ライフサイエンスコーパス: trefoil

1 oncentrations: the beta-hairpin interface of trefoils 1 and 2 and the H2a-H2 helical region.

2 The site in beta-trefoil-1 is located near the binding site of the fascin

3 ed by pseudo-2-fold symmetry to that in beta-trefoil-1.

4 largest of which is the D(3)(h)()-symmetric "trefoil" 2 and is composed of three [18]annulenes fused

5 e topoisomers-an unknot (0(1)) macrocycle, a trefoil (3(1)) knot(6-15), and a three-twist (5(2)) knot

6 The site in beta-trefoil-3 is related by pseudo-2-fold symmetry to that i

7 d that the topological landscape of the beta-trefoils allows for the population of diverse, geometric

8 s, propellers, 2-solenoid, super-roll, clam, trefoil and box are not widely distributed and were prob

9 components in both PK and DSAEK groups were trefoil and coma from the anterior corneal surface (P <

10 variety of eutectic mesostructures including trefoil and hexafoil are observed, the former resembling

11 We note that the trefoil and hexafoil patterns resemble Archimedean honey

12 olecular topologies (including catenanes and trefoil and pentafoil knots).

13 CC harbors two lectin-like domains: the beta-Trefoil and the beta-Prism domains; however, precise con

14 sitions in the pseudo-symmetric units of the trefoil, and are juxtaposed to one another in conformati

15 hanges in astigmatism, spherical aberration, trefoil, and coma with accommodation, which must arise f

16 Corneal higher-order aberrations (SA, coma, trefoil, and corneal asphericity) for a 6 mm pupil were

17 r generally poor thermal stability, the beta-trefoil architecture appears capable of substantial ther

18 a homotrimer, producing a thermostable beta-trefoil architecture.

19 iary structure symmetry inherent in the beta-trefoil architecture.

20 linear DNAs demonstrates that the two chiral trefoils are produced in equal amounts, suggesting that

21 led lone-pair Sn states involved in in-plane trefoil aromatic interactions.

22 The "trefoil" aromaticity, previously postulated for aromatic

23 or (EGF-R) activation was also necessary for trefoil auto- and cross-induction, and both spasmolytic

24 ites, which are consistent with general beta-trefoil carbohydrate-binding sites (alpha, beta), and al

25 tructure and comparison with homologous beta-trefoil - carbohydrate complexes allows for a functional

26 ations and surface features of the family of trefoil cell motility factors (porcine SP, pS2, and hITF

27 tailed structural comparisons with the other trefoil cell motility factors.

28 an square of total higher order aberrations, trefoil, coma, tetrafoil, secondary astigmatism, and sph

29 P > 0.05), but the WF-guided group had less trefoil compared with the WF-optimized group (0.14 +/- 0

30 e N- and C-terminal regions outside the beta-trefoil core in FGF9 are ordered and involved in the for

31 The FHF1b beta-trefoil core is remarkably similar to that of classical

32 he betaC'-betaE loop interacts with the beta-trefoil core region of FGF1, in the FGF1-FGFR3c structur

33 s dependent on sequences outside of the beta-trefoil core.

34 structure of the TFF3 monomer and with other trefoil dimer structures (TFF1 and TFF2).

35 transcription factors, but a surprising beta-trefoil domain (BTD) is inserted between them.

36 RAM region of the Notch receptor to the beta-trefoil domain (BTD) of CSL.

37 n motifs, we expressed the isolated VVH beta-trefoil domain and used glycan-chip screening to identif

38 intermolecular disulfide bonds via an extra-trefoil domain cysteine residue and are present in vivo

39 The core of the trefoil domain in hITF consists of a two-stranded antipa

40 gnificant structural differences between the trefoil domain in the monomer and dimer TFF3 are in the

41 However, neither an intact trefoil domain nor dimerization was required to promote

42 RAM domain of Notch interacts with the beta trefoil domain of CSL; however, the C-terminal domain of

43 nt in the ZP domain and 6 are present in the trefoil domain of VEalpha and VEbeta.

44 Each contains one trefoil domain that is characterized by several conserve

45 s in loop regions within the C-terminal beta-trefoil domain which showed greatly reduced ganglioside

46 egions to a key interaction domain (the beta trefoil domain, or BTD) of human CSL.

47 de (SP, 106 residues) form a small family of trefoil domain-containing mammalian cell motility factor

48 VEalpha and VEbeta also have a trefoil domain.

49 vities are housed within the C-terminal beta-trefoil domain.

50 egions of high sequence conservation in beta-trefoil domains 1 and 3.

51 s compared with the TFF1 dimer where the two trefoil domains are connected by a flexible region with

52 h N-terminal mART and C-terminal tandem beta-trefoil domains associate to form an overall architectur

53 triplicated repeats in each of the four beta-trefoil domains of fascins are significantly similar in

54 eals a novel arrangement of four tandem beta-trefoil domains that form a bi-lobed structure with appr

55 Fascin consists of four beta-trefoil domains.

56 been proposed to form the functional site of trefoil domains.

57 the recently synthesized cycloparaphenylene trefoil E creates a more ribbon-like structure with redu

58 f strongly induced after mucosal damage, the trefoil/EGF-R relationship may be pivotal in the generat

59 e factors revealed that the human intestinal trefoil factor (ITF) gene promoter bears a previously un

60 ' flanking sequence of the murine intestinal trefoil factor (ITF) gene was found to confer goblet cel

61 Intestinal trefoil factor (ITF) is an essential regulator of coloni

62 Intestinal trefoil factor (ITF) is selectively expressed in goblet

63 Intestinal trefoil factor (ITF) is selectively expressed in intesti

64 GF-I, interleukin (IL)-1beta, and intestinal trefoil factor (ITF) messenger RNAs (mRNAs) were measure

65 out inducing marker genes such as intestinal trefoil factor (ITF) or myo-inositol-1-phosphate synthas

66 The trefoil peptide intestinal trefoil factor (ITF) plays a critical role in the protec

67 Intestinal trefoil factor (ITF) promotes epithelial cell migration

68 ially ameliorate injury including intestinal trefoil factor (ITF), a small protease-resistant peptide

69 Intestinal trefoil factor (ITF), a small, compact protease-resistan

70 in the intestine-specific peptide intestinal trefoil factor (ITF), in which colonic restitution is le

71 n of the goblet cell gene product intestinal trefoil factor (ITF).

72 The secreted proteins intestinal trefoil factor (ITF, 59 residues), pS2 (60 residues), an

73 The intestinal trefoil factor (ITF/TFF3) protects intestinal epithelia

74 and efficacy of recombinant human intestinal trefoil factor (rhITF) administered as topical oral spra

75 eceptor (TLR) 2 and modulation of GC-derived trefoil factor (TFF) 3 are functionally linked in the in

76 Trefoil factor (TFF) peptides are pivotal for gastric re

77 Trefoil factor (TFF) peptides, with a 40-amino acid moti

78 ed in malignant brain tumors (DMBT1) and the trefoil factor (TFF) proteins have all been proposed to

79 d for Ki67, ER, progesterone receptor (PgR), trefoil factor 1 (PS2), HER1 (epidermal growth factor re

80 repress estrogen-stimulated transcription of trefoil factor 1 (TFF1 or pS2) by stalling RNA polymeras

81 ), comprising the regulatory elements of the trefoil factor 1 (Tff1) gene and the tamoxifen-inducible

82 Trefoil factor 1 (TFF1) is a secreted protein involved i

83 Trefoil factor 1 (TFF1) is a tumor suppressor gene that

84 Epigenetic alterations of the trefoil factor 1 (TFF1) tumor suppressor gene were evalu

85 and negatively associated with expression of trefoil factor 1 (TFF1).

86 -mediated induction of many genes, including trefoil factor 1 and keratin 14, were inhibited by great

87 n of the estrogen-regulated proteins PgR and trefoil factor 1, regardless of HER1/2 status (P < 0.000

88 also up-regulated in gastric tumors from the trefoil factor 1-knockout mouse model.

89 Trefoil factor 2 (TFF2) acts via chemokine C-X-C recepto

90 To determine the role of trefoil factor 2 (TFF2) and intracellular calcium (Ca(2+

91 erstood, this study investigated the role of trefoil factor 2 (TFF2), a well-established regulator of

92 o strong downregulation of the gene encoding trefoil factor 2 (Tff2), preventing maturation of the pr

93 previously identified hypomethylated genes (trefoil factor 2 and lipocalin 2) between pancreatic and

94 se tags corresponded to genes (lipocalin and trefoil factor 2) previously shown to be overexpressed i

95 his study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair mol

96 of cells that coexpressed intrinsic factor, trefoil factor 2, and Griffonia (Bandeiraea) simplicifol

97 The capacities of urinary trefoil factor 3 (TFF3) and urinary albumin to detect ac

98 The Cytosponge-trefoil factor 3 (TFF3) is a non-endoscopic test for Bar

99 a specialized cell type of IEC that secrete Trefoil factor 3 (TFF3) to regulate mucus viscosity and

100 munohistochemical staining for the biomarker Trefoil Factor 3 (TFF3), could be used to identify patie

101 x10(-16); MAF=0.22) in LRP2 (associated with trefoil factor 3 [TFF3]), and rs11048230 (P=4.77x10(-8);

102 a14) and masculine (cytochrome P450 4a12 and trefoil factor 3) genes, as well gender-neutral (H19 fet

103 gelatinase-associated lipocalin, cystatin C, trefoil factor 3, tissue inhibitor of metalloproteinase

104 probably because of the higher expression of trefoil factor 3, Toll-interacting protein, and zonula o

105 ion (cyclooxygenase-2 [COX-2] and intestinal trefoil factor [ITF]), and prostaglandin E2 (PGE2) level

106 ecreased apoptosis, and decreased intestinal trefoil factor expression in the mucosa of both the smal

107 observed robust regulation of the secretory trefoil factor family (TFF) members, including a causal

108 n IPMTs corresponded to three members of the trefoil factor family (TFF1, TFF2, and TFF3).

109 Trefoil factor family 2 (TFF2) is up-regulated in Helico

110 The secreted trefoil factor family 2 (TFF2) protein contributes to th

111 neck cells located below the isthmus express trefoil factor family 2 (TFF2) protein, TFF2 messenger R

112 Trefoil factor family 2 (TFF2), also known as spasmolyti

113 cursor compartment for IPMNs and the role of Trefoil factor family 2 (TFF2)-a protein expressed by PD

114 e rapid emergence of spasmolytic polypeptide/trefoil factor family 2 (TFF2)-expressing metaplasia (SP

115 We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide)

116 Trefoil factor family 2/spasmolytic polypeptide and intr

117 Microarray analysis identified trefoil factor family 3 (TFF3) as a gene expressed in bi

118 gene that encodes a peptide belonging to the trefoil factor family of protease-resistant peptides.

119 the first demonstration that a member of the trefoil factor family of proteins is bound covalently to

120 Trefoil factor family-1 (TFF1) is a key gastric tumor-su

121 nknown protein that we have called TFIZ1 for trefoil factor interactions(z) 1.

122 The trefoil factor peptides are a family of small highly con

123 Immunohistochemical analysis of trefoil factor TFF1, 2 and 3 showed that TFF1 and 3 loca

124 -defensins Defa24 and Defa-rs1) and colonic (trefoil factor Tff2) mucus barrier.

125 al control of GalNAc transfer by single TFF (Trefoil factor) domains as high stringency determinants.

126 Intestinal trefoil factor, an intestinal peptide that mediates anti

127 nes (multidrug resistance gene-1, intestinal trefoil factor, CD73), resulting in attenuated loss of b

128 other surface molecules, such as intestinal trefoil factor, help to maintain the structural integrit

129 Trefoil factor-1 (Tff1) expression is remarkably down-re

130 he potential for rapid up-regulation of this trefoil factor.

131 ed by expression and staining for intestinal trefoil factor.

132 he genes (claudin4, lipocalin2, 14-3-3sigma, trefoil factor2, S100A4, mesothelin, and prostate stem c

133 In the intestinal mucosa trefoil factors (TFF) and mucins (Muc) - primarily produ

134 Trefoil factors (TFFs) are secreted molecules that are i

135 rices consist of curli nanofibers displaying trefoil factors (TFFs), known to promote intestinal barr

136 forming growth factor, melatonin, serotonin, trefoil factors and H2S all enhance mucosal barrier func

137 Mucins, growth factors, and trefoil factors are involved in accelerating gastric inj

138 Although trefoil factors have been shown to activate signaling pa

139 Trefoil factors promote mucosal homeostasis.

140 hanisms in ulcer healing, the interaction of trefoil factors with the mucus gel, the interaction of g

141 Epithelial cells secrete trefoil factors, heat shock proteins, and secretory leuk

142 rget genes upregulated by GATA-4 and -5, the trefoil factors, inhibinalpha, and disabled-2 (Dab2) are

143 talloproteinases, heat-inducible factors and trefoil factors, protective functions of submucosal mono

144 ts indicate that the global fold of the beta-trefoil family determines the energy landscape but that

145 Trefoil family factor 2 (TFF2), also known as spasmolyti

146 other proteins of unknown function, are beta-trefoil family homologues.

147 spasmolytic polypeptide, is a member of the trefoil family of peptides and is expressed primarily in

148 can potentially be exploited for other beta-trefoil family proteins in the IL-1 and FGF families.

149 eta (IL-1beta) is a cytokine within the beta-trefoil family.

150 s of the cytolytic domain and contain a beta-trefoil fold and a beta-prism fold.

151 Complex folds like the beta-trefoil fold and functional loops like the beta-bulge of

152 lop designer cytokine activity into the beta-trefoil fold and may be of general use in regulation of

153 a single ricin B lectin domain with its beta-trefoil fold and one carbohydrate-binding site.

154 This hints at how the beta-trefoil fold arose from the duplication of an ancestral

155 The beta-trefoil fold characteristic of native IL-1ra was preserv

156 The FHF1b core domain assumes a beta-trefoil fold consisting of 12 antiparallel beta strands

157 tly identified FGF-2 as a member of the beta-trefoil fold family.

158 the design of a foldable, thermostable beta-trefoil fold is possible.

159 interactions within the pseudosymmetric beta-trefoil fold of IL-1beta highlight the backbone water in

160 The regulatory role of the beta-trefoil fold of ppGalNAc-Ts in enzymatic activity of gly

161 FGF4 adopts a beta-trefoil fold similar to other FGFs.

162 FGF9 adopts a beta-trefoil fold similar to other FGFs.

163 11 transmembrane helices and a lumenal beta-trefoil fold termed the MIR domain.

164 the extrinsic effect of lectin domains (beta-trefoil fold) of polypeptide GalNAc-transferases (ppGalN

165 n architecture (the threefold symmetric beta-trefoil fold).

166 phobic core residues that stabilize the beta-trefoil fold, as well as interfacial residues that are l

167 viously revealed that they both adopt a beta-trefoil fold, similar to those found in Kunitz soybean t

168 tor-1, a member of the 3-fold symmetric beta-trefoil fold, was subjected to a series of symmetric con

169 and contain a luminal MIR domain with a beta-trefoil fold, which is susceptive for missense mutations

170 llowed by closure of the barrel in this beta-trefoil fold.

171 interleukin-1beta (IL-1beta), adopts a beta-trefoil fold.

172 toxin complex consists of a reoccurring beta-trefoil fold.

173 e interactions essential for maintaining the trefoil fold.

174 ructure revealed that the protein has a beta-trefoil fold.

175 rands, distinguishing cospin from other beta-trefoil-fold serine protease inhibitors in which beta4-b

176 aberration for Kelman Duet (P = .753) and in trefoil for Acrysoft (P = .059).

177 the anterior corneal surface (P < 0.05) and trefoil from the posterior corneal surface (P < 0.05).

178 The trefoil gene family of mucus cell-secreted proteins is a

179 Transcription of trefoil genes is induced during mucosal repair, but the

180 ed, showed reduced expression of the gastric trefoil genes SP and pS2, suggesting that trefoil peptid

181 n (HSQC) NMR spectra confirmed that the beta-trefoil global fold was largely intact under these three

182 within the immunodominant H chain as a beta-trefoil (Hcbetatre) structure; we hypothesize that induc

183 uces more negative-noded than positive-noded trefoils, indicating an asymmetry in the interaction bet

184 x months postoperatively and NCVA, while the trefoil, internal higher order aberration (HOA) and tota

185 The inversion product is a trefoil, its unique topology being conferred by the exte

186 f this tail suggests that ClpXP tightens the trefoil knot against GFP, which prevents GFP unfolding.

187 These and the earlier discovery of a trefoil knot also suggest that the number of rigid compo

188 ein AFV3-109 is transformed into a tightened trefoil knot by applied pulling force.

189 Despite possessing the trefoil knot characteristic of SPOUT enzymes, Trm10 does

190 strategy for the preparation of a molecular trefoil knot from a flexible bipyridine oligomer and a z

191 ere the near-quantitative self-assembly of a trefoil knot from a naphthalenediimide-based aqueous dis

192 e stereoselective synthesis of a left-handed trefoil knot from a tris(2,6-pyridinedicarboxamide) olig

193 losing olefin metathesis to form a molecular trefoil knot in 58% yield.

194 etathesis affords a single enantiomer of the trefoil knot in 90% yield.

195 lexities involved in the formation of a deep trefoil knot in a polypeptide backbone.

196 n the SpoU family of MTases, contains a deep trefoil knot in its C-terminal region.

197 to show that the free energy cost to form a trefoil knot in the denatured state of a polypeptide cha

198 slipknot can be transformed into a tightened trefoil knot involving approximately 13 amino acid resid

199 ut the use of only (R,R)-1 leads solely to a trefoil knot of Lambda-handedness, whereas (S,S)-1 forms

200 ional methods to investigate the effect of a trefoil knot on the breaking strength of a polymer stran

201 rial TrmD has the unusual class IV fold of a trefoil knot structure.

202 pocket, and reveals an unusually formed deep trefoil knot that stabilizes this region.

203 ials, the acoustic fields with Hopf link and trefoil knot vortex lines have been observed experimenta

204 tein Data Bank, a previously unreported deep trefoil knot was found in acetylornithine transcarbamyla

205 The first synthetic molecular trefoil knot was prepared in the late 1980s.

206 -handedness, whereas (S,S)-1 forms the Delta-trefoil knot with complete stereoselectivity.

207 ed here to six Hopf and two Solomon links, a trefoil knot, and a [3]catenate.

208 the AdoMet-binding pocket, formed by a deep trefoil knot, contains a bound phosphate molecule, which

209 bute to an early and a late formation of the trefoil knot, respectively.

210 ll single domain protein harboring a shallow trefoil knot, we allow the protein to refold from either

211 he metathesis product results in a molecular trefoil knot.

212 kbone polypeptide chain folds to form a deep trefoil knot.

213 ly generates the wholly organic 81-atom-loop trefoil knot.

214 TrmD features a trefoil-knot active-site structure whereas Trm5 features

215 The specific production of (+) trefoil knots in the presence of condensin and a type II

216 that belong to the SpoU-TrmD family contain trefoil knots in their backbone fold.

217 embers of the alpha/beta-knot clan form deep trefoil knots in their native backbone structure, a topo

218 hesis to form topologically chiral molecular trefoil knots of single handedness.

219 roteins considered to be knotted form simple trefoil knots with one end of the chain extending throug

220 rom small-molecule building blocks have been trefoil knots, the first pentafoil knot was recently syn

221 structures and colloidal particles, such as trefoil knots, with 'frozen' orientational order of flak

222 strategy is reported for the production of a trefoil knotted polymer from a copper(I)-templated helic

223 ts, confirmed the formation of the resulting trefoil knotted polymer.

224 sm of knotting and folding for two bacterial trefoil-knotted methyltransferases.

225 Here, we characterized the effects of the trefoil-knotted protein MJ0366 from Methanocaldococcus j

226 argeting domain predicted to resemble a beta-trefoil lectin fold.

227 biaceae type 1 RIPs fused with a double beta trefoil lectin gene similar to the actual Cucurbitaceae

228 lover (Trifolium pratense L.), and birdsfoot trefoil (Lotus corniculatus L.).

229 Trefoil-mediated transcriptional regulation required act

230 nctional regions are not central to the beta-trefoil motif and cause slow folding.

231 ITF contains a unique three-looped trefoil motif formed by intrachain disulfide bonds among

232 Any alteration of the trefoil motif or truncation resulted in loss of protease

233 of macromolecules indicates that the simple trefoil or 'overhand' knot is likely to be present in an

234 y favour the formation of constructs tied in trefoil or pentafoil, or even of more exotic torus knots

235 Posterior trefoil (P <= 0.034), secondary astigmatism (P <= 0.042)

236 showed the lowest values at central zone for trefoil (P = .043) and tetrafoil (P = .002) in AC group.

237 ned unchanged (P = 0.07) while the change in trefoil (P = 0.047) postoperatively, was not clinically

238 The trefoil peptide intestinal trefoil factor (ITF) plays a

239 The dimer contains two deep trefoil peptide knots and a peptide loop extending from

240 the pancreas, under control of the pS2 mouse trefoil peptide promoter.

241 -coated pits, suggesting that integration of trefoil peptide responses may occur after internalizatio

242 surface receptor has been directly linked to trefoil peptide signaling.

243 Gastrin-stimulated expression of the trefoil peptide TFF1 in mouse fundus and in the gastric

244 Trefoil peptide-2-deficient mice were more susceptible t

245 to block apoptosis correlated with a loss of trefoil peptide-induced transactivation of the EGF recep

246 al anti-inflammatory agents, confirming that trefoil peptides increased the barrier properties of the

247 ic trefoil genes SP and pS2, suggesting that trefoil peptides may individually regulate transcription

248 enerating bicarbonate, mucus, phospholipids, trefoil peptides, prostaglandins (PGs), and heat shock p

249 there have been striking findings regarding trefoil peptides, the protective effect of regulatory pe

250 d repair predominantly through production of trefoil peptides.

251 l cell line that does not express endogenous trefoil peptides.

252 Analysis of the chirality of trefoils produced by cyclization of two linear DNAs demo

253 Using a minimally tied trefoil protein as the framework for understanding the s

254 a are shared among other members of the beta-trefoil protein family, although clear differences can e

255 op 2/loop 3 regions, which suggest that each trefoil protein has a specific target or group of target

256 The beta-trefoil protein human fibroblast growth factor-1 (FGF-1)

257 These showed that the 6.67 kDa secreted trefoil protein is present as an approximately 25 kDa co

258 The human trefoil protein TFF1 is a small cysteine-rich secreted p

259 The trefoil protein TFF3 forms a homodimer (via a disulfide

260 The trefoil protein TFF3 stimulates invasion and angiogenesi

261 This process culminated in a beta-trefoil protein with exact 3-fold primary-structure symm

262 e accurately the folding pathway of the beta-trefoil protein, interleukin-1beta (IL-1beta).

263 cules and proteins (eg, the mucin-associated trefoil proteins and estrogens).

264 have explored the sequence space of all beta-trefoil proteins and have determined that the actin-bind

265 provide statistical evidence that these beta-trefoil proteins are all homologues, having arisen from

266 The human trefoil proteins TFF1 and TFF3 are expressed predominant

267 ns within the folded ensembles of other beta-trefoil proteins, such as IL-1beta and hFGF-1.

268 Unlike other beta-trefoil proteins, the triplicated repeats in each of the

269 gnition properties of Cys-MR with other beta-trefoil proteins.

270 ation rate of this material-template system, trefoil, quatrefoil, cinquefoil and hexafoil mesostructu

271 ared to 5 years, CDVA improved (P < .05) and trefoil reduced (P < .05).

272 o an approximately three-fold symmetric beta-trefoil shape resembling fibroblast growth factor.

273 Here, we characterize trefoil-shaped outer-sphere lanthanide chloride and nitr

274 synthesis and characterization of star- and trefoil-shaped polyethynyl aromatic structures, which re

275 The beta-trefoil structural family members IL-1beta, hisactophili

276 at might function either supporting the beta-trefoil structure or in the communication between both s

277 -1beta (IL-1beta) structural motif is a beta-trefoil super fold created by six two-stranded beta-hair

278 beta) is a cytokine and a member of the beta-trefoil superfamily of protein structures.

279 risms is varied from small lobed, big lobed, trefoil, T-shaped to a reuleaux triangle by increasing t

280 tion of apoA-I on the midsize disks and the "trefoil/tetrafoil" arrangement on spherical HDL.

281 The interaction between DMBT1(gp340) and trefoil TFFs proteins was investigated using an ELISA as

282 We show that supercoiling of a DNA trefoil, the simplest knotted ring, perturbs differently

283 lly important cytokine with a symmetric beta-trefoil topology, are characterized using optical spectr

284 lass of proteins characterized by their beta-trefoil topology.

285 Golden trefoils: Tris(alkyne)gold complex [(coct)(3)Au][SbF(6)]

286 the 5'-OH leaving group of the reaction by a trefoil turn in the RNA backbone.

287 forms, especially in the P1.1 helix and the trefoil turn in the single-stranded region connecting P4

288 that this local conformational change in the trefoil turn is kinetically coincidental with a previous

289 76) is stacked with other bases and that the trefoil turn is not formed.

290 By modifying G(76) of the trefoil turn of a synthetic trans-cleaving HDV ribozyme

291 these substrate analogues on the ribozyme's trefoil turn of the catalytic core.

292 Our results demonstrate that the trefoil turn of the HDV ribozyme catalytic core is in a

293 pair and the A-minor motif of the catalytic trefoil turn that depend on the identity of the N-1 base

294 cked and solvent-exposed as evidenced in the trefoil turn.

295 cultures of Lotus corniculatus (bird's foot trefoil) using genetic manipulation.

296 Trefoil was significantly lower in the WFG group and was

297 In gastric cell lines, the trefoils were shown to act in a manner suggestive of imm

298 versions of an extant protein fold (the beta-trefoil) were produced by top-down symmetric deconstruct

299 (bird's foot trefoil) were transformed with an antisense chalcone syn

300 Vertical trefoil (Z3(-3)) was the predominant higher-order aberra

301 tively were vertical coma (Z3(-1)), vertical trefoil (Z3(-3)), and secondary astigmatism (Z4(4)).