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1 betaine is as an osmolyte and methyl donor (transmethylation).
2 roach to achieve transalkylation rather than transmethylation.
3 ilic substitution (SN2) transition state for transmethylation.
4 nly metahydroxyl groups to be positioned for transmethylation.
5 he intermediates of phosphatidylethanolamine transmethylation.
6 t this mutation affects the chemical step of transmethylation.
7 n, as a key direct target of METTL3-mediated transmethylation.
8 Despite the presence of motifs essential for transmethylation activity, catalytic activity of DNMT2 h
11 their common S-adenosylmethionine-dependent transmethylation and has implications for human MTHFD1-a
12 e N-methyltransferase regulates flux through transmethylation and hence the S-adenosylmethionine/S-ad
13 We aimed to measure methionine flux, its transmethylation and its transsulfuration, and homocyste
16 is study, we observed broad dysregulation of transmethylation and polyamine synthesis/catabolism, inc
18 centrations of metabolites in the methionine transmethylation and transsulfuration pathways in childr
19 thylation or methionine transsulfuration and transmethylation between the groups at clinical phase 1.
20 o catalyze S-adenosyl-L-methionine-dependent transmethylation by UPM1 in a multistep process involvin
23 analyzing the transcripts and activities of transmethylation enzymes in the livers of the same micro
24 raised about labile methyl balance and total transmethylation fluxes, and further discussion has been
25 onstrating the necessity of pcMTase-mediated transmethylation for steroid induced Na(+) reabsorption.
27 r, despite considerable effort in the 1980s, transmethylation has never been established as a compone
29 hionine and its rate of transsulfuration and transmethylation in healthy women with advancing gestati
30 definitive measurements of the rate of total transmethylation in humans of both sexes on various diet
31 pathways for S-adenosylmethionine-dependent transmethylation in mammals are the syntheses of creatin
38 The significant improvements observed in transmethylation metabolites and glutathione redox statu
39 ify this methodology by means of a one-stage transmethylation method and a fast GC run, evaluating th
40 enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), which regu
41 ial diet for 18 weeks and then switched to a transmethylation micronutrient-supplemented (MS) or -res
43 zes the S-adenosylmethionine (SAM)-dependent transmethylation of 6-TPs and shares 45% similarity (33%
44 ent O-methyltransferases (OMTs) catalyze the transmethylation of a variety of phenolics in bacteria,
45 e deregulated MTHFR cells undergo continuous transmethylation of homocysteine by methyltetrahydrofola
46 e in the methionine cycle that catalyzes the transmethylation of homocysteine to methionine in a coba
52 hilic nature of S-adenosyl-l-methionine, the transmethylation of the demethylated precursor of vitami
54 tiation and nephrogenesis, whereas enhancing transmethylation or increasing METTL3 activity facilitat
56 that methionine transamination, and not the transmethylation or transsulfuration pathways, contribut
58 xogenous adenosine reduces activation of the transmethylation pathway and attenuates the endothelial
59 rther show that the up-regulation of the SAM transmethylation pathway and the efficiency of the immun
60 lux of homocysteine through the MS-dependent transmethylation pathway in HepG2 and 293 cells, respect
62 dings reveal a modifiable methionine-SAM-RNA transmethylation pathway that can be targeted to enhance
63 ine in endothelial cells, and activating the transmethylation pathway through increasing the associat
65 hylation potential and increased flux in the transmethylation pathways, increased demand on antioxida
66 rwardly and quickly way by using a one-stage transmethylation procedure followed by a fast GC-FID run
67 S-adenosyl-L-homocysteine (AdoHcy/SAH), the transmethylation product of AdoMet-dependent methyltrans
68 nd the protein catalyzed a methyl iodide:CoM transmethylation reaction at a rate of 2.3 micromol/min/
71 enosylmethionine (AdoMet), a key molecule in transmethylation reactions and polyamine biosynthesis.
73 onine and ATP, is the major methyl donor for transmethylation reactions and propylamino donor for the
75 mpairment because of its requirement for two transmethylation reactions that can both be inhibited by
77 r SAH), a common product of AdoMet-dependent transmethylation reactions, is first hydrolyzed by recom
78 ble for purine and thymidylate synthesis and transmethylation reactions, plays a critical role in emb
79 it is needed to metabolize the by-product of transmethylation reactions, S-adenosylhomocysteine (AdoH
81 hibition of purine and pyrimidine synthesis, transmethylation reactions, translocation of nuclear fac
87 rs to be established, but several aspects of transmethylation remain uncertain: definitive measuremen
88 that S-adenosylmethionine (SAM) and cellular transmethylation status are crucial determinants of the
89 Here we provide the first evidence that the transmethylation step of the SDPM pathway occurs in the
90 studies provide the first evidence that the transmethylation step of the SDPM pathway of P. falcipar
92 PET) and indicated that the contribution of transmethylation to total hind limb methionine utilizati
93 centrations by altering its flux through the transmethylation, transsulfuration, and transamination m
94 acid, would improve plasma concentrations of transmethylation/transsulfuration metabolites and glutat
96 etabolism is homocysteine, which can undergo transmethylation via methionine synthase (MS) or transsu
97 ing the first trimester, whereas the rate of transmethylation was higher during the third trimester.