ライフサイエンスコーパス: translation initiation

1 d upstream of open reading frames facilitate translation initiation.

2 the 40S-eIF complex to the 5'UTR, leading to translation initiation.

3 irectly on the ribosome recruitment phase of translation initiation.

4 e, permitting transcriptional readthrough or translation initiation.

5 EAD-box RNA helicase with essential roles in translation initiation.

6 tent inhibitory activity against prokaryotic translation initiation.

7 olysome collapse characteristic of inhibited translation initiation.

8 gregates formed in response to inhibition of translation initiation.

9 tial GTPase Initiation Factor 2 (IF2) during translation initiation.

10 Ccr4-Not complex, eIF4A2 represses mRNAs at translation initiation.

11 nd the function of the PABP-eIF4G complex in translation initiation.

12 adjacent probable RNA-binding domain mediate translation initiation.

13 functional implications of such noncanonical translation initiation.

14 nteraction with eIF2.GTP at an early step in translation initiation.

15 ype level by a feedback mechanism increasing translation initiation.

16 al elongation in coupling mRNA structures to translation initiation.

17 uggesting a regulatory role of processing on translation initiation.

18 ory formation was blocked by an inhibitor of translation initiation.

19 ) 5' cap to promote ribosome recruitment and translation initiation.

20 unctional structure involved in noncanonical translation initiation.

21 by initiation factor 3 (IF3), which promotes translation initiation.

22 res translational frameshift or non-standard translation initiation.

23 on by modulating transcription elongation or translation initiation.

24 ing-incompatible conformation and regulating translation initiation.

25 pensable for phosphorylation and nonstressed translation initiation.

26 S-box riboswitches is predicted to regulate translation initiation.

27 complex at the 5' end of mRNAs and regulates translation initiation.

28 algarno (SD) sequence and freeing the SD for translation initiation.

29 During translation initiation, 40S ribosomes scan the mRNA unti

30 In translation initiation, a 43S preinitiation complex (PIC

31 We propose that inefficient translation initiation allows these stall-containing end

32 In support of this model, translation initiation also contributes to synthesis def

33 s in central carbon metabolism by modulating translation initiation and degradation of target mRNAs i

34 substitutions of these residues reduce bulk translation initiation and diminish initiation at near-c

35 ribosome profiling in yeast, we observe that translation initiation and elongation are close to their

36 Our work provides new measures of translation initiation and elongation efficiencies, emph

37 Dynamic regulation of mRNA translation initiation and elongation is essential for t

38 ctly image and quantify, for the first time, translation initiation and elongation kinetics with sing

39 ribosome footprinting data, we here inferred translation initiation and elongation rates for over a 1

40 g ribosome profiling, we found that rates of translation initiation and elongation were markedly slow

41 , Mss116 is required for efficient COX1 mRNA translation initiation and elongation.

42 conserved DEAD-box RNA helicase involved in translation initiation and other processes of RNA metabo

43 ct the evolution and function of prokaryotic translation initiation and other RNA-mediated processes.

44 tural features involved in c-JUN specialized translation initiation and provides a basis to search fo

45 F2B to block eIF2 recycling, thereby halting translation initiation and reducing global protein synth

46 ion results in specific misregulation of the translation initiation and ribosome biogenesis machinery

47 sential for post-transcriptional processing, translation initiation and stability.

48 licases involved in messenger (m)RNA export, translation initiation and termination, and stress granu

49 ubset of tRNAs, leading to the inhibition of translation initiation and the assembly of stress granul

50 matically studying the general principles of translation initiation and the development of computatio

51 directly, in real time, the pathways of late translation initiation and the transition to elongation.

52 hanistic studies of eukaryotic cap-dependent translation initiation and translational control.

53 gies for reducing the likelihood of internal translation initiation and truncated product formation.

54 tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongation factors, and ribos

55 processing and export, ribosome biogenesis, translation initiation, and protein processing/sorting i

56 , the mechanisms underlying clock control of translation initiation, and the impact of this potential

57 equester ribosome-binding sites (RBS) impair translation initiation, and thus protein output.

58 n factor 2 (eIF2) plays an important role in translation initiation as it selects and delivers the in

59 tors but is primarily considered to activate translation initiation as part of the PABP-eIF4G-eIF4E c

60 cryo-microscopy (cryo-EM) and reconstituted translation initiation assays with native components, we

61 recise quantification of the rules governing translation initiation at N-terminal coding regions, imp

62 Aberrant translation initiation at non-AUG start codons is associ

63 all, this study provides evidence of protein translation initiation at noncanonical TISs and argues t

64 In translation initiation, AUG recognition triggers rearran

65 f2ak2/Eif2alpha) axis is the key mediator of translation initiation block in late-phase sepsis.

66 lating ribosome binding, GTP hydrolysis, and translation initiation both in vitro and in vivo.

67 Loss of n-Tr20 altered translation initiation by activating the integrated stre

68 anisms, while others can repress or activate translation initiation by affecting ribosome binding.

69 Modulation of the fidelity of translation initiation by OCM opens new avenues to under

70 Phosphorylation of eIF2alpha controls translation initiation by restricting the levels of acti

71 has been shown that non-AUG or noncanonical translation initiation can also occur.

72 n its linker region by viral proteinase 3CD, translation initiation ceases allowing the next stage of

73 uch as hypoxia, glycolysis, cell metabolism, translation initiation, cell cycle, and antigen presenta

74 ssion of a large number of genes involved in translation initiation, cell cycle, DNA damage and prote

75 ucture reveals insights into early events of translation initiation complex assembly, as well as how

76 The plant-specific translation initiation complex eIFiso4F is encoded by th

77 eIF4A RNA helicase, a component of the eIF4F translation initiation complex, abrogates this selective

78 eIF4G, the major scaffolding protein in the translation initiation complex, directly binds G4s and t

79 eractions driving assembly of the Leishmania translation initiation complex.

80 pete with eIF4G for eIF4E binding within the translation initiation complex.

81 or start codon and prevents formation of the translation initiation complex.

82 s organelles that are condensates of stalled translation initiation complexes and mRNAs.

83 large macromolecular aggregates that contain translation initiation complexes and mRNAs.

84 We determined that translation initiation complexes and ribosomes purified

85 ovides new insights into the organization of translation initiation complexes on active mRNAs and una

86 teins, PABP2, and one of the six cap-binding translation initiation complexes, EIF4E6-EIF4G5.

87 Translation initiation controls protein synthesis by reg

88 Translation initiation determines both the quantity and

89 sed in mitotic cells, consistent with active translation initiation during mitosis.

90 te that 4E-BP1 does not specifically inhibit translation initiation during mitosis.

91 maturation, which is critical for efficient translation initiation during protein biosynthesis.

92 his effect is independent of tRNA abundance, translation initiation efficiency, or overall mRNA struc

93 ssion and the mutational effects influencing translation initiation efficiency.

94 At each of the three major steps of translation-initiation, elongation, and termination-cell

95 , our model reveals that all three stages of translation-initiation, elongation, and termination/rein

96 non-AUG (RAN) translation is a noncanonical translation initiation event that occurs at nucleotide-r

97 The heterotrimeric eukaryotic translation initiation factor (eIF) 2 plays critical rol

98 BYDV-like CITE or BTE) that binds eukaryotic translation initiation factor (eIF) 4F and recruits 40S

99 ration of the cap-binding protein eukaryotic translation initiation factor (eIF4E) is enhanced.

100 example is EIF1AY, which encodes eukaryotic translation initiation factor 1A Y-linked, together with

101 of the host cell; therefore, the eukaryotic translation initiation factor 2 (eIF2) gene family is a

102 ntly increases phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in

103 Dephosphorylation of translation initiation factor 2 (eIF2alpha) terminates s

104 orylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) was decrease

105 interacts with and can methylate eukaryotic translation initiation factor 2 alpha (eIF2alpha), in vi

106 nase R [PKR]) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha), which

107 process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha).

108 and EIF2AK2 encode members of the eukaryotic translation initiation factor 2 alpha kinase (EIF2AK) fa

109 nt, c.388G>A, p.Gly130Arg, in the eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2)

110 hereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF

111 tein kinase R, phosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2alpha), t

112 EIF2AKs phosphorylate eukaryotic translation initiation factor 2 subunit 1 (EIF2S1, also

113 hen phosphorylates its substrate, eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha

114 result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or

115 ated stress response (ISR) by phosphorylated translation initiation factor 2, eIF2(alphaP).

116 otein translation mediated by the eukaryotic translation initiation factor 2-alpha kinase 2/eukaryoti

117 determined that activation of the eukaryotic translation initiation factor 2-alpha kinase 2/eukaryoti

118 protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2-alpha/activating transcr

119 nitiation factor 2-alpha kinase 2/eukaryotic translation initiation factor 2alpha (EIF2AK2/eIF2alpha)

120 nitiation factor 2-alpha kinase 2/eukaryotic translation initiation factor 2alpha (Eif2ak2/Eif2alpha)

121 ding increased phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) and reg

122 The eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase

123 out (PERK-KO) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse e

124 , in which the phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) results

125 ase 1alpha (PP1alpha) to dephosphorylate the translation initiation factor 2alpha (eIF2alpha) to prev

126 -dependent phosphorylation of the eukaryotic translation initiation factor 2alpha and enhanced transl

127 h activating pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

128 s both the phosphorylation of the eukaryotic translation initiation factor 2alpha subunit and the spl

129 the reversible polymerization of eukaryotic translation initiation factor 2B, an essential enzyme in

130 Here, we show that human eukaryotic translation initiation factor 3 (eIF3) acts as a distinc

131 h encodes a core component of the eukaryotic translation initiation factor 3 (eIF3) complex, as a key

132 epatitis C virus (HCV) IRES binds eukaryotic translation initiation factor 3 (eIF3), but the exact fu

133 nslation, a process that involved eukaryotic translation initiation factor 3 subunit b as a P311 bind

134 addition, mTOR co-localised with Eukaryotic translation initiation factor 3 subunit F (eIF3F) at the

135 the canonical translation factor eukaryotic translation initiation factor 4 gamma I (eIF4GI) is clea

136 tured 5' UTRs by interacting with eukaryotic translation initiation factor 4A (eIF4A) and inhibiting

137 ts antitumor activity by clamping eukaryotic translation initiation factor 4A (eIF4A) onto polypurine

138 d4(157-469), a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently i

139 Further, we found that eukaryotic translation initiation factor 4B (eIF4B) played a key ro

140 The eukaryotic translation initiation factor 4E (EIF-4E) protein, a key

141 Dysregulation of translation initiation factor 4E (eIF4E) activity occurs

142 Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP

143 ift assays (EMSAs) indicated that eukaryotic translation initiation factor 4E (eIF4E) binds the MTE d

144 ess p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to

145 Eukaryotic translation initiation factor 4E (eIF4E) selectively pro

146 Here, we discovered that eukaryotic translation initiation factor 4E (eIF4E), itself a cap-b

147 K-interacting kinase 1 (MNK1) and eukaryotic translation initiation factor 4E (eIF4E), resulting in e

148 e analogues were bound tightly to eukaryotic translation initiation factor 4E (eIF4E), with CCl2-subs

149 Moreover, eukaryotic translation initiation factor 4E (EIF4E)-associated prot

150 Eukaryotic translation initiation factor 4E (eIF4E)-binding protein

151 d translation of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding protein

152 inhibited phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein

153 ate the importance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production

154 gy by activating mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and U

155 ), a protein that binds to eIF4E (eukaryotic translation initiation factor 4E) and prevents mRNA deca

156 e cap, inhibits interactions with eukaryotic translation initiation factor 4E, and resists decapping.

157 rget of rapamycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-bind

158 ted with increased recruitment of eukaryotic translation initiation factor 4E-binding protein (4E-BP)

159 and protein synthesis, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

160 mTORC1) and its downstream target eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

161 n, measured by phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-B

162 ibosomal protein S6 kinase 1, and eukaryotic translation initiation factor 4E-binding protein 1 durin

163 the translation repressor, 4E-BP (eukaryotic translation initiation factor 4E-binding protein).

164 malian target of rapamycin (mTOR)-eukaryotic translation initiation factor 4F (eIF4F) and eIF2alpha p

165 ip between the O-GlcNAcylation of eukaryotic translation initiation factor 4gamma1 (eIF4G1) and carbo

166 dditionally, expression levels of eukaryotic translation initiation factor 4GI (eIF4GI) and of its ho

167 6 deletion disrupted the putative eukaryotic translation initiation factor 4GI-binding domain and pro

168 , we have shown downregulation of eukaryotic translation initiation factor 5 A (elF5A), expressed onl

169 Mechanistically, Klf5 activates eukaryotic translation initiation factor 5a (eIF5a) transcription t

170 anslation initiation via an interaction with translation initiation factor 5B (eIF5B).

171 Eukaryotic translation initiation factor 6 (eIF6) is essential for

172 omitant with elevated phosphorylation of the translation initiation factor alpha subunit of eukaryoti

173 Phosphorylation of the translation initiation factor eIF2 alpha at a conserved

174 the synthesis of proteins controlled by the translation initiation factor eIF2(11).

175 mma subunit of the heterotrimeric eukaryotic translation initiation factor eIF2, cause MEHMO syndrome

176 e or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, revers

177 is exerted by phosphorylation of the general translation initiation factor eIF2.

178 n of protein synthesis by phosphorylation of translation initiation factor eIF2.

179 gers phosphorylation of the alpha-subunit of translation initiation factor eIF2.

180 actor 4 (ATF4) and phosphorylated eukaryotic translation initiation factor eIF2.

181 tion, DeltaN146 precludes phosphorylation of translation initiation factor eIF2alpha (alpha subunit o

182 Phosphorylation of the translation initiation factor eIF2alpha anchors a revers

183 at precisely controls phosphorylation of the translation initiation factor eIF2alpha via the unfolded

184 Phosphorylation of the translation initiation factor eIF2alpha within the medio

185 rol nonderepressible 2 (GCN2) phosphorylates translation initiation factor eIF2alpha, initiating the

186 he branch comprising the kinase PERK and the translation initiation factor eIF2alpha, is a pathologic

187 s (MRV) infection induces phosphorylation of translation initiation factor eIF2alpha, which promotes

188 otein translation via phosphorylation of the translation initiation factor eIF2alpha.

189 s MITF via ATF4 in response to inhibition of translation initiation factor eIF2B.

190 urs, strongly enhances the dependence on the translation initiation factor eIF2B5.

191 sm involving EIF3C, a subunit of the protein translation initiation factor EIF3, as the direct target

192 3, earlier shown to interact with eukaryotic translation initiation factor eIF3, in termination.

193 Tim Barrel domain protein and the eukaryotic translation initiation factor eIF3b.

194 e regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppress

195 is required for RNAs to bind the eukaryotic translation initiation factor eIF4E and associate with t

196 lation is supported by the localization of a translation initiation factor eIF4E and by ribosome-boun

197 Here we employ conditional overexpression of translation initiation factor eIF4E to increase protein

198 0-fold heterogeneity for interactions of the translation initiation factor eIF4E with the universal m

199 We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, dri

200 ltiple ribosome biogenesis genes and the key translation initiation factor eIF4E.

201 It relies on its ability to compete with the translation initiation factor eIF4F to specifically reco

202 s, including therapy resistance, require the translation initiation factor initiation elongation fact

203 Consequently, this essential translation initiation factor is nearly twice as abundan

204 genome that allows the virus to usurp a host translation initiation factor, eIF4E, in a way that diff

205 mulate the activity of the m(7)G cap-binding translation initiation factor, eIF4E, respectively.

206 tion of eIF2alpha (P-eIF2alpha), a conserved translation initiation factor, is clock controlled in Ne

207 und in a single cellular protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolo

208 nhances translation through eIF4B, a general translation initiation factor.

209 NCBP3 and RHA substitutes for the eukaryotic translation initiation factors 4E and 4G and activates m

210 has also been detected on several eukaryotic translation initiation factors and ribosomal proteins.

211 Notably, detection of translation initiation factors at the RTC was instrument

212 d activity of mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as well

213 pha translation by modulating the binding of translation initiation factors eIF4E and eIF4G to p63alp

214 y studies have implicated aberrant levels of translation initiation factors in cancer etiology and pr

215 In eukaryotic cells, numerous translation initiation factors prepare ribosomes for pol

216 report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic pro

217 c RNA-binding proteins but none of the major translation initiation factors, consistent with a functi

218 e based on mutations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their

219 pendent and autophagy-related processes, and translation initiation factors.

220 fold, which was not observed before in other translation initiation factors.

221 t of a 5' cap and some/all of the associated translation initiation factors.

222 the viral RNAs, using different sets of host translation initiation factors.

223 ort of a broad-spectrum mechanism regulating translation initiation for both plant- and animal-hosted

224 hat the truncation resulted from an internal translation initiation from a GTG codon (encoding Val) w

225 In the human genome, translation initiation from non-AUG codons plays an impo

226 Translation initiation from non-canonical start codons m

227 TITER extracts the sequence features of translation initiation from the surrounding sequence con

228 rmed frameshift mutation-induced alternative translation initiation (fsATI), that may explain why onl

229 (Met) on the ribosome in the later stages of translation initiation, gating entrance into elongation.

230 The cap-dependent translation initiation gene, EIF4E, is one of the most M

231 Translation initiation generally occurs at AUG codons in

232 IRES usually function when 5' cap-dependent translation initiation has been blocked or repressed.

233 Although the canonical mechanism of translation initiation has been studied extensively, her

234 ibosome profiling to gain insights into mRNA translation initiation, highlighting distinctions betwee

235 etabolites regulate the fidelity and rate of translation initiation in bacteria and eukaryotic organe

236 1 stabilises GIGYF2 at collisions to inhibit translation initiation in cis via 4EHP.

237 UG) are considered as the 'start codons' for translation initiation in Escherichia coli.

238 near-cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies

239 tion score can be related to the strength of translation initiation in various biological scenarios,

240 an be recognized by the ribosomes and direct translation initiation in vitro and in vivo.

241 eukaryotic translation posits that efficient translation initiation increases protein expression and

242 ies with synapse type.SIGNIFICANCE STATEMENT Translation initiation is a central regulator of long-te

243 in the brain, suggesting that regulation of translation initiation is a conserved response to tRNA l

244 Translation initiation is a key step in the regulation o

245 Translation initiation is a major rate-limiting step for

246 Specialized translation initiation is a novel form of regulation of

247 Upregulation of translation initiation is common to and preserved in gen

248 As translation initiation is globally reprogrammed by envir

249 In G0 cells, canonical translation initiation is inhibited; yet we find that in

250 Translation initiation is tuned by mRNA secondary struct

251 NA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the

252 ins were less edited, whereas those encoding translation initiation machinery were edited more.

253 -organize helical domains for recruiting the translation initiation machinery.

254 resistance strategies, we characterized the translation initiation mechanism of MCMV.

255 ERK-dependent switching to an eIF3-dependent translation initiation mechanism, resulting in partial,

256 lation independently of the 5' cap-dependent translation initiation mechanism.

257 the absence of mS38 preferentially disturbs translation initiation of COX1, COX2, and COX3 mRNAs, wi

258 Here, we quantified translation initiation of green fluorescent protein and

259 In prokaryotic systems, the translation initiation of many, though not all, mRNAs de

260 gnized by eIF3 and essential for specialized translation initiation of this well-known oncogene.

261 translation leads to specific inhibition of translation initiation on that message.

262 strate that circularization inhibits de novo translation initiation on ZIKV and DENV RNA, whilst the

263 ch as dynamic folding of riboswitches during translation initiation or the synthesis of alarmones, wh

264 Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with struc

265 CT-1/MCTS1) oncoprotein support noncanonical translation initiation, promote translation reinitiation

266 n chemical kinetic principles to measure the translation-initiation rate, transcriptome-wide elongati

267 gating the transition from 30S biogenesis to translation initiation, RbfA and IF3 maintain the fideli

268 ory secondary structures from forming in the translation initiation region, thus rendering the mRNA a

269 n of DENR-MCT-1 activities in unconventional translation initiation, reinitiation, and recycling.

270 al ribosome entry sites (IRESs), specialized translation initiation requires the recruitment of eukar

271 Global reductions in translation initiation resulting from mutations in the t

272 regions of mRNA targets, causing changes in translation initiation, RNA stability, and/or transcript

273 scanning model of translation based on Kozak translation initiation sequences alone does not adequate

274 e Shine-Dalgarno sequence towards a stronger translation initiation signal.

275 RISPR technology to mutate a single internal translation initiation site in Cx43 (M213L mutation), wh

276 of the assembly of Hfq and Crc bound to the translation initiation site of a target mRNA.

277 Moreover, we observe a striking shift in translation initiation site usage.

278 e 40S ribosomal subunit and in selecting the translation initiation site.

279 However, the evidence for noncanonical translation initiation sites (TISs) is largely indirect

280 In addition to the annotated translation initiation sites (TISs), the translation pro

281 s drug treatment allowed us to confirm known translation initiation sites and also reveal putative no

282 The use of alternative translation initiation sites enables production of more

283 isoforms, long and short, due to alternative translation initiation sites in the N-terminal cytoplasm

284 o the N terminus that can act as alternative translation initiation sites.

285 omal protein S1 plays important roles in the translation initiation step of many Escherichia coli mRN

286 structure near the start codon that impacts translation initiation, structures located adjacent to U

287 universal initiation factor in cap-dependent translation initiation that functions beyond its role in

288 We show that a combination of the rate of translation initiation, the availability of secretory ap

289 In the scanning model of translation initiation, the decoding site and latch of t

290 PKR inhibits translation initiation through eIF2alpha phosphorylation

291 The development of the translation initiation (TI) sequencing (TI-seq) techniqu

292 is how eukaryotic ribosomes transition from translation initiation to elongation.

293 with critical roles defined in mRNA export, translation initiation, translation termination, and str

294 reveal the importance of the aSD in plastid translation initiation, uncover chloroplast genes whose

295 ed or identified two forms of unconventional translation initiation: usage of AUG-like sites (near co

296 The shorter translation initiation variants display reduced ubiquiti

297 This dysregulation of translation initiation via alteration of the Tsc2-mTor-E

298 The WIG1-AGO2 complex attenuated translation initiation via an interaction with translati

299 protein that inhibits cap-dependent protein translation initiation via phosphorylation of eIF2alpha.

300 tein synthesis is largely controlled by mRNA translation initiation, whether cellular translation elo