ライフサイエンスコーパス: transmigration

1 otypic transformation during cerebrovascular transmigration).

2 NPs does not alter neutrophil activation and transmigration.

3 lling endothelial permeability and leukocyte transmigration.

4 's role as a negative regulator of leukocyte transmigration.

5 ediated neutrophil crawling and paracellular transmigration.

6 n was a critical prerequisite for successful transmigration.

7 brain endothelial cells inhibited leukocyte transmigration.

8 required for this crucial step in neutrophil transmigration.

9 sses, including cell adhesion, polarity, and transmigration.

10 thelial adhesion, intravascular crawling and transmigration.

11 r bounds of constriction size for successful transmigration.

12 odulators of nuclear deformation during cell transmigration.

13 on the contribution of endothelial cells to transmigration.

14 Swollen conidia did not expedite epithelial transmigration.

15 and myelin-reactive T-cells prevented T-cell transmigration.

16 tion was required for GM-CSF priming-induced transmigration.

17 nd thereby facilitate leukocyte adhesion and transmigration.

18 ) mice displayed a 40% decrease in leukocyte transmigration.

19 ophages, which leads to decreased neutrophil transmigration.

20 generation, reduction in R(T), and bacterial transmigration.

21 delta decreased IL-1beta-mediated neutrophil transmigration.

22 ascular endothelium and unchecked neutrophil transmigration.

23 uent crawling on the endothelium to sites of transmigration.

24 mportant for several steps in the process of transmigration.

25 than CDCs, reproduced this robust neutrophil transmigration.

26 ong the vascular wall to permissive sites of transmigration.

27 ccelerated as a result of increased cellular transmigration.

28 thelial barriers as well as their subsequent transmigration.

29 VE-cadherin, thereby facilitating efficient transmigration.

30 to support leukocyte rolling, adhesion, and transmigration.

31 th docking structure formation and leukocyte transmigration.

32 ations of BV-associated MMPs increased viral transmigration.

33 forming gaps in the endothelium to initiate transmigration.

34 tes plays a prominent role in efficient cell transmigration.

35 fluid homeostasis and normalizing leukocyte transmigration.

36 R-alpha to prompt neutrophil arrest and then transmigration.

37 PC contractility and facilitating neutrophil transmigration.

38 h decreased lactate secretion and macrophage transmigration.

39 th a CB(2) agonist blocked their endothelial transmigration.

40 alpha4-integrin-mediated T cell adhesion and transmigration.

41 ion, aberrant crawling, and strongly reduced transmigration.

42 al cells and in vivo neutrophil adhesion and transmigration.

43 ce of the blood-brain barrier to immune cell transmigration.

44 traction and enhance PC-regulated neutrophil transmigration.

45 expression and were required for lymphocyte transmigration.

46 o endothelial cells but inhibited neutrophil transmigration.

47 g of gaps before the initiation of leukocyte transmigration.

48 , but TspanC8s remain unstudied in leukocyte transmigration.

49 bose polymerase in ECs of mice prevented PMN transmigration.

50 confirm a role for CD13 in impaired MO-MDSC transmigration.

51 endothelial adhesion molecules and leukocyte transmigration.

52 dherin expression and promoting T lymphocyte transmigration.

53 with wild-type PMNs and failed to induce PMN transmigration.

54 adhesion (66.1 vs. 23.7% of input cells) and transmigration (35.1 vs. 7.20% of input cells) than did

55 C/PC bilayers support intermediate levels of transmigration (37.7%).

56 l binding (54.6% vs. 7.1%, respectively) and transmigration (63.7 vs. 8.8%, respectively) despite com

57 esion with ~25% of these cells proceeding to transmigration, a process dependent on CCR4.

58 pro-inflammatory gene products and enhanced transmigration across a blood-brain barrier model.

59 his induction is instrumental for neutrophil transmigration across an activated endothelium and for i

60 Finally, ART facilitated PBMC transmigration across an in vitro blood-brain barrier mo

61 eading to CAR phosphorylation and subsequent transmigration across cell junctions.

62 ted paracellular permeability and tumor cell transmigration across EC barriers.

63 ial cells, but profoundly inhibited monocyte transmigration across endothelial barriers.

64 mote myeloid and plasmacytoid dendritic cell transmigration across endothelial cell monolayers throug

65 o disrupted adhesion of myeloid cells to and transmigration across endothelial monolayers in vitro an

66 Neutrophil transmigration across HEVs is faster than across convent

67 asement membrane, and facilitates spirochete transmigration across host endothelial cell barriers.

68 l peptide cryptdin-4 but decreases bacterial transmigration across intestinal epithelial cells, colon

69 s further validated for studying cancer cell transmigration across lymphatic endothelium.

70 tor, CLEC12A, in facilitating DC binding and transmigration across the BBB in response to CCL2 chemot

71 models, however, some mechanistic aspects of transmigration across the BBB still remain largely unkno

72 99 (expressed on all 3 cell types) inhibited transmigration across the composites (14.5% of control)

73 f control), and venular shear stress reduced transmigration across the ECs (17.3% of static) more tha

74 whereas TNF-alpha-activated PC-CM decreased transmigration across the ECs, and culturing on PC-deriv

75 PC-derived BM decreased both adhesion to and transmigration across the ECs.

76 CD95L promoted T helper 17 (Th17) lymphocyte transmigration across the endothelial barrier at the exp

77 Monocyte rolling, adhesion, and transmigration across the endothelium are mediated by sp

78 that CX3CR1 is critical for Ly6Clo monocyte transmigration across the endothelium in murine CRC tumo

79 previously shown to be involved in leukocyte transmigration across the endothelium.

80 d produce this cytokine as a result of their transmigration across the inflamed blood-spinal cord bar

81 tivated EC-conditioned medium (CM) increased transmigration across the PCs, whereas TNF-alpha-activat

82 t role in polymorphonuclear neutrophil (PMN) transmigration across tissue cells and extracellular mat

83 ared with WT, showed defects in adhesion and transmigration across tumor necrosis factor-alpha (TNF-a

84 Leukocyte transmigration across vessel walls is a critical step in

85 omes significantly stimulated proliferation, transmigration and 3D-invasion of primary normal and tum

86 ession and contribute to monocyte/macrophage transmigration and adhesion, we isolated Exos from monoc

87 Neutrophil transmigration and airway infiltration were all but lost

88 trating CID peptide that prevented Th17 cell transmigration and alleviated clinical symptoms in lupus

89 lphai2 controls arrest and Galphai3 controls transmigration and chemotaxis in response to chemokine s

90 us 15d-PGJ(2) significantly reduced monocyte transmigration and exerted a pronounced anti-inflammator

91 ul means of directly inactivating neutrophil transmigration and hence mitigating vascular inflammatio

92 n the current study, the role of CD47 in PMN transmigration and infiltration into tissues was further

93 cellular level in order to predict leukocyte transmigration and plaque evolution.

94 ing host tissues, dysregulated/excessive PMN transmigration and resultant bystander-tissue damage are

95 y HUVECs as well as directing their cellular transmigration and spreading through transwell filters.

96 rin that promotes fibrin-dependent leukocyte transmigration and thereby inflammation.

97 te adhesive properties and enhances monocyte transmigration and viral dissemination to neural cells.

98 esion in vivo; however, neutrophil crawling, transmigration, and chemotaxis were reduced in these mic

99 iple steps of the cascade, including arrest, transmigration, and chemotaxis.

100 n implicated in the regulation of neutrophil transmigration, and previous work demonstrates that endo

101 Functional assays (killing, phagocytosis, transmigration, and respiratory burst) were used to asse

102 lular domain of endoglin, enhanced leukocyte transmigration, and this increased motility was inhibite

103 Leukocyte adhesion, crawling, and transmigration are regulated by clustering of the endoth

104 ansmitted variants also did not have greater transmigration as compared to chronic-infection strains.

105 n strengthening, intravascular crawling, and transmigration, as each step necessitates the proper fun

106 hemotaxis assays and flow-based adhesion and transmigration assays.

107 solution not easily achieved in conventional transmigration assays.

108 were investigated by using flow chamber and transmigration assays.

109 diated by reverse migration from tissues and transmigration back into the vasculature.

110 ng vascular leakage or transendothelial cell transmigration being altered in denervated limbs.

111 se in T lymphocyte adhesion and consequently transmigration both in static and under flow conditions.

112 e endothelin-1 and a reduction in neutrophil transmigration, both known to be microtubule dependent.

113 alphai3-deficient neutrophils showed reduced transmigration but normal arrest in mice.

114 ted endothelial polymorphonuclear neutrophil transmigration, but not chemotaxis, is enhanced versus r

115 ICAM-1 was not required for local neutrophil transmigration, but supported optimal intravascular and

116 endothelial cell (EC) is known to facilitate transmigration, but the cellular and molecular mechanism

117 -phosphate (S1P), which promoted endothelial transmigration by activating the S1P receptor 3.

118 y regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interacti

119 decreases the PC barrier to human neutrophil transmigration by increasing intercellular PC gap format

120 ular scissor that is implicated in leukocyte transmigration by proteolytically cleaving its endotheli

121 ether these data show that Treg adhesion and transmigration can be driven by different molecular mech

122 Their CNS transmigration capacity was confirmed using brain endoth

123 riod of 4 days was required before bacterial transmigration commenced.

124 functions, including decreasing Ly6G(+) cell transmigration, delaying migration, and relieving suppre

125 Inflammation is driven by excessive transmigration (diapedesis) of leukocytes from the blood

126 hat are thought to mediate basement membrane transmigration during development and tumor disseminatio

127 Basement membrane transmigration during embryonal development, tissue home

128 on is a key step for leukocytes adhesion and transmigration during leukocytes' inflammatory infiltrat

129 To begin transmigration, ECs deploy actin-based membrane protrusi

130 cal event determining the mode of neutrophil transmigration, either at the EC junction (paracellular)

131 prolidase reduced cocaine-mediated monocyte transmigration, establishing a key role of prolidase in

132 ethasone and bevacizumab inhibited leukocyte transmigration from angiogenic vessels; however, dexamet

133 o technique for visualization of immune cell transmigration from corneal vessels toward implanted cyt

134 lts detail the metabolism of macrophages for transmigration from perivascular cuffs into the CNS pare

135 l adhesion under shear stress conditions and transmigration in a ChemR23-dependent manner.

136 nd CXCR2-dependent neutrophil but not T cell transmigration in a parallel-plate flow chamber system.

137 present a case report of a mandibular canine transmigration in a patient aged 12.

138 interaction was affirmed by lower macrophage transmigration in culture using the MCT-4 inhibitor, alp

139 rved irreversible nuclear deformations after transmigration in lamin-A/C-deficient cells, whereas the

140 live imaging of immune cell trafficking and transmigration in meningeal lymphatics.

141 METHODS AND We observed defective PMN transmigration in response to lipopolysaccharide challen

142 ZAP-70 gene-deficient mice exhibited ablated transmigration in response to MIF or CXCL12.

143 CL12/CXCR4 and CCL19/CCR7 enhanced fibrocyte transmigration in the Asthma AE group and in patients wi

144 icient mice, reduced neutrophil adhesion and transmigration in the TNF-alpha-inflamed cremaster muscl

145 efficient extravasation of TRCs in vivo and transmigration in vitro are determined by TRC deformabil

146 PMN basolateral-to-apical transmigration in vitro significantly increased apical-t

147 ly unknown roles for pericytes in neutrophil transmigration in vivo and add additional steps to the l

148 nd led to a functional increase in leukocyte transmigration in vivo and CXCR2-dependent neutrophil bu

149 microscopy, we show how pericytes facilitate transmigration in vivo.

150 ctor (VWF) resulted in vascular leaks during transmigration, indicating that platelets interacting wi

151 24 h, Tregs adhered but no longer underwent transmigration, instead remaining in prolonged contact w

152 changes consistent with greater immune cell transmigration into brain via increased ICAM1, which cou

153 However, the regulatory mechanisms of transmigration into infected tissue are not yet complete

154 al, whereas, in contrast, integrin-dependent transmigration into the alveolar space was impaired.

155 ation of alveolar macrophage precursors: (1) transmigration into the alveoli, and (2) engraftment in

156 buprenorphine limits CCL2-mediated monocyte transmigration into the CNS, thereby reducing neuroinfla

157 hil recruitment was impaired in fMLP-induced transmigration into the cremaster muscle, thioglycollate

158 othelium, endothelial activation, and T-cell transmigration into the perivascular space, where (ii) b

159 Transmigration is a phenomenon of movement of an unerupt

160 The next step in transmigration is creation of a migratory pore, and we f

161 Transmigration is more prevalent in females than in male

162 these underlying mechanisms of T lymphocyte transmigration is of great value to develop new strategi

163 r antigenic inflammation, basophils initiate transmigration like other granulocytes but, upon activat

164 Monocyte transmigration may represent an important mechanism requ

165 timulus-dependent; PKCdelta was required for transmigration mediated by IL-1beta and fMLP (integrin-d

166 junction disassembly, and blood endothelial transmigration, MMP16 supported nodular-type growth of a

167 Use of a novel transmigration model recapitulates this pathological phe

168 ng neutrophil migration, we used an in vitro transmigration model with human pulmonary microvascular

169 in the CNS, where inflammation and leukocyte transmigration must be tightly regulated.

170 Although transmigration of activated encephalitogenic T cells acr

171 mRNA expression of these markers, suggesting transmigration of activated neutrophils into the brain.

172 for the treatment of cancer, suppresses the transmigration of activated T cells through an inflamed

173 The adhesion and transmigration of antigen-nonspecific (bystander) effect

174 Increased transmigration of Arhgap25-deficient leukocytes is demon

175 ferentially migrate during wound healing and transmigration of cancer cells.

176 ing to direct cytoskeletal rearrangement for transmigration of cancer cells.

177 with human CCL17 significantly increased the transmigration of CCR4+ huTreg under physiological shear

178 in and bryostatin-1 also affect adhesion and transmigration of CD4(+) and CD8(+) T cells as well as m

179 MCAM blockade restricts the transmigration of CD8(+) T lymphocytes across human bloo

180 Transmigration of cell-free and cell-associated HIV acro

181 Here, we show that chitosan facilitates transmigration of DCs across the vaginal epithelium in t

182 n a more efficient manner chemerin-dependent transmigration of dendritic cells.

183 abilization of the BBB, thus suppressing the transmigration of encephalitogenic T cells.

184 MK hyperpolarization triggers GPIb-dependent transmigration of entire MKs into BM sinusoids.

185 ckdown on primary HUVECs was found to impair transmigration of freshly isolated human peripheral bloo

186 a definitive role for endothelial ADAM10 in transmigration of freshly isolated primary leukocytes un

187 initial chemotactic gradient that guides the transmigration of hematogenous immune cells into the inj

188 a role for Notch signaling in GM-CSF-primed transmigration of human blood eosinophils in vitro and i

189 Transmigration of human dendritic cells across retinal e

190 is required to promote the early epithelial transmigration of human neutrophils into the airspace in

191 reduce the leakage of dyes and to block the transmigration of immune cells towards chemoattractants.

192 isease is influenced by the infiltration and transmigration of inflammatory cells across the endothel

193 D88-mediated signalling is essential for the transmigration of inflammatory monocytes from the blood

194 This results in inadequate transmigration of Itk(-/-) CD4(+) T cells into the CNS a

195 ricted to the fibrotic niche and enhance the transmigration of leucocytes.

196 ges in cellular or humoral immunity, reduced transmigration of leukocytes into neural tissue, or redu

197 with junctional proteins associated with the transmigration of leukocytes.

198 Here, we explore the genes that control the transmigration of metastatic cancer cells across the BBB

199 n WT and Myh9(-/-) mice, indicates increased transmigration of MKs from the BM.

200 urface has been implicated in enhancement of transmigration of monocytes across the brain blood barri

201 stranded RNA and LL-37 promoted adhesion and transmigration of monocytes across the endothelial cell

202 This results in greater adhesion and transmigration of monocytes across the endothelium.

203 e tethering, mechanical factors important in transmigration of monocytes through the BBB.

204 e, the initial mechanical step governing the transmigration of monocytes.

205 Finally, cocaine treatment increased transmigration of monocytic cells through the HBMEC barr

206 cose-treated proximal tubule cells to induce transmigration of mononuclear cells.

207 ng domain of PECAM-1 significantly inhibited transmigration of NB1-positive neutrophils through IL-1b

208 we determined that PR3 activity facilitated transmigration of NB1-positive neutrophils under both st

209 tively inhibits chemokine-induced arrest and transmigration of neutrophils by inhibition of protein k

210 /TTC haplotype cells significantly increased transmigration of neutrophils confirming the functional

211 scular adherence and subsequent paracellular transmigration of neutrophils elicited by the chemokine

212 s was paralleled by diminishing the adhesion/transmigration of neutrophils in kidneys and liver after

213 ar adenosine levels in vitro, diminished the transmigration of neutrophils, and improved the epitheli

214 and interfering with LBRC trafficking blocks transmigration of neutrophils, monocytes, and lymphocyte

215 conidial cell wall amplified the epithelial transmigration of neutrophils, using primary human airwa

216 mmatory response and, as such, modulates the transmigration of neutrophils.

217 antly reduces intravascular accumulation and transmigration of neutrophils.

218 he regulation of intravascular adherence and transmigration of neutrophils.

219 ted intravascular adherence and paracellular transmigration of neutrophils.

220 TgWIP enhances the motility and transmigration of parasitized dendritic cells, likely ex

221 Thus, endotoxin-induced transmigration of PMNs was secondary to TRPM2-activated

222 l, we used a trans-well assay to measure the transmigration of primary neutrophils incubated with sup

223 Transmigration of purified lymphocytes was dependent on

224 Transmigration of T lymphocytes is highly dependent on a

225 ions CXCL12-induced crawling and endothelial transmigration of Th1 cells was desensitized by CXCL9.

226 y, we showed that BBB disruption accelerates transmigration of the neurotropic fungus Cryptococcus ne

227 ients treated with natalizumab revealed that transmigration of this subset depends on the alpha4beta1

228 vital microscopy to investigate adhesion and transmigration of Tregs in the dermal microvasculature i

229 ting the endocervical epithelium, permitting transmigration of virus through the epithelium to infect

230 BVAB CM and MMPs significantly increased the transmigration of virus through the epithelium, and trea

231 n of endothelial Galpha(i2) caused decreased transmigration of wild-type neutrophils.

232 howed PF-271 reduced monocyte attachment and transmigration on HAoECs.

233 ation by abrogating endothelial adhesion and transmigration; paradoxically, it also promoted plaque i

234 uman ECs to FSS effectively reduced monocyte transmigration particularly through monolayers of CC-gen

235 all neutrophil functions including adhesion, transmigration, phagocytosis, degranulation, and neutrop

236 in renal carcinomas, in which, after nuclear transmigration, PKCalpha binds directly to pri-miRNA 15a

237 g of interferon-gamma (IFNgamma) reduced the transmigration potential and antigen-presenting function

238 Paracellular transmigration predominates (>/=90% of events) in the cr

239 rstanding of the mechanism of the neutrophil transmigration process.

240 -mediated stimulation of in vitro tumor cell transmigration, proliferation, and migration and in vivo

241 This impairment was due to delayed transmigration rather than a complete block, and was ove

242 incorporation of ECM exclusively within the transmigration regions.

243 ated adhesion to prevent excessive leukocyte transmigration remain unknown.

244 Subsequent lymphocyte arrest and transmigration require activation through binding of HEV

245 that cryptococcal association, invasion, and transmigration require host actin cytoskeleton rearrange

246 ls from Cxcr7(-/-) mice exhibited an ablated transmigration response to MIF, indicating that CXCR7 is

247 for the transcellular over the paracellular transmigration route.

248 Moreover, in vitro transmigration studies reveal that IL-15 selectively att

249 t experimental data suggest that during cell transmigration the deformability of the nucleus could be

250 its barrier function, and promoting monocyte transmigration; these effects were reversed by T770A/T77

251 -dimensional migration through Matrigel, and transmigration through an endothelial cell monolayer of

252 etain important cellular functions including transmigration through an endothelial monolayer and diff

253 e production as well as decreases neutrophil transmigration through aortic endothelial cells.

254 most neurologic adverse events, (ii) T-cell transmigration through brain microvascular endothelium,

255 Leukocyte transmigration through cell monolayers of endoglin trans

256 oward monocyte chemoattractant protein-1 and transmigration through collagen.

257 When we examined the effect of CVF on HIV-1 transmigration through endocervical epithelium, we demon

258 arrest and significantly impaired neutrophil transmigration through endothelial cells by inhibition o

259 X11(+) MCL cells have higher cell migration, transmigration through endothelial cells, adhesion to st

260 ng important cellular processes such as cell transmigration through extracellular matrix and endothel

261 dhesion molecule E-Selectin production, (ii) transmigration through HUVEC monolayer by stabilizing en

262 ssion of CD44 limited T-cell adhesion to and transmigration through murine endothelial monolayers in

263 il adhesion to (41.4%), it does not increase transmigration through PC monolayers.

264 to the underlying biophysical factors during transmigration through small constrictions is still lack

265 e and for nuclear plastic deformation during transmigration through small constrictions.

266 neural inflammation by supporting leukocyte transmigration through the blood-brain barrier and, ther

267 awling on the surface of the endothelium and transmigration through the endothelial layer.

268 udes cell rolling, activation, adhesion, and transmigration through the endothelium commonly referred

269 lial cell adhesion molecule E-selectin, (ii) transmigration through TNF-alpha-activated confluent HUV

270 ion disrupted T cell and DC localization and transmigration through tolerant LNs.

271 ow production, release into the circulation, transmigration to and activation in peripheral tissues,

272 LAIV increased bacterial transmigration to and persistence within the middle ear.

273 more, C5a significantly decreased neutrophil transmigration to IL-8, but did not affect respiratory b

274 us and bacteria, LAIV may increase bacterial transmigration to the middle ear and could thus increase

275 s, constitute barriers regulating leukocytes transmigration to the site of inflammation.

276 and they become activated during endothelial transmigration toward the inflammatory site.

277 al pneumonia, whether it may alter bacterial transmigration toward the middle ear, where it could hav

278 iment, but slightly enhanced response to and transmigration toward, the chemoattractant fMLF.

279 rved that IC-activated neutrophils underwent transmigration, triggered further IC formation, and tran

280 al ligands induced proliferation, migration, transmigration, tube formation of HIMEC, vessel sproutin

281 and NOD2, and cell proliferation, migration, transmigration, tube formation, and production of pro-an

282 tional increase in T cell but not neutrophil transmigration under laminar shear flow.

283 ediates leukocyte slow rolling, adhesion and transmigration upon binding of CD95-ligand (CD95L) that

284 on with the extracellular matrix, it reduced transmigration velocity.

285 ly enhanced leukocyte rolling, adhesion, and transmigration via localized dissociation to mCRP in inf

286 igration was restored, although in this case transmigration was CCR4 independent, instead involving t

287 Consequently, leukocyte transmigration was inhibited after 6-MP/6-T-GTP treatmen

288 Although PMN transmigration was not delayed in CD47(-/-) mice, fewer

289 Four hours after a second challenge, Treg transmigration was restored, although in this case trans

290 To study the role of endothelial ASM in transmigration, we generated brain endothelial cells lac

291 slow rolling, chemokine-induced arrest, and transmigration were investigated by using flow chamber a

292 d that CXCL1-induced neutrophil adhesion and transmigration were reduced in the absence of CD37, cons

293 reased on NB1-positive neutrophils following transmigration, whereas neutrophils lacking NB1 demonstr

294 s in periodontitis is regulated by leukocyte transmigration, whereas the neutrophilic antimicrobial p

295 role for CtsB in leukocyte extravasation and transmigration, which advances our understanding of the

296 endothelial venules (HEVs) permit lymphocyte transmigration while maintaining vascular integrity is u

297 Promoting epithelial transmigration with Aspergillus required prolonged expos

298 report that CD99 is critical for lymphocyte transmigration without affecting adhesion in a human blo

299 sporter activity, plasma membrane, leukocyte transmigration, Wnt signaling pathways and angiogenesis.

300 ow S1P concentrations near exit sites before transmigration, yet S1PR1 signaling is rapidly terminate