ライフサイエンスコーパス: transmembrane helix

1 disposed 16-residue motif follows the final transmembrane helix.

2 main being uncoupled from the motions of the transmembrane helix.

3 transmembrane helix and a buckling of the M2 transmembrane helix.

4 in a truncation within the carboxyl-terminal transmembrane helix.

5 ne dynamics of the amyloid precursor protein transmembrane helix.

6 on S270T, at the extracellular end of the M2 transmembrane helix.

7 which were predicted to contain at least one transmembrane helix.

8 41A1, resulting in an in-frame deletion of a transmembrane helix.

9 TatA assembly is mediated entirely by the transmembrane helix.

10 e normal and forms an extension of the first transmembrane helix.

11 rtially destabilized insertion of the eighth transmembrane helix.

12 main, resulting in the exposure of a nascent transmembrane helix.

13 and NAD(P)H binding domains and a C-terminal transmembrane helix.

14 e-forming activity resides in the C-terminal transmembrane helix.

15 ochondrial targeting signal and a downstream transmembrane helix.

16 ced at the beginning, middle, and end of the transmembrane helix.

17 r between the N-terminal helix and the first transmembrane helix.

18 segment between the C-terminus and the inner transmembrane helix.

19 htly acidic conditions (pH 6-6.5), forming a transmembrane helix.

20 slower (100 sec) insertion pathway to give a transmembrane helix.

21 distal to the cytoplasmic end of the second transmembrane helix.

22 elix in the C-terminal portion of the fourth transmembrane helix.

23 ons it inserts into lipid bilayers forming a transmembrane helix.

24 Rs that contain a GXXXN motif in their first transmembrane helix.

25 ccompanied by the striking rotation of a key transmembrane helix.

26 ion of its C-terminus and the formation of a transmembrane helix.

27 ar the inserting C-terminal end of the pHLIP transmembrane helix.

28 embrane curvature even in the absence of the transmembrane helix.

29 have shown that the acidic residues E106 in transmembrane helix 1 (TM1) and E190 in TM3 contribute t

30 One clue may lie in two openings between transmembrane helix 1 (TM1) and TM7 and between TM5 and

31 functional contribution of highly conserved transmembrane helix 1 (TM1) on the hASBT transport cycle

32 mmetrical dimerization interface mediated by transmembrane helix 1 and the cytoplasmic helix 8 of rho

33 sodium-binding sites, the unwound portion of transmembrane helix 1 and the substrate-binding site tha

34 s) between at least three lysine residues in transmembrane helix 1 are essential for both COPI comple

35 and a second essential aspartyl residue from transmembrane helix 1 into close proximity for catalysis

36 ntracellular loop or the Phe(223) residue in transmembrane helix 1 of alpha6 with the corresponding a

37 Further, we have shown that transmembrane helix 1 plays an essential, but as yet und

38 w that sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required

39 us, irrespective of sequence, the ability of transmembrane helix 1 to bind to COPI complex appears to

40 The transmembrane helix 1 unwinds when the K(+) channel ente

41 id membrane revealed water penetration along transmembrane helix 1 with the cooperation of a polar re

42 nstrate that substitution of the lysine-rich transmembrane helix 1 with the COPI binding portion of t

43 on connecting the outer transmembrane helix (transmembrane helix 1) and the pore helix behind the sel

44 brane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular l

45 h as TPP(+) and the essential residue E14 in transmembrane helix 1.

46 ions 359 and 448 of extracellular loop 4 and transmembrane helix 10, respectively.

47 e multiple distinctions, including a kink in transmembrane helix 12 halfway across the membrane bilay

48 revealing an unexpectedly large movement of transmembrane helix 1a (TM1a).

49 ional changes include a distinct movement of transmembrane helix 2 (M2), from its position in the pre

50 ken together, we demonstrate that the top of transmembrane helix 2 (TM2) and the top of transmembrane

51 Transmembrane helix 2 (TM2) of the Tar chemoreceptor und

52 influenced by residues at the C-terminus of transmembrane helix 2 (TM2).

53 We specifically focused on the putative transmembrane helix 2 (TMH2) and observed that cells exp

54 onserved tyrosine residue (Tyr81) located in transmembrane helix 2 adjacent to the aromatic arginine

55 -AR:CXCR4 heteromeric complexes by targeting transmembrane helix 2 of CXCR4 and depletion of the hete

56 ch to delineate the role of highly conserved transmembrane helix 2 on the expression and function of

57 We examined the functional role of transmembrane helix 3 (TM3) in NKCC1 using cysteine- and

58 e transport domain, including the peripheral transmembrane helix 3 (TM3), moves relative to the trime

59 Our primary interest was focused on transmembrane helix 3 (TM3), which is identified as bein

60 To further probe GCR1, we have aligned transmembrane helix 3 of GCR1 to each of the six GPCR cl

61 e outward motion of an asparagine residue in transmembrane helix 3, might be a prerequisite to the la

62 m the membrane involves the repositioning of transmembrane helix 4 (TM4) following its disengagement

63 te that the GLP-1R forms homodimers and that transmembrane helix 4 (TM4) provides the primary dimeriz

64 ubstitution of four lipid-facing residues in transmembrane helix 4 (TM4) that is known to be importan

65 s agonist, serotonin, cholesterol binding at transmembrane helix 4 biases bound serotonin molecules t

66 Elevated cholesterol density near transmembrane helix 4 is considered to be conducive to t

67 Here, we show that the predicted transmembrane helix 4 of Escherichia coli FtsW (this pro

68 a heterodimer between S. Typhi MgtR and the transmembrane helix 4 of Mtb MgtC.

69 interface by introducing point mutations in transmembrane helix 4 of PAR1 or PAR4 that prevented het

70 e dimer interface to hydrophobic residues in transmembrane helix 4.

71 tion motifs but identified a requirement for transmembrane helix 4.

72 bonds with two conserved serine residues in transmembrane helix 5 (Ser(5.42) and Ser(5.46)), but par

73 ize a near-native state with a highly mobile transmembrane helix 5 (TM5) that is significantly popula

74 terface than ARC, especially in the receptor transmembrane helix 5 (TM5), TM6, and TM7 intracellular

75 predicted to lie near the cytoplasmic end of transmembrane helix 5 (TM5).

76 its distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tai

77 a substrate-induced disulphide crosslink in transmembrane helix 5 of TatC.

78 the cooperation of a polar residue (Y147 in transmembrane helix 5) in the adjacent protomer.

79 nsmembrane helix 8 or a threonine residue in transmembrane helix 5.

80 ntified the conserved aspartate in the upper transmembrane helix 6 (Asp(6.59)) of the receptor as the

81 s incorporated on the cytosolic interface of transmembrane helix 6 (Cys-265), (19)F NMR spectra of th

82 e transport cycle, conformational changes in transmembrane helix 6 (TM6) alter the glutathione-bindin

83 tward movements of the intracellular side of transmembrane helix 6 (TM6) and movements of TM5 toward

84 of the chromophore, (ii) displacement of the transmembrane helix 6 (TM6) away from the binding pocket

85 Specifically, transmembrane helix 6 (TM6) movements associated with G-

86 rge-scale movement (ca. 6 to 14 angstrom) of transmembrane helix 6 (TM6) to a conformation which bind

87 he retinal leaving the protein and return of transmembrane helix 6 (TM6) to the inactive conformation

88 protein coupling entail outward movements of transmembrane helix 6 (TM6).

89 ns reveal that peptide binding to the ECS on transmembrane helix 6 (TMH6) and TMH7 at the base of ext

90 artial unwinding of the carboxyl terminus of transmembrane helix 6 and induces a sharp kink at the mi

91 ansmembrane domains into close contact along transmembrane helix 6 and ultimately inducing conformati

92 gests that the mutated residue at the top of transmembrane helix 6 mimics Arg(19) by interacting with

93 trong anchors to two intracellular loops and transmembrane helix 6 of the kappaOR.

94 ed state, except that the cytoplasmic end of transmembrane helix 6 partially occludes the G-protein-b

95 results indicated that two substitutions in transmembrane helix 6 reverse stereoselectivity of Sp-AB

96 tation of the nucleotide binding domains and transmembrane helix 6 which is of particular relevance t

97 ld and exhibits an unusual loop structure on transmembrane helix 6, creating an extended cavity that

98 utward movement of the intracellular side of transmembrane helix 6, resulting in G-protein interactio

99 main result in a sharp kink in the middle of transmembrane helix 6, which pivots its intracellular ha

100 ular loop three and the extracellular tip of transmembrane helix 6.

101 fferent amplitude of the outward movement of transmembrane helix 6.

102 It contains two homologous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence

103 l rearrangements such as the displacement of transmembrane helix-6.

104 uses distinct structural elements, including transmembrane helix 7 and helix 8, to recruit arrestin.

105 shows an approximately 10 angstrom shift of transmembrane helix 7 that exposes a large membrane-acce

106 at either a conserved asparagine residue in transmembrane helix 8 or a threonine residue in transmem

107 transporters is the helix-loop transition in transmembrane helix 8, which likely forms the structural

108 3 domains and vice versa, we show that GLUT1 transmembrane helix 9 (TM9) is necessary for optimal ass

109 the fifth cytoplasmic loop (CL5) connecting transmembrane helix 9 (TM9) to TM10 are critical for sta

110 D863, Q864 and T867 lie within transmembrane helix 9.

111 20 in the pH gate in the hinges of the inner transmembrane helix (98-103), and in the selectivity fil

112 ond to, SMALP encapsulated membrane and ZipA transmembrane helix, a separate short compact tether, an

113 pecific binding of a sphingolipid to the p24 transmembrane helix affects p24 dimerization in membrane

114 ive site of the enzyme, possibly mediated by transmembrane helix alpha7, which contains both Y241(Vc)

115 a tilting and straightening of the M4 inner transmembrane helix and a buckling of the M2 transmembra

116 realistic model of CYP3A4, complete with its transmembrane helix and a membrane, has been constructed

117 hipathic alpha-helix that precedes the first transmembrane helix and a subtle rigid-body repositionin

118 related proteins that comprise an N-terminal transmembrane helix and an adjacent amphipathic helix.

119 e needed to show how interaction between the transmembrane helix and catalytic domain might influence

120 Each repeat includes a discontinuous transmembrane helix and forms half of a channel across t

121 s between residues in a C-terminally located transmembrane helix and in more N-terminally located hel

122 multiple mutations were introduced into the transmembrane helix and its surroundings.

123 rising the membrane interactive domains, the transmembrane helix and the cytoplasmic helix, displayed

124 a linker of ~20 residues between the second transmembrane helix and the cytosolic domain.

125 Although the transmembrane helix and the intracellular module togethe

126 sting that the membrane-proximal region, the transmembrane helix and the kinase domain of PDGFRbeta a

127 of Cys-35 at the C-terminus of the predicted transmembrane helix and thereby close to the surface of

128 The 3 kDa SdhF forms a single transmembrane helix and this helix plays a role in block

129 (associated membrane protein), ZipA (single transmembrane helix), and PgpB (integral membrane protei

130 membrane glycoprotein with an ectodomain, a transmembrane helix, and a short carboxyl-terminal tail,

131 ntains a small cytosolic region, a predicted transmembrane helix, and an extracellular domain with a

132 f RPTPs comprises an extracellular region, a transmembrane helix, and two tandem intracellular cataly

133 within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single

134 Comparison of the transmembrane helix architecture with other G-protein-co

135 Threonine mutations within this transmembrane helix are known to alter the cleavage patt

136 s, whereas only resonances from the immobile transmembrane helix are observed in the solid-state (1)H

137 helix and the hinge that connects it to the transmembrane helix are significantly more dynamic than

138 Transmembrane helix association is a fundamental step in

139 highly packed residues that facilitate tight transmembrane helix association.

140 structured but folds across the bilayer as a transmembrane helix at pH approximately 6.

141 9) to Lys in the cytosolic portion of the M1 transmembrane helix at the other end of the molecule bro

142 ed (TA) proteins, defined as having a single transmembrane helix at their C terminus, are post-transl

143 omain (LBD), (2) the resulting separation of transmembrane helix attachment points across subunit dim

144 first cytoplasmic loop and the beginning of transmembrane helix B with the fluorescent dye fluoresce

145 rked differences in the histidine-containing transmembrane helix behavior between acidic and neutral

146 ne classifier to predict the likelihood of a transmembrane helix being involved in pore formation.

147 evolution has been able to liberally exploit transmembrane helix bending for the optimization of memb

148 LptC inserts its transmembrane helix between the two transmembrane domain

149 M3 loop (deltaIle-288) and the delta subunit transmembrane helix bundle (deltaPhe-232 and deltaCys-23

150 The catalytic core of VKOR is a four transmembrane helix bundle that surrounds a quinone, con

151 binds at the extracellular end of the seven-transmembrane-helix bundle and forms extensive contacts

152 lecular hinge points about which the two six transmembrane-helix bundles flex and straighten to open

153 omplex are as follows: (i) substitution of a transmembrane helix by a lipid and chlorin ring, (ii) li

154 the membrane-embedded Fo subcomplex, as its transmembrane helix can be removed.

155 structure of the DAP12-NKG2C immunoreceptor transmembrane helix complex, five functionally required

156 intracellular "gates" and by an unfavorable transmembrane helix configuration when both gates are cl

157 function, using variations of a shared seven-transmembrane helix design and similar photochemical rea

158 20 that also contains the motif in the first transmembrane helix, did not undergo RAT.

159 e and not part of the structurally important transmembrane helix dimer crossing region.

160 re, the stability of the human glycophorin A transmembrane helix dimer has been analyzed in lyso-phos

161 Here, we find that the transmembrane helix dimer, glycophorin A (GpATM), is act

162 a complex involving the alpha/beta integrin transmembrane helix dimer, the head domain of talin (a c

163 x relationships among DR5 network formation, transmembrane helix dimerization, membrane cholesterol,

164 mate in the extracellular part of the fourth transmembrane helix, distant to site III.

165 izes and induces structural changes in the 7-transmembrane helix domain, triggering G protein activat

166 FEX proteins consist of two homologous four-transmembrane helix domains folded into an antiparallel

167 dynamics not only reveals the importance of transmembrane helix dynamics in interpretation of SSNMR

168 The structures reveal a monomeric eight-transmembrane helix fold that supports a periplasmic car

169 The structure has a seven-transmembrane-helix fold that features two triple-helix

170 ular dichroism analysis revealed a very long transmembrane helix for E5 of approximately 26 amino aci

171 t undergoes membrane insertion, resulting in transmembrane helix formation, on exposure to acidity at

172 MCU is a homo-oligomer in which the second transmembrane helix forms a hydrophilic pore across the

173 g at Na(+) site II, possibly via movement of transmembrane helix four.

174 upled receptors (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wi

175 H-1 serves as a scaffold, anchoring the lone transmembrane helix from nicastrin and supporting the fl

176 This prevented the inner transmembrane helix from undergoing conformational chang

177 thod to the well-characterized glycophorin A transmembrane helix (GpATM) reveals a dimer that is dram

178 Introducing a competing R-opsin transmembrane helix H1 or helix H8 peptide, but not heli

179 53) at the cytoplasmic terminus of the third transmembrane helix (H3C), a region within class A G pro

180 n overall topology to class A GPCRs, but the transmembrane helix H4 is shifted by more than 20 angstr

181 ization event drives the outward rotation of transmembrane helix H6, a hallmark of activated G protei

182 the intracellular surface, and is closer to transmembrane helix H7 of the receptor when compared wit

183 lycosylated region followed by a hydrophobic transmembrane helix, has been notoriously resistant to a

184 a large ligand-binding pocket and the first transmembrane helix having a 'stalk' region that extends

185 The GXGD motif and a short transmembrane helix, helix 4, are positioned at the cent

186 These dimers are stabilized by specific transmembrane helix-helix interactions, including a disu

187 DGFR) beta in a ligand-independent manner by transmembrane helix-helix interactions.

188 served disulfide bridge (7TM bridge) linking transmembrane helix III (TMIII) and ECL-2 is crucial for

189 rough endoproteolytic cleavage in the second transmembrane helix; importantly, we identified the endo

190 y site close to the kinked part of the first transmembrane helix, in a region loaded with negatively

191 ng channel by regulating signal sequence and transmembrane helix insertion in a substrate-dependent m

192 e itself plays an active role in driving DR5 transmembrane helix interactions or in the formation of

193 Several of these structures have the five transmembrane-helix inverted-topology repeat, LeuT-like

194 The mechanism through which a single transmembrane helix is able to recognize and interact wi

195 at the position of the motif relative to the transmembrane helix is critical.

196 n which a bulge conformation at Ser-382 in a transmembrane helix is eliminated to open the water chan

197 at sequence-specific dimerization of the p24 transmembrane helix is mediated by a LQ7 motif, with Gln

198 exibility at this point in the cavity-lining transmembrane helix is necessary for normal RyR function

199 Most notably, we also show that the transmembrane helix is tilted ~13 degrees from the lipid

200 The protein's N terminus, a predicted transmembrane helix, is not represented in the crystal s

201 (40), residing at the C-terminal side of the transmembrane helix, is observed to cause local membrane

202 We show that cholesterol binds to transmembrane helix IV, and cholesterol occupancy at thi

203 helices I and II, but a reduced presence of transmembrane helix IV, is observed at the dimer interfa

204 ii) stabilization of the iron-sulfur protein transmembrane helix, (iv) n-side charge and polarity com

205 hem to the extracellular C-type gate through transmembrane helix M4 and pore helix 1.

206 A glutamine in transmembrane helix M8 (Q925) appears from the crystal s

207 Replacement of the cysteine C932 in transmembrane helix M8 of Na(+),K(+)-ATPase with arginin

208 nner membrane protein will ultimately form a transmembrane helix may therefore depend on whether or n

209 In the 12-transmembrane-helix MFS transporters, four triple-helix

210 k of extracellular salt bridges and blocking transmembrane helix motions necessary for activation.

211 Our experimental analyses show that the transmembrane helix of ADCK3 oligomerizes, with an inter

212 The third transmembrane helix of claudin-3 is clearly bent compare

213 A peptide derived from the second transmembrane helix of CXCR4 induced chemical shift chan

214 odified wild-type sequences of the conserved transmembrane helix of E is sufficient to lyse host cell

215 In the TatBC receptor complex the transmembrane helix of each TatB molecule is sandwiched

216 CIQ modulation in the region near the first transmembrane helix of GluN2D, including in a putative p

217 howed that rs3749171 is located in the third transmembrane helix of GPR35 and could possibly alter ef

218 main and associates primarily with the first transmembrane helix of MCU.

219 of a critical cysteine (Cys195) in the third transmembrane helix of Orai1.

220 nner membrane is sensed by the 17-amino acid transmembrane helix of PilA to activate the PleC-PleD tw

221 he receptor dimer causes a shift in a single transmembrane helix of roughly 0.15 nm towards the cytop

222 e of residues in the cytosolic cavity-lining transmembrane helix of RyR (G(4864)LIIDA(4869) in RyR2)

223 dimer-specific subunits e and g or the first transmembrane helix of subunit 4 lack both dimers and la

224 We isolated substitutions, locating to the transmembrane helix of TatB that restored transport acti

225 ed by mutations affecting amino acids in the transmembrane helix of TatB.

226 g substitutions were identified in the fifth transmembrane helix of TatC.

227 y sequential proteolytic cleavage within the transmembrane helix of the 99 residue C-terminal fragmen

228 serine residue at position 296 in the third transmembrane helix of the alpha1/alpha3 GlyR.

229 ino acid peptide corresponding to the second transmembrane helix of the CXCR4 forms self-assembled pa

230 ars to be independent of the presence of the transmembrane helix of the full-length enzyme, significa

231 between the macroglycopeptide region and the transmembrane helix of the GPIbalpha subunit.

232 The M1 transmembrane helix of the muscle endplate AChR is linke

233 nce of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the endo

234 epends on a GXXXN motif present in the first transmembrane helix of TM4SF20.

235 secutive addition of individual helices to a transmembrane helix or helix bundle, in contrast to curr

236 vides a means to simultaneously extract both transmembrane helix orientation and dynamics information

237 cted to reside along the same surface of the transmembrane helix, our results suggest that interactio

238 mismatch is the dominant factor guiding the transmembrane helix packing.

239 effects reaching from as far away as the M2 transmembrane helix perturb the function of the catalyti

240 pic integral membrane proteins with a single transmembrane helix play diverse roles in catalysis, cel

241 el configuration to produce the 6- and 6 + 1-transmembrane-helix pores, respectively.

242 se permease of Escherichia coli (LacY), a 12-transmembrane helix protein LacY that catalyzes symport

243 G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extr

244 The rotation of the transmembrane helix (Q16-A46) around its long axis chang

245 Proteus mirabilis revealed an inverted five-transmembrane-helix repeat similar to that in the amino

246 er Kv channel was truncated after the fourth transmembrane helix S4 (Shaker-iVSD).

247 ns affecting arginine residues in the fourth transmembrane helix (S4) of the Na(V)1.4 VSDs can result

248 ectrophysiology, mainly regarding the fourth transmembrane helix (S4), which constitutes a moderate v

249 ied by opening of the L5 cap and movement of transmembrane helix S5 toward S6 in a direction differen

250 -to-pi-helical transition in the pore-lining transmembrane helix S6 at an alanine hinge just below th

251 ved residue within the C-terminal end of the transmembrane helix S6 region of the ion permeation path

252 to-pai helical transition in the pore-lining transmembrane helix S6.

253 x bundle formed by the intracellular ends of transmembrane helix six of each subunit.

254 ion efflux domain, putatively disrupting its transmembrane helix structure.

255 cal pattern of accessibility changes along a transmembrane helix, suggesting a rigid-body helical re-

256 ctive mutations at the cytoplasmic face of a transmembrane helix suggests that they restore biogenesi

257 ging motion at the center of the pore-lining transmembrane helix that underlies channel gating either

258 minal amphipathic helix preceding a putative transmembrane helix that would constrain the catalytic d

259 ly transporters that occurs before the first transmembrane helix, the signal sequence recognized by t

260 In addition to the transmembrane helix, the SNARE motif consists of two wel

261 Our previous study showed that transmembrane helix (TM) 11 of NaDC1 is important for so

262 In contrast, the mutation of residues within transmembrane helix (TM) 2 and the second extracellular

263 milar mode of binding in which they straddle transmembrane helix (TM) 3, wedge between TM3/TM8 and TM

264 agenic or posttranslational modifications of transmembrane helix (TM) 6b, which structurally links th

265 Synaptotagmin-1 contains a single transmembrane helix (TM) and two tandem C2 domains (C2A

266 l site between the extracellular segments of transmembrane helix (TM)-III and TM-IV and a lipid-expos

267 helix, which propagates to the pore-forming transmembrane helix TM1.

268 terminal tail of SERCA2b consists of an 11th transmembrane helix (TM11) with an associated 11-amino a

269 er advocate that the elimination of the last transmembrane helix (TM14) of NuoM and the TM16 (at leas

270 conformation, which involve the movement of transmembrane helix TM1a away from the transmembrane hel

271 conformational changes transmitted through a transmembrane helix (TM2), a five-residue control cable

272 extracellular N-terminal domain and a second transmembrane helix (TM2), it is different from the foun

273 In the conductive state, rotation of a transmembrane helix (TM4) about a central hinge seals th

274 ix bundles, connected by an inversion linker transmembrane helix (TM4) to create the translocation pa

275 lly on key movements that occur in the sixth transmembrane helix (TM6) during GPCR activation.

276 or necrosis factor receptor superfamily, the transmembrane helix (TMH) alone in the receptor directly

277 enhanced detection of peptides encompassing transmembrane helix (TMH) domain, as compared with stron

278 occur at Asp-61 in the middle of the second transmembrane helix (TMH) of Fo subunit c.

279 61 translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass integral me

280 py identify a pivotal role of the oligomeric transmembrane helix (TMH) of Mga2 for intra-membrane sen

281 ddle of the membrane at Asp-61 on the second transmembrane helix (TMH) of subunit c, which folds in a

282 Of these residues, Gln(332) in transmembrane helix (TMH) VI was protected against MTS i

283 tonation of a conserved Asp/Glu at the outer transmembrane helix (TMH).

284 , if occluded by aromatic rings, may cause a transmembrane helix to exit the lipid bilayer.

285 mbrane surface and becomes parallel with the transmembrane helix to form one nearly continuous long h

286 -spin hemes and conformational adaption of a transmembrane helix to generate a distinct oxygen-bindin

287 re, protein fold, protein structural domain, transmembrane helix topology, metal binding sites, regio

288 The charged S4 transmembrane helix transduces changes in transmembrane

289 that the turret region connecting the outer transmembrane helix (transmembrane helix 1) and the pore

290 erium-exchange analysis, we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD

291 mation of the conserved NP(7.50)xxY motif in transmembrane helix VII.

292 ned from engineered proteins, from which the transmembrane helix was absent.

293 nteraction between TatC helix 5 and the TatB transmembrane helix was confirmed by the formation of a

294 Recombinant AcCYP51 with a truncated transmembrane helix was purified as a heterogeneous mixt

295 R's photoactive retinal along with the first transmembrane helix, we unfolded bR in the presence of i

296 6 near the extracellular domain on the third transmembrane helix were found to be crucial for Br-PBTC

297 creases the probability of forming the 3(rd) transmembrane helix, which impairs the pore structure of

298 the linker region connecting the head to the transmembrane helix while still not disrupting the ACE2

299 label rigidly coupled to the backbone of the transmembrane helix, while SERCA was reacted with a Cys-

300 her characterize the interaction site of the transmembrane helix with MraY demonstrating E forms a st