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1 signal sequence transfer from the SRP to the translocon.
2 ed the proposal of a model of the functional translocon.
3 at SecYEG dimers are functional units of the translocon.
4 , and removal of misfolded proteins from the translocon.
5 d mutant forms of ZMPSTE24 fail to clear the translocon.
6 ation of the nascent chain through the Sec61 translocon.
7 estroy proteins that persistently engage the translocon.
8 molecular chaperone, and a component of the translocon.
9 ypeptide through the membrane via the SecYEG translocon.
10 ignal sequence affinity and targeting to the translocon.
11 in the release of membrane proteins from the translocon.
12 ctions between import motor subunits and the translocon.
13 nd transient subunit of the bacterial SecYEG translocon.
14 p destabilized interaction of Tim44 with the translocon.
15 of targeted LacZ fusions that do not jam the translocon.
16 ion of the mutations that identified the Sec translocon.
17 ization of the interaction of Pam17 with the translocon.
18 rt motor, which is associated with the TIM23 translocon.
19 y from the cytosol using the newly assembled translocon.
20 talyzed by a protein-conducting channel, the translocon.
21 , suggesting functional asymmetry within the translocon.
22 se, allowing the assembly of the peroxisomal translocon.
23 of assembly and the pore properties of this translocon.
24 localized at the ER in the proximity of the translocon.
25 n Escherichia coli via the homologous SecYEG-translocon.
26 ypothesize it is important for gating the ER translocon.
27 process, achieved in every cell by the 'Sec' translocon.
28 a primary interaction partner of the SecYEG translocon.
29 arbitrary polypeptide sequences into the Sec translocon.
30 nding groove of the SRP M domain towards the translocon.
31 increase the transport capacity of the Sec61 translocon.
32 ere the signal peptide is transferred to the translocon.
33 ic reticulum (ER) membrane by the ER protein translocon.
34 the SRP-SR in the 'activated' state and the translocon.
35 import of substrates that require the TIM23 translocon.
36 ents of the type III secretion system (T3SS) translocon.
37 ions between ribosomes and membrane-embedded translocons.
38 ne protein folding are mediated by the Sec61 translocon, a molecular machine that facilitates the lat
39 onent of this highly conserved system is the translocon, a pore formed in the host membrane that is e
40 ral to this task is the machinery of the Sec translocon, a transmembrane channel that is involved in
41 ribosome-nascent chain complex to the Sec61 translocon, a universally conserved protein-conducting c
42 of endomembrane organelle proteins, whereas translocon accessory proteins, such as ribophorin I, wer
43 ein translocation and insertion, we analyzed translocon activity, SecYEG stability and its interactio
44 it co-purifies with both PpiD and the SecYEG translocon after immunoprecipitation and blue native/SDS
45 cific regions in SRalpha reprogramme the Sec translocon and facilitate recruitment of ribosome-nascen
47 d in vivo for the stability of the bacterial translocon and its efficient function in co-translationa
48 computational effort has focused on the Sec translocon and its role in nascent protein biosynthesis,
49 A) and UV-photo-cross-linking in E.coli, the translocon and LPS intermediates were obtained at the N-
50 artitioning process between the water-filled translocon and membrane lipid bilayer, suggesting that p
52 small-molecule cotransin CT8 binds the Sec61 translocon and prevents the signal peptide of the nascen
54 part of a secretion platform composed of the translocon and several secretion substrates and that it
56 taining membrane microdomain enriched in Sec translocons and postsecretion protein biogenesis factors
57 brane proteins is a complex process in which translocons and proteases function in a concerted way.
58 aller analog of ES1, ES24, targets the Sec61-translocon, and captures it in an open conformation that
59 e been implicated as constituents of the TIC translocon, and it remains to be determined how they int
60 f DDR1 with SEC61B, a component of the Sec61 translocon, and nonmuscle myosin IIA and beta-actin.
61 teins insert into the membrane via the TIM23 translocon, and some are then further acted upon by the
62 centrated in components of the mitochondrial translocon, and the ubiquitylation kinetics of the vast
65 is relatively constant regardless of whether translocons are actively engaged with protein substrate
66 ted role for Mgr2 of the mitochondrial TIM23 translocon as a gatekeeper in the release of membrane pr
67 t to be a novel ancillary subunit of the Sec translocon as it co-purifies with both PpiD and the SecY
68 he pore-forming subunit of the Sec61 protein translocon, as a direct binding partner of ipomoeassin F
69 approaches: an experimental microsomal Sec61 translocon assay, a biophysical (spectroscopic) characte
72 e elucidation of the molecular nature of the translocon-assisted protein insertion is a challenging p
73 RAP) complex is an integral component of the translocon, assisting the Sec61 protein-conducting chann
74 asmic reticulum (ER) is scanned by two Sec61 translocon-associated large membrane machines for protei
77 Ste24, promote degradation of characterized translocon-associated substrates of the other enzyme in
78 interferon genes), an endoplasmic reticulum translocon-associated transmembrane protein, acts to det
79 ns we previously identified as important for translocon association resulted in cross-linking to Tim2
80 brane form stable supercomplexes with a 1-MD translocon at the inner chloroplast envelope membrane of
81 ed that phyllobilin hydroxylation depends on TRANSLOCON AT THE INNER CHLOROPLAST ENVELOPE55 (TIC55).
82 ue component of the recently identified 1-MD translocon at the inner envelope membrane of chloroplast
83 ort apparatus of plastids, designated as the translocon at the outer and inner envelope membranes of
84 d translocation-independent formation of the translocon at the outer envelope membrane of chloroplast
86 s the membrane channel of the protein import translocon at the outer envelope of chloroplasts (TOC).
87 cin colicin E9 (ColE9) assembles a cytotoxic translocon at the surface of Escherichia coli that incor
89 ptides to enter the chloroplasts through the translocons at the outer and inner chloroplast envelope
90 of hundreds of different proteins depends on translocons at the outer and inner chloroplast membrane
91 is guided by the interaction between SRP and translocon-bound FtsY in a quaternary targeting complex.
92 targeting of the nascent chain to the Sec61 translocon but with its subsequent productive translocat
93 C, and Hsp93, are present in the chloroplast translocon, but none has been shown to directly bind pre
94 e fifth cytosolic loop of SecY in the SecYEG translocon, but the functional role of the interaction i
95 nctions as an LPS transfer protein in the OM translocon by disaggregating LPS during transport to all
97 ted proteins are exported through the SecYEG translocon by the SecA ATPase motor via the general secr
99 brane complex (EMC) or mutation of the Sec61 translocon causes reduced synthesis of misfolded forms o
102 of two Asi substrates analyzed and caused a translocon-clogging Ste24 substrate to accumulate in a f
103 plasmic reticulum (ER) by the ribosome Sec61-translocon complex (RTC) through iterative cycles of tra
104 did not successfully translocate through the translocon complex are subjected to a preemptive quality
105 pendent and due to the operation of a unique translocon complex dubbed PTC (Pchlide-dependent translo
106 To examine the state of water in a SecY translocon complex embedded in a lipid bilayer, we carri
111 re, we provided evidence indicating that the translocon complex Sec61 mediates the release of beta-DG
112 GFP11, revealing that endoplasmic reticulum translocon complex Sec61B has reduced abundance in certa
113 1u mRNA, is recruited to the Ire1alpha-Sec61 translocon complex through its nascent chain, which cont
114 ractions among TTSS components of the needle-translocon complex using a chemical cross-linking-based
116 ionally recognized and retained by the Sec61 translocon complex, providing a time window for efficien
117 er, including the endoplasmic reticulum (ER) translocon complex, which mediates protein translation i
123 revealed molecular architecture of a central translocon component advances our understanding of membr
124 rmined how the nascent polypeptide modulates translocon component associations during defined cotrans
125 ation of the major type III secretion system translocon component in both membrane-bound and chaperon
127 ide further knowledge on the function of the translocon components and the molecular basis for their
128 c and ER-bound polysome fractions identified translocon components as selective polysome-interacting
129 any functions, such as stabilizing other Sec translocon components within the membrane, maintaining t
130 lar ERAD-associated isomerases, lectins, and translocon components, including ERAD E3 ubiquitin ligas
131 omised while the levels of individual SecYEG translocon components, SecA and insertase YidC were larg
137 ion of a protein that aberrantly engages the translocon (Deg1-Sec62) and substrates with luminal degr
141 g membrane proteins are targeted to membrane translocons early in translation, by the ubiquitous sign
142 and NEMF, core RQC components, are bound to translocon-engaged 60S subunits on native ER membranes.
143 nslocation and reduce the extent of aberrant translocon engagement by a model substrate diminish cell
144 h-throughput mRNA sequencing shows selective translocon engagement with hundreds of different multi-p
145 ed across the inner-membrane through the Sec-translocon for delivery to periplasmic chaperones, for e
149 This observation suggests that the SecYEG translocon forms different substrate-independent subasse
150 etion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positi
152 lous water behavior affects the mechanism of translocon function and, more generally, the partitionin
155 wn translation, and release of arrest at the translocon has been proposed to occur by mechanical forc
156 ansport in vitro However, in vivo the SecYEG translocon has been shown to associate with multiple par
158 , they failed to identify any outer-membrane translocon homologs, which raised the question of the or
159 -mannosyltransferases (PMTs) also act at the translocon, however, in recent years it turned out that
161 -YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion and membr
165 es the targeting of membrane proteins to the translocon in a multistep process controlled by GTP hydr
166 rough a transmembrane conduit called the Sec translocon in a process that is facilitated by ancillary
167 letion of SRP, the SRP receptor or the Sec61 translocon in cells leads to reduced Ire1alpha-mediated
168 y (CET) to study the structure of the native translocon in evolutionarily divergent organisms and dis
172 ular weight preproteins and imported via the translocons in the outer (TOC) and inner (TIC) envelope
173 erved, posttranslational mechanism involving translocons in the outer (TOC) and inner envelope (TOC).
174 nto a synthetic bilayer without the need for translocon insertase apparatus that is essential in vivo
175 ce of cross-linkable LcrV-YscF interactions, translocon insertion is abolished, but Yersinia still re
178 ian cells requires Yersinia to both insert a translocon into the host cell membrane and sense contact
179 residues are quickly released from the Sec61 translocon into the membrane or the ER lumen, resulting
184 n the ribosome and its insertion through the translocon is analyzed, focusing on the recently discove
188 th previous data, this implies that the ColN translocon is distinct from those of other known colicin
190 nts during nascent-chain passage through the translocon is generally viewed as a simple partitioning
191 ults suggest that direct RNC transfer to the translocon is guided by the interaction between SRP and
192 is to movements of the precursor through the translocon is much less efficient than the coupling by t
193 s SA-I immediately, the interaction with the translocon is perturbed and topology of the protein in E
198 h the YopBD pore, and/or (iii) the YopB-YopD translocon itself or its membrane insertion is proinflam
200 SecY dimer can be captured associated with a translocon-jammed substrate, indicative of SecY dimer fu
202 ined path through the ribosome, the ribosome translocon junction, the Sec61-translocon pore, and into
206 ro transcription/translation system to study translocon-mediated folding of the WT pro-SP-C poly-Val
207 lecular dynamics simulations reveal that the translocon-mediated membrane integration of a transmembr
208 g pathways by sorting and docking cargos for translocon-mediated transport across membranes, by shutt
210 testable predictions regarding the effect of translocon mutations on membrane protein topogenesis.
211 tric representations of the ribosome and Sec translocon, obtained directly from experimental structur
213 Moreover, Sec62/63 stabilization within the translocon occurred for native endogenous substrates, su
215 proved the presence of a reduced form of the translocon of inner membrane, they failed to identify an
216 Although some PRAT proteins, such as the translocon of the mitochondrial inner membrane (TIM) pro
217 Tom22 (TgTom22), a central component of the translocon of the outer mitochondrial membrane (TOM) com
218 f E. gracilis by machinery homologous to the translocons of outer and inner chloroplast membranes, re
219 of well-known transport machineries like the translocons of the outer/inner chloroplast membranes (To
221 coordinated processes that take place at the translocon-oligosaccharyltransferase (OST) complex.
222 on the outer chloroplast membrane) and TIC (translocon on the inner chloroplast membrane) machinerie
223 , protein import is accomplished by the TOC (translocon on the outer chloroplast membrane) and TIC (t
225 rotein import pathways into mitochondria use translocons on the outer membrane (TOM) and inner membra
232 the ribosome translocon junction, the Sec61-translocon pore, and into the ER lumen coincident with c
237 ins from all the major mitochondrial protein translocons present in yeast, suggesting these arose ear
238 ins that clog the endoplasmic reticulum (ER) translocon prevent the movement of other proteins into t
239 st acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-ret
240 GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing
241 eractions of VKORC1v2, vIL-6, and pCatD with translocon proteins (SEL1L and/or HRD1) and ERAD-associa
243 s indicate that lysosomal damage by Yersinia translocon proteins promotes inflammasome activation and
244 virulence by limiting hyperinjection of the translocon proteins YopD and YopB into cells, thereby li
246 ivation with the type three secretion system translocon providing the second signal for inflammasome
248 m44, interacting with the matrix face of the translocon, recruits other motor subunits and binds inco
249 c protrusion of SecYEG demonstrates that the translocon remains competent for binding after tens of m
254 odopsin from Halobacterium salinarum and the translocon SecYEG from Escherichia coli, we demonstrate
255 established a reconstitution system for the translocon SecYEG in proteoliposomes in which 55% of the
256 engaged in protein transport, the bacterial translocon SecYEG must maintain the membrane barrier to
258 that a single protein component of the T3SA translocon-Shigella IpaC, Salmonella SipC, or Chromobact
259 uggested to work alongside SecY2 to form the translocon, similar to the associated SecY, SecE, and Se
260 cid-dependent secretion process in which the translocon SseB moves away from the bacterial cell surfa
263 p delimit residues 400-710 of CyaA as an "AC translocon" sufficient for translocation of the AC polyp
264 the required features of the putative retro-translocon, suggesting alternative retro-translocation m
265 achinery are in close proximity to the SEC61 translocon, suggesting that this modification plays a di
266 ubstrate detection and suggest that a robust translocon surveillance infrastructure maintains functio
269 of cpSecA1, the stromal motor of the cpSec1 translocon that inserts unfolded Plsp1 into the thylakoi
270 s a hetero-oligomeric complex with the Sec61 translocon that is activated upon ER stress with little
271 protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its leth
272 This level corresponds to the fraction of translocons that are active in vitro when assessed in th
273 ryotes, relatively little is known about the translocons that transport proteins across the two membr
274 ed membrane protein systems such as the SecY translocon, the Bam complex and the MetNI transporter, w
275 e insertion of RodZ requires only the SecYEG translocon, the SecA ATPase motor, and the TM proton mot
276 cognition particle (SRP), SRP receptors, the translocon, the signal peptidase complex, and over 100 o
278 Therefore, the free energy of transfer from translocon to bilayer is different from the transfer fre
279 ectly targets the alpha subunit of the Sec61 translocon to block the production of secreted and integ
281 rane complex (EMC) cooperates with the Sec61 translocon to co-translationally insert a transmembrane
283 These proteins then traffic via an export translocon to the host membrane, where they form a nutri
284 ing the trafficking of proteins from the Sec translocon to the periplasmic chaperone network that con
286 hat IRE1alpha forms a complex with the Sec61 translocon, to which its substrate XBP1u mRNA is recruit
287 coarse-grained simulations that combine the translocon (TR) insertion profile and the effective chem
289 tly emergent new biological roles including "translocon unclogger" and (non-enyzmatic) broad-spectrum
290 ely synthesized GPCRs in the vicinity of the translocon until the complete receptor is released into
291 responding to conformational changes in the translocon upon a translocating polypeptide entering the
292 could demonstrate that Ste24 approaches the translocon upon clogging, and it interacts with and gene
294 of nascent proteins are thought to exit the translocon via a lateral gate in SecY, where YidC facili
295 the bacterial SecY nor the eukaryotic Sec61 translocon was able to efficiently transport proteins en
296 into the molecular mechanism of this dynamic translocon, we determined the structure of mammalian Sec
297 CTD serves primarily to anchor Tim44 to the translocon, whereas the NTD is a dynamic arm, interactin
298 modular and versatile composition of the Sec translocon, which is probably essential for its ability
299 ocation and membrane integration via the Sec translocon, while retaining sufficient chemical and stru
300 with components of PTEX, a putative protein translocon within the membrane of the parasitophorous va