ライフサイエンスコーパス: transmembrane region

1 rst transmembrane region) and Thr-338 (sixth transmembrane region).

2 d mctp (Multiple C2 Domain Proteins with Two Transmembrane Regions).

3 between the headpiece and the Ca(2+)-binding transmembrane region.

4 M-score of the I-TASSER models by 37% in the transmembrane region.

5 domains located in the N-terminus and 5(th) transmembrane region.

6 the residue at a single GluN2 site in the M3 transmembrane region.

7 critical arginine or lysine just before the transmembrane region.

8 a kinase domain, which are interconnected by transmembrane region.

9 -ms timescale conformational exchange in the transmembrane region.

10 iles for sodium and chloride ions inside the transmembrane region.

11 hare 40% sequence homology in the C-terminal transmembrane region.

12 on with 2 helices intertwined throughout the transmembrane region.

13 nel with a unique hydrophobic double-helical transmembrane region.

14 dissimilar, bind to the same site within the transmembrane region.

15 olated transmembrane helices of the targeted transmembrane region.

16 l cytoplasmic domains as well as the central transmembrane region.

17 hoice of costimulatory domains, or the hinge/transmembrane region.

18 protease domain and the C-terminal predicted transmembrane region.

19 distal segments of the Ca(2+)-ATPase (SERCA) transmembrane region.

20 nto the plasma membrane independent of their transmembrane region.

21 structural and functional constraints in the transmembrane region.

22 nd binds the extracellular face of the seven transmembrane region.

23 transcript lacking exon10, which encodes the transmembrane region.

24 h the sterol-sensing domain (SSD)-containing transmembrane region.

25 , inhibition in vivo requires the Kek1 juxta/transmembrane region.

26 pendently mediated by its cytosolic tail and transmembrane region.

27 secretases that cleave APP N-terminal to the transmembrane region.

28 in is much less conserved than the remaining transmembrane region.

29 nal flexibility within the carboxyl-terminal transmembrane region.

30 e extracellular ligand-binding domain to the transmembrane region.

31 ertebrate RyRs, including a highly conserved transmembrane region.

32 sence of a solvent-exposed cavity within its transmembrane region.

33 energy of the lipid-facing residues in their transmembrane regions.

34 s different YidC residues in four of the six transmembrane regions.

35 ttached complexes between the N terminus and transmembrane regions.

36 e into four-helix bundles, and often precede transmembrane regions.

37 of PfRh2a and PfRh2b, not the ectodomain or transmembrane regions.

38 rmini of short proteins containing predicted transmembrane regions.

39 ain leader sequences and putative C-terminal transmembrane regions.

40 s between the alpha and beta subunits in the transmembrane regions.

41 acids that are located adjacent to predicted transmembrane regions.

42 ease that cleaves its substrates along their transmembrane regions.

43 a protein containing multiple C2 domains and transmembrane regions.

44 s thought to be on the cis side of the known transmembrane regions.

45 ructure between the third and fourth helical transmembrane regions.

46 eptors, have identified binding sites in the transmembrane regions.

47 protein-coupled receptors (GPCRs) with seven transmembrane regions.

48 ein-cofactor interactions in the hydrophobic transmembrane regions.

49 helices and six of them form five potential transmembrane regions.

50 olymer through a channel formed by their own transmembrane regions.

51 rs share a conserved region composed of five transmembrane regions.

52 explanations, such as intrinsic disorder or transmembrane regions.

53 for E and were especially erroneous for the transmembrane regions.

54 ng subsites, receptor subunit interfaces, or transmembrane regions.

55 (hyg-B), (iv) amino acids 118-148 comprising transmembrane region 1 (TM1) of NS3 are critical for Gol

56 ) deletion of amino acids 156-181 comprising transmembrane region 2 (TM2) of NS3 has little to no aff

57 , binds in an extended vestibule formed from transmembrane regions 2 and 7 (TM2 and TM7) and extracel

58 e, because the highly conserved DRY motif in transmembrane region 3 has evolved into DRF.

59 tify key residues (Met(547) and Thr(550)) in transmembrane regions 3 and 4 (TM3/4) of rat and human T

60 e in the membrane-associated stretch between transmembrane regions 3 and 4 of the GlyR alpha3 subunit

61 We have studied how aspects of transmembrane region 5 (TM5) of the dopamine D(2L) recep

62 Selective targeting of CB(2)R transmembrane region 5 mimicked THC effects.

63 of beta-adrenoceptors highlight residues in transmembrane region 5 that initially bind specifically

64 E-Syts contain an N-terminal transmembrane region, a central juxtamembranous domain t

65 otetramer, with each monomer consisting of a transmembrane region, a stalk, and a globular head with

66 st of a periplasmic ligand-binding domain; a transmembrane region; a cytoplasmic HAMP (histidine kina

67 2 or 24 residues between the SNARE motif and transmembrane region abolished the ability of synaptobre

68 a-amyloid precursor protein (APP) within the transmembrane region, after prior processing by beta-sec

69 e coevolutionary signal was strongest in the transmembrane region, although the distances between coe

70 ean square deviation (RMSD) of 2.2 A for the transmembrane region and 5 A for the second extracellula

71 gella T3SS consists of a cytoplasmic bulb, a transmembrane region and a hollow 'needle' protruding fr

72 from other chemokines because it has both a transmembrane region and active, soluble chemokine forms

73 each protomer, namely one for protons in the transmembrane region and another for drugs in the peripl

74 Thus, the transmembrane region and cytoplasmic tail of TIM-4 are d

75 ncated version of glycoprotein B lacking the transmembrane region and endodomain [gBDeltaTM], phospho

76 The position of the transmembrane region and ensemble of membrane structures

77 by tight coupling of the SNARE motif to the transmembrane region and hence forcing the membranes int

78 at depleted of FKBP12.6, particularly in the transmembrane region and in the clamp structures.

79 OPA1) and short form (S-OPA1) that lacks the transmembrane region and is generated by cleavage of L-O

80 lated when it lacks its cytoplasmic tail and transmembrane region and is secreted from the cell.

81 studied a 38-residue M2 peptide spanning the transmembrane region and its C-terminal extension.

82 function is the binding of Cu(+) within the transmembrane region and its coupled translocation acros

83 ved glutamic acid (Glu-176) within the beta3 transmembrane region and its potential for functionally

84 ide insertion in exon 5 corresponding to the transmembrane region and no cytoplasmic tail, was increa

85 , four methionine pairs-three located in the transmembrane region and one in the periplasmic domain.

86 ds, that establishes the organization of the transmembrane region and proximal coiled coil of the com

87 the N terminus of the peptide to contact the transmembrane region and result in receptor activation.

88 oorly characterized neck region coupled to a transmembrane region and short intracellular tail.

89 due at the beta"+"-alpha"-" interface in the transmembrane region and the beta(Y143) residue near the

90 o lysosomes in liver and that the N-terminal transmembrane region and the C-terminal CBM20 domain are

91 hrough at least two independent domains, the transmembrane region and the CRAC activation domain (CAD

92 gest that other regions of gB, including the transmembrane region and the cytoplasmic domain, may be

93 These sites reside in the transmembrane region and tune the spectral sensitivity o

94 uitous synaptic vesicle protein, comprises a transmembrane region and two C2 domains.

95 ted to be a membrane-bound protein with nine transmembrane regions and conserved functional domains s

96 the kinase domain with the extracellular and transmembrane regions and is essential for EGFR activati

97 apping of cavities and ligand binding sites, transmembrane regions and protein domains.

98 The Pob protein contains putative transmembrane regions and protein-sorting signals.

99 chored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but n

100 The sequence and number of Ig domains, transmembrane regions and signaling motifs vary between

101 e that conserved charged residues within the transmembrane regions and the intravesicular glycosylati

102 rameters indicate that both the well-defined transmembrane regions and the less structured intramembr

103 mbrane-tethered AICD (i.e. AICD coupled to a transmembrane region) and not free AICD (i.e. soluble AI

104 ify cysteines substituted for Leu-102 (first transmembrane region) and Thr-338 (sixth transmembrane r

105 t of a putative N-terminal binding domain, a transmembrane region, and a C-terminal catalytic domain.

106 llular region containing three Ig modules, a transmembrane region, and a cytoplasmic region.

107 ion containing two sets of two Ig domains, a transmembrane region, and a previously unreported cytopl

108 signal sequence, an extracellular region, a transmembrane region, and a short conserved cytoplasmic

109 III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail.

110 ted between the fourth EF-hand and the first transmembrane region, and one C-terminal (PBR-C), betwee

111 S1R has a GXXXG motif in its second transmembrane region, and these motifs are often involve

112 tidomain extracellular N-terminal region, 11 transmembrane regions, and a short C-terminal region.

113 e N-terminal sequence, three C2 domains, two transmembrane regions, and a short C-terminal sequence.

114 e both cytosolic, implying an even number of transmembrane regions, and ferroportin was mainly locali

115 mino acids 82-87 in the putative cytoplasmic/transmembrane region appear to be critical for the oncog

116 ere, we find that nine of the putative inter-transmembrane regions are accessible from the extracellu

117 Several putative transmembrane regions are identified using hydrophobicit

118 creased interhelical packing interactions in transmembrane regions are promoted by increased receptor

119 nds in soluble proteins and membrane protein transmembrane regions are statistically identical.

120 operly folded ECD independent from the seven-transmembrane region as a thioredoxin fusion protein in

121 site for 24(S),25-epoxycholesterol in the 7-transmembrane region, as well as a G(i)-coupled activati

122 Following their release we propose that the transmembrane regions assemble into beta-hairpins via to

123 The S5-P linker was docked to the transmembrane region based on data from previous NMR and

124 Thus, the Hrd1p transmembrane region bears determinants of high specific

125 eviously unrecognized structural constraint: Transmembrane regions bury more residues than extramembr

126 ive drugs, XAP044 does not act via the seven-transmembrane region but rather via a binding pocket loc

127 ive protein-protein contacts within presumed transmembrane regions, but whether this is the case for

128 d extracellular (EC-II) loop closed over the transmembrane regions by making a disulfide linkage betw

129 es to a family of proteins that contain four-transmembrane regions, called tetraspanins.

130 due to either the translocated region or the transmembrane region can switch the insertion requiremen

131 and that the predicted ECSCR cytoplasmic and transmembrane regions can each confer association with K

132 ta suggest an extended binding pocket in the transmembrane regions close to the second extracellular

133 These data point to the predicted transmembrane region closest to the APOL1 C terminus as

134 plification with degenerated primers against transmembrane regions conserved in the GPCR superfamily.

135 a three-bladed propeller shape with a curved transmembrane region containing at least 26 transmembran

136 residue 238 in the D2 domain and 320 in the transmembrane region contribute to the difference in rec

137 rstood: How is the information sensed by the transmembrane region converted into a rearrangement in t

138 ng a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric

139 tic alanine replacement of putative loop and transmembrane region cysteine residues (Cys(4), Cys(81),

140 glucoside showed decreased alpha-helicity in transmembrane regions, decreased alpha-helical packing,

141 This prohibited NMD, and the lack of a transmembrane region (DeltaTM) prevented the formation o

142 e LRRs of Kek1 in conjunction with its juxta/transmembrane region direct association and inhibition o

143 The transmembrane region encapsulates a hydrophobic cavity,

144 Openings within the transmembrane region expose the pore to the lipid bilaye

145 ocated at positions 191 and 192 in the juxta-transmembrane region exposed to the cytoplasm.

146 on and a smaller cytosolic region, and has a transmembrane region formed by Emc4, Emc5 and Emc6 plus

147 e counterion one alpha-helical turn into the transmembrane region from the native position.

148 ent of gp120 (residues 252 to 482) linked to transmembrane regions from CD4 showed b12 binding compar

149 sidues at the luminal interface of the third transmembrane region function specifically in promoting

150 has a PAS domain, while CetA has a predicted transmembrane region, HAMP domain and the HCD.

151 re consistent with alternating access to the transmembrane regions, however with the open state facin

152 The contribution of transmembrane regions I, II, and III of the Rickettsia p

153 oop I with downstream signaling dependent on transmembrane region II.

154 Here we show that the first of the two transmembrane regions in human SAC1 (TM1) functions in G

155 Hence, each set of six transmembrane regions in Nav1.5 likely constitutes a Sig

156 actor receptor (NGFR, p75; extracellular and transmembrane regions) in a dominant manner.

157 king of the gating rings with respect to the transmembrane region, indicating symmetry breakage acros

158 The transmembrane region is a novel alpha-helical barrel.

159 proinflammatory mediators and show that the transmembrane region is critical for adhesion-GPCR funct

160 hilic residues, and peptide backbones in the transmembrane region is essential to restrain thermal is

161 US11 is modified with ubiquitin, whereas the transmembrane region is integrated in the ER membrane, a

162 ton-relay network of charged residues in the transmembrane region is linked to this tunnel supporting

163 racellular surface of the NBCe1-A C-terminal transmembrane region is minimally exposed to aqueous med

164 ) of RTNLB13, we show that the length of the transmembrane regions is directly correlated with the ab

165 Here, we show that the evolution of transmembrane regions is slowed by a previously unrecogn

166 of an ankyrin-repeat domain and a predicted transmembrane region, is a necessary positive regulator

167 s 20 to 38, which are upstream of a putative transmembrane region, is luminal.

168 epitope and "helix-breaking" residues in the transmembrane region just upstream of the peptide, indic

169 e show that cholesterol bound to the TCRbeta transmembrane region keeps the TCR in a resting, inactiv

170 evealed a hydrated pathway in the C-terminal transmembrane region leading from the ion-binding sites

171 ate recognition site and the fourth membrane transmembrane region (M4).

172 A coordinate root mean-square (CRMS) in the transmembrane region main-chain atoms.

173 GPI)-anchored molecule containing no peptide transmembrane regions, making it an attractive candidate

174 protein-protein interactions mediated by the transmembrane region may be required for YneA activity.

175 D values to the native of 2 A or less in the transmembrane regions) may be obtained for template sequ

176 d somatic mutations, commonly located in the transmembrane regions, may induce constitutive activatio

177 This suggests that one of the predicted transmembrane regions might be re-entrant.

178 ues, extracellular domain of 198 residues, a transmembrane region of 21 residues, and a cytoplasmic d

179 tosolic domain of a mammalian Kir3.1 and the transmembrane region of a prokaryotic KirBac1.3 (Kir3.1

180 of sildenafil within the large cavity of the transmembrane region of ABCB1.

181 her with a portal between two helices in the transmembrane region of ABCB10, assist transport substra

182 three inhibitor classes, suggesting that the transmembrane region of CCR5, a key interaction site for

183 cholesterol depletion and do not require the transmembrane region of CD47.

184 a highly conserved glutamate residue in the transmembrane region of E. coli TatC, which when modifie

185 rane domain of Emc4 tilts away from the main transmembrane region of EMC and is partially mobile.

186 The transmembrane region of FtsLB is stabilized by hydrophob

187 Chimaera containing the S1-S6 transmembrane region of HERG showed functional and pharm

188 Alanine substitution of residues in the transmembrane region of human T1R3 revealed 4 key residu

189 le depends on only a few residues within the transmembrane region of human T1R3.

190 rminal 21 amino acid residues and C-terminal transmembrane region of IFITM3 are required for its anti

191 also reveals structural peculiarities at the transmembrane region of IrtAB that result in a partially

192 Mutation F427I in the transmembrane region of JUNV envelope glycoprotein GP2 h

193 se results highlight the significance of the transmembrane region of Kit in activation of the molecul

194 gutless adenovirus vector revealed that the transmembrane region of m4/gp34 was required for efficie

195 r" triplet in the distal region of the third transmembrane region of most G-protein-coupled receptors

196 roduced cysteines clearly indicates that the transmembrane region of NBCe1-A contains 14 transmembran

197 Our findings suggest that the C-terminal transmembrane region of NBCe1-A is tightly folded with u

198 can calculate the folding free energy of the transmembrane region of outer membrane beta-barrel prote

199 bind to a hydrophobic pocket located in the transmembrane region of SERCA near the biomembrane surfa

200 The transmembrane region of TARM1 contained a conserved argi

201 tward-facing hydrophobic residues within the transmembrane region of the AT1R.

202 rs containing a point mutation in the second transmembrane region of the beta3 subunit (beta3N265M).

203 Subsequent gamma-secretase cleavage in the transmembrane region of the C-terminal fragment induces

204 tein that transforms cells by binding to the transmembrane region of the cellular platelet-derived gr

205 tial substrate-binding surface groove in the transmembrane region of the complex.

206 contributed to the density representing the transmembrane region of the complex.

207 ant MACV containing a single mutation in the transmembrane region of the glycoprotein.

208 y crystal and solution NMR structures of the transmembrane region of the M2 homo-tetrameric bundle bo

209 Models of the transmembrane region of the NaChBac channel were develop

210 rrected a previously identified error in the transmembrane region of the original cryo-electron micro

211 id bovine papillomavirus E5 protein bind the transmembrane region of the PDGF beta receptor tyrosine

212 as a probe for small molecule binding to the transmembrane region of the PPR, driven by the assumptio

213 The transmembrane region of the proteins is then surrounded

214 d, whose N terminus then penetrates into the transmembrane region of the receptor to initiate signali

215 ins non-covalently associated with the seven-transmembrane region of the receptor, as indicated by co

216 terally between helices I and VII within the transmembrane region of the receptor.

217 engage with TAK-013 upon its binding to the transmembrane region of the receptor.

218 of the membrane environment surrounding the transmembrane region of the receptor.

219 specific microdomain interactions within the transmembrane region of the receptor.

220 ther analysis showed that the C-terminal non-transmembrane region of the SKOR protein was required fo

221 substitution just outside the second helical transmembrane region of the SLC25A40 inner mitochondrial

222 multaneously altering the cytosolic tail and transmembrane region of the STcys isoform.

223 f the distribution of water molecules in the transmembrane region of these GPCR structures and find c

224 ut two chlorides and no cations bound in the transmembrane region of this anion-selective channel.

225 everal binding poses of FPR2 agonists in the transmembrane region of this receptor.

226 Moreover, replacement of the transmembrane region of TIM-4 with a glycophosphatidylin

227 he transmembrane region, suggesting that the transmembrane region of ZipA has little influence on the

228 olution suggests a mechanism for chaperoning transmembrane regions of a protein substrate during its

229 s to cysteines introduced into two different transmembrane regions of CFTR from both the intracellula

230 e have generated computational models of the transmembrane regions of different mGluR subtypes in two

231 Mutagenesis studies implicated the transmembrane regions of each protein as important for t

232 The amino acid sequences of transmembrane regions of helical membrane proteins are h

233 sitioned on the exoplasmic, cytoplasmic, and transmembrane regions of HRG-1-related proteins.

234 g, we identified numerous amino acids within transmembrane regions of ICMT that dramatically reduced

235 ntal tool to interrogate the conformation of transmembrane regions of integral membrane proteins.

236 suggesting that the Sig1R interacts with the transmembrane regions of its partners.

237 t domain recombination is not common for the transmembrane regions of membrane proteins, a majority o

238 ll as with truncations of the N-terminal and transmembrane regions of Pom152p.

239 boid-1 (PfROM1), a protease that cleaves the transmembrane regions of proteins involved in invasion.

240 us accessibility of Cys substitutions in the transmembrane regions of subunit c was probed by testing

241 We determined the structure of the transmembrane regions of the bacterial cyclic nucleotide

242 , as single amino acid changes in the second transmembrane regions of the chimera drastically reduced

243 SSP interacts with the membrane-proximal or transmembrane regions of the G2 fusion protein.

244 ic region of FCRL5 and the extracellular and transmembrane regions of the IgG Fc receptor FcgammaRIIB

245 eric proteins in which the extracellular and transmembrane regions of the MHC-I allele HLA-A2 were fu

246 s reveal two different conformers within the transmembrane regions of the protein in this activating

247 t cell biological features determined by the transmembrane regions of the proteins.

248 s support the idea that steroids bind in the transmembrane regions of the receptor.

249 but not identical amino acid residues in the transmembrane regions of the receptor.

250 s implies that the pore is formed by several transmembrane regions of the same ANX molecule.

251 e genomic RNA, and its interactions with the transmembrane regions of the surface proteins.

252 face of interaction is conserved between the transmembrane regions of the two proteins.

253 ium channels, we engineered chimeras wherein transmembrane regions of TRPV1 were transplanted into th

254 engineered mutations in the periplasmic and transmembrane regions of VirA on vir-inducing capacity a

255 In contrast, mutations altering the transmembrane region or conserved hydrophobic patches ca

256 that the J/K helices and the fourth membrane transmembrane region participate in transducing alloster

257 It comprises five putative transmembrane regions, predominantly resides in the endo

258 Multiple C2 domain and transmembrane region proteins (MCTPs) are evolutionarily

259 mber of the family of multiple C2 domain and transmembrane region proteins (MCTPs), to mediate FT tra

260 e now describe MCTPs (multiple C2 domain and transmembrane region proteins), a novel family of evolut

261 ferlins, and MCTPs (multiple C(2) domain and transmembrane region proteins).

262 al changes within the nucleotide-binding and transmembrane regions push conserved hydrophobic residue

263 ide-rich ligand-binding domains, yet lacks a transmembrane region separating the ligand-binding regio

264 (HMM) domains, protein family HMMs, motifs, transmembrane regions, signal peptides, hydropathy plots

265 In the transmembrane region, sites that coevolved according to

266 Via a putative transmembrane region, subunit C of NHE initiates binding

267 ing of the soluble form of ZipA, lacking the transmembrane region, suggesting that the transmembrane

268 have significant sequence homology in their transmembrane regions, suggesting a similar mode of bind

269 mical shift changes for many residues in the transmembrane region support an allosteric mechanism of

270 icted to dock to a binding pocket within the transmembrane region that includes these 4 key residues.

271 ns: the N-terminal extracellular region, the transmembrane region that spans the cell membrane once,

272 Probes placed sequentially throughout a transmembrane region that was identified by crosslinking

273 ins identified, is characterized by multiple transmembrane regions that exhibit homology to sugar tra

274 esidues out of 22, residing within prestin's transmembrane regions, that contribute to unitary charge

275 A recent mutagenesis study identified transmembrane region (TM)4 of the beta1-adrenoceptor as

276 the second, third, fourth, fifth, and sixth transmembrane regions (TM) of the hMC4R with the homolog

277 in RscS: two transmembrane helices forming a transmembrane region (TMR), a large periplasmic (PP) dom

278 d to a cysteine positioned at the end of the transmembrane region (TMR).

279 bly catalyzes membrane fusion by pulling the transmembrane regions (TMRs) of SNARE proteins together,

280 n membrane fusion have been proposed for the transmembrane regions (TMRs) of SNARE proteins, includin

281 Here we hypothesize a pivotal role for AQP4 transmembrane regions (TMs) in epitope assembly.

282 te and to an increased susceptibility of the transmembrane regions to disease-causing single-nucleoti

283 oops connecting the "A" domain to the ATPase transmembrane region undergo greater fluctuation than ex

284 monstrate that truncated syntaxins lacking a transmembrane region universally block exocytosis, but o

285 ly mild Cx26 mutations located at the second transmembrane region (V84L, V95M, and A88S) and a Cx30 m

286 The transmembrane region was modeled after the crystal struc

287 Similar asymmetry of the transmembrane region was observed in the AA simulations

288 -function studies of the Fo-sector, the Su e transmembrane region was structurally characterized in m

289 that these PAMs bind within the alpha7 nAChR transmembrane region, we generated and validated new str

290 re deleted or the sequence and length of the transmembrane region were altered.

291 taining a spin label in the cytosolic or the transmembrane region were tested.

292 Kv1.2/2.1 chimera in the S2-S3 linker and S3 transmembrane region, where the organization of secondar

293 MSL1 channel contains an unusual bowl-shaped transmembrane region, which is reminiscent of the evolut

294 sitioned at key locations within or near the transmembrane region, which requires desolvating charged

295 These proteins have a single transmembrane region with a putative Ca(2+) binding doma

296 TRC8 interacts through the transmembrane region with hERG and decreases hERG functi

297 an N-terminal alpha-helix that connects the transmembrane region with two C-terminal beta-domains.

298 hydrolysis within otherwise water-excluding transmembrane regions with purified proteins is a challe

299 the cytosolic domain of ATF6alpha to ABCD3's transmembrane regions without inhibiting or depending on

300 These regulators have homologous transmembrane regions, yet they differ in their cytoplas