ライフサイエンスコーパス: trend toward

1 ubjects with CKD, there was a nonsignificant trend toward a better MACCE outcome with CABG and a sign

2 A significant trend toward a decrease in absolute N1 amplitude values

3 pill burden, reduced treatment costs, and a trend toward a decreased rate of discontinuing sorafenib

4 table thereafter; there was a nonsignificant trend toward a flatter posterior KA and steeper posterio

5 of death or graft loss, although there was a trend toward a greater risk of posttransplant metabolic

6 tor containing a deletion in B19R inducing a trend toward a higher magnitude of CD4(+) and CD8(+) T c

7 There was a trend toward a higher proportion of cysts resolved and a

8 pooled proportion meta-analysis indicates a trend toward a higher rate of tracheal stenosis and an i

9 They had a nonsignificant trend toward a lower graft survival.

10 We observed a trend toward a lower HEI-2010 in Supplemental Nutrition

11 mRNAs were detected only in B cells, with a trend toward a lower level among patients with pSS.

12 ockers on outcome in patients with MINOCA, a trend toward a positive effect of beta-blocker treatment

13 disease related to steroid treatment shows a trend toward a protective effect (odds ratio, 0.16; 95%

14 ma among TFV gel users was associated with a trend toward a reduced risk of HSV-2 acquisition, after

15 FV detection in plasma was associated with a trend toward a reduced risk of HSV-2 seroconversion, wit

16 se of a bowel protocol was associated with a trend toward a reduction in constipation (risk ratio, 0.

17 stents, DES implantation was associated to a trend toward a reduction of target lesion (hazard ratio,

18 ncreased risk of incident CVD and DM, with a trend toward a significant association with bone events.

19 ment, rs111200466-deletion carriers showed a trend toward a slower, recovery rate (time required to r

20 and pharmacological treatment, except for a trend towards a larger infarct size and longer symptom-t

21 ies are needed to confirm the nonsignificant trend towards a lower graft survival in CMV high-risk pa

22 s shown that prior to a polarization event a trend towards a more uniform distribution of relative in

23 By contrast, >/=98% RVP trended toward a lower risk of an appropriate shock (haz

24 r IL6, both downstream of IL1beta signaling, trended toward a shorter time to lung cancer diagnosis.

25 tus was the only patient characteristic that trended toward a significant clinical impact (P = 0.056)

26 c and health covariates, but the association trended towards a higher mortality rate ratio when contr

27 e analysis, higher AF genetic susceptibility trended towards a higher risk of recurrence (HR, 1.08 [9

28 AG heterozygotes whereas the AA homozygotes trended towards a protective effect against scarring (od

29 The PDRBD+ group trended towards a reduced mean MRI locus coeruleus: pons

30 le and found several HLA alleles that showed trends toward a lower risk of hospitalized disease were

31 However, our results show trends toward a more pronounced benefit of ReLACS compar

32 ic salmon in southeast Alaska, USA, regional trends toward a warmer, wetter climate are predicted to

33 With the demographic trend towards ageing and projected rise in important ris

34 This results in a trend toward an altered activation of nuclear factor kap

35 king subjects with schizophrenia; however, a trend toward an effect was observed on negative symptoms

36 There is a patient trend toward an excess of de novo and potentially disrup

37 There was a trend toward an increase in total toughness of the glass

38 A trend toward an increased bleeding rate at presentation

39 Patients with systemic disease showed a trend toward an increased risk of recurrence, but it was

40 Currently, there is a trend toward an increasing use of biopesticides assumed

41 A trend toward an inverse association between triclosan an

42 tern of rotavirus rates was observed, with a trend toward an older median age.

43 on patterns across gestation, with a general trend towards an increase in methylation over gestation.

44 and when accounting for putative overdosing, trended toward an increase in the survival benefit affor

45 nteractive influences exhibited considerable trend towards association.

46 short-term bevacizumab therapy resulted in a trend toward BBB restoration (P = 0.055) and long-term t

47 er an oral-glucose-tolerance test (P = 0.10) trended toward being lower in the WG than in the RG.

48 The trend toward benefit observed in the TN, node-positive s

49 We observed a trend toward better 12-month allograft function for kidn

50 Decompressive craniectomy showed a trend toward better health-related quality of life in th

51 There was a trend toward better OS in DS+LDLT versus non-DS LDLT gro

52 zanubrutinib treatment was associated with a trend toward better response quality and less toxicity,

53 ssociated with better diagnostic yield and a trend toward better visual outcomes.

54 accounting for patient factors and existing trends toward better outcomes, there was no association

55 study outcomes after accounting for overall trends toward better outcomes.

56 , whereas rodents show evidence of a greater trend toward birth of new hypomethylated regions.

57 p showed lower reward learning (P = 0.02), a trend towards blunted reward-related prediction error si

58 An increasing trend toward C(4) herbivory has been observed with atten

59 Based on these results, the trend toward centralized core laboratories negatively im

60 4; 95% confidence interval, 1.06-1.21) and a trend toward cerebrovascular accident (10-year hazard ra

61 cture elements they are part of show a clear trend toward conserving a rigid backbone.

62 Electrolysis is participating in the trend toward continuous flow synthesis, and this has led

63 The pretransplant DAA treatment strategy trended towards cost-effectiveness as HCV(+) donor liver

64 h the outcomes are comparable, we observed a trend toward decreased EFS for patients assigned to rece

65 terior edge and square posterior edge show a trend toward decreased incidence of PD.

66 ant changes in soluble markers, apart from a trend toward decreased levels of soluble CD163 levels (P

67 A trend toward decreased liver fibrosis with endothelial c

68 There was a trend toward decreased pruritus in FIC1 after IE and GBC

69 Higher fruit intake was associated with a trend toward decreased risk of BRAF-mutated tumors [OR 4

70 eliminary efficacy evaluation demonstrated a trend towards decreased AKI in the high dose AP group.

71 ry chain defect in complexes I and II, and a trend towards decreased ATP levels.

72 IOP elevation in Brown Norway rats showed a trend towards decreased expression of ATP5H.

73 These alterations were characterized by a trend towards decreased overall microbial diversity as w

74 There was a trend towards decreased transfusion in the diet group (1

75 ng rhabdomyosarcoma cell growth in vitro and trending toward decreased tumor growth in vivo.

76 However, there was a trend toward decreasing complication rates with increasi

77 tometry and biolayer interferometry showed a trend toward decreasing EGFR affinity with increasing nu

78 ze and fishing mortality are currently in or trending toward desirable states: extensiveness of stock

79 different ortholog classes, with an obvious trend toward differential replaceability inside gene fam

80 restingly, D4.2 subgenotype viruses showed a trend toward diminished susceptibility to neutralization

81 The trends toward earlier PPT discovered here have co-occurr

82 ected to increase in light of global secular trends towards earlier puberty timing.

83 dients in mean seasonal timing and nonlinear trends towards earlier seasonal timing that varies in fo

84 roups (</=12 and >12 years), and there was a trend toward early EBV infections among the case subject

85 A trend toward early-stage diagnosis for select cancers in

86 However, there was only a trend towards ECV(salvage) being higher than ECV(remote)

87 stulas (SDAVF), there has been an increasing trend towards embolisation.

88 e plasma ceramides in rodents, have a slight trend toward enhanced insulin sensitization in DIO mice,

89 cent positive selection with an evolutionary trend towards enhanced immune response.

90 lete wound closure, the vacuum-treated honey trended towards faster wound closure.

91 Changes in emotion comprehension trended toward favoring intervened children.

92 Over time, there was a trend toward fewer 80-hour work week violations in the f

93 There was a trend toward fewer cardioversions and hospital admission

94 pared with 7.8 mg/L, P = 0.03), and showed a trend toward fewer episodes of severe malaria (incidence

95 e treated with CC alone, although there is a trend towards fewer infections in those given CPIs, part

96 characteristic, 0.72; 95% CI, 0.61-0.84) and trended toward fewer organ failure-free days although da

97 aldafermin reduced liver fat and produced a trend toward fibrosis improvement.

98 f stroke subtype, there were non-significant trends towards future ICH with statins.

99 HFD-islet analysis revealed clear trends toward global reductions in mRNA translation with

100 A trend toward greater discrimination under higher CO2 lev

101 on of ecomorphs, and we identify a long-term trend toward greater ecomorphological specialization ove

102 ALGS patients experienced a trend toward greater freedom from xanthomata after PEBD.

103 09, 1.58) and a statistically nonsignificant trend toward greater risk of relapse (RR: 1.17; 95% CI:

104 oup, while greater gray matter atrophy and a trend toward greater sentence comprehension deficits (me

105 nalysis of the aggregate-level data showed a trend towards greater shared environmental variation of

106 Cells at RT also showed a trend towards greater survival-rates when cultured (74.3

107 For MD-IPMN, there was not a clear trend towards guideline adherence, and the rate of high-

108 Drinking >=1.5 drinks per day showed a trend toward harm (HR = 1.16, 95% CI 0.99-1.36, P = 0.11

109 (P = 0.013), and there was a nonsignificant trend toward higher Bifidobacterium spp. in the Fe+GOS g

110 carotene when adjusting for dose, although a trend toward higher cleavage of beta-carotene was observ

111 A trend toward higher discrimination capacity was also obs

112 were compared to those who had and showed a trend toward higher hydrogen peroxide levels (mean 172.8

113 There was a nonsignificant trend toward higher in-hospital stroke (OR, 1.64; 95% CI

114 2; 4.7%) had more stage III-IV disease and a trend toward higher IPI and non-GCB subtype.

115 ble FEVAR and PMEG were similar, there was a trend toward higher long-term mortality with PMEG compar

116 s (25 [24-28] vs 20 [14-23]; p = 0.02) and a trend toward higher mortality (30% vs 0%; p = 0.2) compa

117 ELA also showed a trend toward higher numbers of CCR4(+)CXCR3(-)CCR6(+) CD

118 There is a trend toward higher rate of sensory fusion for patients

119 We found a trend toward higher rates of global developmental delay

120 atment (each P < 0.001) with a significantly trend toward higher rates of pain in smaller hernias.

121 ransplant and HIV outcomes were excellent; a trend toward higher rejection with D+ raises concerns th

122 Histopathology showed a trend toward higher rejection/inflammation grades in all

123 There was a trend toward higher risk of acute kidney injury requirin

124 There was a trend toward higher risk of stroke (pooled HR: 1.25; 95%

125 % CI, 1.24-3.10; 8 studies; I2, 48%), with a trend toward higher risks for exposure to more severe de

126 Compared with white women, there was a trend toward higher unadjusted 1-year major adverse card

127 There was a trend toward higher weekly PC-entry nAb titers (P = .07)

128 ficant increase in mean insulin levels and a trend towards higher C-peptide levels.

129 influenced by treatment although there was a trend towards higher molecular weight fractions which in

130 some internalization of the IgG, but with a trend towards higher surface CASPR2 expression.

131 GC also showed a trend towards higher values in dystonia than controls.

132 series contains a statistically significant trend towards higher values, i.e. warmer conditions, beg

133 115.9 nM; p = 0.25), and these patients also trended toward higher hydrogen peroxide than healthy par

134 Trabecular and total BMD at the tibia trended toward higher values (P < 0.06) in the calcium g

135 condensate hydrogen peroxide concentrations trended toward higher values in asthma patients compared

136 ns were well tolerated and immunogenic, with trends toward higher anti-circumsporozoite antibody tite

137 There was a mild but significant trend toward hyperventilation, albeit within safe clinic

138 py number between the 2 groups, but a global trend towards hypomethylation in the progressor group wa

139 nate under airway conditions follow the same trend toward IL-1alpha dependency.

140 Levodopa resulted in a strong trend towards impairing timing processes and caused a de

141 R-CHOP showed a trend toward improved complete (53% versus 71%; P = 0.06

142 etes mellitus, allopurinol associated with a trend toward improved flow-mediated dilation (+1.4% [3.9

143 , 0.54; 95% CI, 0.44 to 0.66; P < .01) and a trend toward improved OS (HR, 0.77; 95% CI, 0.59 to 1.01

144 to 48 hours or 48 to 72 hours demonstrated a trend toward improved outcomes (HR, 0.49; 95% CI, 0.21-1

145 A trend toward improved overall survival also favored nint

146 athologic responses in some patients, with a trend toward improved pathologic outcomes with ELAP.

147 correlate with ORR, PFS, or OS, there was a trend toward improved PFS and OS in patients with progra

148 I trial, this retrospective study revealed a trend toward improved survival in favipiravir- treated p

149 and outcomes, but there was a nonsignificant trend toward improved survival to hospital discharge in

150 e of LRT is associated with a nonsignificant trend toward improved waitlist and posttransplant outcom

151 in major limb amputees, TMR improved PLP and trended toward improved residual limb pain compared with

152 s with stage III/IV disease (P = .001), with trends toward improved 4-year overall survival.

153 Group A showed statistically nonsignificant trends toward improved freedom from pulsed-steroid thera

154 While trends towards improved visual acuity and reduction in I

155 There was a trend toward improvement in QOL for ivabradine versus pl

156 There was a trend toward improvement in QOL parameters.

157 efore and after treatment showed a very weak trend toward improvement in the C-82-treated skin of bio

158 [83 of 100]; P = .046), whereas specificity trended toward improvement (79% [111 of 140]) vs 77% [10

159 The 1-year complication rate trended toward improvement from the first to last quarti

160 fulness-based cognitive therapy, they showed trends toward improvement (p=0.09) in depression (g=.76,

161 Finally, probable trends towards improving the quality of the synthesized

162 ccurred during a period marked by an overall trend toward increased C(4) grazing by cooccurring mamma

163 production associated with a nonsignificant trend toward increased FMDBA in the placebo group (P=0.0

164 Yet, a trend toward increased NKG2C(+/del) and reduced NKG2C(+/

165 t3 and Erk1/2 proteins were increased, and a trend toward increased phospho-Stat5 and phospho-Stat1 w

166 5% confidence interval 1.5-3.0) and showed a trend toward increased risk of post-transplant graft los

167 In weighted models, a trend toward increased risk was seen in low (wIRR = (0.7

168 L5 show decreased dendritic complexity but a trend toward increased spine density.

169 st significance thresholds (P<0.001), with a trend toward increased variation explained at more strin

170 ed soluble lung collagen (p = 0.049), with a trend towards increased airway inflammation with nicotin

171 d prediction error signals (P = 0.07), and a trend towards increased amphetamine-induced dopamine rel

172 re (>=80th percentile) was associated with a trend towards increased ASCVD risk in all 3 cohorts indi

173 The past 30 years were characterized by a trend towards increased authorship by women, with new au

174 he brains of CASPR2-IgG injected mice, but a trend towards increased CASPR2 expression; these results

175 There has been a trend towards increased dining out in many countries.

176 -6 PUFAs in colostrum were associated with a trend towards increased odds of allergic diseases, with

177 A trend towards increased proliferative capacity by pathog

178 POAF despite greater SR Ca(2+)-leak, with a trend towards increased SR Ca(2+)-ATPase activity.

179 tendons that were significantly stiffer and trending towards increased strength by four weeks post-r

180 There were also trends toward increased risks, although nonsignificant,

181 There were encouraging trends towards increased procurement of CD4 and VL/EID i

182 of functional guilds, on Norikura there were trends towards increased saprotrophism (Zygomycota), sym

183 scales showed statistically non-significant trends toward increases.

184 ponse, a movement has emerged to counter the trend toward increasing consolidation of control and own

185 The trend toward increasing rates of ciprofloxacin resistanc

186 Although there was a trend toward increasing use of moderate-intensity to hig

187 Over time, there was a trend toward increasing WAZ and LAZ scores in HEU childr

188 red winter snowfall patterns, and there is a trend towards increasing winter snow in semi-arid region

189 been characterized as a long-term ecological trend toward increasingly active and predatory lifestyle

190 h precipitation since the late-1990's, and a trend toward increasingly high precipitation associated

191 an 90 years, which suggests that such clones trend towards inevitability with advancing age.

192 find that CH is very common in the elderly, trending toward inevitability.

193 In addition, AML developing after RAI trended toward inferior survival compared with matched c

194 ge, between annual and perennial races and a trend towards LA among populations within montane habita

195 the last 15 years, and operations, which are trending toward large multiwell pads, release hazardous

196 ust tens of metres, diverse microbial clades trend towards larger genome size, higher genomic GC cont

197 ral frontal and cingulate regions and showed trends toward larger dentate gyrus and CA1 regions of th

198 In light of increasing trends toward legalization of cannabis, the knowledge ga

199 se ticagrelor is consistent over time with a trend toward less excess bleeding.

200 al intervention is well established, a clear trend toward less-aggressive, often minimally invasive t

201 There was a trend toward long-term survival in favor of GemErlo (est

202 h clinically relevant reduced toxicity and a trend toward longer survival suggest that carboplatin pl

203 S has a relationship to lifespan, and show a trend towards longer lifespan in individuals with the ri

204 tio (P=0.012) compared with controls, with a trend toward lower concentration of circulating CD34(+)/

205 ss and kurtosis, lower MPP (P < .001), and a trend toward lower entropy (P = .07) compared with contr

206 A trend toward lower hemorrhage rate in an exploratory ana

207 and cardiogenic shock on presentation had a trend toward lower in-hospital mortality compared with t

208 n types used in pharmaceutical patents but a trend toward lower median yield for some of the reaction

209 voriconazole treatment (13 patients, 43%) A trend toward lower mortality (46% vs 59% p=0.30) and red

210 nitoring reduced brain tissue hypoxia with a trend toward lower mortality and more favorable outcomes

211 itaxel-coated balloons was associated with a trend toward lower mortality when compared with control

212 vely breast-fed for more than 4 months had a trend toward lower rates of FPIES to multiple food group

213 There was a nonsignificant trend toward lower rates of GUSTO-defined severe/life-th

214 mL/min randomized to apixaban demonstrated a trend toward lower rates of major bleeding when compared

215 Multivariable analyses showed a trend toward lower risk of superficial incisional SSI in

216 ction of 3 or all 4 LVAD components showed a trend toward lower survival than did infection of 2 or f

217 s associated with lower aspect ratio, with a trend towards lower height/width ratio and smaller flow

218 A trend towards lower IL-8 responses was shown following g

219 ction of 3 or all 4 LVAD components showed a trend towards lower survival vs infection of 2 or less c

220 ad significantly lower tryptophan levels and trended toward lower IFN-gamma levels compared to women

221 p (12.6+/-1.31 mL/kg per minute; P=0.01) and trended toward lower in the tetralogy of Fallot group (1

222 BI had significantly lower SE (P < .001) and trended toward lower mean FA (P = .07) compared with con

223 lly assigned as hepatic markers demonstrated trends towards maximum relative abundance between differ

224 Israeli health-care system include a growing trend towards medicalisation of prenatal care, ensuring

225 rease in relative brain size accompanied the trend toward miniaturization or evolution of flight duri

226 iotic use immediately postoperatively, and a trend toward more biopsy-proven rejection (P = 0.073).

227 There was a trend toward more invasive coronary angiographies among

228 subjects who received DEC, consistent with a trend toward more rapid and complete microfilarial clear

229 There was a trend toward more severe brain lesions amongst patients

230 re reported for TC (one for EC-T), despite a trend toward more-severe adverse events in the latter.

231 aeruginosa virulence factors, we observed a trend towards more mutations in the transcriptional regu

232 We also found a trend towards more undulating cell margins on abaxial le

233 ing ternary blends, which represents a clear trend toward multicomponent active layer blends.

234 ConvLASIK eyes revealed a nonsignificant trend toward myopic regression from 3 to 12 months posto

235 There is also a strong trend towards non-traditional approaches, including dive

236 s of the intervention modality, indicating a trend toward nutrition resilience.

237 A trend towards offering DBS in the earlier stages of PD c

238 % [95% CI, 53.1% to 80.6%]; P = .02), with a trend toward OS advantage (95.0% [95% CI, 89.5% to 100%]

239 used to stabilize nanoemulsions, there is a trend towards plant-based formulations.

240 lusters in preoperative Pe blood predicted a trend toward poor prognosis.

241 BMP4 or low Smad4 immunoexpression showed a trend toward poor prognosis.

242 Moreover, we found a trend toward poorer outcome in CCA patients with elevate

243 In CALGB 30801, a trend toward poorer progression-free survival was observ

244 We found trends toward poorer memory performance in APP/PS1 mice

245 re consistent with the observed 20th-century trend toward positive SAM anomalies concomitant with the

246 After absorption, beta-carotene trended toward preferential cleavage compared with alpha

247 , p = 0.05 and p = 0.02, respectively) and a trend towards presence of specific antibodies (p = 0.09)

248 e to delayed drainage of corneal edema and a trend towards prolonged corneal opacification.

249 We found a trend towards prophylactic aortic root surgery at younge

250 tule formation; logistic regression showed a trend toward protection for the TLR9 +2848 GG genotype.

251 0.0004), presence of fibrin (P = 0.02), and trended toward receiving only observation (P = 0.10).

252 lets and coronavirus RNA in aerosols, with a trend toward reduced detection of coronavirus RNA in res

253 There was a trend toward reduced healthcare-associated transmission

254 ed frequencies of natural killer cells and a trend toward reduced ILC populations, regardless of diag

255 AVA was reduced and a trend toward reduced IVNV was seen in UPI/OIR compared t

256 ells (P=0.02) compared with controls, with a trend toward reduced lymph node T follicular helper cell

257 This was consistent with a trend towards reduced affinity of the nitrated chemokine

258 features were interpreted as an evolutionary trend towards reduced hydraulic resistance.

259 A trend towards reduced primary failure should be further

260 radiotracer [(11)C]DPA-713 revealed a strong trend towards reduced TSPO binding in the middle frontal

261 peanut EPIT-treated participants, along with trends toward reduced basophil activation and peanut-spe

262 In the high thrombus burden group, the trends toward reduced cardiovascular death and increased

263 continuous spontaneous alternation test with trends towards reduced short-term and long-term memories

264 ovement in cardiometabolic parameters, and a trend toward reduction in preference for sweet taste and

265 PC786 showed a trend towards reduction of symptom score and mucous weig

266 ents and dilatation of normal segments, with trends toward reversal with nitroglycerin.

267 presence of TP53 or SF3B1 mutations showed a trend toward shorter PFS vs without these factors.

268 sivist days worked were also associated with trends toward shorter hospital length of stay without in

269 cases and matched controls (P = 0.01) and a trend toward significance difference between cases and n

270 SMILE, the first-operated eye had a marginal trend toward significance for enhancement (P = 0.054).

271 tazar group and change in HOMA-beta showed a trend towards significance with SI(clamp) (r = 0.503, p

272 5%; P = 0.02), recurrence-free survival only trended toward significance among the groups (P = 0.053)

273 ian selection strength and evolutionary rate trended toward significance, especially for CDRs, but ca

274 d low-grade dysplasia while colonic adenomas trended towards significance.

275 ction in vasoconstrictive reactivity to 5-HT trending toward significance (P = 0.09).

276 A trend toward significant consumption of C(4) foods in ho

277 subretinal fluid volume under PFO tamponade trended toward significantly worse visual acuity outcome

278 d by biome-based modeling, but are likely to trend toward simplified community composition as communi

279 duction areas and the increasing consumption trend towards single origin products induced the necessi

280 hazard ratio=1.35; P=0.006), and exhibited a trend towards slightly lower mortality (hazard ratio=0.8

281 (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % differ

282 There was a trend toward superior OS for paclitaxel.

283 A trend towards superior motion coherence thresholds in th

284 There was also a trend towards suppression of activation in the parabrach

285 Evolutionary inferences suggested a trend toward the acquisition of gene induction relativel

286 ess syndrome similarly demonstrates a strong trend toward the development of acute kidney injury.

287 An evolving trend toward the ever-growing market of portable and wea

288 ion to the linkage signal (p < 0.001), and a trend towards the same association was observed in the S

289 to stabilize food emulsions have inspired a trend towards the use of natural ingredients like starch

290 s that received combination therapy showed a trend toward thickening of the suprachoroidal space (SCS

291 more heterogeneous micro-architecture, with trends towards thicker cortical bone plate, higher trabe

292 gies are proposed which aim at returning the trend towards uniform influence across users while refra

293 There has been a more recent trend toward using hypothetical cohorts and modeling sce

294 ly worse depressive symptoms (p=0.04), and a trend toward worse anxiety symptoms (p=0.06), while at 1

295 xistence of two SHH subgroups and observed a trend toward worse outcome for SHH-I patients.

296 AS-CA has worse clinical presentation and a trend toward worse prognosis, unless treated.

297 A trend toward worse SCD/VT/VF (p = 0.062) and DHF/HTx/VAD

298 as less precise; with medium to low category trending towards worse 2-week survival (42%) compared wi

299 anretinal ischemic index did not improve and trended toward worsening.

300 Patients with 2 rare variants had a trend toward younger age at presentation when compared w