ライフサイエンスコーパス: transsulfuration

1 ynthesis of cysteine and glutathione through transsulfuration.

2 mediated increase in serine biosynthesis and transsulfuration.

3 mitment of methionine cycle intermediates to transsulfuration.

4 ete AMC of H. pylori in a process of reverse transsulfuration.

5 ry position between the methionine cycle and transsulfuration.

6 ry position between the methionine cycle and transsulfuration.

7 Thus, reverse transsulfuration alone, without any sulfur recycling rea

8 yl methionine: higher in AD, p = 0.005); (2) transsulfuration and glutathione synthesis (cysteine: hi

9 .1.22] catalyzes the first committed step of transsulfuration and is the enzyme deficient in classica

10 ine other than serving as an intermediate in transsulfuration and to date, the possible contribution

11 in homocysteine remethylation or methionine transsulfuration and transmethylation between the groups

12 e the kinetics of methionine and its rate of transsulfuration and transmethylation in healthy women w

13 , associated with slower rates of methionine transsulfuration and transmethylation or homocysteine re

14 regulates the flux through remethylation and transsulfuration, and glycine N-methyltransferase regula

15 ethionine flux, its transmethylation and its transsulfuration, and homocysteine remethylation in chil

16 ering its flux through the transmethylation, transsulfuration, and transamination metabolic pathways.

17 betaine homocysteine methyl transferase and transsulfuration catalyzed by cystathionine beta-synthas

18 e kynurenine pathway, one-carbon metabolism, transsulfuration (cystathionine), and glycine decarboxyl

19 n humans is associated with a higher rate of transsulfuration early in gestation and a higher rate of

20 sms, but also by elevating expression of the transsulfuration enzyme CTH-2 to increase hydrogen sulfi

21 rt to a 38% increase in the abundance of the transsulfuration enzyme cystathionine beta-synthase; tre

22 euromodulator that can be synthesized by the transsulfuration enzymes cystathionine beta-synthase (CB

23 r than Cys-SSH is the primary product of the transsulfuration enzymes with CSE being the dominant pro

24 biogenesis of H(2)S involves the cytoplasmic transsulfuration enzymes, cystathionine beta-synthase an

25 o targeted CSE in cultured cells, inhibiting transsulfuration flux by 80-90%, as monitored by the tra

26 iol and S(0), thus providing a mechanism for transsulfuration in the sulfane sulfur pool.

27 sa affects eye development by increasing the transsulfuration intermediate homocysteine and inducing

28 -carbon metabolism (OCM), and the downstream transsulfuration metabolic pathway (TSP) are all essenti

29 ve plasma concentrations of transmethylation/transsulfuration metabolites and glutathione redox statu

30 35S-methionine demonstrating that functional transsulfuration occurs in mammary cells.

31 The fractional rate and total rate of transsulfuration of methionine was significantly (P < 0.

32 etic or nutrient-related disturbances in the transsulfuration or remethylation pathways for homocyste

33 SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine gamm

34 The transsulfuration pathway (TSP) is a highly conserved mec

35 The transsulfuration pathway also generates H(2)S, a signali

36 mocysteine (SAH) is product of methionine in transsulfuration pathway and a potent competitive inhibi

37 es of the methionine cycle regulate both the transsulfuration pathway and As methylation; c) GSH serv

38 catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolit

39 study establishes the presence of an intact transsulfuration pathway and demonstrates its contributi

40 r cysteine and glutathione synthesis via the transsulfuration pathway as a defense against oxidative

41 cells and support further exploration of the transsulfuration pathway as a mechanistic and therapeuti

42 thionine is formed as an intermediate of the transsulfuration pathway by the condensation of serine a

43 The redox sensitivity of the transsulfuration pathway can be rationalized as an autoc

44 The transsulfuration pathway converts homocysteine to cystei

45 We posit that regulation of the transsulfuration pathway during monocyte differentiation

46 The transsulfuration pathway enzymes can synthesize cysteine

47 the diversity of reactions catalyzed by the transsulfuration pathway enzymes, cystathionine beta-syn

48 capacity for Cys-SSH production by the human transsulfuration pathway enzymes, cystathionine beta-syn

49 of H(2)S in mammals and is catalyzed by the transsulfuration pathway enzymes, cystathionine beta-syn

50 he increase in homocysteine flux through the transsulfuration pathway exhibited a linear dose depende

51 The transsulfuration pathway generates cysteine, the limitin

52 ontrol design, we measured biomarkers of the transsulfuration pathway in a population-based sample of

53 ely, genetic or metabolic restoration of the transsulfuration pathway in SAA metabolism significantly

54 the presence of an intact functional reverse transsulfuration pathway in T. gondii and demonstrates t

55 the importance of the homocysteine-dependent transsulfuration pathway in the maintenance of the intra

56 cultured human astrocytes, flux through the transsulfuration pathway increased under oxidative stres

57 thionase, has led to the suggestion that the transsulfuration pathway is incomplete in the brain.

58 These findings suggest that targeting the transsulfuration pathway may serve as a means of redirec

59 In conclusion, the diversion to the transsulfuration pathway means that this Met precursor i

60 and/or pathway inhibitors indicates that the transsulfuration pathway plays a significant role in pro

61 However, neither provision of the transsulfuration pathway product, cysteine, nor overexpr

62 l 5'-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homo

63 disease patients suggest impairments in the transsulfuration pathway that connects these metabolites

64 LP)-dependent enzyme, which functions in the transsulfuration pathway that converts homocysteine to c

65 CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to c

66 gical confounders the combined assessment of transsulfuration pathway thiols shows that glutamylcyste

67 e investigated combined associations between transsulfuration pathway thiols, including homocysteine,

68 n of .NO in endothelial cells reprograms the transsulfuration pathway to increase biogenesis of hydro

69 Metabolites in the transmethylation/transsulfuration pathway were measured before and after

70 omarkers of oxidative stress involved in the transsulfuration pathway were significantly higher in wo

71 H was proposed as the primary product of the transsulfuration pathway with H2S representing a decompo

72 Blockade of the transsulfuration pathway with propargylglycine suppresse

73 several ways: a) GSH is synthesized via the transsulfuration pathway, and Cys is the rate-limiting s

74 stathionine beta-synthase, a key gene in the transsulfuration pathway, and various glutathione produc

75 thionine gamma-lyase (CTH), an enzyme in the transsulfuration pathway, as a means of regulating the c

76 (cbsa), which encodes the key enzyme of the transsulfuration pathway, as one of the mutated genes re

77 Produced by the enzymes involved in the transsulfuration pathway, cystathionine beta-synthase (C

78 s were affected in these mutants, as was the transsulfuration pathway, leading also to a disruption i

79 ystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation

80 The transsulfuration pathway, through which homocysteine fro

81 the nonessential amino acid cysteine in the transsulfuration pathway, to be essential for glioblasto

82 tween the integrated stress response and the transsulfuration pathway, we used homocysteine (Hcy) as

83 ne beta-synthase are critical enzymes in the transsulfuration pathway, which also regulate cellular r

84 that HMTBA is preferentially diverted to the transsulfuration pathway, which gives antioxidant metabo

85 is the first and rate-limiting enzyme in the transsulfuration pathway, which is critical for the synt

86 e (CBS) catalyzes the committing step in the transsulfuration pathway, which is important for clearin

87 eine, and indirectly from methionine via the transsulfuration pathway.

88 he methionine cycle is closely linked to the transsulfuration pathway.

89 stathionine gamma-lyase (CGL) in the reverse transsulfuration pathway.

90 ich is synthesized from homocysteine via the transsulfuration pathway.

91 athway while CBS participates in the reverse transsulfuration pathway.

92 thionine, in the first step of the bacterial transsulfuration pathway.

93 oint in the biosynthesis of cysteine via the transsulfuration pathway.

94 r cells is derived from homocysteine via the transsulfuration pathway.

95 lites in the methionine transmethylation and transsulfuration pathways in children diagnosed with aut

96 nsamination, and not the transmethylation or transsulfuration pathways, contributed to methionine-ind

97 ino acid intermediate in the methylation and transsulfuration pathways.

98 cursor to methylation, aminopropylation, and transsulfuration pathways.

99 This transsulfuration reaction represents one of two major ce

100 rn of inhibition compared with the canonical transsulfuration reaction.

101 Because of its central role in transsulfuration, redox status, and H2S biogenesis, CBS

102 compounds modulating hCBS activity and thus transsulfuration, redox status, and H2S biogenesis.

103 (or betaine in an alternative reaction); and transsulfuration to cystathionine, which requires pyrido

104 ylated back to methionine or metabolized via transsulfuration to cystathionine.

105 reased folate and vitamin B12 levels and Hcy transsulfuration to cysteine.

106 accumulation of Hcy, which is channeled via transsulfuration to increase glutathione and enhance ars

107 re in which the flux of homocysteine through transsulfuration under normoxic and oxidative conditions

108 for independent modulation of the canonical transsulfuration versus H(2)S-generating reactions catal

109 smethylation via methionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).