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1 lecular weight peptides were cross-linked by transglutaminase.
2 sign better substrates or inhibitors of this transglutaminase.
3 which then trigger the enzymatic activity of transglutaminase.
4 e fibrin network and cross-linking by plasma transglutaminase.
5 results from the polyamination of tubulin by transglutaminase.
6 that neuronal tubulin can be polyaminated by transglutaminase.
7 odification method involving thermolysin and transglutaminase.
8 followed by repolymerization with microbial transglutaminase.
9 l differences making FXIII unique from other transglutaminases.
10 n of antibodies against epidermal and tissue transglutaminases.
11 b, -2f, and -2g proteins), the cross-linking transglutaminase 1 enzyme (Tg-1) and Muc5AC mRNA transcr
13 ldren tested positive for IgA against tissue transglutaminase (1.0%; 95% confidence interval, 0.4%-1.
14 into the pathophysiology of TGM1 ichthyoses, transglutaminase-1 enzymatic activity, and potential the
17 celiac disease or antibodies against tissue transglutaminase 2 (controls), healthy family members of
19 isease (CD), a condition in which antitissue transglutaminase 2 (TG2) Abs are suspected to contribute
20 evious work in our laboratory has shown that transglutaminase 2 (TG2) acting as a coreceptor for inte
21 s of total IgA antibodies, IgA antibodies to transglutaminase 2 (TG2) and endomysium, as well as IgA
23 um domain of the fibronectin binding site on transglutaminase 2 (TG2) and its importance in mediating
26 A plasma cells (PCs) specific for the enzyme transglutaminase 2 (TG2) are abundant in the small intes
28 We and others have previously identified transglutaminase 2 (TG2) as a participant in adverse fib
33 the autoantibody response against the enzyme transglutaminase 2 (TG2) in celiac disease patients by g
44 The multifunctional, protein cross-linking transglutaminase 2 (TG2) is the main autoantigen in celi
47 e is presented in this study that shows that transglutaminase 2 (TG2) plays a critical role in the ad
48 For example, Trx activates extracellular transglutaminase 2 (TG2) via reduction of an intramolecu
49 ssion by interacting with its ligand, tissue transglutaminase 2 (TG2), but the molecular basis for th
50 aspase-3 activation through stabilization of transglutaminase 2 (TG2), which cross-links and inactiva
51 ion plasma cells (PCs), we have analyzed the transglutaminase 2 (TG2)-specific VH:VL autoantibody rep
55 isfolded keratins; 2) elevated levels of the transglutaminase 2 (TG2); 3) increased K8 phosphorylatio
57 es the AP-1 transcription factor Fos and the transglutaminase 2 (TGase2), a cross-linking enzyme with
61 activation in different species and identify Transglutaminase 2 as a conserved M2 marker that is high
63 ERalpha as a direct regulator of macrophage transglutaminase 2 expression, a multifunctional atherop
65 patients, who have antibodies against tissue transglutaminase 2 in the absence of villous atrophy.
67 e deposits (sCD89, transferrin receptor, and transglutaminase 2) decreased markedly 1 week after trea
68 rypsin (modified or unmodified by the enzyme transglutaminase 2) or the peptic-tryptic digest of glia
69 uced mesangial surface expression of TGase2 (transglutaminase 2), which in turn up-regulated TfR1 exp
70 l ECM, including the multi-functional enzyme transglutaminase 2, which we show is crucial for neuroge
73 linical presentation (86%) and positive anti-transglutaminase 2/endomysium antibodies (99%) was obser
74 transition gene signature characteristic of transglutaminase 2/transforming growth factor-beta activ
75 tein keratin 8 (K8) and its cross-linking by transglutaminase-2 (TG2) are essential for MDB formation
81 lts (for levels of antibodies against tissue transglutaminase-2 and deamidated gliadin peptide), symp
82 nct from the two CD hallmark antigens tissue transglutaminase-2 and deamidated gliadin, exhibiting 71
83 uired for MDB formation, including increased transglutaminase-2 and keratin overexpression, with a gr
85 ysyl oxidase, lysyl oxidase-like 2-4, tissue transglutaminase-2), and ECM turnover genes/enzymes (mat
86 en fibrillar collagens, introduced by tissue transglutaminase-2, are necessary for the self-assembly
87 elastin and fibrillin can be cross-linked by transglutaminase-2, but the function of cross-linking on
90 PADI3 (peptidylarginine deiminase 3), TGM3 (transglutaminase 3), and TCHH (trichohyalin) in a total
93 epidermal desmosomes, upregulated epidermal transglutaminase activity and heightened resistance to S
94 -out mice, led to a rapid rise in intestinal transglutaminase activity in a manner that could be inhi
98 his study aimed to evaluate the influence of transglutaminase addition on the technological propertie
101 B (SS-A and SS-B, respectively), antitissue transglutaminase and antiendomysial antibodies, and para
104 erologic tests for antibodies against tissue transglutaminase and deamidated gliadin peptide, greatly
105 f the profibrotic cleavage substrates tissue transglutaminase and endoglin accompanied MMP-14 suppres
106 esults of serum tests for IgA against tissue transglutaminase and endomysium or on both a health care
108 on-(gamma-glutamyl) lysine cross-linkages by transglutaminase and that enzymatic cross-linking increa
109 our antibody tests including IgA anti-tissue transglutaminase and/or IgA anti- endomysium permitted d
110 ults (IgA/IgG gliadin, endomysium, or tissue transglutaminase) and compared them with 213,208 age- an
111 bodies against gliadin, 1.22% against tissue transglutaminase, and 0.61% against endomysium (P>.05 vs
112 idase, gastric parietal cells (PCAs), tissue transglutaminase, and 21-hydroxylase was tested using a
113 g of VEGF165, catalysed by the enzyme tissue transglutaminase, and associates with MVs through its in
115 anti-dpgli, IgG anti-dpgli, IgA anti- tissue transglutaminase, and IgA anti-endomysium) yielded posit
116 +SPI, WPI+CN and SPI+CN, were produced using transglutaminase, and their in vitro IgE reactivity and
117 high levels of autoantibodies against tissue transglutaminase (anti-TG2) are strongly indicative of a
118 years and analyzed for antibodies to tissue transglutaminase (anti-TG2A) using a radiobinding assay,
119 Serum samples were analyzed for anti-tissue transglutaminase (anti-tTG) concentrations at age 6 y.
120 between levels of antibodies against tissue transglutaminase (anti-tTG, a marker of celiac disease)
121 , antinuclear antibodies (ANAs), anti-tissue transglutaminase antibodies (AGTAs), and anti-thyroid pe
122 tive results from serologic tests for tissue transglutaminase antibodies (anti-TG2) but normal duoden
123 d optimized for determination of anti-tissue transglutaminase antibodies (anti-tTG) in human serum.
124 gneto immunosensor for the detection of anti-transglutaminase antibodies (ATG2) in celiac disease was
125 tive results from serologic tests for tissue transglutaminase antibodies (tTGA) without endoscopic de
126 ific screening serologic tests (anti- tissue transglutaminase antibodies IgA [anti-TTG] and ednomysea
128 itivities of Simtomax, endomysial and tissue-transglutaminase antibodies were compared in 133 prospec
131 ning for celiac disease using the IgA tissue transglutaminase antibody (IgA tTG) and, if positive, te
132 ounger (P = .03), had lower titers of tissue transglutaminase antibody (P = .001), and less frequentl
133 The majority (98%) of FPs requested anti-transglutaminase antibody (tTG-Ab) titres for CD diagnos
134 ions revealed a slightly elevated IgA tissue transglutaminase antibody level in the setting of serum
137 independent of coagulation factor 13 (FXIII) transglutaminase, as ANIT challenge in FXIII-deficient m
140 efined as being positive for islet or tissue transglutaminase autoantibodies at 2 consecutive clinic
141 ase autoimmunity, defined as positive tissue transglutaminase autoantibodies found in 2 consecutive s
142 Screening for celiac disease with tissue transglutaminase autoantibodies was performed annually i
144 bodies (HR, 0.99; 95% CI, 0.95-1.03), or the transglutaminase autoantibody (HR, 1.00; 95% CI, 0.98-1.
146 sults suggest that a risk of islet or tissue transglutaminase autoimmunity need not influence the rec
149 cation of a disulfide bond and pH-controlled transglutaminase-catalyzed modification of lysine, respe
154 uggest that the proposed evolution of animal transglutaminase cross-linking activity from ancestral b
158 techniques for monitoring the intramolecular transglutaminase cross-links of pea proteins, based on p
159 f 5.7 mum were fabricated and charged into a transglutaminase-cross-linked whey protein solution that
163 of celiac disease is believed to involve the transglutaminase-dependent response of CD4(+) T cells to
166 Cross-linking the dialyzed emulsion with transglutaminase eliminated the detection of free lactas
167 beads (MBs) as a solid support in which the transglutaminase enzyme (TG2) is covalently immobilized
169 sed on the covalent immobilization of tissue transglutaminase enzyme in its open conformation (open-t
171 gelatin and gum arabic with or without using transglutaminase enzymes and to develop a functional kef
172 ion tomography/magnetic resonance imaging of transglutaminase factor XIII (FXIII) and myeloperoxidase
174 nt study, we determined that activity of the transglutaminase factor XIII (FXIII) is critical for rbc
175 Here, we demonstrate that the coagulation transglutaminase, factor XIII (fXIII), drives arthritis
176 ogical importance of inactive members of the transglutaminase family, which are found throughout euka
178 factor of 10 below the recommended amount of transglutaminase for raw as well as heated restructured
180 faba bean protein isolates were treated with transglutaminase from Streptomyces mobaraensis and tyros
182 hypothesised that the dosing of xylanase and transglutaminase has a positive impact on rye dough and
183 l cycle regulated and we unearth a bacterial transglutaminase homolog, HvyA, as restriction factor th
187 ts with concentrations of IgA against tissue transglutaminase (IgA-TTG) >10-fold the upper limit of n
188 tients should also be tested for anti-tissue transglutaminase, IgA against deamidated gliadin peptide
190 cient between the CDAT score and anti-tissue transglutaminase immunoglobulin A (anti-t-TG-IgA) titer
191 ion and diagnosis of CD, particularly tissue transglutaminase-immunoglobulin A (TG2-IgA), IgA testing
192 vidence for an increased risk of anti-tissue transglutaminase in patients with IBD vs controls (RR 1.
193 ibuted to glutamine deamidation by microbial transglutaminase in the absence of sufficient lysine thr
194 s have circulating antibodies against tissue transglutaminase; in children, European guidelines allow
195 assay using an assay for IgA against tissue transglutaminase; in subjects with positive test results
198 vitro antioxidative hydrolysate, followed by transglutaminase-induced cross-linking and microemulsifi
199 ts into the mechanism and inhibition of this transglutaminase-induced ubiquitination by MavC, but als
200 Furthermore, treatment of mice with the pan-transglutaminase inhibitor cystamine resulted in signifi
201 I deficiency had normal retention, and a pan-transglutaminase inhibitor T101 had only a modest inhibi
202 encoding factor XIII subunit A (FXIII-A), a transglutaminase involved in hemostasis, wound healing,
203 here is no confirmation that TG2 is the only transglutaminase involved, neither there are strategies
207 ins are previously undetected members of the transglutaminase-like cysteine protease superfamily, and
212 observed ratio allowed the identification of transglutaminase-mediated gamma-glutamyl isomers as inte
213 rgenic protein products could be produced by transglutaminase-mediated heterologous polymerization of
214 terogeneous lysine conjugation and bacterial transglutaminase-mediated site-specific conjugation.
223 general role for the catalytically inactive transglutaminases of fungi and animals, some of which ha
225 er limit of detection and IgG against tissue transglutaminase or deamidated gliadin peptide, or endom
227 Among tests for celiac disease, IgA tissue transglutaminase presented the best diagnostic test accu
228 has been indicated previously that during a transglutaminase reaction activated factor XIII (FXIIIa)
230 Analysis of heparin binding of the main transglutaminases revealed that although the interaction
232 ic ATPase, anti-thyroid peroxidase, and anti-transglutaminase seropositivity, and these autoantibodie
233 use a proteomic approach in combination with transglutaminase-specific labeling to identify FXIIIa pl
234 lar methodologies to demonstrate that tissue transglutaminase (TG) activates downstream NF-kappaB sig
237 -MS/MS-method for the detection of microbial transglutaminase (TG) from Streptomyces mobaraensis in d
238 for the simultaneous detection of microbial transglutaminase (TG) from Streptomyces mobaraensis, and
242 The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversib
246 ssion of the pro-inflammatory protein tissue transglutaminase (TG2) reprograms the transcription regu
247 inhibits melanoma growth and binds to tissue transglutaminase (TG2), a major crosslinking enzyme in E
249 tural GPR56 ligands, collagen III and tissue transglutaminase (TG2), and one small-molecule agonist,
250 performance of antibody tests against tissue transglutaminase (TG2), deamidated gliadin peptide (DGP)
251 ated with the sulfhydryl-rich protein tissue transglutaminase (TG2), thereby endowing the membrane su
252 ignificant increases in the levels of type-2 transglutaminase (TG2, which is implicated in transamida
253 nd levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper lim
258 a milk base in the absence or presence of a transglutaminase (TGase) protein cross-linking step on t
259 atin hydrolysates and glucosamine (GlcN) via transglutaminase (TGase), as well as glycation between f
260 designed to detect the catalytic activity of transglutaminase (TGase), which creates a covalent bond
264 evident 2 d after birth, followed by reduced transglutaminase (TGM) activity, transepidermal water lo
269 t extents on stiffer substrates; TAZ, tissue transglutaminase (TGM2), and soluble frizzled-related pr
270 ins (Krts), keratin-associated proteins, and transglutaminases (Tgms) and their substrates were signi
271 ormed by extensive cross-linking activity of transglutaminases (TGs) during terminal epidermal differ
274 Plasma coagulation factor XIII (FXIII) is a transglutaminase that promotes cross-linking of the extr
276 edicted after GC-1g, and the mean IgA-tissue transglutaminase titers declined, contrary to the predic
277 ne, TIG3 interacts with and activates type I transglutaminase to enhance keratinocyte terminal differ
278 lyacrylamide gel electrophoresis profiles of transglutaminase-treated low concentration (0.01% w/w) p
279 milar with known CD-specific antigens tissue transglutaminase (tTG) and deamidated gliadin, and the c
280 Immunoglobulin A (IgA) antibodies to tissue transglutaminase (tTG) are the serologic test of choice
285 ecognition scaffold is the following: tissue transglutaminase (tTG) is immobilized as a capturing age
286 glycated haemoglobin (HbA1c) and IgA tissue transglutaminase (tTg) were collected prior to, and foll
287 al antibodies (EMA) and antibodies to tissue transglutaminase (tTG) were developed to screen for celi
288 to different antigens, in particular tissue transglutaminase (tTG), gliadin (Glia), and endomysium.
297 re than 12000 participants) found IgA tissue transglutaminase was associated with high accuracy (sens
300 protein was crosslinked to some extent with transglutaminase with higher dosages (100 and 1000nkat/g