ライフサイエンスコーパス: transpeptidase

1 ibits both a D,D-carboxypeptidase and an L,D-transpeptidase.

2 vidual steps catalyzed by a purified E. coli transpeptidase.

3 ly modifies the active-site threonine of the transpeptidase.

4 f the Staphylococcus aureus sortase A (SrtA) transpeptidase.

5 t by the action of the enzyme gamma-glutamyl transpeptidase.

6 which are the substrate of transglycosylase/transpeptidase.

7 phylococcus aureus sortase (SrtA) is a thiol transpeptidase.

8 ates are sequestered in the active site of a transpeptidase.

9 ibers; it contains urease and gamma-glutamyl transpeptidase.

10 cross-linked, and LdtMt2 is the dominant ld-transpeptidase.

11 rminal step in its biosynthesis catalyzed by transpeptidases.

12 ymes, a group of widely distributed cysteine transpeptidases.

13 as conceived as an inhibitor specific for DD-transpeptidases.

14 d designed specifically for inhibition of DD-transpeptidases.

15 es, a recently discovered family of cysteine transpeptidases.

16 m of the cross-linking reaction catalyzed by transpeptidases.

17 y specific D-alanyl-D-alanine(DD)-peptidases/transpeptidases.

18 design of new antibiotic drugs targeting l,d-transpeptidases.

19 gamma-Glutamyl transpeptidase 1 (GGT1) is a cell surface, N-terminal nu

20 first time, we demonstrate that loss of L,D-transpeptidases 1 and 2 of M. tuberculosis (LdtMt1 and L

21 28.6U/L vs 23.8 +/- 14.1U/L), gamma-glutamyl transpeptidase (34.3 +/- 16.6 vs 24.5 +/- 16.8U/L), and

22 , three penicillin-binding proteins, two L,D-transpeptidases, a LytR-CpsA-Psr-family protein predicte

23 % CI, 1.10; 3.18; P = 0.021); gamma-glutamyl transpeptidase above the upper limit of normal (HR, 1.96

24 We demonstrate that this transpeptidase accepts a set of structurally diverse D-a

25 nd to multiple different beta-lactams in the transpeptidase active site and complement these data wit

26 omain--a remarkable 60 A distant from the DD-transpeptidase active site--discovered by crystallograph

27 in separate domains the transglycosylase and transpeptidase activities required for the biosynthesis

28 ptococcus pneumoniae and characterized their transpeptidase activities, using a thioester analog of s

29 ; for example, beta-lactam resistance by L,D-transpeptidase activities.

30 cosyltransferase) and peptide cross-linking (transpeptidase) activities.

31 lkaline phosphatase activity, gamma-glutamyl-transpeptidase activity and physiological responses to s

32 Whereas cleavage-dependent transpeptidase activity has been reported for other plan

33 PBP 3 displayed weak transpeptidase activity in a model transpeptidase reacti

34 PBP2 has peptidoglycan transpeptidase activity in the presence of active PBP1A.

35 nd a large periplasmic domain that encodes a transpeptidase activity involved in synthesis of septal

36 an essential protein, a mutant lacking PBP1 transpeptidase activity is viable, showing that this pro

37 interpretation of these results is that the transpeptidase activity of FtsI is required, directly or

38 of beta-lactam antibiotics that inhibit the transpeptidase activity of FtsI.

39 ocopied by pharmacological inhibition of the transpeptidase activity of GGT in all readouts.

40 rmone by RelA lead to full bypass of the D,D-transpeptidase activity of PBPs and to broad-spectrum be

41 target of beta-lactam antibiotics is the D,D-transpeptidase activity of penicillin-binding proteins (

42 The transpeptidase activity of sortase has been demonstrated

43 We exploit the transpeptidase activity of sortase to install modified p

44 lose proximity of histidine 120, reduces the transpeptidase activity of sortase.

45 susceptible to beta-lactam antibiotics, the transpeptidase activity of their penicillin binding prot

46 dase activity of DacA in addition to the L,D-transpeptidase activity of YcbB.

47 with comparable rates, but exhibited limited transpeptidase activity relative to mammalian gammaGT.

48 B penicillin-binding proteins (PBPs) carry a transpeptidase activity that cross-links peptidoglycan s

49 No transpeptidase activity was apparent in a model transpep

50 gamma-Glutamyl transpeptidase activity was deficient in kidney homogena

51 mpair division but not membrane insertion or transpeptidase activity were found to interfere with loc

52 of Tat on glutathione levels, gamma-glutamyl transpeptidase activity, and the expression and activity

53 activity, acyl-donor substrate specificity, transpeptidase activity, inhibition by a number of activ

54 ically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment

55 tathione levels and increases gamma-glutamyl transpeptidase activity.

56 one levels and an increase in gamma-glutamyl transpeptidase activity.

57 vides direct genetic evidence that PBP2A has transpeptidase activity.

58 that can be compensated for by PBP2A is the transpeptidase activity.

59 ild-type spores, possibly due to the loss of transpeptidase activity.

60 s, and monofunctional class B PBPs with only transpeptidase activity.

61 Sortase A (SrtA) is a bacterial enzyme with transpeptidase activity.

62 to possess as many as five proteins with L,D-transpeptidase activity.

63 acid (BA) levels, and normal gamma-glutamyl transpeptidase activity.

64 riplasmic domain that encodes the catalytic (transpeptidase) activity.

65 ntly to Brucella virulence, including an l,d-transpeptidase, an ABC transporter solute-binding protei

66 Surface gamma-glutamyl transpeptidase, an indirect indicator of redox potential

67 ant PBP1b and PBP5 of Escherichia coli, a dd-transpeptidase and a dd-carboxypeptidase, respectively.

68 Our study suggests that a combination of L,D-transpeptidase and beta-lactamase inhibitors could effec

69 tures, which are positive for gamma-glutamyl transpeptidase and CK-14 and CK-19 and do not express de

70 Two of the PBP activities include dd-transpeptidase and DD-carboxypeptidase activities, which

71 0 kg/m(2), genotype 2, normal gamma-glutamyl transpeptidase and increased alanine aminotransferase le

72 we delineated the motion of the septal PBP2x transpeptidase and its FtsW glycosyl transferase-binding

73 ntrations of the liver enzyme gamma-glutamyl transpeptidase and lower scores on a measure of alcohol-

74 including PlsX and KASII (FA metabolism), DD-transpeptidase and MurB (peptidoglycan synthesis), glyox

75 Using single-particle tracking of the transpeptidase and Rod-complex component PBP2, we found

76 inding proteins such as PBP1b that have both transpeptidase and transglycosylase activities.

77 Bacterial transpeptidase and transglycosylase on the surface are e

78 investigated as potential inhibitors of both transpeptidases and beta-lactamases.

79 anations for the existence of monofunctional transpeptidases and glycosidases (glycoside hydrolases),

80 as real-time activity assays of D,D- and L,D-transpeptidases and sortases in vitro.

81 cantly reduced levels of ALP, gamma-glutamyl transpeptidase, and alanine aminotransferase, compared w

82 ed aspartate aminotransferase, gammaglutamyl transpeptidase, and alkaline phosphatase levels were ind

83 al aspartate aminotransferase, gammaglutamyl transpeptidase, and alkaline phosphatase levels.

84 of alanine aminotransferase, gamma-glutamyl transpeptidase, and alkaline phosphatase.

85 hermostable carboxypeptidase, gamma glutamyl-transpeptidase, and deblocking aminopeptidases are absen

86 sage (glutathione peroxidase, gamma-glutamyl transpeptidase, and glutathione S-transferase).

87 alase, glutathione reductase, gamma-glutamyl transpeptidase, and glutathione synthetase in the regene

88 alase, glutathione reductase, gamma-glutamyl transpeptidase, and glutathione synthetase.

89 erases, alkaline phosphatase, gamma glutamyl transpeptidase, and homeostasis model assessment of insu

90 onverted to a dipeptide due to the action of transpeptidase, and the dipeptide is then transported in

91 o simulate how individual transglycosylases, transpeptidases, and endopeptidases could introduce new

92 BPs, which are both glycosyltransferases and transpeptidases, and monofunctional class B PBPs with on

93 -linking of the cell wall, carried out by dd-transpeptidases, and the dd-peptidase activity, that rem

94 and detoxification, including transporters, transpeptidases, and thioredoxins.

95 The L,D-transpeptidase Atu0845 was detected mainly at the growth

96 oglycan is polymerized by monofunctional d,d-transpeptidases belonging to class B penicillin-binding

97 at LdtMt5 is not a functionally redundant ld-transpeptidase, but rather it serves a unique and import

98 sferase pi 7, and for luminal gamma-glutamyl transpeptidase, but they did not express immunoreactive

99 ble pili by a distinct mechanism involving a transpeptidase called sortase.

100 one facilitates occupancy by a second at the transpeptidase catalytic site, thus lowering the minimal

101 It was recently discovered that the same transpeptidases catalyze the metabolic incorporation of

102 cell wall, such that NG PBP3 would act after transpeptidase-catalyzed reactions generate the acylated

103 Sortase, a membrane-anchored transpeptidase, cleaves P2 between the threonine (T) and

104 Sortase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anch

105 icillin-binding protein (PBP), including the transpeptidase conserved motifs SXXK, SXN, and KTG.

106 GGL and gamma-glutamyl transpeptidase constitute a small gene family.

107 Sortase cysteine transpeptidases covalently attach proteins to the bacter

108 Transpeptidases cross-link peptidoglycan oligopeptides t

109 ions of alkaline phosphatase, gamma-glutamyl transpeptidase, cystatin C, neutrophil gelatinase-associ

110 The bacterial D-alanyl-D-alanine transpeptidases (DD-peptidases) are the killing targets

111 rough their inhibition of D-alanyl-D-alanine transpeptidases (DD-peptidases) that catalyze the last s

112 vertheless, the bacterial D-alanyl-D-alanine transpeptidases (DD-peptidases), the killing targets of

113 condary end points, levels of gamma-glutamyl transpeptidase decreased 48%-63%, on average, among subj

114 isease, and 4 others with low gamma-glutamyl transpeptidase disease (levels <100 U/L), were identifie

115 ain relative to that of the carboxy-terminal transpeptidase domain indicate interdomain flexibility.

116 The PBP1b transpeptidase domain is a major target of beta-lactams,

117 in of the native staphylococcal PBP2 and the transpeptidase domain of the PBP2A, a protein imported b

118 h a leucine at amino acid residue 458 of the transpeptidase domain of the protein, close to the SFN c

119 ere, we report the crystal structures of the transpeptidase domain of WT PBP2 in complex with cefixim

120 netically spliced into a surface loop of the transpeptidase domain that contains three conserved loop

121 of the transglycosylase domain, but not the transpeptidase domain, of PBP2 of S. aureus prevents exp

122 domain of unknown function, and a catalytic (transpeptidase) domain.

123 Their lethal targets are the transpeptidase domains of penicillin binding proteins (P

124 valently acylate the active sites of the PBP transpeptidase domains.

125 ype serine/threonine kinase and phosphatase, transpeptidase E-transglycosylase Pbp1A are found in FNV

126 ine type D-alanyl-D-alanine carboxypeptidase/transpeptidase (EC ) from Streptomyces sp. strain R61 re

127 ed to be a gamma-glutamylcysteine dipeptidyl transpeptidase (EC 2.3.2.15) and, more recently, as exem

128 ase (14 of 44, 32%), elevated gamma-glutamyl transpeptidase (eight of 44, 18%), hyperbilirubinemia (s

129 d pilus polymers are assembled by a specific transpeptidase enzyme called pilus-specific sortase.

130 cterial peptidoglycan by sortase, a cysteine transpeptidase enzyme.

131 e polymer to peptidoglycan, catalyzed by two transpeptidase enzymes - the pilus-specific sortase and

132 ive bacterial cell wall involves 2 conserved transpeptidase enzymes named sortases: One for polymeriz

133 jacent peptide stems are cross-linked by the transpeptidase enzymes of cell wall biosynthesis to prov

134 or the evaluation of three predicted sortase transpeptidase enzymes, which mediate the cell surface p

135 nd the defects were abrogated by lack of l,d-transpeptidases, enzymes catalyzing the formation of mDA

136 d proteins, and transmembrane gamma-glutamyl transpeptidase exhibited the expected apical localizatio

137 ver histology was normal, but gamma-glutamyl transpeptidase expression was observed, with altered ant

138 The C-terminal domain is a typical transpeptidase fold and contains the three conserved act

139 substrates of sortase A (SrtA), a bacterial transpeptidase, for enzymatic coupling.

140 for the first time an atomic model of an l,d-transpeptidase from Bacillus subtilis bound to its natur

141 litate septal peptidoglycan synthesis by the transpeptidase FtsI (penicillin-binding protein 3).

142 al for subsequent recruitment of its cognate transpeptidase FtsI but not for stabilization of FtsZ ri

143 GSNO), and GSNO activation by gamma-glutamyl transpeptidase (gamma-GT) is required.

144 We found that inhibition of gamma-glutamyl-transpeptidase (gamma-GT) protects human acute promyeloc

145 ucts that could be cleaved by gamma-glutamyl transpeptidase (gamma-GT), found predominantly in renal

146 asis (PFIC) with raised serum gamma-glutamyl transpeptidase (gamma-GT).

147 gamma-Glutamyl transpeptidase (gammaGTase) catalyzes the transfer of th

148 gamma-Glutamyl transpeptidases (gammaGTases) are the only enzymes known

149 persistence determinants, the gamma-glutamyl-transpeptidase GGT and the vacuolating cytotoxin VacA, a

150 i virulence determinants, the gamma-glutamyl transpeptidase GGT and the vacuolating cytotoxin VacA, c

151 The contribution of glutamyl transpeptidase (GGT) (gamma-glutamyltransferase [EC 2.2.

152 bile duct hypoplasia and low gamma glutamyl transpeptidase (gGT) activity.

153 rs of NAFLD, such as elevated gamma glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT)

154 The role of gamma-glutamyl transpeptidase (GGT) and cysteine-S-conjugate beta-lyase

155 e complex by the ectoproteins gamma-glutamyl transpeptidase (GGT) and dipeptidase.

156 Plasma levels of gamma-glutamyl transpeptidase (GGT) are associated with risk factors fo

157 d an additional member of the gamma-glutamyl transpeptidase (GGT) family, gamma-glutamyl leukotrienas

158 ewly identified member of the gamma-glutamyl transpeptidase (GGT) family, we generated null mutations

159 VacA, lipopolysaccharide, or gamma-glutamyl transpeptidase (GGT) implicated the latter in H. pylori-

160 e of altering the activity of gamma-glutamyl transpeptidase (GGT) in human prostate carcinoma cells.

161 Expression of gamma-glutamyl transpeptidase (GGT) in tumors contributes to resistance

162 gamma-Glutamyl transpeptidase (GGT) is a heterodimeric membrane enzyme

163 gamma-Glutamyl transpeptidase (GGT) is an enzyme located on the surface

164 Expression of the ectoenzyme gamma-glutamyl transpeptidase (GGT) is regulated on T lymphocytes.

165 gamma-Glutamyl transpeptidase (GGT) is the enzyme responsible for break

166 gamma-Glutamyl transpeptidase (GGT) is the only enzyme known that can c

167 rtate transaminase (AST), and gamma-glutamyl transpeptidase (GGT) levels (P <.01).

168 Both the presence of gamma-glutamyl transpeptidase (GGT) on the apical brush-border membrane

169 We used mice deficient in gamma-glutamyl transpeptidase (GGT) to analyze the effects of GGT defic

170 The cell surface glycoprotein gamma-glutamyl transpeptidase (GGT) was isolated from healthy human kid

171 lori These include flagellin, gamma-glutamyl transpeptidase (ggt), collagenase, the secreted serine p

172 ssed alpha-fetoprotein (AFP), gamma-glutamyl transpeptidase (GGT), cytokeratin 19 (CK-19), OC.2, and

173 by the sequential reaction of gamma-glutamyl transpeptidase (GGT), gamma-glutamyl cyclotransferase, a

174 ich inhibits GSH breakdown by gamma-glutamyl transpeptidase (GGT), had no effect on the enhanced upta

175 Apical proteins, including gamma-glutamyl transpeptidase (GGT), Na(+)-glucose cotransporter (SGLT1

176 , alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), or total bilirubin.

177 m of leukotriene C4 (LTC4) in gamma-glutamyl transpeptidase (GGT)-deficient mice and have found subst

178 tin-glutathione complex via a gamma-glutamyl transpeptidase (GGT)-dependent pathway in the proximal t

179 , serial sections stained for gamma-glutamyl-transpeptidase (GGT, a marker of fetal hepatoblasts) and

180 The ectoenzyme, gamma-glutamyl transpeptidase (GGT, EC ) cleaves glutathione (GSH) to f

181 rtate aminotransferase [AST], gamma-glutamyl transpeptidase [GGT], alkaline phosphatase [ALP], twice

182 mpounds have been identified: gamma-glutamyl transpeptidase (GGT1) and gamma-glutamyl leukotrienase (

183 Overexpression of gamma-glutamyl transpeptidase (GGT1) has been implicated in an array of

184 Blood levels of gamma glutamyl transpeptidase (GGTP), a liver enzyme indicator of alcoh

185 gamma-Glutamyl transpeptidases (GGTs) are essential for hydrolysis of t

186 Sortase A (SrtA), a bacterial transpeptidase, has become widely used for its ability t

187 ntibiotics have been developed to target the transpeptidase; however, the problem of antibiotic resis

188 le under the direction of the gamma-glutamyl transpeptidase-I promoter were developed.

189 a-lactams via a similar mechanism as the l,d-transpeptidases, implying the different reaction outcome

190 spartate aminotransferase, or gamma-glutamyl transpeptidase in donors with HGV infection alone or tho

191 ory increase in the participation of the L,D-transpeptidase in peptidoglycan synthesis.

192 ription of pbpB, the gene encoding the major transpeptidase in S. aureus.

193 isms, and we present the emerging role of LD-transpeptidases in peptidoglycan remodelling.

194 t MRSA by inhibiting essential peptidoglycan transpeptidases, including the beta-lactam resistance de

195 antibiotics, which inhibit the bacterial d,d-transpeptidases involved in cell wall biosynthesis, have

196 appear to work in conjunction with dedicated transpeptidases involved in division, elongation, or spo

197 The transpeptidases involved in the synthesis of the bacteri

198 nhibitor of vacuolar gamma-glutamyl cysteine transpeptidase, involved in the breakdown of glutathione

199 isoform of the Staphylococcus aureus sortase transpeptidase is responsible for the covalent attachmen

200 The function of gamma-glutamyl transpeptidase is to cleave glutathione and S-nitrosoglu

201 The cross-linking reaction, catalyzed by transpeptidases, is the last step in cell wall biosynthe

202 These cysteine transpeptidases join proteins bearing an appropriate sor

203 inary protein and creatinine, gamma-glutamyl transpeptidase, lactate dehydrogenase, histologic parame

204 dependent on a developmentally regulated L,D-transpeptidase (Ldt).

205 s well tolerated for inactivation of the L,D-transpeptidase LdtMt1 target.

206 -binding proteins (aPBPs) as well as the L,D-transpeptidases (LDTs).

207 blood alcohol concentration, gamma glutamyl transpeptidase level, and short Michigan Alcoholism Scre

208 greater phosphorylation, and gamma-glutamyl transpeptidase levels are reduced compared with those fr

209 mean corpuscular volume, and gamma-glutamyl transpeptidase levels remained significantly different f

210 but all of them had elevated gamma-glutamyl transpeptidase levels.

211 dy mass index, triglycerides, gamma-glutamyl transpeptidase, maximum alanine aminotransferase/asparta

212 Increased activity of gamma-glutamyl transpeptidase may be one mechanism underlying increased

213 osphatase of 75.6%; P<0.0001; gamma-glutamyl transpeptidase of 117.9%, P<0.0001; bilirubin of 50.0%,

214 d localization of the major transglycosylase/transpeptidase of the cell, PBP1.

215 anspeptidase, which in contrast to the other transpeptidases of S. aureus does not experience inhibit

216 terstitium, the overexpressed gamma-glutamyl transpeptidase on the cell membrane cleaves the gamma-gl

217 -glutamylcysteine synthetase, gamma-glutamyl transpeptidase, or multidrug resistance protein were fou

218 in) and fibrosis (P<.0001 for gamma-glutamyl transpeptidase, P=.01 for alkaline phosphatase, P<.0001

219 richia coli peptidoglycan glycosyltrasferase-transpeptidase PBP1A interacts with the cell elongation-

220 We show that the peptidoglycan transpeptidase Pbp2 also forms a helical pattern that pa

221 interacts with the cell elongation-specific transpeptidase PBP2 in vitro and in the cell.

222 perative functioning of two native S. aureus transpeptidases (PBP2 and PBP4) and an acquired transpep

223 nspeptidases (PBP2 and PBP4) and an acquired transpeptidase (PBP2A) in staphylococcal cell wall biosy

224 tly transcribed pbp4 gene, which encodes the transpeptidase Pbp4.

225 ch specifically inhibits the cell elongation transpeptidase penicillin binding protein 2 in Escherich

226 acteria is mediated by structural changes in transpeptidase penicillin-binding proteins.

227 While bacterial d,d-transpeptidases (penicillin-binding proteins) employ a n

228 While the PBP2 and PBP3 transpeptidases perform highly specialized functions tha

229 action of gamma-glutamylcysteine dipeptidyl transpeptidases (phytochelatin synthases; EC 2.3.2.15),

230 f TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cell

231 in families, SEDS transglycosylases and bPBP transpeptidases, proposed to function in cognate pairs.

232 ug2, and Dug3) but not by the gamma-glutamyl-transpeptidase, raising the question of the role of this

233 ily of low-molecular-weight PBPs that act as transpeptidases rather than hydrolases, but they do not

234 ayed weak transpeptidase activity in a model transpeptidase reaction but was active as an endopeptida

235 nspeptidase activity was apparent in a model transpeptidase reaction.

236 to be monitored in real time by visualizing transpeptidase reactions in live cells, as well as real-

237 lyze d-alanyl-d-alanine carboxypeptidase and transpeptidase reactions in vivo.

238 (also called PBP3) of Escherichia coli is a transpeptidase required for synthesis of peptidoglycan i

239 (also called PBP3) of Escherichia coli is a transpeptidase required for synthesis of peptidoglycan i

240 known as penicillin-binding protein 3, is a transpeptidase required for the synthesis of peptidoglyc

241 n-binding protein 4 (PBP4) is a nonessential transpeptidase, required for the high levels of peptidog

242 Here, we present a gamma-glutamyl transpeptidase-responsive camptothecin-polymer conjugate

243 These clusters include the transpeptidase(s) of the sortase family that is/are requ

244 The Staphylococcus aureus transpeptidase Sortase A (SrtA) anchors virulence and co

245 gation that relies on the specificity of the transpeptidase Sortase A (SrtA) for short peptide sequen

246 The Staphylococcus aureus transpeptidase sortase A (SrtA) is responsible for ancho

247 covalently anchored to the cell wall by the transpeptidase Sortase A (SrtA).

248 C-terminal LPXTG motif, whereas the related transpeptidase Sortase B (SrtB) recognizes a C-terminal

249 Here we use the transpeptidase sortase to covalently attach disease-asso

250 ll peptidoglycan by catalysis with the thiol transpeptidase sortase.

251 thogens such as Staphylococcus aureus by the transpeptidase sortase.

252 ugh a peptide ligation reaction catalyzed by transpeptidase sortase.

253 d by linking two non-toxic fragments using a transpeptidase (sortase).

254 The Staphylococcus aureus transpeptidase SrtA catalyzes the covalent attachment of

255 The Staphylococcus aureus sortase transpeptidase SrtA isoform is responsible for the coval

256 izations of staphylococcal SrtA, and related transpeptidases SrtB from S. aureus and Bacillus anthrac

257 t linkage of Cpa to T3 by the sortase family transpeptidase SrtC2 requires the VPPTG motif in the cel

258 g us to (a) identify recognition elements of transpeptidase substrates, (b) reveal a novel mechanism

259 ded as an essential cell elongation-specific transpeptidase, switches its localization from a dispers

260 ive bacteria have been shown to attach via a transpeptidase, termed sortase, that cleaves an LPXTG se

261 ignal of protein A as well as sortase A, the transpeptidase that anchors polypeptides to cell wall cr

262 ding protein 3 (PBP3; also called FtsI) is a transpeptidase that catalyzes cross-linking of the pepti

263 ity of the SrtC sortase (BaSrtC), a cysteine transpeptidase that covalently attaches the BasH and Bas

264 Deletion of sortase A, the transpeptidase that covalently couples multiple surface-

265 Here we identify MT2594 as an L,D-transpeptidase that generates 3-->3 linkages in M. tuber

266 ptidoglycan cell wall by sortase, a cysteine transpeptidase that targets proteins displaying a cell w

267 -glutamylcysteine (gamma-Glu-Cys) dipeptidyl transpeptidases that catalyze the synthesis of heavy met

268 s into high-molecular-weight PBPs, which are transpeptidases that form peptidoglycan cross-links, and

269 rium tuberculosis is catalyzed by ld- and dd-transpeptidases that generate 3-->3 and 4-->3 transpepti

270 the result of synergistically inhibiting the transpeptidases that introduce 3,3-cross-links while sim

271 These beta-lactams target the transpeptidases that introduce interpeptide cross-links

272 The transpeptidases that perform this cross-linking are impo

273 f excess CapD, a B. anthracis gamma-glutamyl transpeptidase, the protective capsule is degraded, and

274 The existence of a second class of transpeptidases, the L,D-transpeptidases, was recently r

275 On acylation of the active sites of dd-transpeptidases, the molecule would organize itself in t

276 function consecutively after gamma-glutamyl transpeptidase to cleave cystinyl-bis-glycine (cys-bis-g

277 eed for GSNO bioactivation by gamma-glutamyl transpeptidase to increase CFTR maturation; 4) surprisin

278 he ability of PBP2a and two native S. aureus transpeptidases to cross-link peptidoglycan strands bear

279 We exploited the promiscuity of bacterial transpeptidases to develop a novel assay for profiling d

280 or sporulation--is to recruit their cognate transpeptidases to the correct subcellular location.

281 say to analyze PG glycosyltransfer (PGT) and transpeptidase (TP) activities of Escherichia coli penic

282 -amino acids (FDAA) showed that areas of new transpeptidase (TP) activity catalyzed by penicillin-bin

283 a PG glycosyltransferase (PGT) domain and a transpeptidase (TP) domain.

284 show here that PBP4 preferentially acts as a transpeptidase (TP) in vitro.

285 ial class B penicillin-binding protein PBP2b transpeptidase (TP).

286 contain both glycosyltransferase (GTase) and transpeptidase (TPase) activities, are particularly attr

287 pretreatment body mass index, gamma-glutamyl transpeptidase, triglyceride, IL-28B TT genotype, and se

288 ents were increased levels of gamma-glutamyl transpeptidase (two [4%]), a reduction in the number of

289 proteins) employ a nucleophilic serine, l,d-transpeptidases use a nucleophilic cysteine.

290 Level of gamma-glutamyl transpeptidase was significantly higher in the placebo g

291 f a second class of transpeptidases, the L,D-transpeptidases, was recently reported.

292 cular volume, SGOT, SGPT, and gamma-glutamyl transpeptidase were significantly higher.

293 Unusual 3-->3 cross-links formed by L,D-transpeptidases were first detected in Escherichia coli

294 PBP 2a is a transpeptidase, which in contrast to the other transpept

295 studies of a related enzyme, gamma-glutamyl transpeptidase, which is subject to inhibition by a labi

296 structures were positive for gamma-glutamyl transpeptidase, which suggests that they possess liver-s

297 of antibiotics in human history, inhibit D,D-transpeptidases, which catalyze the final step in peptid

298 Sortase A (SrtA) is a transpeptidase widely used to site-specifically modify p

299 The covalent complexes formed by l,d-transpeptidases with some beta-lactam antibiotics underg

300 Here we show that production of the L,D-transpeptidase YcbB in combination with elevated synthes