213 m by which the cell cycle is coupled to post-transcriptional repression of key stem cell identity fac

214 member SIRT7 participates in the epigenetic transcriptional repression of L1 genome-wide in both mou

215 terodimer Partner (SHP/NR0B2) have a role in transcriptional repression of lipogenesis.

216 by tRF-GG modulates heterochromatin-mediated transcriptional repression of MERVL elements by supporti

217 on of chromatin factors is essential for the transcriptional repression of methylated retrotransposon

218 Here, we show that transcriptional repression of mitochondrial deacetylase

219 NF-kappaB is the downstream pathway for the transcriptional repression of MMP-3 in CAFs.

220 indicate that G9a contributes critically to transcriptional repression of MORs in primary sensory ne

221 umour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that enco

222 en phenotypes were caused by the direct post-transcriptional repression of multiple Notch pathway pro

223 Thus, we predict defective transcriptional repression of MYC by the Hfp orthologue,

224 duction of the smooth muscle lineage through transcriptional repression of Myocardin.

225 reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mb

226 stained in hepatic cells, largely because of transcriptional repression of nicotinamide phosphoribosy

227 muscle cell fusion correlates well with the transcriptional repression of Npnt, Itgb1D and Cav3, gen

228 esis that ANG II plays critical roles in the transcriptional repression of Npr1 (encoding NPRA) and r

229 deprivation of an essential nutrient induces transcriptional repression of organellar biogenesis invo

230 es restricted to the optic cup by reciprocal transcriptional repression of pax6 and pax2 However, it

231 3K27me3, which is otherwise dedicated to the transcriptional repression of protein-coding genes in fl

232 oes not affect R-loops, PRC1 recruitment, or transcriptional repression of R-loop-positive genes.

233 DSBs induced in pre-B cells signal rapid transcriptional repression of Rag1 and Rag2, causing dow

234 phosphorylated and inhibited FOXO1-dependent transcriptional repression of rhotekin 2 (RTKN2), an oxy

235 While SMAR1-dependent transcriptional repression of Slug by direct recruitment

236 Finally, we present evidence for direct transcriptional repression of Sox2 by YAP1, WWTR1 and TE

237 inase c-Abl increases HDAC2 levels, inducing transcriptional repression of synaptic genes.

238 regulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and g

239 (TGF)-beta signaling through Notch-mediated transcriptional repression of TGF-beta pathway genes.

240 CDC25A cooperates with previously described transcriptional repression of the CDC25A promoter and pr

241 iated polypeptide N (Snrpn), contributing to transcriptional repression of the gene.

242 We determined that Myc-mediated transcriptional repression of the miR-15 and let-7 famil

243 ressors of AML that function in part through transcriptional repression of the MYC-driven oncogenic p

244 With the enhanced repressor, we demonstrate transcriptional repression of the Myeloid differentiatio

245 ks cell cycle exit via methylation-dependent transcriptional repression of the MyoD target genes p21(

246 zone exit, and migration initiation through transcriptional repression of the partitioning-defective

247 In mice, transcriptional repression of the paternal X-chromosome

248 osis requires STAT and Wg and is mediated by transcriptional repression of the pro-apoptotic gene rea

249 ial sugar utilization has been attributed to transcriptional repression of the secondary metabolic pa

250 TbMCM-BP is also important for transcriptional repression of the specialized subtelomer

251 rthermore, the introduced methylation causes transcriptional repression of the targeted genes.

252 erlying the tumorigenesis of KSHV is through transcriptional repression of the tumor suppressor gene

253 the four populations, we revealed a striking transcriptional repression of the X chromosome coinciden

254 providing insight into a novel strategy for transcriptional repression of this gene by small molecul

255 ucleotides and is frequently associated with transcriptional repression of transposable elements.

256 uided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi.

257 of primary B lymphocytes resulted in global transcriptional repression of TSGs through engagement of

258 iated prostate cancer (PCa) cells via direct transcriptional repression of Twist1 and CD44.

259 e mechanism by which yeaG acts, involves the transcriptional repression of two toxin/antitoxin module

260 FOXO1-mediated transcriptional repression of UBE3A was sufficient to st

261 Transcriptional repression of ubiquitin B (UBB) is a can

262 Pax5 mediates the transcriptional repression of Wapl through a single Pax5

263 Myc activation results in the transcriptional repression of Wnt antagonists through th

264 oting degradation of SNAI2 and relieving its transcriptional repression of YAP.

265 YL-DNA PHOSPHODIESTERASE1 (TDP1), AN imposes transcriptional repression on MYB46, encoding a transcri

266 A higher abundance of Hsp90 causes increased transcriptional repression on RAD53 in a dose-dependent

267 A biosynthesis, while releasing TDP1-imposed transcriptional repression on WRKY33, a master regulator

268 xpress Sox2 as early as the four-cell stage, transcriptional repression prevents the premature expres

269 s-acting factor ZF6-DB without the intrinsic transcriptional repression properties of the canonical E

270 to underlying molecular mechanism(s) through transcriptional repression regulation.

271 istone-modifying activities are required for transcriptional repression remains controversial.

272 rve as a platform for understanding how post-transcriptional repression restricts interpretation of B

273 le genes, promoter occupancy correlated with transcriptional repression, resulting in differential le

274 Hence, high resolution mapping of transcriptional repression reveals complex and interdepe

275 hylation (H3K9me2), which is associated with transcriptional repression, specifically to the Cdk5 loc

276 establishes a robust and extensive region of transcriptional repression spreading from DSB sites and

277 a herpesviral RNA endonuclease induces host transcriptional repression that is mediated through the

278 roup (PcG) proteins form memory of transient transcriptional repression that is necessary for develop

279 se 1 (TREE1) interacts with EIN3 to regulate transcriptional repression that leads to an inhibition o

280 repressive complex 2 (PRC2), plays a role in transcriptional repression through histone H3 Lys-27 tri

281 repressive complex 2 (PRC2) participates in transcriptional repression through methylation of histon

282 nism in which ectopic PHF7 overcomes its own transcriptional repression through promoter switching.

283 mechanism coupling H3K27me3 recognition with transcriptional repression through the alteration of Pol

284 Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostl

285 cause human CAKUT by interference with TBX18 transcriptional repression, thus implicating ureter smoo

286 Furthermore, we found unexpected transcriptional repression upon either loss of the de no

287 RNA genes are strongly associated with their transcriptional repression upon miR-494 overexpression,

288 routes are inhibited, but the mechanisms of transcriptional repression upon sugar sensing have remai

289 lysine residues on histone tails, promoting transcriptional repression via condensation of chromatin

290 ed hypoxia inducible factor-2alpha-dependent transcriptional repression via histone deacetylase 1-med

291 ion by binding to its promoter and mediating transcriptional repression via histone deacetylases.

292 v and ELBA proteins are competent to mediate transcriptional repression via Insv consensus sequences

293 Chaf1a reinforces transcriptional repression via its interaction with memb

294 This glucose-dependent transcriptional repression was in part mediated by O-Glc

295 This IFN-beta-mediated transcriptional repression was independent of the effect

296 Because protein sumoylation can promote transcriptional repression, we hypothesized that LMP1-in

297 7me3), an epigenetic modification that marks transcriptional repression, were changed in miR combo-tr

298 palindromes throughout the genome to mediate transcriptional repression, whereas Bsg25A and Elba2 het

299 eby antagonizing full-length SON function in transcriptional repression while not impairing full-leng

300 inflammation characterized by rapid primary transcriptional repression without local GR occupancy an