ライフサイエンスコーパス: transferrin

1 revealed a significant impairment of CME of transferrin.

2 (-) AMs had an impaired ability to sequester transferrin.

3 s into the mechanism of Tfr2's regulation by transferrin.

4 r and BBB transporter for the iron chaperone transferrin.

5 in metal-binding serum proteins, albumin and transferrin.

6 ficient hepatocytes to internalize iron from transferrin.

7 ated by conserved iron-transporting proteins transferrins.

8 ens mediated by iron-binding proteins called transferrins.

9 Here, the effect of excess iron (holo-transferrin 0-2 g/L for 24 and 48 h) on EMT biomarkers i

10 ceptors for macromolecular nutrients such as transferrin(2,3).

11 aled an abnormal N-glycosylation profile for transferrin, a clinical diagnostic marker for congenital

12 in HEK293 cells inhibited internalization of transferrin, a process that depends on clathrin-mediated

13 studies, supports the immune role of insect transferrins against infections via an iron withholding

14 ling a recombinant form of an 80 kDa protein transferrin allowed Ru(III) to be selectively placed wit

15 Holo-transferrin also triggers proper induction of Hamp mRNA,

16 In this study, (89)Zr-transferrin and (18)F-FDG imaging were compared in precl

17 Transferrin and albumin productions were monitored durin

18 of corrole NPs prepared in combination with transferrin and albumin were alike, but the former were

19 ating mutant, were able to rescue defects in transferrin and EGF internalization caused by loss of en

20 5 cancer cell lines increased endocytosis of transferrin and EGF receptors (TfR and EGFR) concurrent

21 y by endocytosis upon binding of iron-loaded transferrin and ferritin.

22 Newly absorbed iron binds to plasma transferrin and is distributed around the body to sites

23 xc(-) or activation of the iron transporters transferrin and lactotransferrin), whereas the intrinsic

24 on and epitopes on CD71 for interaction with transferrin and pathogenic hosts were identified.

25 African Americans with elevated saturated transferrin and serum ferritin show higher prevalence of

26 sing mTORC1 activity is sufficient to target transferrin and sphingomyelin to the lysosomes.

27 ing, for nonheme iron, the transport protein transferrin and the intracellular iron-storage protein f

28 rough the synthesis of the serum transporter transferrin and the iron hormone hepcidin.

29 Internalization of transferrin and these G protein-coupled receptors was al

30 their iron status including iron, ferritin, transferrin and transferrin saturation and serum lipid p

31 terminal pro-B-type natriuretic peptide, and transferrin), and apolipoprotein A1 >75th percentile.

32 We used bovine RNase B, human transferrin, and bovine fetuin as models to demonstrate

33 Herein, adsorption of proteins, transferrin, and catalase on the polystyrene (PS) or iro

34 sed extravascular hemolysis, saturated serum transferrin, and produced circulating nontransferrin-bou

35 ed to perinuclear vesicles that harbor CD71, transferrin, and Rab8, markers of the recycling endosome

36 Supplementation with insulin, transferrin, and selenium (ITS) is commonly used to keep

37 Using endocytosis of transferrin as an indicator for clathrin-mediated endocy

38 Y-1 in virus-infected cells colocalized with transferrin as determined by confocal microscopy, indica

39 In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrapping al

40 s administration of tocotrienol entrapped in transferrin-bearing vesicles resulted in tumor suppressi

41 amics simulation infers that facet-dependent transferrin binding is also induced by the differential

42 hat facet-engineering significantly enhances transferrin binding to cadmium chalcogenide nanocrystals

43 Transferrin binds and releases iron via either or both o

44 Iron-loaded transferrin binds to transferrin receptor 1 on the surfa

45 Moreover, iron-loaded transferrin blocked MT2-mediated Tfr2 cleavage, providin

46 g that dietary iron overload or elevated non-transferrin bound iron (NTBI) aggravates atherosclerosis

47 but no difference in the accumulation of non-transferrin bound iron or ferritin.

48 rload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress

49 rsinia enterocolitica O9) by controlling non-transferrin-bound iron (NTBI) rather than iron-transferr

50 Biodistribution studies revealed increased transferrin-bound iron accumulation in the kidneys of al

51 ptor 1 (Tfr1) mediates uptake of circulating transferrin-bound iron to developing erythroid cells and

52 The value of hepcidin, non-transferrin-bound iron, and reticulocyte indexes is bein

53 very to tissues, b) induction of hepcidin by transferrin-bound iron, c) ferroportin-dependent iron ex

54 olysis, and the formation of circulating non-transferrin-bound iron.

55 d glycoproteins bovine ribonuclease B, human transferrin, bovine fetuin and human alpha1-acid glycopr

56 of in vitro studies, it was speculated that transferrin can bind Ti(IV) assisted by a synergistic an

57 tein antigen to the iron transport molecule, transferrin, can significantly enhance mucosal immune re

58 Transferrin-coated endocytic gold nanorod cargoes initia

59 In vivo results revealed that the transferrin-coated NPs can effectively be transported ac

60 -coated vesicles are superior to uncoated or transferrin-coated vesicles for delivering cargo to the

61 enabled to analyze 16 serum samples with the transferrin concentration from 90 to almost 350 mg dL(-1

62 ansferrin-bound iron (NTBI) rather than iron-transferrin concentration.

63 rrin saturation (cutoff 55%), and high serum transferrin concentrations (cutoff 1.6 g/L) were associa

64 Transferrin conjugated haemagglutinin induced a signific

65 In this study, we developed transferrin-conjugated porous silicon nanoparticles (Tf@

66 ract than intranasally delivered antigen and transferrin conjugation had a more marked effect on subl

67 ther conjugating influenza haemagglutinin to transferrin could improve the immune response to subling

68 es the bioavailability of iron in urine by a transferrin-dependent mechanism.

69 ctivation, and surprisingly, upregulation of transferrin despite increased levels of ferritin.

70 exposure of trypanosomes to AEE788 inhibited transferrin endocytosis, altered cell morphology, and de

71 accumulation of early endosomes and impaired transferrin endocytosis.

72 Transferrin excretion was significantly increased in alb

73 us proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the ava

74 iation of plasma catalytic iron, total iron, transferrin, ferritin, free hemoglobin, and hepcidin wit

75 ver, we find that a single receptor can bind transferrin from a broad range of mammals, indicating th

76 which has been proposed to allow binding to transferrin from different mammalian hosts(5,6).

77 iron occupancy in the N vs C lobe influences transferrin function, we generated mice with mutations t

78 identified two patients with defective serum transferrin glycosylation and mutations in the MAGT1 gen

79 munogold) to map the available epitopes on a transferrin grafted silica particle (SiO2-PEG8-Tf) as a

80 Human serum transferrin (hTF) is a central part of the transport pro

81 ted nanogels (nanoMIPs), selective for human transferrin (HTR), were prepared via a template assisted

82 Analysis (MCFA) system for determination of transferrin in human serum has been developed.

83 an in vivo model to investigate the role of transferrins in host defense.

84 te many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions

85 Apo-transferrin increased the formation of hydroxyl radicals

86 Our data account for transferrin-independent binding of ferritin to CD71 and

87 n with the receptor-enhanced permeability of transferrin indicates that the phenomena observed for Ig

88 following dietary iron manipulations or holo-transferrin injection.

89 Lalphas knockout (XLKO) pups showed enhanced transferrin internalization.

90 SNX9 in XLKO Ocy454 cells prevented enhanced transferrin internalization.

91 ting greater right-to-left shunting); higher transferrin iron saturation index; intravenous iron use

92 baseline serum samples tested for ferritin, transferrin, iron, and hepcidin.

93 (89)Zr-transferrin is a useful tool to interrogate MYC via TfR-

94 Transferrin labeled with (89)Zr has successfully identif

95 h short and longer polymers colocalized with transferrin-labeled early endosomes.

96 e-associated macrophage protein-1 (NRAMP-1), transferrin, lactoferrin, and heme-binding proteins.

97 21 to 74 y with complete relevant data, with transferrin levels <=50%, without hepatitis B or C, who

98 On the contrary, serum iron and transferrin levels were decreased in ICU subjects with l

99 in, and transferrin saturation and decreased transferrin levels, thus serving as instruments for syst

100 Toposome is a major calcium-binding transferrin-like protein contained within the sea urchin

101 es Fe acquisition in Spn under conditions of transferrin-mediated Fe starvation.

102 ed inclusion of the following mechanisms: a) transferrin-mediated iron delivery to tissues, b) induct

103 e for relative N vs C lobe iron occupancy in transferrin-mediated regulation of iron homeostasis and

104 We found that, with the assistance of the transferrin moiety binding to the transferrin receptor,

105 Furthermore, neither high concentrations of transferrin nor knock-out of cytosolic lipid peroxidases

106 re, we investigate peak narrowing in a model transferrin-nylon system under salting out conditions us

107 intracellular iron level by addition of holo-transferrin or FeCl(3) suppressed SubAB-induced PARP cle

108 against TfR1-ECD that does not compete with transferrin or ferritin for receptor binding.

109 We hypothesized that (89)Zr-transferrin PET will noninvasively detect MYC and TfR an

110 ing patients by body mass index, prealbumin, transferrin, phosphate, urinary urea nitrogen, and nitro

111 t these cells can acquire (59)Fe from (59)Fe-transferrin, presumably via Tfr2.

112 esign through the introduction of proinsulin-transferrin (ProINS-Tf) fusion protein as a liver-specif

113 .006), a lower mean concentration of soluble transferrin receptor (6.1 compared with 7.8 mg/L, P = 0.

114 ulating red blood cells were found to retain transferrin receptor (CD71) in their membrane, demonstra

115 owever, the selective tropism of P vivax for transferrin receptor (CD71)-positive reticulocytes remai

116 nt glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1).

117 ators serum ferritin <15 ug/L, serum soluble transferrin receptor (sTfR) >4.4 mg/L, and calculated to

118 that is calculated from ferritin and soluble transferrin receptor (sTfR) allows for the evaluation of

119 ons.We assessed the relation between soluble transferrin receptor (sTfR) concentrations and inflammat

120 = 0.04) and France (P = 0.04) and on soluble transferrin receptor (sTfR) for participants in Poland (

121 time, measured by sFer, hemoglobin, soluble transferrin receptor (sTfR), and estimated total body ir

122 rically to include plasma ferritin), soluble transferrin receptor (sTfR), and total body iron (TBI) w

123 in (SF), transferrin saturation, and soluble transferrin receptor (sTfR), as well as erythrocyte prot

124 ) (B = -0.17), hepcidin (B = -0.36), soluble transferrin receptor (sTfR; B = 0.33), and EPO (B = 0.28

125 t external cues induced up-regulation of the transferrin receptor (TfR) and down-regulation of ferrit

126 ealed differences in the dynamic behavior of Transferrin Receptor (TfR) and Langerin proteins.

127 a, low retinol, zinc, and ferritin, and high transferrin receptor (TfR) at 15 mo.

128 The P2Ns manifest transferrin receptor (TfR) colocalization in ex vivo int

129 Increased surface expression of transferrin receptor (TfR) is a downstream event of MYC

130 Transferrin receptor (TFR) is an important iron transpor

131 The transferrin receptor (TfR) of the bloodstream form (BSF)

132 Transferrin receptor (TfR) represents a unique target fo

133 in the form of tunable nanosystems (NS) for transferrin receptor (TfR) utilizing gambogic acid (GA),

134 , and utilization of a CDP that binds to the transferrin receptor (TfR), a native receptor and BBB tr

135 NHE5 is associated with transferrin receptor (TfR)- and Rab11-positive recycling

136 fect on the clathrin-mediated endocytosis of transferrin receptor (TfR).

137 The posttranslational regulation of transferrin receptor (TfR1) is largely unknown.

138 PN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is incre

139 transmembrane protease, serine 6 (TMPRSS6), transferrin receptor (TFR2), N-acetyltransferase 2 (aryl

140 biquitin C (UBC) in head and neck cancer and Transferrin receptor (TFRC) and beta-Glucuronidase (GUSB

141 Human transferrin receptor 1 (CD71) guarantees iron supply by

142 However, the role of transferrin receptor 1 (CD71)-expressing AMs in IPF is n

143 These NWAs use human transferrin receptor 1 (hTfR1) as a host cell receptor f

144 viral hemorrhagic fever is the use of human transferrin receptor 1 (hTfR1) for cellular entry.

145 PC7 sheds human transferrin receptor 1 (hTfR1) into soluble shTfR1 in en

146 iptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage prote

147 enic arenaviruses from South America utilize transferrin receptor 1 (TfR1) as a cellular receptor, th

148 ptide ligase, butelase 1, to label the human transferrin receptor 1 (TfR1) in established human cell

149 Overexpression of transferrin receptor 1 (TFR1) is common across cancer an

150 Transferrin receptor 1 (TfR1) mediated transcytosis is a

151 Transferrin receptor 1 (Tfr1) mediates uptake of circula

152 CF macrophage transferrin receptor 1 (TfR1) was reduced with ivacaftor

153 igh affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeu

154 had a homozygous p.Tyr20His substitution in transferrin receptor 1 (TfR1), encoded by TFRC.

155 T1), the ferritin heavy chain (Fth), and the transferrin receptor 1 (Tfr1), were postnatally ablated

156 F)-bound iron by modulating the synthesis of transferrin receptor 1 (TfR1).

157 GPC architecture and share a host receptor, transferrin receptor 1 (TfR1).

158 lating iron homeostasis via interacting with transferrin receptor 1 (TFR1).

159 restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy anti

160 ransporters mediating placental iron uptake (transferrin receptor 1 [TFR1]) and export (ferroportin [

161 Iron-loaded transferrin binds to transferrin receptor 1 on the surface of most body cells

162 pathogenic New World arenaviruses use human transferrin receptor 1 to enter cells.

163 ion of the divalent metal transporter 1, the transferrin receptor 1, and the ferritin heavy chain in

164 We demonstrate that loss of transferrin receptor 1, but not loss of ferroportin, can

165 However, loss of transferrin receptor 1, involved in iron uptake, caused

166 Transferrin receptor 2 (TFR2) is a transmembrane protein

167 regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2).

168 administration or modulating the ability of transferrin receptor 2 [Tfr2] to control red blood cell

169 n), HFE (hemochromatosis protein), and TfR2 (transferrin receptor 2), these proteins do not control t

170 and Mk-biased commitment after knockdown of transferrin receptor 2, a putative iron sensor.

171 MPO was associated with a lower risk of high transferrin receptor [0.86 (0.74, 0.98)], NEO with a low

172 P]) and biomarkers of MN status (pF, soluble transferrin receptor [sTfR], RBP, and pZn), and compare

173 Expression of transferrin receptor and 24p3R were reduced in tubules f

174 brogates the somatodendritic polarity of the transferrin receptor and several glutamate receptor type

175 s) target cerebral endothelial cells through transferrin receptor and the receptor for advanced glyca

176 ake of therapeutically relevant transferrin, transferrin receptor antibody and plasma.

177 leaves unchanged the rate by which MC4R and transferrin receptor are constitutively excluded from th

178 e calculated from serum ferritin and soluble transferrin receptor concentrations, can be used to asse

179 not contacting transferrin, suggesting that transferrin receptor diversification is driven by a need

180 CD4, the asialoglycoprotein receptor, or the transferrin receptor eliminates intramembrane proteolysi

181 This was reflected in increased transferrin receptor expression and increased splenic ir

182 rmined the structure of a Trypanosoma brucei transferrin receptor in complex with human transferrin,

183 pid stress disrupted later steps of MC4R and transferrin receptor internalization to endosomes as wel

184 Anti-transferrin receptor monoclonal antibody (OX26)-PEGylate

185 Type 1 transferrin receptor mRNA was unexpectedly decreased in

186 Transferrin receptor mRNA, which contains two highly con

187 >/=1 biomarker of iron [ferritin or soluble transferrin receptor or vitamin A status (retinol-bindin

188 nnose glycosylation at the helical domain of transferrin receptor protein 1 promotes conformational c

189 chlamydial growth and replication, including transferrin receptor protein 1, the amino acid transport

190 ing complex pathway, its knockdown arresting transferrin receptor recycling.

191 cysteines 556 and 558 on the surface of the transferrin receptor resulting in subsequent endocytic u

192 300Lys) altered the binding of the capsid to transferrin receptor type 1 (TfR), particularly during v

193 ecies-specific binding to the host receptor, transferrin receptor type-1 (TfR).

194 Transferrin receptor was positively related to HAZ (0.18

195 umours respect to surrounding liver, whereas transferrin receptor was up-regulated.

196 otocol makes use of cargo protein (e.g., the transferrin receptor) coupled to a pH-sensitive fluoresc

197 interleukin 2 receptor alpha subunit or Tac, transferrin receptor, and cluster of differentiation 8a,

198 Serum ferritin, serum transferrin receptor, and hemoglobin concentrations were

199 on and vitamin A biomarkers (ferritin, serum transferrin receptor, and retinol binding protein) in se

200 nd decreased expression of the iron importer transferrin receptor, likely reflecting a regulatory res

201 biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-

202 nce of the transferrin moiety binding to the transferrin receptor, the activated ProINS-Tf exhibited

203 Consistently, expression of transferrin receptor, the brain's main iron-influx prote

204 ytosis and coincided with the recruitment of transferrin receptor, VAMP3, and dynamin-2.

205 sion of hepcidin and increased expression of transferrin receptor-1 and erythroferrone, suggesting th

206 brain is >10-fold greater than antibodies to transferrin receptor-1 and intercellular adhesion molecu

207 fectively depleted cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regu

208 Hemojuvelin (HJV), HFE, and transferrin receptor-2 (TfR2) facilitate this process pr

209 nclude newly identified interactions between transferrin receptor-2 and the erythropoietin receptor.

210 ize, low cellular toxicity and the efficient transferrin receptor-mediated uptake render the AspA tag

211 red in the recycling pathway of the exocytic transferrin receptor.

212 eceptor, while New World arenaviruses hijack transferrin receptor.

213 ed for hemoglobin, serum ferritin, and serum transferrin receptor.

214 with a monoclonal antibody against the mouse transferrin receptor.

215 were internalized to a greater extent by the transferrin-receptor-rich DU-145 cells.

216 However, variation in hepcidin, soluble transferrin receptors (sTfR), and hemoglobin/anemia was

217 y recognized CPV host-to different carnivore transferrin receptors (TfRs) using single-particle track

218 eceptors and plasma membrane lipids, such as transferrin receptors and sphingomyelin, are delivered t

219 ereas the CME of constitutively internalized transferrin receptors is mainly dependent on the ubiquit

220 nosome genome contains a family of around 14 transferrin receptors(4), which has been proposed to all

221 ritin, transferrin saturation, serum soluble transferrin receptors, and the serum soluble transferrin

222 uent delivery into cancer cells, mediated by transferrin receptors, in a complex biological matrix.

223 Maternal hemoglobin, ferritin, transferrin receptors, retinol binding protein (RBP), zi

224 transferrin receptors, and the serum soluble transferrin receptors-ferritin index are more accurate t

225 ES2-14 did not affect EXO70 localization or transferrin recycling in mammalian cells.

226 s ferritin <100 mug/L, or 100-299 mug/L with transferrin saturation <20%), and had a left ventricular

227 cy (ferritin<100 mug/L or 100-300 mug/L with transferrin saturation <20%).

228 Low transferrin saturation (<10%) was similarly associated w

229 itin (304 ng/mL; 95% CI, 217-391; P<0.0001), transferrin saturation (6.8%; 95% CI, 2.7-10.8; P=0.002)

230 r iron (29.1% vs. 34.5 umol/L; P < 0.05) and transferrin saturation (60.9% vs. 79.1%; P < 0.01), but

231 low iron levels (cutoff 10.5 mumol/mL), low transferrin saturation (cutoff 55%), and high serum tran

232 days 2, 3), serum iron (depressed days 2-4), transferrin saturation (depressed days 2-4), and retinol

233 increases in AUC for serum iron (P < 0.01), transferrin saturation (P < 0.001), and nontransferrin-b

234 r regression analyses, ferritin (B = -0.43), transferrin saturation (TSAT) (B = -0.17), hepcidin (B =

235 ate with increased serum iron, ferritin, and transferrin saturation and decreased transferrin levels,

236 /fl);Cre(+) mice exhibited approximately 90% transferrin saturation and massive liver iron overload,

237 us including iron, ferritin, transferrin and transferrin saturation and serum lipid profile on a rout

238 A profound reduction in transferrin saturation occurred within the first 12 h of

239 tin concentration of <200 mug per liter or a transferrin saturation of <20% being a trigger for iron

240 erum ferritin level of 101 to 299 ng/mL with transferrin saturation of less than 20%.

241 um ferritin was higher than 21,000 ng/mL and transferrin saturation reached 102%.

242 concentration was >700 mug per liter or the transferrin saturation was >=40%), or low-dose iron sucr

243 Transferrin saturation was also associated with a greate

244 of septic ICU subjects, low iron levels and transferrin saturation went along with a nonlethal outco

245 ancer), higher serum iron concentrations and transferrin saturation were associated with increased ri

246 Samples pooled by transferrin saturation were used to conduct ex-vivo grow

247 t alcohol use, viral hepatitis, or increased transferrin saturation, 4,568 participants with NAFLD we

248 um iron, total iron binding capacity (TIBC), transferrin saturation, and ferritin in a Hispanic/Latin

249 sed serum iron, total iron binding capacity, transferrin saturation, and serum albumin.

250 complex significantly increased hemoglobin, transferrin saturation, and serum ferritin, and it signi

251 sed indicators, such as serum ferritin (SF), transferrin saturation, and soluble transferrin receptor

252 can children when defined using ferritin and transferrin saturation, but not when defined by hepcidin

253 hich has high levels of hemoglobin, iron and transferrin saturation, has hitherto been used as a prox

254 Measurement of serum ferritin, transferrin saturation, serum soluble transferrin recept

255 parameters of iron metabolism, particularly transferrin saturation, that reflect serum iron availabi

256 pathogens was strongly associated with serum transferrin saturation.

257 M significantly increased serum ferritin and transferrin saturation.

258 els, and serum iron correlated strongly with transferrin saturation.

259 1.83 (95% CI: 1.21, 2.76; P < 0.01); HR for transferrin saturation: 1.68 (95% CI: 1.18, 2.38; P < 0.

260 : 2.45 (95% CI:1.12, 5.34; P < 0.05); HR for transferrin saturation: 1.90 (95% CI:1.02, 3.56; P < 0.0

261 Removal of insulin-transferrin-selenium completely inhibited the effect of

262 i transferrin receptor in complex with human transferrin, showing how this heterodimeric receptor pre

263 Human serum transferrin (sTf) is a protein that mediates the transpo

264 Holo-transferrin substantially increased intracellular iron.

265 ions on the receptor surface, not contacting transferrin, suggesting that transferrin receptor divers

266 Conclusion:(89)Zr-transferrin targets human TNBC primary tumors significan

267 Head-to-head comparison showed that (89)Zr-transferrin targets TNBC tumors significantly better (P

268 elates from host-derived proteins, including transferrin (TbpA), lactoferrin (LbpA), and hemoglobin (

269 Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a ce

270 ions between endosomes containing iron-bound transferrin (Tf) and mitochondria have been shown to fac

271 alpha-1-Acid glycoprotein (AGP) and transferrin (Tf) are the main glycoproteins present in t

272 ptides was tested for the ability to enhance transferrin (Tf) association with cells.

273 somal delivery system, surface modified with transferrin (Tf) for receptor mediated transcytosis and

274 her modified by conjugation with a protein - transferrin (Tf) for targeted capture of CTCs.

275 oxicity, and could be further decorated with transferrin (Tf) for Tf-receptor targeting.

276 docytosis is responsible for reabsorption of transferrin (Tf) in renal proximal tubules (PTs).

277 tions, despite blocking of the receptor with transferrin (Tf) noncompetitively, i.e., independently o

278 In vitro, linking doxorubicin (Dox) and transferrin (TF) to CND (CND-Dox-TF, CDT) was 10-100 tim

279 n with epidermal growth factor (EGF) but not transferrin (Tf) trafficking pathways as shown by live c

280 oss-linker chemistry to conjugate anti-EGFR, transferrin (TF), 4-carboxyphenylboronic acid (CPBA), fo

281 lized to HCHS/SOL, including variants at the transferrin (TF), hemochromatosis (HFE), fatty acid desa

282 e amount of iron they acquire in the form of transferrin (TF)-bound iron by modulating the synthesis

283 trafficking and degradation of the EGFR and transferrin (TFR1) receptors.

284 Transferrin, the major plasma iron-binding molecule, int

285 LC-ICP-MS confirm the Fe(III) can move from transferrin to apo-PiuA in an NE-dependent manner.

286 B also indirectly compromised the ability of transferrin to chelate iron, as iron chelation combined

287 ces brain uptake of therapeutically relevant transferrin, transferrin receptor antibody and plasma.

288 knockdown of which stalled transit of a1 and transferrin-transferrin receptor, decreased proton efflu

289 tigate the outcome of different schedules of transferrin treatment in beta-thalassemia.

290 , gene expression analysis, and phagocytosis/transferrin uptake assays to delineate the role of AMs e

291 , associates with TfR1 and partially rescues transferrin uptake in patient-derived fibroblasts, sugge

292 ld-type but not mutant TfR1 rescued impaired transferrin uptake in patient-derived fibroblasts.

293 ndocytosis and plays a critical role in iron/transferrin uptake in vivo.

294 requirements are achieved, in the context of transferrin uptake, we determined the structure of a Try

295 ssion of endophilin delayed both fission and transferrin uptake.

296 acet of greenockite preferentially bind with transferrin via inner-sphere thiol complexation.

297 ng with receptor-mediated internalization of transferrin, was also significantly decreased upon drug

298 Concentrations of BAL transferrin were enhanced in IPF-BAL, and furthermore, C

299 ukin-6) and iron status (ferritin, hepcidin, transferrin) were assessed in a subset of 109 patients t

300 le the surface-coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular