ライフサイエンスコーパス: translational repression

1 and Ded1), indicating a common mechanism of translational repression.

2 ger RNAs (mRNAs) either by degradation or by translational repression.

3 motif in the 3'UTR of TRF1, resulting in its translational repression.

4 md4) is an RNA binding protein that mediates translational repression.

5 dons within the uORF is sufficient to reduce translational repression.

6 ed region of the HIST1H2AC locus that confer translational repression.

7 icity of XTUT7 and abolished XTUT7-dependent translational repression.

8 not universally required for miRNA-mediated translational repression.

9 in Rim4 protein levels, thereby alleviating translational repression.

10 target mRNAs by endonucleolytic cleavage or translational repression.

11 TR of the XIAP messenger RNA (mRNA) to exert translational repression.

12 y mislocalized Oskar that results from leaky translational repression.

13 olecules that act by mRNA degradation or via translational repression.

14 ner and independently of exotoxin A-mediated translational repression.

15 e and non-cleavage-based mRNA degradation or translational repression.

16 is a cause or consequence of miRNA-mediated translational repression.

17 RNA is an authentic target of Nanos1/Pumilio translational repression.

18 slicer-independent turnover mechanisms, and translational repression.

19 anscripts is maintained during mRNA-specific translational repression.

20 ith P-bodies and stress granules, leading to translational repression.

21 highlighting the importance of TCE-mediated translational repression.

22 ient to move an mRNA from an active state to translational repression.

23 ted by the let-7 family of miRNAs leading to translational repression.

24 lear accumulation, or transcriptional and/or translational repression.

25 genin-, tiRNA-, and oxidative stress-induced translational repression.

26 of mRNA, which leads to mRNA degradation and translational repression.

27 laces SPN-2 from the zif-1 3' UTR, releasing translational repression.

28 m with itself or with cofactors required for translational repression.

29 slated region by miR-98 or let-7 resulted in translational repression.

30 t at the posterior and plays a role in Nv-hb translational repression.

31 Z bind to the hilD mRNA 5' UTR, resulting in translational repression.

32 3'-UTR, suggesting that Nos is regulated by translational repression.

33 odium pump subunit abundance is modulated by translational repression.

34 et genes by cleavage of the targeted mRNA or translational repression.

35 a deadenylase to specific mRNAs, leading to translational repression.

36 3'-untranslated region by miR-513 results in translational repression.

37 identified as a potential target of miR-155 translational repression.

38 eins needed to respond to hypoxia evade this translational repression.

39 independent mechanism that leads to profound translational repression.

40 nvironmental stressors by acting as sites of translational repression.

41 lation, and a reduction of microRNA-mediated translational repression.

42 er significantly in their capacity to direct translational repression.

43 target accumulation through mRNA cleavage or translational repression.

44 association with the GluR1 mRNA and relieves translational repression.

45 et repertoire and/or enhance mRNA decay over translational repression.

46 nstead as an antagonist of PUMILIO-dependent translational repression.

47 mRNA-bound L13a elicits transcript-specific translational repression.

48 le mRNA dictate their degradation or mediate translational repression.

49 specific mRNAs and triggering mRNA decay or translational repression.

50 heterochromatin assembly, mRNA cleavage and translational repression.

51 t regulate gene expression primarily through translational repression.

52 ied that the sRNA P27 is responsible for the translational repression.

53 s influence the proteome under conditions of translational repression.

54 necessary and sufficient to mediate a strong translational repression.

55 on increases Nrf2 levels by overcoming basal translational repression.

56 terminant of the magnitude of miRNA-mediated translational repression.

57 n both by destabilization of the mRNA and by translational repression.

58 toplasmic stress granules is a mechanism for translational repression.

59 RNA-binding protein involved in splicing and translational repression.

60 dendrites, where it inhibits miRNA-mediated translational repression.

61 on asd mRNA, and both are required for full translational repression.

62 ecapping factors, and promote mRNA decay and translational repression.

63 mRNA, thereby mediating mRNA degradation or translational repression.

64 regulates mRNA processing events, including translational repression.

65 eting complementary mRNAs for destruction or translational repression.

66 to SGs but is dispensable for tiRNA-mediated translational repression.

67 cing by facilitating posttranscriptional and translational repression.

68 Moreover, ADAR1 knockdown leads to robust translational repression.

69 ncluding blocking XBP1u splicing and causing translational repression.

70 on of RiBi genes, followed by their apparent translational repression 1 hour (h) after stimulation to

71 ping, extensive, and independent programs of translational repression across sporozoite maturation to

72 etworks, which are based primarily on mutual translational repression, act via interlocked feedback l

73 ular switch between target mRNA cleavage and translational repression activities of Ago2.

74 Analysis of IRE binding affinity and translational repression activity of the resulting IRP1

75 Translational repression afforded by the intron fulfils

76 has been reported to promote miRNA-mediated translational repression, amp1 did not prevent the trans

77 ssages are downregulated by a combination of translational repression and accelerated decay caused by

78 atrial fibrillation caused dystrophin (DYS) translational repression and accelerated mRNA degradatio

79 d siRNAs is a complex process involving both translational repression and accelerated mRNA turnover,

80 homodimer by RPL26 may be the switch between translational repression and activation after stress.

81 MicroRNAs (miRNAs) predominantly induce translational repression and are emerging as a major reg

82 s, granule formation does not correlate with translational repression and can also take place in the

83 X6-4E-T interaction mediates miRNA-dependent translational repression and de novo P-body assembly, im

84 et mRNAs and silence gene expression through translational repression and deadenylation but not cleav

85 4-NOT complex plays an important role in the translational repression and deadenylation of mRNAs.

86 g bodies (P bodies), which are sites of mRNA translational repression and decay.

87 miRNAs) control gene expression through both translational repression and degradation of target messe

88 ces in messenger RNA transcripts, leading to translational repression and destabilization of the targ

89 n and de novo P-body assembly, implying that translational repression and formation of new P-bodies a

90 ng ribosome profiling, we find both a global translational repression and identified ~200 mRNAs that

91 Bicc1 are essential for both Bicc1-dependent translational repression and maternal vertebrate develop

92 ess, a condition when both microRNA-mediated translational repression and microRNA-directed mRNA clea

93 plex which results in different pathways for translational repression and mRNA deadenylation.

94 However, the magnitude of both translational repression and mRNA decay induced by miRNA

95 Translational repression and mRNA degradation are critic

96 MicroRNAs are well known to mediate translational repression and mRNA degradation in the cyt

97 non-translating mRNAs and targeting them for translational repression and mRNA degradation.

98 3' untranslated regions (3'UTRs) and mediate translational repression and mRNA degradation.

99 We also determine the relative dynamics of translational repression and mRNA destabilization for en

100 For targets with less complementarity, both translational repression and mRNA destabilization mechan

101 gulate target mRNAs through a combination of translational repression and mRNA destabilization, with

102 Here we describe the importance of mRNA translational repression and mRNA subcellular location f

103 e specialized cytoplasmic compartments where translational repression and mRNA turnover may occur.

104 Our results showed that DCP5 is required for translational repression and P-body formation and plays

105 onjunction with Dhh1p, as it is required for translational repression and P-body formation in pat1Del

106 While stress-induced translational repression and recruitment of key SG prote

107 stomeres by a process that is independent of translational repression and requires the CCCH finger pr

108 r31, Ser34, and Ser35 of Puf6p increases its translational repression and results in ASH1 mRNA deloca

109 o examine the role of YB-1 in tiRNA-mediated translational repression and SG assembly.

110 tardation protein, proteins that function in translational repression and stress granule regulation.

111 TR interaction regions are critical for both translational repression and stress induction of p53 by

112 nd reveals a previously unknown link between translational repression and transcription of inflammato

113 ed eIF2alpha phosphorylation bypasses global translational repression and underlies an increase in lo

114 As (miRNAs) regulate gene expression through translational repression and/or messenger RNA (mRNA) dea

115 mentary binding to target mRNAs and inducing translational repression and/or mRNA degradation.

116 by a posttranscriptional mechanism involving translational repression and/or promoting messenger RNA

117 n is linked to enhanced p-eIF2 alpha levels, translational repression, and a decrease in Ki67, pH 3,

118 rt their influence by guiding mRNA cleavage, translational repression, and chromatin modification.

119 d for both NCL dimerization and NCL-mediated translational repression, and is the domain of NCL that

120 Stress granule formation coincides with translational repression, and stress granules actively s

121 ctional: both clusters of BREs contribute to translational repression, and the 3' cluster has an addi

122 onal termination and RNA structure-dependent translational repression, and the level of holin functio

123 including messenger RNA (mRNA) degradation, translational repression, and transcriptional gene silen

124 ments, these data indicate that two waves of translational repression are implemented and relieved at

125 sensitivity to NMD occurs when transport and translational repression are simultaneously impaired.

126 g cold shock proteins escape cooling-induced translational repression are unknown.

127 hile their roles in mRNA destabilization and translational repression are well appreciated, their inv

128 These results identify gene-specific translational repression as a means of controlling the m

129 rgets of FXR1 in striated muscle and support translational repression as a novel mechanism for regula

130 he 5'-UTR identified linkers supporting full-translational repression as well as a range of partial r

131 The inactivation of UPF1 led to translational repression, as manifested by a global shif

132 iRNAs predominantly mediated highly specific translational repression at 5' coding regions with limit

133 he Fst ribosome binding site is required for translational repression but a helix sequestering the 5'

134 equired for binding to the m(7)G cap and for translational repression but do not affect the assembly

135 calization to P granules is not required for translational repression but is required to enrich mRNAs

136 by microRNA-98 (miR-98) or let-7 resulted in translational repression, but not CIS mRNA degradation.

137 Here, we address further the mechanism of translational repression by 4E-T by first identifying an

138 3'UTR of a miRNA-targeted reporter modulates translational repression by affecting the translation ef

139 ternal Caudal protein is established through translational repression by Bicoid of homogeneous caudal

140 n anabolic transcription program to overcome translational repression by eIF2alpha phosphorylation.

141 slational modification of histone marks, and translational repression by miRNA (microRNA)-673/menin.

142 teraction is RNA-dependent and essential for translational repression by Puf6p.

143 This constitutes a novel mechanism for translational repression by this family of regulators.

144 Here we present evidence that translational repression can also make a substantial con

145 We demonstrate that this translational repression can be overcome by blocking the

146 principle is straightforward, the extent of translational repression can be tuned and the regulator

147 zed cytoplasmic foci where mRNA turnover and translational repression can take place.

148 inhibition is primarily a result from global translational repression caused by R-DPRs.

149 Thus, transcriptional induction and translational repression combine to form a negative feed

150 her mRNP assembly into a PB is important for translational repression, decapping, or decay has remain

151 the representative genes examined, measured translational repression depended on their promoters rat

152 ng attenuation protein (TRAP), showed potent translational repression, dependent on the level of TRAP

153 RNA sensors, demonstrated that miRNAs induce translational repression depending on their complementar

154 miRNA (argonaute), NMD (Upf1p), and general translational repression (Dhh1p/Me31B) pathways.

155 Translational repression during mRNA transport is essent

156 , we demonstrate two separable mechanisms of translational repression employed by Puf5p: a Pab1p-depe

157 e mRNA level and emphasize the importance of translational repression for the maintenance of proteome

158 g protein Pab1p is required for PUF-mediated translational repression for two distantly related PUF p

159 orylated, suggesting rapid inhibition of its translational repression function.

160 Bicc1 is an RNA-binding protein with robust translational repression function.

161 RNA cleavage, but examples of miRNA-mediated translational repression have also been reported.

162 to the translation apparatus to (i) maintain translational repression, (ii) mount various transcripti

163 f claudin-14 mRNA; induce its mRNA decay and translational repression in a synergistic manner.

164 h bind the 3' UTR of target mRNAs to mediate translational repression in animals.

165 identify proteins that evade stress-induced translational repression in arsenite-treated cells expre

166 These findings emphasize the importance of translational repression in balancing stem cell self-ren

167 We report that TCS elements exert translational repression in both the Wee1 mRNA 3' UTR an

168 ecessary and sufficient to mediate selective translational repression in cells.

169 er light treatment, which implies widespread translational repression in dark-grown seedlings.

170 r hitch) in FMRP-driven, argonaute-dependent translational repression in developing eye imaginal disc

171 tigate the mechanism by which miRNAs mediate translational repression in human cells.

172 ment in the RINGO/Spy 3'UTR is necessary for translational repression in immature (G2-arrested) oocyt

173 n (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and

174 ng protein expression indicating large scale translational repression in P. falciparum female gametoc

175 destruction, most likely as a consequence of translational repression in the context of robust mRNA d

176 s by their uORFs, the range of uORF-mediated translational repression in vertebrate genomes is largel

177 ry neurons; and (3) in bantam miRNA-mediated translational repression in wing imaginal discs.

178 Particularly, microRNA (miRNA)-mediated translational repression involving PIWI/Argonaute family

179 e actively synthesized during stress-induced translational repression, irrespective of FUS genotype.

180 Aberrant translational repression is a feature of multiple neurod

181 pathway in Arabidopsis and demonstrate that translational repression is a functionally important asp

182 There is growing evidence that translational repression is a key transition that preced

183 er, our knowledge of the proteins that evade translational repression is incomplete.

184 Translational repression is mediated by BREs, regulatory

185 epresses the male fate as NOS-3 functions in translational repression leading to inactivation of the

186 In this paper, we report that translational repression may also play a role in MEI-1 d

187 on of the AccA and AccD subunits is due to a translational repression mechanism exerted by the protei

188 se operon is consistent with an RNA-mediated translational repression mechanism for this target.

189 and probably in numerous other bacteria by a translational repression mechanism in which nucleotide-r

190 Importantly, the translational repression mediated by miR-155 can be regu

191 Translational repression mediated by RNA-binding protein

192 ss the expression of protein-coding genes by translational repression, messenger RNA degradation, or

193 miRNA regulates gene expression by translational repression, mRNA cleavage, and mRNA decay

194 challenge to establish whether miRNAs induce translational repression, mRNA decay, or both.

195 nto PBs is governed by the relative rates of translational repression, mRNP multimerization, and mRNA

196 Translational repression occurs before complete deadenyl

197 he message remains constant, suggesting that translational repression occurs by reducing the rate of

198 Although translational repression occurs rapidly, its effect is r

199 This mutation resulted in translational repression of a reporter gene in a Dicer-d

200 he generation of neurogenic progeny involves translational repression of a subset of mRNAs, including

201 Lowering HuR or let-7 levels relieved the translational repression of c-Myc.

202 onally by guiding transcript cleavage and/or translational repression of complementary mRNA targets,

203 Rbp4 and Fest are required for translational repression of cycB in immature spermatocyt

204 ecent findings, is the maskin hypothesis for translational repression of cyclin B1 in Xenopus oocytes

205 rease in cyclin T1 mRNA levels, suggesting a translational repression of cyclin T1 in resting CD4(+)

206 iR-378a-5p upregulation were associated with translational repression of CYPs.

207 ciated effects of miR-34 require adult-onset translational repression of Eip74EF, an essential ETS do

208 We show that full APC activation requires translational repression of Emi1 in addition to its degr

209 which downregulates cleavage and upregulates translational repression of endogenous microRNA (miRNA)-

210 a has been implicated in transcriptional and translational repression of genes encoding contractile p

211 ism that involves (1) direct recruitment and translational repression of genes that promote spermatog

212 n during prion replication causes persistent translational repression of global protein synthesis by

213 hen binds to CsrA and relieves CsrA-mediated translational repression of hag for flagellin synthesis

214 ved function in embryonic patterning through translational repression of hb, the timing and mechanism

215 d, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells.

216 inhibitory protein IkappaBA followed by the translational repression of IkappaBA.

217 n of ribosomal protein L13a is essential for translational repression of inflammatory genes by the in

218 ranscriptional activation of miR-302 and the translational repression of its targets, such as cyclin

219 interaction was shown to be responsible for translational repression of manX and to contribute to de

220 oli and Salmonella identified a mechanism of translational repression of manY mRNA by the sRNA SgrS t

221 Also, we observed widespread translational repression of microRNA target genes in bot

222 In addition, Sbp1p promotes translational repression of mRNA during glucose deprivat

223 nction is restricted to the posterior by the translational repression of mRNA that is not incorporate

224 yeast results in nonsense-mediated decay and translational repression of mRNA, and that these roadblo

225 e cell differentiation predominantly through translational repression of mRNAs encoding pro-different

226 Overexpression of FBP1 resulted in translational repression of NPM mRNAs, whereas depletion

227 yeast, the RNA-binding protein Rim4 mediates translational repression of numerous mRNAs, including th

228 ger RNA, the Tribolium Otd gradient forms by translational repression of otd mRNA by a posteriorly lo

229 ponse through coordinate transcriptional and translational repression of p53 levels, which reduces p5

230 that the full-length protein is required for translational repression of para mRNA.

231 slation assay, we examined the mechanisms of translational repression of PUF proteins in the budding

232 n Rubisco deficiency and was correlated with translational repression of rbcL.

233 enous miRNAs to mediate RNA-like cleavage or translational repression of reporter mRNAs.

234 onal inhibition of the miR cluster by Runx2, translational repression of Runx2 and of SATB2 by the cl

235 tranded noncoding RNAs that function through translational repression of specific target mRNAs.

236 NA molecules that have been shown to mediate translational repression of target mRNAs involved in cel

237 ivo experiments to test CT tetramer-mediated translational repression of the accA and accD mRNAs.

238 frames initiated by ATG but not CTG mediated translational repression of the downstream main open rea

239 maphrodite spermatogenesis requires germline translational repression of the female-promoting gene tr

240 ogenesis in an otherwise female body through translational repression of the gene tra-2.

241 istinct regions of FsrA are required for the translational repression of the GltAB and SDH enzyme com

242 In Caenorhabditis elegans, translational repression of the key sex-determination ge

243 In the current study, we report that translational repression of the manY and manZ genes by S

244 ational repression, amp1 did not prevent the translational repression of the miR156 target SPL9 or th

245 asome-mediated degradation of C/EBPalpha and translational repression of the p53 protein by the CUGBP

246 as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4.

247 that Bic-C functions in spatially regulated translational repression of the xCR1 mRNA during Xenopus

248 anslational activation of tumor suppressors, translational repression of transcripts enriched with mi

249 Not4 is involved in translational repression of transcripts that cause trans

250 predict a model in which Cup and Sqd mediate translational repression of unlocalized grk mRNA, and PA

251 estricted Nanos synthesis is accomplished by translational repression of unlocalized nanos mRNA toget

252 pole of the oocyte and early embryo through translational repression of unlocalized nos mRNA coupled

253 Here, we show that vegetal cell-specific translational repression of xCR1 mRNA contributes to thi

254 tantly, this interaction is required for the translational repression of Zfp36's target mRNAs in reso

255 ority of these regulatory mechanisms involve translational repression, one example of translational a

256 ts strongly support the model that S(MK) box translational repression operates through occlusion of t

257 the regulation of gene expression by either translational repression or degradation of target mRNAs.

258 ract with multiple mRNAs resulting in either translational repression or degradation.

259 Ago) protein complex that usually results in translational repression or destabilization of the targe

260 tary sequences of target mRNAs, resulting in translational repression or target degradation and thus

261 sequence-specific messenger RNA degradation, translational repression, or transcriptional inhibition.

262 We found that translational repression preceded P granule localization

263 rom mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylat

264 is present in cytoplasmic granules with the translational repression proteins Dcp1 and 4E-T.

265 arget complementary mRNAs for degradation or translational repression, reducing or preventing protein

266 Yet, synaptic mechanisms regulated by 4E-BP2 translational repression remain unknown.

267 represents a novel target of Bruno-mediated translational repression required for cystoblast differe

268 A combination of translational repression, RNA degradation, and activatio

269 Transfected NSCLC cells with enhanced translational repression showed pronounced cell death fo

270 particular, Clb3 is regulated by a striking translational repression specific to meoisis I.

271 rticle that has been linked to pathogenesis, translational repression, starvation responses, and ribo

272 zation has been correlated with release from translational repression, suggesting an important regula

273 hus, Smaug2 and Nanos1 function as a bimodal translational repression switch to control neurogenesis,

274 Although this led to a 5.4-fold general translational repression, the protein coding open readin

275 a consequence of a defect in miRNA-mediated translational repression; the effect of suo on vegetativ

276 ost & Microbe, Zhang et al. (2017) show that translational repression through eIF2alpha phosphorylati

277 tion was required directly or indirectly for translational repression through elements of the glp-1 3

278 important RNA-binding protein that mediates translational repression through mTOR-dependent signalin

279 Finally, a one-hybrid screen based on translational repression through the 5'-UTR identified l

280 tor 2alpha (eIF2alpha), which caused general translational repression to inhibit HIF-1alpha expressio

281 ow that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state

282 iated deadenylation concurrently shifts from translational repression to mRNA destabilization.

283 for eIF2alpha phosphorylation and subsequent translational repression to occur.

284 t proteasomal degradation acts together with translational repression to prevent premature accumulati

285 The absence of Not4 affected global translational repression upon nutrient withdrawal, enhan

286 Reversal of eIF2alpha-mediated translational repression using ISRIB potently suppressed

287 volved in mRNA metabolic processes including translational repression via coordinated storage of mRNA

288 for miRNA-mediated gene regulation in which translational repression via eIF4A2 is required first, f

289 biologically relevant molecular mechanism of translational repression via modulating the cytoplasmic

290 In actively dividing cells, translational repression was followed by mRNA decay; how

291 Translational repression was relieved during oocyte matu

292 known to function in microRNA (miRNA)-based translational repression, we lack a comprehensive unders

293 To understand the mechanism of translational repression, we used rabbit reticulocyte ly

294 oRNA-directed target transcript cleavage and translational repression were impaired in the AGO3 mutan

295 (ALAS2) levels attributable to IRP-mediated translational repression were observed in erythroid cell

296 ly equivalent with bulged miRNA duplexes for translational repression, whereas Ago1 and Ago2 appear t

297 This allele is thought to primarily affect translational repression, which has been linked with the

298 lear genes (PhANGs) are largely regulated by translational repression, while HiToP ribosomal protein

299 by stress are predominantly associated with translational repression, while more actively initiating

300 of basic or hydrophobic amino acids induces translational repression without differential induction