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1 f MNX (hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine).
2 DLLME-SFO) was developed for the analysis of triazines.
3 es, pyrazines, pyrimidines, pyridazines, and triazines.
4 the triazine to provide imidazo[1,2-a][1,3,5]triazines.
5 he impact is of a magnitude to convert 1,2,3-triazine (1) and its modest cycloaddition scope into a h
6 um, and potassium salts of 2,4,6-trimethyl-s-triazine (1) with 2-halomethyl-4,6-dimethyl-s-triazine (
8 ,2,4,5-tetrazines; 1,2,4-, 1,3,5-, and 1,2,3-triazines; 1,2-diazines; and 1,3,4-oxadiazoles), 1-aza-1
9 4-triazol-5-ylm ethoxy)pyrazolo[1,5-d][1,2,4]triazine (13) has been identified as a functionally sele
11 rom 3-chloro- (1c) and 3-iodobenzo[ e][1,2,4]triazine (1d) obtained in three steps from 2-nitroanilin
12 The selectively (15)N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by
13 riazine (1) with 2-halomethyl-4,6-dimethyl-s-triazine (2) (X = Cl, Br) in glyme have been studied and
14 -3,3'-bicarbazole (BCzPh):3',3'",3'""-(1,3,5-triazine-2,4,6-triyl)tris(([1,1'-biphenyl]-3-carbonitril
15 )(TATB)(2), where TATB represents 4,4',4''-s-triazine-2,4,6-triyl-tribenzoate with a formula of C(24)
16 ng a triazine-based planar ligand, 4,4',4"-s-triazine-2,4,6-triyltribenzoate (TATB) and mixed lanthan
17 trazine (6-Chloro-n-ethyl-n'-(1-methylethyl)-triazine-2,4-diamine), a prevalent herbicide in the Unit
18 of the side chain to the N,N-dimethyl-1,3,5-triazine-2,4-diamine-6-ethyl moiety by NMR spectroscopy,
19 hyl-2-oxazoline)-b-poly(2-N,N-dimethyl-1,3,5-triazine-2,4-diamine-6-ethyl-2-oxazoline) (PMeOx-PcBOx),
20 4-(N-phenylanilino)-6-pyrrolidin-1-yl-1,3,5-triazine-2-carbonitrile (CP243522), showed a K(i) of 21
21 m, 6-hydroxy-2-(naphthalen-1-ylmethyl)-1,2,4-triazine-3,5(2H,4H)-dione 11h was found to be selective
22 A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized a
24 yl)piperazin-1-yl]butyl}-4- methyl-2H-[1,2,4]triazine-3,5-dione (10), a potential high affinity (K(i)
25 yl)piperazin-1-yl]butyl}-4-methyl-2H-[1,2,4 ]triazine-3,5-dione (9) and [(11)C]CH(3)OTf in 25 +/- 5%
26 use in promoting the cycloaddition of 1,2,3-triazine 4 with enamine 3 as the key step of a concise t
27 s 4-amino-3,7-dinitrotriazolo-[5,1-c][1,2,4] triazine 4-oxide (DPX-27), which is also predicted to be
28 synthesis of 3-methyl-5-phenylethynyl[1,2,4]triazine (4), 6-methyl-3-phenylethynyl[1,2,4]triazine (5
29 riazine; 4,4',6,6'-tetra(azido)hydrazo-1,3,5-triazine; 4,4',6,6'-tetra(azido)azo-1,3,5-triazine; and
30 compounds, for example, 2,4,6-triazido-1,3,5-triazine; 4,4',6,6'-tetra(azido)hydrazo-1,3,5-triazine;
31 triazine (4), 6-methyl-3-phenylethynyl[1,2,4]triazine (5), and 5-methyl-3-phenylethynyl[1,2,4]triazin
32 ture of 4-amino-7-benzylpyrrolo[2,3-d][1,2,3]triazine-5-carbonitrile (19) and 2-amino-1-benzylpyrrole
33 4-[1H-indazol-5-ylamino]pyrrolo[2,1-f][1,2,4]triazine-6-carbamates identified dual human epidermal gr
35 zine (5), and 5-methyl-3-phenylethynyl[1,2,4]triazine (6a) as analogues of 2-methyl-6-(phenylethynyl)
36 ere 3-(3-methylphenylethynyl)-5-methyl[1,2,4]triazine (6b), 5-(3-chlorophenylethynyl)-5-methyl[1,2,4]
37 b), 5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine (6c), and 3-(3-bromophenylethynyl)-5-methyl[1,2
39 -thiadiazole (4), phenyl- and diphenyl-1,3,5-triazines (7 and 8), and a trace quantity of diphenyl-1,
40 ighly sensitive functional groups, such as a triazine, a ketone, an aldehyde, or a nitro group, were
42 novel 2,7-disubstituted pyrrolo[2,1-f][1,2,4]triazine ALK inhibitors are described along with synthes
44 razines derivatives of [1,2,4]triazolo[1,5-a]triazine also possessed good oral efficacy in rodent mod
45 re, functional analysis of aminophenyl-1,3,5-triazine analogs elucidated structure-activity relations
46 along with X-ray structures with a series of triazine analogues aids in deciphering the mechanism by
49 was modified with 2,6-diamino-4-phenil-1,3,5-triazine and characterized by FTIR, SEM and elemental an
50 etween 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine and hydrogen sulphide, the principle by-product
51 etween 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine and hydrogen sulphide, to be measured for a spe
53 ecular coordination complexes (SCCs) bearing triazine and porphyrin faces with promising light-harves
54 nitio study of the interaction between 1,3,5-triazine and the fluoride, chloride, and azide ion at th
55 mplexes between a star-shaped tris(triazolyl)triazine and triphenylene-containing benzoic acids is de
56 n family, from a conveniently prepared 1,2,4-triazine and via a common tetrasubstituted pyridine inte
57 zadiene, complementary to the isomeric 1,2,4-triazines and 1,3,5-triazines, capable of dependable par
58 between substituted electron-deficient 1,2,3-triazines and a highly functionalized and chiral primary
61 nisms of Diels-Alder reactions between 1,2,3-triazines and enamines have been explored with density f
64 ntaining RDX (hexahydro-1,3,5-trinitro-1,3,5-Triazine) and HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-
65 yl-oxazoles, -thiazoles, -imidazoles, -1,2,4-triazines, and -pyridines are available from the diazoke
66 ectron-demand Diels-Alder reactions of 1,2,3-triazines, and that these mechanisms can be altered by e
67 olyzed other N-substituted amino dihydroxy-s-triazines, and those with linear N-alkyl groups had high
68 azabenzenes (pyridine, three diazines, three triazines, and three tetrazines) with the ethylene dieno
69 ,5-triazine; 4,4',6,6'-tetra(azido)azo-1,3,5-triazine; and 2,5,8-tri(azido)-1,3,4,6,7,9,9b-heptaazaph
70 diazine, 1,3-diazine, 1,4-diazine, and 1,3,5-triazine are 110.4 +/- 2.0, 111.3 +/- 0.7, 113.4 +/- 0.7
73 , neutral and basic pesticides (phenylureas, triazines) are more sensitive using APCI (especially pos
74 r studies demonstrate the versatility of the triazine as a modular scaffold to generate potent and se
75 Here we present the trifunctionalized 1,3,5-triazine as an ideal modular scaffold for generating lib
76 sing C3-symmetric 2,4,6-tri(4-pyridyl)-1,3,5-triazine as pore-partition agent in MIL-88 type (the acs
77 tin as the tumor-targeting moiety, and 1,3,5-triazine as the tripod splitter module, were designed an
78 common synthon affording access to pyridinyl triazines as the 4,4'-amino derivatives which are commer
79 ichael addition to substituted 3-vinyl-1,2,4-triazines, as original bifunctional platforms for the do
80 no-1,3,5-triazine with 2,4,6-trichloro-1,3,5-triazine at 1.0-1.5 GPa and 500-550 degrees C and also t
82 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine (atrazine), 2.4-dichlorophenoxyacetic acid (2,4
83 mical genetic screenings were performed with triazine-based combinatorial libraries that include vari
85 bottlebrush nanofibers from an acridine- and triazine-based donor/acceptor pair, which have been show
88 fluoro-1H-indol-5-yloxy)pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of vascular endothelial growth
91 ch rapidly isomerizes to a 3,4-dihydro-1,2,4-triazine-based nitrone, namely 6-phenyl-3-pyridin-2-yl-2
92 imiralisib), a potent 4,6-dimorpholino-1,3,5-triazine-based pan-class I PI3K inhibitor, which targets
93 -organic frameworks were synthesized using a triazine-based planar ligand, 4,4',4"-s-triazine-2,4,6-t
94 activation chemistry was developed using the triazine-based reagent 4-(4,6-dimethoxy (1,3,5)triazin-2
96 s as the point of intersection of multiple s-triazine biodegradative pathways and is completely essen
97 xplosive RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) by microorganisms involves sequential reductio
98 The synthesis of a pyrazolo[1,5-a]-1,3,5-triazine C-nucleoside (dA(PT)), designed to form two hyd
99 tether from the imidazole N1 position to the triazine C3 proceed in excellent yields to produce 1,2,3
100 ry to the isomeric 1,2,4-triazines and 1,3,5-triazines, capable of dependable participation in invers
101 four pesticide classes (chloroacetanilides, triazines, carbamates organophosphates) and two pesticid
102 Because of the presence of the acceptor (triazine) center and strong donors in the arms (diarylam
103 high-throughput screening, aminophenyl-1,3,5-triazine CFTRact-K089 (1) that activated CFTR with EC50
106 with the recent introduction of industrial s-triazine compounds such as atrazine and melamine into th
107 Organophosphates, triazoles, pyrethroids and triazines compounds showed good linearity in the range 0
108 salts) was developed and led to the desired triazines compounds, thus allowing a one-step economy in
111 ster substituent of the pyrrolo[2,1-f][1,2,4]triazine core with heterocyclic bioisosteres, such as su
112 cules consist of an electron-deficient 1,3,5-triazine core with three fluorene arms substituted with
114 8-(substituted pyridyl)pyrazolo[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF(
115 of 8-(4-methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF(
117 iterative synthesis of a second generation, triazine dendrimer with 12 protected amines on the perip
119 ed that the guest capacity of odd-generation triazine dendrimers increased until generation 7 but dec
120 benzene-functionalized high-molecular weight triazine dendrimers up to generation 9, demonstrating th
124 onversion of new carboxamides (5 and 6) to s-triazine derivatives (7) was demonstrated in mouse and h
125 fluorinated nitrile 1e was converted to the triazine derivatives 2a and 2b by catalysis with Ag(2)O
127 ent, selective, and orally efficacious 1,2,4-triazine derivatives have been identified using structur
131 (6-ethynyl-pyridin-2-yl)-5,6-diphenyl-[1,2,4]triazine dipolarophiles with structurally diverse 4-meth
132 ound and the desired fused tricyclic 1,2,3,4-triazine display interesting thermal behavior and are pr
133 rate salts with a 1,3,5-tris(dipicolylamine)-triazine (dpat) ligand yielded two unprecedented example
135 The excited-state dynamics of an aniline-triazine electron donor-acceptor dyad with an alkyne spa
136 in that it contains an amine reactive group (triazine ester) targeting the N-terminus and epsilon-ami
137 ing groups (-CO2R) at C4 and C6 of the 1,2,3-triazine even if C5 is unsubstituted (Me or H), highligh
138 lass 3a carcinogen, is a pesticide of chloro triazine family and is known to severely affect the huma
140 mily of hexaazatriphenylene-based conjugated triazine frameworks (CTFs) for efficient CO2 capture.
141 The synthesis of highly crystalline covalent triazine frameworks (CTFs) with ultrastrong covalent bon
142 ic frameworks, microporous polymer, covalent triazine frameworks etc.) and their heterostructures.
144 ching of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) from particulates deposited in live-fire milit
145 ractions upon binding to the kinases via its triazine functional group, which is considerably larger
148 this series of [1,2,4]triazolo[1,5-a][1,3,5]triazine have now been shown to be orally active in the
149 s piperazine series of [1,2,4]triazolo[1,5-a]triazine have now been shown to have good oral bioavaila
150 ves of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been demonstrated to be potent an
151 ric 2-(hydroxytolyl)-4,6-dimethylamino-1,3,5-triazines have been synthesized in high yields in a cont
152 rse electron-demand Diels-Alder reactions of triazines have wide applications in bioorthogonal chemis
155 s insecticides, phenoxy-acid herbicides, and triazine herbicide) to inhibit butyrylcholinesterase, al
159 Here we analyse effects of applications of triazine herbicides in conventional maize regimes on key
162 eference adsorbent graphite was conducted of triazine herbicides, substituted anilines, heterocyclic
163 nce and trematode exposure was observed with triazine herbicides, this effect was driven by increases
168 phenylene vinylene) derivative with a ureido-triazine hydrogen bonding unit self-assembles into rows
169 ring nitrogen was protonated in the enzyme s-triazine hydrolase (TrzN) where (iii) TrzN crystal struc
172 ionation pattern for identifying microbial s-triazine hydrolysis in the environment caused by multipl
173 amino acids, sugars, organic acids, amides, triazine, imidazole, protein, and biological tissue.
174 synthesis of the layered bulk material poly(triazine imide), PTI, followed by one-step liquid exfoli
175 rrole with 2,4,6-tris(trifluoromethyl)-1,3,5-triazine in THF-d(8) to give a pyrrolo[2,3-d]pyrimidine
176 erized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively de
177 cient methodology for the synthesis of 1,3,5-triazines in good to excellent yields under transition-m
178 synthesis of highly fused furo[3,4-d][1,2,3]triazines in good-to-excellent yields under mild conditi
180 Dispersion (MSPD) for determination of nine triazines in mussels has been optimised in terms of the
181 xplosive RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) in an aquifer near the Iowa Army Ammunition Pl
183 ectron demand Diels-Alder reactions of 1,2,3-triazines is disclosed, including an examination of the
185 dyl-based ligands, 2,4,6-tri-4-pyridyl-1,3,5-triazine (L1) and 5,10,15,20-tetra(4-pyridyl)-21H,23H-po
186 aled that the oxindole-pyrrolo[2,1- f][1,2,4]triazine lead 2a displayed potent enzyme inhibition (IC
188 ibition of regeneration, we screened a novel triazine library, based on the ability of compounds to i
190 first 1:2 bis-complex of a quadridentate bis-triazine ligand to be characterized by crystallography.
191 trong covalent bonds (aromatic C N) from the triazine linkage presents a great challenge to synthetic
192 -Alder reaction between imidazoles and 1,2,4-triazines linked by a trimethylene tether from the imida
193 target, a generation-13 dendrimer comprising triazines linked by diamines, is stable across ranges of
194 nctional monomer (2,4,6-trisacrylamido-1,3,5-triazine), mixed templates (ascorbic acid and dopamine),
195 on reaction revealed that the inherent 1,2,3-triazine mode of cycloaddition (C4/N1 vs C5/N2) as well
197 lamino)-4-hydroxy-6-(N-isopropylamino)-1,3,5-triazine] N-ethylaminohydrolase (AtzB) is the sole enzym
198 high-throughput screen of cruzain identified triazine nitriles, which are known inhibitors of other c
201 n nanoring to two tridentate ligands (with s-triazine or benzene cores) occurs with high negative all
204 ction initially produces a population of sym-triazine partitioned between the 3s Rydberg and pi* <--
205 pite stereoregio backbone heterogeneity, the triazine polymers bind T/U-rich DNA or RNA with nanomola
206 d and exothermic decomposition of a reactive triazine precursor, C 3N 3(NHCl) 3, was examined by bypr
207 2-substituted imidazoles with various 1,2,4-triazines produced both imidazo[4,5-c]pyridines (3-deaza
209 nd compound B led to the discovery of [1,3,5]triazine-pyridine as a new series of potent CDK inhibito
211 es containing hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and 2,4,6-trinitrotoluene (TNT) from poly
212 ne compounds, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-
213 hmarks, such as 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-
214 ively removes hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) from groundwater but generates RDX-laden
215 mines such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) have been updated with the insensitive mu
219 The explosive Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is known to be degraded aerobically by va
221 losive molecule 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) via combined nanomechanical photothermal
223 azocine (HMX), 1,3,5-trinitroper-hydro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), 2-amino-4,6
225 otoluene (TNT), 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), and pentaerythritol tetranitrate (PETN)
226 oluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and pentaerythritol tetranitrate (PETN)
227 on of the explosives trinitrohexahydro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tet
228 ermination of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tet
230 nvironment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), one of the most widely used military exp
231 oglycerin (NG), 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), pentaerythritol tetranitrate (PETN), tri
235 eacted 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine remaining; the only source of inorganic sulphid
238 identification and (ii) suggested that the s-triazine ring nitrogen was protonated in the enzyme s-tr
239 alyze the sequential hydrolytic removal of s-triazine ring substituents from the herbicide atrazine t
241 electronic structure of the benzo[ e][1,2,4]triazine ring was investigated by spectroscopic methods
242 for formation of the 1,4-dihydrobenzo[1,2,4]triazine ring was investigated using the B3LYP/6-31G(2d,
243 Substrates required a monohydroxylated s-triazine ring with a minimum of one primary or secondary
244 ive complexes for nucleophilic attack on the triazine ring, and pi-stacking interactions (with azide)
248 lane, covalent organic frameworks containing triazine rings (t-COFs) hold great promise in this regar
249 st compounds 5-methyl-3-phenylethynyl-[1,2,4]triazine (RTI-4229-707), 5-methyl-3-(4-phenoxy-phenyleth
250 , 5-methyl-3-(4-phenoxy-phenylethynyl-[1,2,4]triazine (RTI-4229-766), and 3-(3-methylphenylethynyl)-5
251 3-(2,5-dimethylphenylethynyl)-5-methyl[1,2,4]triazine (RTI-4229-785) and 3-(2-methylphenylethynyl)-5-
252 nd 3-(3-methylphenylethynyl)-5-methyl-[1,2,4]triazine (RTI-4229-787) resulted in a dose-dependent blo
255 novel 2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazine scaffold has been designed as a new kinase inhi
256 validation of this new pyrrolo[2,1-f][1,2,4]triazine scaffold will be described for inhibitors of an
257 n maps confirmed triphenylene/tris(triazolyl)triazine segregation into hexagonal sublattices and latt
258 side chain provides a proton to N-1 of the s-triazine substrate to facilitate nucleophilic displaceme
261 zed to generate protonated 2,4,6-trimethyl-s-triazine tautomers in situ, which undergo Aldol condensa
263 ent cyanuric chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2
264 Chemical reduction of 2,4,6-tricyano-1,3,5-triazine, TCT, results in the formation of an unstable r
268 TPT)(4) (TPT = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine), thus allowing for utilization of crystallogra
269 1, was made by linking 2,4,6-trimethyl-1,3,5-triazine (TMT) and 4,4'-biphenyldicarbaldehyde (BPDA) th
270 he chelating reagent 2,4,6-trimercapto-1,3,5-triazine (TMT) in the first step and separated by mixed
271 and water, with another equivalent of 1,3,5-triazine to give compounds containing three linked heter
272 d from rigorous structural investigations of triazine to heptazine thermal conversion processes have
273 nhibitors by a fused imidazole ring with the triazine to provide imidazo[1,2-a][1,3,5]triazines.
274 n, including core scaffold modification from triazine to purine, improved the in vitro potency agains
276 ligand, such as 2,4,6-tri(4-pyridinyl)-1,3,5-triazine (tpt), or a metal-complex cluster, into the hex
278 I) acceptor with 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPyT) or 5,10,15,20-Tetra(4-pyridyl)-21H,23H-p
279 amed 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine (TTBP-TAZ) is reported for the first time in pl
280 le and efficient one-step synthesis of 1,2,4-triazines under mild conditions from readily accessible
281 One popular precursor building block is the triazine unit (C 3N 3), and most postulated amorphous CN
283 n of highly substituted pyridines from 1,2,4-triazines via the inverse-electron-demand Diels-Alder re
287 Reaction of 3-aminopyrrole with seven 1,3,5-triazines was studied in a one-step reaction (in situ fo
288 eries of hybrid analogues of monastrol-1,3,5-triazine were designed and developed via one-pot synthes
289 )-substituted derivatives of benzo[ e][1,2,4]triazine were synthesized from 3-chloro- (1c) and 3-iodo
290 en 2,4,6-trifluoro- or 2,4,6-trichloro-1,3,5-triazine were used--1,3,5-triazines that had leaving gro
292 RAP reagent contains 2,4,6-tris(2-pyridyl)-s-triazine, which forms a blue-violet complex ion in the p
293 id-mediated cyclodehydration gives the fused triazines, which upon alkali treatment afford the desire
294 solid-state reaction of 2,4,6-triamino-1,3,5-triazine with 2,4,6-trichloro-1,3,5-triazine at 1.0-1.5
295 of the C6 ester of the pyrrolo[2,1- f][1,2,4]triazine with amides afforded compounds with increased p
296 hetic scheme was developed to derivatize the triazine with an electrophile for covalent modification
297 4'-methylphen-2'-yl)-4,6-dimethylamino-1,3,5-triazine with ICl provides species differing in the posi
298 ine, pyridazine, pyrimidine, pyrazine, and s-triazine with N and O atoms are studied both experimenta
299 steps in the IEDDA cascade reaction of 1,3,5-triazines with amino-containing dienophiles has been obt
300 s to pyridyl (or pyridone)-substituted 1,3,5-triazines with high potential in various fields of appli
301 amination of functionalized pyridinyl-1,2,4-triazines with low catalyst/ligand loadings enabling the
302 on the cycloaddition reactivity of the 1,2,3-triazine without altering, and perhaps even enhancing, t