ライフサイエンスコーパス: transmural

1 V:apico-basal, LV:anterior-posterior, and LV:transmural.

2 nd confined to the lamina propria, and 1 was transmural.

3 ; LV:anterior-posterior, 51+/-27 ms; mean LV:transmural, 14+/-7 ms; all n=9).

4 0.5+/-1.4 mm, P<0.001) and more likely to be transmural (80% versus 0%, P=0.002).

5 g (RT-MRI) system, leading to a complete and transmural ablation in the atrium.

6 We determined transmural action potential duration (APD) before and af

7 ential duration resulting in the decrease of transmural action potential duration dispersion (64 +/-

8 Initial post-shock transmural activation occurred at a later time in the in

9 in LV site selection and yield more natural transmural activation patterns.

10 In the failing hearts, transmural activation was significantly slowed from the

11 occurred in 5.2+/-1.9 ms, suggesting direct transmural activation.

12 suggestive of independent rather than direct transmural activation.

13 s MRI as an excellent tool in characterizing transmural and extraluminal changes of Crohn's disease.

14 The SERF catheter created more transmural and larger ablative lesions in both normal an

15 tion of APD, which significantly reduces the transmural and local APD gradients.

16 Furthermore, both transmural and luminal flow induced expression of matrix

17 tic with thin rims, and were associated with transmural (and often more extensive) myocardial scarrin

18 Current energies used to create contiguous, transmural, and durable atrial lesions can result in ser

19 he patients, the epicardial lesions were not transmural, and endocardial touch-up was necessary.

20 endocardial than epicardial cells, reducing transmural APD dispersion consistent with experimental d

21 breviate rat ventricular APD and ERP, reduce transmural APD dispersion, but augment transmural ERP di

22 first time direct experimental evidence of a transmural APD gradient in the human heart.

23 he nonfailing hearts we observed significant transmural APD gradient: subepicardial, midmyocardial, a

24 subendocardium, respectively, while reducing transmural APD80 difference from 111+/-13 to 29+/-6 ms (

25 The scar pattern is particularly dense and transmural as compared with the more erratic/patchy scar

26 to 0.43 (AL) and 0.39 to 0.40 (ATTR) and to transmural at 0.48 to 0.55 (AL) and 0.47 to 0.59 (ATTR).

27 describes long-term lead performance using a transmural atrial (epicardial to endocardial) pacing app

28 For transmural atrial (TMA) lead access, a bipolar, steroid-

29 cle of normal canines in vivo (n = 14) using transmural bead markers under biplane cineradiography.

30 Transmural beadsets were inserted into the lateral and a

31 l for the possibility of generating either a transmural block or a transmural reentry.

32 The model predictions of transmural circumferential and compressive radial stress

33 A distinct transmural circumferential strain gradient was observed

34 Transmural circumferential, longitudinal, and radial sys

35 Additionally, the transmural conduction of excitation waves in 1-dimension

36 n (EED) of electric activations resulting in transmural conduction of fibrillation waves (breakthroug

37 cardiomyopathy, VT and septal scar, delayed transmural conduction time (>40 ms) and fractionated, la

38 rements of the conduction anisotropy and the transmural conduction time in pig ventricles.

39 434; P<0.001) in all hearts, and reduced the transmural conduction velocity from 36 cm/s (95% CI, 30-

40 breakthrough and to test the plausibility of transmural conduction versus ectopic focal discharges as

41 ost of the breakthroughs can be explained by transmural conduction, whereas ectopic focal discharges

42 kthroughs (86%; n=564) could be explained by transmural conduction, whereas only 13% (n=85) could be

43 allowed transformation of these strains into transmural contributions of sheet extension, thickening,

44 s was defined as grade 3b injuries; signs of transmural CT necrosis included absence of postcontrast

45 of images were acquired, with and without a transmural defect (TD).

46 erved VT termination is due to ChR2-mediated transmural depolarization of the myocardium, which cause

47 th zotarolimus concentration decreasing with transmural depth as opposed to the multiple peaks displa

48 tolic fiber shortening was identical at each transmural depth in both the anterior and lateral LV sit

49 tolic fiber shortening was identical at each transmural depth in these regions.

50 particular, beta2-stimulation increases the transmural difference between [Ca(2+)]i transients durat

51 These data show that transmural differences in MHC isoform expression contrib

52 To assess the functional consequences of transmural differences in myofilament protein expression

53 These transmural differences were diminished in Hey2(+/-) mice

54 Simulations coupling transmural diffusion and reversible binding to tissue pr

55 ntal sleeve resection to ensure clearance of transmural disease.

56 electrical repolarization in vivo, there is transmural dispersion of myofiber relaxation as well as

57 endocardial layers (p = 0.004), resulting in transmural dispersion of myofiber relaxation of 83 ms.

58 epicardial layers (p < 0.001), resulting in transmural dispersion of myofiber shortening of 39 ms.

59 cell types during repolarization, increasing transmural dispersion of repolarization (DOR) and the sp

60 t a pathophysiologic link between electrical transmural dispersion of repolarization and abnormal myo

61 Transmural dispersion of repolarization and conduction v

62 (DeltaT(p)-T(e)), a relatively new index of transmural dispersion of repolarization and potential ar

63 Although the concept of transmural dispersion of repolarization has helped expla

64 -peak to T-end (TpTe) interval, representing transmural dispersion of repolarization, is associated w

65 results suggest beta-AR-mediated increase of transmural dispersion of repolarization, which could pos

66 e of QT prolongation than to drug effects on transmural dispersion or variability of repolarization.

67 s well as an increase in both epicardial and transmural dispersions of repolarization (EDR and TDR, r

68 ry compliance, and enhanced left ventricular transmural distending pressure (all P <0.01), with no in

69 The transmural distribution of apamin-sensitive small conduc

70 The transmural distribution of connexin 43 was quantified wi

71 ET tomograph allow regional estimates of the transmural distribution of MBF over a wide flow range, a

72 omputational model was used to determine the transmural distribution of stresses and strains across t

73 and shear, but the regional variability and transmural distribution of these 3 mechanisms are incomp

74 However, the respective transmural dominance of these phenomena seems distinct.

75 be superior to plastic stents for endoscopic transmural drainage of necrosis.

76 th pancreatic disease, with the exception of transmural drainage of pancreatic necrosis.

77 Endoscopic therapy through transmural drainage of WON may be preferred, as it avoid

78 sting of percutaneous drainage or endoscopic transmural drainage using either plastic stents and irri

79 who do not adequately respond to endoscopic transmural drainage using large-bore, self-expanding met

80 l endoscopic or endoscopic ultrasound-guided transmural drainage, hybrid interventions (endoscopic ul

81 g release kinetics, matrix coating transfer, transmural drug partitioning, dissolution rate and relea

82 ina propria, villus blunting and fusion, and transmural edema and hemorrhage.

83 Finally, in failing heart, asymmetry of transmural electrical propagation was abolished.

84 ardial tissue within the bead set to measure transmural electrical sequence.

85 mural mechanics could yield insight into the transmural electrical sequence.

86 immunohistochemical staining, together with transmural electrical stimuli confirmed that the myenter

87 mutations and introduced in a 1-dimensional transmural electrocardiography computer model.

88 mias through ultrasound-based mapping of the transmural electromechanical activation sequence reliabl

89 study uncovers a role of HEY2 in the normal transmural electrophysiological gradient in the ventricl

90 among the three ventricular sections and the transmural, endocardial, and epicardial parameters.

91 PRACTICE ADVICE 7: Percutaneous drainage and transmural endoscopic drainage are both appropriate firs

92 998 to 2006, 53 patients underwent transoral/transmural endoscopic drainage/debridement of sterile (2

93 Experience with minimal access, transoral/transmural endoscopic drainage/debridement of walled-off

94 Transmural endoscopic necrosis was defined as grade 3b i

95 delivery via point-source release generated transmural epinephrine gradients directly beneath the si

96 However, the transmural ERP dispersion was augmented.

97 educe transmural APD dispersion, but augment transmural ERP dispersion.

98 is distinct from the subendocardially based transmural extension patterns described with clinical my

99 The transmural extent and intramural types (endocardial, mid

100 unravel the mechanisms underlying how size, transmural extent and location of ischemia determine arr

101 myocardial infarction (MI), segments with a transmural extent of infarct (TEI) of </=50% are defined

102 erformed in those without MVO and with <=75% transmural extent of infarct.

103 ging, sensitivity is mildly reduced, and the transmural extent of infarction may be underestimated.

104 Overall, regional transmural extent of infarction scores were highly conco

105 %) considered predominantly infarcted (> 50% transmural extent of infarction) by the standard techniq

106 technique were considered viable (< or = 25% transmural extent of infarction) by the subsecond techni

107 and accurately reflected morphology and the transmural extent of injury in all animals.

108 Both transmural extent of late gadolinium enhancement and FDG

109 FDG uptake, as well as transmural extent of late gadolinium enhancement, acutel

110 d cine MR imaging agreed with the global and transmural extent of microvascular obstruction at first-

111 We found no relationship between the transmural-extent of T2-hyperintense regions and that of

112 pared by (a) quantitative measurement of the transmural-extent of the abnormality and (b) picture mat

113 -hyperintense and infarcted regions, and the transmural-extent of these regions were highly correlate

114 les across the atrial wall revealed that the transmural fiber angle distribution is heterogeneous thr

115 The transmural fiber angle shift was determined using diffus

116 Left ventricular transmural fiber rotation was significantly higher in TG

117 In simplified slab models, in absence of transmural fiber rotation, bath-loading induced transmur

118 When preload was expressed as transmural filling pressure (pulmonary capillary wedge p

119 Much of the total 10 nL/min transmural flow (under normal conditions) was concentrat

120 LECs preconditioned to 1 microm/s transmural flow demonstrated increased uptake and basal-

121 tion of MBF over a wide flow range, although transmural flow differences were underestimated because

122 gs and then experimentally demonstrated that transmural flow guided preferential sprouting toward pat

123 reduced the applied shear stress for a given transmural flow rate, but did not affect the shear thres

124 uminal shear stress over the endothelium and transmural flow through the endothelium above 10 dyn/cm(

125 then combined with Starling's law to predict transmural flow.

126 ree necessary to analyse the distribution of transmural fluid movement.

127 There was no significant transmural gradient in electrical repolarization (p = NS

128 Despite lack of evidence of significant transmural gradient in electrical repolarization in vivo

129 icated angiotensin II (A2) may determine the transmural gradient in Ito, but the effects of A2 on IP

130 Furthermore, the transmural gradient in repolarization time, known to be

131 Second, the transmural gradient of calcium transient duration was si

132 In diabetic rats only, there was a transmural gradient of contractile depression.

133 significantly increased without changing the transmural gradient of I(Ca) distribution.

134 n conclusion, CKD disrupts the physiological transmural gradient of Ito via downregulation of KChIP2

135 ardiomyocytes of UNx rats led to a decreased transmural gradient of Ito.

136 I(Ca) density manifests a significant transmural gradient, and this gradient is preserved in h

137 etrating into the myocardium, resulting in a transmural gradient.

138 cular level, we reduced the apex-to-base and transmural gradients of action potential duration (APD).

139 Transmural heterogeneities in Na/K pump current (IP), tr

140 epicardial activation despite an absence of transmural heterogeneities of repolarization, in sharp c

141 beta2-Stimulation also affected transmural heterogeneity in action potential duration bu

142 , we present direct experimental evidence of transmural heterogeneity of excitation-contraction coupl

143 in mucosal barrier function and developed a transmural ileitis following NSAID exposure.

144 and severe spontaneous Crohn's-disease-like transmural ileitis if both mechanisms are compromised.

145 TNBS-treated-goats exhibited apparent transmural-ileitis on day 7, microscopically low-grade i

146 ndocardium and by faster circumferential and transmural impulse conduction during endocardial LV paci

147 r than epicardial conduction; in all models, transmural impulse conduction was approximately 25% fast

148 as follows: midwall in 33.3% of the hearts, transmural in 23.3%, midwall-subepicardial in 23.3%, and

149 cal for amyloidosis (29% subendocardial, 71% transmural), including right ventricular LGE (96%).

150 .001), as was the correlation with number of transmural infarcted segments by delayed enhancement ima

151 In eight patients with fully transmural infarction, infarct zone strain improved betw

152 subendocardial infarction, leaving n = 1563 transmural infarctions available for analysis.

153 ticle (PM2.5) associations may be limited to transmural infarctions.

154 al aortic aneurysm (AAA) is characterized by transmural infiltration of myeloid cells at the vascular

155 Transmural inflammation induces microvascular neoangioge

156 hypertrophy and fibrotic stenoses from acute transmural inflammatory stenoses in patients with Crohn'

157 atory bowel disease characterized by massive transmural influx of leukocytes and lymphocytes, resulti

158 SAMP1/YP mice develop a spontaneous chronic transmural intestinal lesion specifically in the ileum.

159 olymorph infiltration of the lamina propria, transmural involvement, and micro abscess formation was

160 tomography enterography visualize the lumen, transmural involvement, extraintestinal manifestations a

161 e selective glial stimulation did not affect transmural ion conductance or cell-impermeant dye flux b

162 compared with clinically accepted indexes of transmural ischemia (i.e., STD and STE [> or =1 mm]) it

163 ST elevation reflected ischemic extent in transmural ischemia for LCX and LAD occlusion but not in

164 Transmural ischemia prolonged the QTc interval (using th

165 electrocardiographic manifestations of early transmural ischemia, we studied electrocardiograms (ECGs

166 rval prolongs in 100% of patients with early transmural ischemia.

167 al dome, predicting an increased ventricular transmural Ito gradient.

168 Cardiac magnetic resonance showed regional transmural late gadolinium enhancement and edema exceedi

169 Transmural left and right ventricular tissues were obtai

170 swine with high P(PL) demonstrated unchanged transmural left ventricle pressure and systemic blood pr

171 In the 100- and 200-J cross sections, transmural left ventricular lesions and significant tiss

172 to assess the depth of ablation required for transmural lesion formation to optimize power delivery.

173 In some cases, however, it translates transmural lesion only (with potential reversibility) li

174 ore frequent, larger, deeper, and more often transmural lesions compared with conventional irrigated

175 during radiofrequency applications reflects transmural lesions creation.

176 +/-2.7 versus 5+/-2.4 mm; P<0.001), and more transmural lesions were created (62.5% versus 17%; P<0.0

177 ncy catheter ablation depends on creation of transmural lesions without collateral injury to contiguo

178 roximated esophagus (6 [4.5-14] mm) produced transmural lesions without esophageal injury.

179 etermine, at the histological level, whether transmural lesions, assessed by R morphology completion,

180 a more comprehensive lesion set with durable transmural lesions.

181 g radiofrequency energy, was associated with transmural lesions.

182 Transmural LGE is determined reliably by PSIR and repres

183 Transmural LGE predicted death (hazard ratio, 5.4; 95% c

184 argely found in either adventitial/medial or transmural locations.

185 and in both groups significantly slower than transmural LV conduction ( approximately 30 ms).

186 not only cardiomyocyte contraction but also transmural LV intercellular architecture and geometry.

187 fects of undersized annuloplasty on regional transmural LV wall fiber and sheet strains and wall thic

188 At the time of aortic surgery, a transmural lymphoplasmacytic infiltrate was detected in

189 s arterial stress and brake MMP12 release by transmural macrophages thereby maintaining a strengthene

190 In 7 sheep, left ventricular endocardial and transmural mapping was performed 84 weeks (15-111 weeks)

191 e-tissue-compartment model and compared with transmural MBF (MBFT), defined as MBF as measured with (

192 We investigated whether transmural mechanics could yield insight into the transm

193 Elastin fragmentation and transmural medial breaks of the ascending aorta were obs

194 ods to evaluate whether the relative odds of transmural MI associated with increased PM2.5 concentrat

195 A transmural MI was created by implanting an embolic coil

196 Transmural micro-reentry at the ischemic border zone exp

197 Transmural microreentry did not play a role as source of

198 Apparent transmural migration of rotational activations (n=6) fro

199 ll thinning is believed to represent chronic transmural myocardial infarction and scar tissue.

200 ation; 3) the physiological inhomogeneity of transmural myocardial mechanics and the apex-to-base seq

201 dies that suggest this effect helps maintain transmural myocardial perfusion.

202 ent restraint levels (0, 3, 5, and 8 mm Hg), transmural myocardial pressure (P(tm)) and indices of my

203 We hypothesized that changes in LV transmural myocardial strain represent an early marker o

204 es in LV function detected by alterations in transmural myocardial strain, but not by changes in BNP,

205 and free-breathing rate 2 SMS excitation in transmural myofiber helix angle, mean diffusivity (mean

206 We studied the time course of transmural myofiber mechanics in the anterior left ventr

207 ured, along with quantification of the local transmural myofibre and collagen fibre architecture.

208 osteonecrosis, the associated vessels showed transmural necrosis and thickening of the vessel wall pr

209 ectrogram reflects, in general, irreversible transmural necrosis creation.

210 Pathology revealed transmural necrosis in 9/11 esophagectomy and 16/16 gast

211 s (endocardial, midwall, epicardial, patchy, transmural) of scar were measured in late gadolinium-enh

212 Multisegment transmural optical action potential imaging of left vent

213 ation is ligand-specific; TLR4 ligands cause transmural panarteritis and TLR5 ligands promote adventi

214 f Tie2(Cre) mice disrupts embryonic coronary transmural patterning, leading to embryonic death.

215 on frequency, phase III time) and secretion (transmural potential difference), rectal sensorimotor (b

216 The influences of increased transmural pressure (1-5 cmH2O) and imposed flow (1-5 cm

217 Effective distending transmural pressure (dP(FW)) and transseptal pressure gr

218 The influences of incrementally increased transmural pressure (from 1 to 5 cmH(2)O) were examined

219 ions are not recapitulated on application of transmural pressure (PTM) oscillations (that mimic tidal

220 However, LV transmural pressure (pulmonary capillary wedge pressure-

221 e of microvessels was linear with increasing transmural pressure and was dependent on matrix stiffnes

222 We show that transmural pressure controls airway branching morphogene

223 Higher transmural pressure decreases the interval between syste

224 hydrostatic pressure distribution as well as transmural pressure distribution due to the change in lu

225 at either changes in hydrostatic pressure or transmural pressure distribution in the gravitational di

226 -9 versus 8+/-3 mm Hg; P<0.0001), because LV transmural pressure dropped with exercise in subjects wi

227 ethering can serve the same purpose when the transmural pressure is negative.

228 Positive transmural pressure is required for this suction, provid

229 va decreased during inspiration, whereas the transmural pressure of the right atrium did not change.

230 e of the vena cava is decreased, whereas the transmural pressure of the right atrium is not changed.

231 Transmural pressure of the superior vena cava decreased

232 Additionally, the transmural pressure of the vena cava is decreased, where

233 rt this principle, we report in vitro radius-transmural pressure relations for a range of airway radi

234 venous pressure relative to left ventricular transmural pressure, and greater left ventricular eccent

235 motion, the vascular oscillatory response to transmural pressure, observed in vivo.

236 was significantly decreased with increasing transmural pressure, whereas in cervical vessels only at

237 itions or after the application of 10 cm H2O transmural pressure.

238 sed during ventricular stretch and increased transmural pressure.

239 ows that PTM fluctuations at particular mean transmural pressures can lead to only limited bronchodil

240 sized that stresses generated by airflow and transmural pressures during breathing govern ASL volume

241 enic tone was unchanged, but over a range of transmural pressures, inward remodelling occurred after

242 generates biophysical forces, including high transmural pressures, which exacerbate lung inflammation

243 low FA, low MDI and disruption of normal HA transmural profile on micro-CT were associated with myoc

244 The results of this study suggest that transmural propagation may play a role in atrial fibrill

245 In addition, the increase in transmural pulmonary vascular pressure swings caused by

246 Nine sheep had transmural radiopaque markers inserted into the anterior

247 A slight but significant discrepant transmural radiotracer distribution pattern of (201)Tl i

248 of generating either a transmural block or a transmural reentry.

249 t patients, alcohol septal ablation caused a transmural region of tissue necrosis, located more infer

250 We also observed synergistic augmentation of transmural repolarization gradient by the combination of

251 s is in contrast to sustained alterations in transmural repolarization gradients present on regular s

252 alaemic hearts with transient alterations in transmural repolarization gradients resulting from prema

253 SK current is important in the transmural repolarization in failing human ventricles.

254 riate analysis showed that mutation-specific transmural repolarization prolongation (TRP) was associa

255 The mutation effect on transmural repolarization was determined for each mutati

256 id vascular resistance 1.5[2.2, 0.9] WU, and transmural right ventricle pressure 10[15, 6] mmHg durin

257 We aimed to characterize transmural right ventricular activation in ARVD patients

258 Transmural right ventricular activation is modified by A

259 Transmural scar occupying left ventricular (LV) pacing r

260 Transmural scar was more likely to be seen in the biopsy

261 al abnormal electrograms are associated with transmural scar with low endocardial BV, the additional

262 Eleven of the 22 specimens (50%) revealed transmural scar, and 11 (50%) showed viable myocardium w

263 farcted myocardium was highest in areas with transmural scar, and the standardized uptake valuemean w

264 ectrograms (130 of 151) were associated with transmural scar.

265 pectively) and confluent, indicating a dense/transmural scarring process in CC.

266 Transmural sections of jejunum were stained with fluores

267 , LV endocardial versus epicardial pacing at transmural sites yielded equivalent dP/dt(max) values.

268 tected between LV epicardial and endocardial transmural sites.

269 n at sufficiently high resolution to examine transmural spatial distribution.

270 tivation from the scar border, not by direct transmural spread from the endocardium.

271 optimal role of endoscopic ultrasound-guided transmural stent placement.

272 s lower in patients with DPDS with permanent transmural stents (17.4% vs 1.7%, P < 0.001).

273 Transmural stents were left permanently in situ in DPDS

274 their difference yielded the circumferential transmural strain difference (cTSD).

275 aluate myocardial strain and circumferential transmural strain difference (cTSD; the difference betwe

276 ll to radiographically measure 3-dimensional transmural strains during systole and diastolic filling,

277 ies, including location (LAD/LCX occlusion), transmural/subendocardial ischemia, size, and normal/slo

278 The most common LGE pattern was ischemic (transmural/subendocardial).

279 SERF catheter lesions were more often transmural than standard CF lesions with >20 g of CF in

280 At day 7, transmural thermal effects occurred through the atrial w

281 with that using an endocardial site directly transmural to the CRT-coronary sinus lead tip.

282 sites were systematically assessed: the site transmural to the CS lead, the LV apex, the septal midwa

283 A 3D transmural unipolar electrode array consisting of a 9x9

284 Transmural variation in the extent of current blockade i

285 Pes also permits the measurement of transmural vascular pressures during both passive and ac

286 icardial puncture can create deep, wide, and transmural ventricular myocardial lesions.

287 mary mechanism increasing arrhythmic risk in transmural versus subendocardial ischemia, for both LAD

288 explained larger vulnerability to reentry in transmural versus subendocardial ischemia.

289 nderwent cardiac MR imaging and showed large transmural (volume of enhancement on late gadolinium enh

290 nal electric substrate variations within the transmural wall during acute episodes of atrial fibrilla

291 This was in contradistinction to the transmural wall profile of (18)F-LMI1195 (90 +/- 4, 96 +

292 ries revealed discordant activity across the transmural wall.

293 Theoretical analysis suggests that a transmural water flux which is spatially heterogeneous a

294 ffect of the EGL, as well as a heterogeneous transmural water flux, on arterial LDL concentration pol

295 nsmural fiber rotation, bath-loading induced transmural wavefront curvature dominates, significantly

296 icular models modulates bath-loading induced transmural wavefront curvature.

297 lose to the tissue-fluid interface, inducing transmural wavefront curvature.

298 the increase in CV and concomitant change in transmural wavefront profiles upon both propagation and

299 +5, R+10, and R+20 lesions were necrotic and transmural, whereas some R+0 lesions were not (comprisin

300 d into 3 patterns: none, subendocardial, and transmural, which were associated with increasing amyloi