ライフサイエンスコーパス: triene

1 3-dienimidoyl)sulfanyl]acetates (1-aza-1,3,4-trienes).

2 ther elaborated to a densely substituted aza-triene.

3 ated with the generation of megastigma-4,6,8-triene.

4 mino carboxylic acid containing a conjugated triene.

5 c fragments distinguishable from homoallylic trienes.

6 roxide value, acidity, conjugated dienes and trienes.

7 ide values, conjugated dienes and conjugated trienes.

8 the most stable conformation of each of the trienes.

9 LF revealed the most peroxides but the least trienes.

10 of 1,5-allenynes to produce cross-conjugated trienes.

11 Trienes 1 and 3 were obtained in five steps from ethyl 4

12 ((3E,5Z,7E)-dimethyl-5,6-diphenyldeca-3,5,7-triene-1,10-diyl bis(2-bromo-2-methylpropanoate)) and B

13 thyl 5,7-difluoro-4-azaspiro[2.4]hepta-1,4,6-triene-1-carboxylate, presumably via the corresponding k

14 rien-1-yl)isoxazoles and a-(cyclohepta-2,4,6-triene-1-ylcarbonyl)-1H-pyrroles.

15 produces 4,5-benzobicyclo[4.1.0]hepta-2,4,6-triene (11) at lambda = 670 or >613 nm, but without dete

16 -catalyzed coupling with triflate 13 to give triene 16 without the formation of Heck products, a nove

17 Thermolysis of spiro[2.4]hepta-1,4,6-triene (1a) at 50 degrees C yielded bicyclo[3.2.0]hepta-

18 ve the photocyclization of the corresponding triene 2 as a key step leading to a heptacyclic aromatic

19 le-2,3-diones, and 1-azaspiro[4.5]deca-3,6,9-triene-2-ones via the C(sp(2))-C(sp(2)) bond formation i

20 24b and 24C) as the acid components provided trienes 22, 25b, and 25c, respectively, which upon heati

21 te (>4000-fold), C11-alcohol (250-fold), and triene (220-fold) contribution to PP2A inhibition.

22 rature without any trace of initially formed trienes 28a-c.

23 -tetrahydroxy-9-methyl-19-norlanosta-1,5,2 3-triene-3,11,22-trione], JSI-124, or the extracellular si

24 45384), (17beta)-2,4-dibromo-estra-1,3,5(10)-triene-3,17-diol (NSC103054), and methyl N-(pyridine-4-c

25 trile) or 8beta-VE2 (8-vinylestra-1,3,5 (10)-triene-3,17beta-diol).

26 TopFluor-cholesterol, and cholesta-5,7,9(11)-triene-3-beta-ol.

27 ), 2-ethoxy-17-(1'-methylene)estra-1,3,5(10)-triene-3-ol (50) and 2-ethoxy-17alpha-methylestradiol (5

28 tetracyclo[5.2.2.1.(3,5)0(2,6)]dodec-2,8,10-triene (33, psi = 14.4 degrees ).

29 ding 1-aza-benzo[d]bicyclo[4.1.0]hepta-2,4,6-triene 34 and 3-aza-benzo[d]cyclohepta-2,3,5,7-tetraene

30 tural product than are the IMDA reactions of trienes 4 and 7.

31 ed the epoxy dienes 10 and 22, the diacetoxy triene 42, and the heavily functionalized cyclohexane 48

32 affords 6-azabicyclo[3.2.0]cyclohepta-1,3,5-triene 43.

33 Triene 5 has been prepared by the E-selective olefinatio

34 degrees C yielded bicyclo[3.2.0]hepta-1,3,6-triene (5), which dimerized in two different fashions to

35 rene ((3)PN), 2-azabicyclo[3.2.0]hepta-1,3,6-triene (6), and 4-azaspiro[2.4]hepta-1,4,6-triene (7).

36 -dien-2-ylidene, 10, and thiacyclohexa-2,3,5-triene, 6.

37 Triene 6pai electrocyclization, wherein a conjugated tri

38 ions of hepta-1,2,4,6-tetraene 5, hexa-1,3,5-triene 7, Z and E-1-aza-1,3,5-hexatrienes 9 and 10, and

39 6-triene (6), and 4-azaspiro[2.4]hepta-1,4,6-triene (7).

40 btained substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols and their keto derivatives showed high

41 esis of substituted bicyclo[4.3.1]deca-2,4,8-triene-7,10-diols, which form the key structural moietie

42 primarily 2,3-benzobicyclo[4.1.0]hepta-2,4,6-triene (9) accompanied by small amounts of triplet 4,5-b

43 d observability of bicyclo[4.1.0]hepta-2,4,6-triene, a key intermediate in the rearrangement of pheny

44 The bioactive molecules contain conjugated triene and diene double bonds, carry an alcohol at C13 a

45 The conjugated triene and diene units were constructed by Suzuki-Miyaur

46 ich a chiral cyclopropyl group is flanked by triene and enal chromophores, and hence would clarify th

47 Reactions between (E)-hexa-1,3,5-triene and s-trans-buta-1,3-diene are shown to have subs

48 Smaller amounts of H2O lead to mixtures of triene and vinylallene products, where the latter is for

49 previously utilized and produce mixtures of trienes and cyclohexadienes.

50 -dialkylanilino) donor-substituted push-pull trienes and tetraenes showed better electron-accepting p

51 Hydantoins containing trienes and tetraenes undergo selective RCM and cross me

52 allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthes

53 ASAs can be modified at the donor, acceptor, triene, and backbone heteroatom molecular compartments f

54 ular ions of rubrene, cholesterol, C31 diene/triene, and three wax monoesters were detected, represen

55 acid, peroxide and anisidine values, diene, triene, and water contents, fatty acid composition, and

56 gh the peroxide index, conjugated dienes and trienes, and malondialdehyde were determined.

57 d polymerization of diynes, triynes, dienes, trienes, and quinodimethanes, each of which proceed unde

58 t positional isomerizations of the diene and triene are facilitated by simultaneous proton transfers

59 Conjugated trienes are fascinating building blocks for the rapid co

60 The ring closures of these bridged bicyclic trienes are up to a million-fold faster (DeltaDeltaG() =

61 of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed.

62 of the substituents at the 6-position of the triene, as well as noncovalent interactions between the

63 ctivity measured by conjugated autoxidizable triene assay).

64 ta-2,4-diene (BCH), bicyclo[6.1.0]nona-2,4,6-triene (BCN), and 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-tr

65 its valence isomer, bicyclo[4.2.0]octa-2,4,7-triene (BCOT, 3a) and that the iron tricarbonyl complex

66 henylcarbene (PC), bicyclo[4.1.0]hepta-2,4,6-triene (BCT), and 1,2,4,6-cycloheptatetraene (CHTE) has

67 ropene 1,5-difluorobicyclo[4.1.0]hepta-2,4,6-triene becomes stable enough to be characterized in argo

68 Partially conjugated trienes behave similarly to monoenes and conjugated dien

69 -] (formed by coordination of tri-functional trienes: C[double bond, length as m-dash]C, C[double bon

70 show that a variety of conjugated dienes and triene can be enantioselectively diaminated using di-ter

71 Various dienes and a triene can be regioselectively diaminated at the interna

72 A wide variety of conjugated dienes and trienes can be effectively diaminated in good yields wit

73 ed derivatives of s-cis,s-cis (E)-hexa-1,3,5-trienes can lead to derivatives of (Z,Z,E)-cyclodeca-1,3

74 ectively control the functionalization of NH-triene-carbamates.

75 as measured by the conjugated autoxidizable triene (CAT) assay.

76 These two compounds possess a rigid triene chain conjugated to one of the cyclopentadienyl r

77 s in modularity for the donor, acceptor, and triene compartments, the backbone heteroatom remains sta

78 s of Alzheimer's patients and [(125)I]9, the triene compounds showed excellent binding affinities.

79 steps shorter than any prior synthesis of a triene-containing C17-benzene ansamycin.

80 The triene-containing C17-benzene ansamycins trienomycins A

81 ined using peroxide value, conjugated dienes/trienes content, HPLC-HRMS and (1)H NMR spectroscopy.

82 essful synthesis of the ripostatin A skipped triene core.

83 A triene cyclization precursor generated in 12 steps under

84 -2-ones, indenes, aryl-containing dienes and trienes, cyclopentadienes, and polycyclic lactones have

85 d [cmpd LA, (22R)-1 alpha, 25-(OH)2-16,22,23-triene-D3] had an ED50 of 2 x 10(-11) mol/L; it was also

86 he synthesis is enabled by a new dendrimeric triene (Danishefsky [3]-dendralene) and a new method for

87 CN), and 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-triene (DCBCN).

88 l for highly selective reactions of strained trienes despite their high reactivity and short lifetime

89 Unlike conjugated dienes, fully conjugated triene diagnostic ion signal ratios did not follow any p

90 hexaenoic acid and sulfido-conjugate (SC) of triene double bonds that proved to be 13-glutathionyl, 1

91 ement of 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-triene-exo-15N.

92 Triene FAME with both methylene and ethylene interruptio

93 The preparation of phosphorus-containing trienes featuring two diastereotopic vinyl moieties foll

94 of the latter to give a 1,5-diazahexa-1,3,5-triene, followed by 1,6-cyclization.

95 The two possible cis-dienes and a cis-triene formally derived from the tetraazaeicosane skelet

96 Photooxidation of this triene forms a cyclopropanone and subsequent photoextrus

97 llene precursor, and the construction of the triene framework by a palladium-catalyzed intramolecular

98 pling reactions are capable of forming E,E,E-trienes from cinnamaldehydes in good yield.

99 guishes between the two allowed, disrotatory triene geometries at the transition state.

100 Bicyclo[4.1.0]hepta-2,4,6-triene had been proposed as the primary intermediate of

101 e first topochemical 1,6-polymerization of a triene has been observed.

102 s (ARCM) of a challenging class of prochiral trienes has also been achieved.

103 der cycloaddition of N-substituted oxazolone triene I allows direct entry to the functionalized octah

104 iels-Alder reaction of an amino acid derived triene in acetic acid.

105 mediacy of 2-methylbicyclo[4.1.0]hepta-2,4,6-triene in the 3b to 18 rearrangement.

106 ing of simple (E)-1,3-dienes to give (E,Z,E)-trienes in high yield and with high Z selectivities.

107 ractically valuable bicyclo[4.2.1]nona-2,4,7-trienes in high yields (72-88%).

108 Fragmentation of fully conjugated trienes in the MS-1 spectra yields ratios of [M + 54]+/[

109 allows rapid access to various 1,4-dienes or trienes including the biologically active natural produc

110 mportantly, the sensitive conjugated E, Z, E-triene intermediate was generated by a Boland reduction

111 (IMDA) reaction of the camphanate-containing triene intermediate.

112 clization of common (5Z)-1,4-diazahexa-1,3,5-triene intermediates.

113 the thermal conversion of 1-azidohepta-3,4,6-trienes into cyclopentennelated dihydropyrroles are pres

114 A cross-conjugated triene is positioned at the core of an acyclic branched

115 alytic ring-closing metathesis of an achiral triene is used to establish the all-carbon quaternary st

116 While thermolysis of the macrobicyclic triene lactone 12 did not produce the expected bicyclic

117 closing metathesis (ARCM) of various achiral trienes leads to the formation of medium-ring unsaturate

118 and the control, while conjugated dienes and trienes levels remained lower throughout the heating pro

119 on the TADA reactions of 14-membered cyclic triene macrocycles to yield A.B.C[6.6.6] tricycles using

120 ronic esters has been developed via diene or triene metathesis.

121 g macrocycle containing the critical (Z,Z,E)-triene moieties.

122 roduct, resulting in an all-trans-configured triene moiety in the polyketide product.

123 s appear to be kinetic isomers regarding the triene moiety.

124 ile moieties located on a single macrocyclic triene molecule have been recognized as effective synthe

125 litates rapid access to the conjugated Z,Z,Z-triene motif, a structural feature rarely encountered in

126 formation of diazabicyclo[4.1.0]hepta-2,4,6-triene N-oxide and diazacycloheptatetraene N-oxide inter

127 Thus, the all-cis 1,5,9-triene natural product was prepared in 15 steps from com

128 The formation of triene occurs only in the presence of ArB(OH)2.

129 DCBCN to 9,9-dicyanobicyclo[4.2.1]nona-2,4,7-triene occurs with a preferred stereochemistry correspon

130 sahexaenoate backbone and sulfido-conjugated triene or tetraene double-bond systems.

131 acid core component, a cyclohexane ring, two triene polyketide chains, and a 2-amino-3-hydroxycyclope

132 ate cyclohexane ring formation from an 1,3,6-triene precursor during forazoline A biosynthesis, as co

133 The conjugated triene present in alpha-eleostearic acid constitutes an

134 With an excess of H2O, a triene product is selectively formed via allenic C-H act

135 energies than those involving (Z)-hexa-1,3,5-triene reacting with either s-cis- or s-trans-buta-1,3-d

136 on-10 alcohol and geometry of the conjugated triene, required for bioactivity remained to be assigned

137 +pi4s] cycloadditions with cyclic dienes and trienes, respectively, to generate novel bridged azabicy

138 analogue lacking the entire C12-C18 (Z,Z,E)-triene segment, which were used to define the magnitude

139 n tail that harbors two conjugated all-trans trienes separated by a stereogenic hydroxyl group.

140 Synthesis of the C(15)-C(25) skipped triene side chain fragment makes use of a [2,3]-Wittig-S

141 The C45-C48 segment of the eventual triene side chain was introduced by addition of a functi

142 e reactivity of the unique 4,9,11 conjugated triene structure of trenbolone.

143 ta-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene (STX140), a bis-sulfamate derivative of the endog

144 Olefin metathesis of the triene substrate 12 afforded the product diene macrolide

145 e is demonstrated in the direct synthesis of triene substrates for silicon-tethered intramolecular Di

146 dified Julia protocol to elaborate the E,E,E-triene subunit in a stereo-controlled fashion, (d) an ef

147 pling) for the construction of the vitamin D triene system was found convenient for the target compou

148 The triene system was introduced by the Pd-catalyzed tandem

149 (7 and 8) with an unprecedented non-natural triene system were synthesized by thermal isomerization

150 ll as the parent vitamin with the "reversed" triene system, 9-methylene-19-nor-1alpha,25-(OH)2D3, wer

151 f 1,25(OH)(2)D(3) at its side-chain, A-ring, triene system, or C-ring, alone and in combination, as w

152 he B-ring opening, leading to the conjugated triene system.

153 oximation of an intact vitamin D conjugated triene system.

154 hed either to the aromatic nucleus or to the triene system.

155 earomatization and on the replacement of the triene tail of the natural product by an aromatic ring.

156 etraazabicyclo[9.3.1]-pentadeca-1(15),11,13 -triene (Tb-PCTMB) has also been shown to exhibit strongl

157 bstituted, pi-conjugated polycyanohexa-1,3,5-trienes (TCHTs and PCHTs) and polycyanoocta-1,3,5,7-tetr

158 ad to derivatives of (Z,Z,E)-cyclodeca-1,3,7-triene that are stable to Cope rearrangement, and reacti

159 pai electrocyclization of highly substituted trienes that are resistant to thermal cyclization.

160 cycloaddition of tethered diynes with cyclic trienes that generates five rings and six stereogenic ce

161 roxy diastereomers with all-trans-conjugated trienes that incorporated (18)O from H(2)(18)O at C-8, i

162 trocyclizations of chiral 1-azahexa-1E,3Z,5E-trienes that yield functionalized dihydropyridines.

163 e characteristic chromophore of a conjugated triene, the other with a chromophore characteristic of a

164 ective installation of the sensitive (Z,Z,E)-triene through a beta-chelation-controlled nucleophilic

165 [4-(trimethylamino)phenyl]-6-phenyhexa-1,3,5-triene (TMA-DPH), which probes the upper region of the b

166 4-(trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene (TMA-DPH).

167 esis (RC-RO-RC-CM) occurred with a hydantoin triene to give a bicyclic hydantoin dimer in high yield.

168 d concentrations and 22% had a high ratio of triene to tetraene.

169 24 mol %, CH2Cl2, reflux) give the cage-like trienes trans- Fe(CO)3(P((CH2)mCH horizontal lineCH(CH2)

170 ular diene cyclozirconation of the resulting triene under equilibrating conditions led to the tricycl

171 pai electrocyclization, wherein a conjugated triene undergoes a concerted stereospecific cycloisomeri

172 gle-step installation of the sensitive Z,Z,E-triene unit through a chelation-controlled cuprate addit

173 ective monoepoxidation of conjugated di- and trienes using 30% H2O2 at or below room temperature.

174 Boland semireduction, to create the (E,E,Z)-triene via an (E,E)-ynediene, and a selective deprotecti

175 room temperature provided highly substituted trienes via an allylic ring opening followed by decarbox

176 e IMDA reaction of the camphanate-containing triene were obtained from density functional theory calc

177 The requisite starting trienes were prepared stereoselectively in just three st

178 out 50 kcal/mol lower than norborna-1(7),2,5-triene, which was thus excluded as a reaction intermedia

179 nvolves the formation of 1,4-diazahexa-1,3,5-trienes, which rapidly cyclize to 2,2-diaryl-1-sulfonyl-

180 as used as the key transformation to prepare trienes with a carboxamide substituent on the tether.

181 vinyl borate ester, possessing the all-trans triene, with an advanced C(1-19) vinyl iodide followed b

182 ylpyridines are converted to ring-opened aza-triene Zincke ketone structures, followed by simple trea